Composition or kit for making a prognosis of liver cancer, and method for making a prognosis of liver cancer

ABSTRACT

The present disclosure provides a marker for predicting prognosis of liver cancer, a composition or kit for predicting prognosis of liver cancer, preferably, a composition or kit for predicting prognosis of liver cancer for predicting the prognosis according to the stage of liver cancer. The marker, composition or kit, and method of the present disclosure make it possible to effectively predict prognosis of liver cancer, preferably, prognosis of liver cancer according to stage.

TECHNICAL FIELD

The present disclosure relates to a biomarker for predicting prognosisof liver cancer. More particularly, the present disclosure relates to acomposition or kit for predicting prognosis of liver cancer, and amethod for predicting prognosis of liver cancer.

BACKGROUND ART

Liver cancer is known as one of the most fatal cancers in the world. Inparticular, it is reported that at least about five hundred thousandpeople die of liver cancer every year in Asia and in Sub-Saharan Africa.Liver cancer can be largely classified into hepatocellular carcinomawhich arises from the liver cell itself, and metastatic liver cancerwhich is cancer from other tissues spread to the liver. About 90% ofliver cancer is hepatocellular carcinoma, and the term liver cancer isgenerally understood to refer to hepatocellular carcinoma.

Prognosis of liver cancer refers to anticipating various conditions ofthe patient suffering from liver cancer such as possibility of fullrecovery from liver cancer, possibility of recurrence after treatment,possibility of survival of patient after being diagnosed of livercancer, etc. This may vary depending on various conditions such asseverity of the disease, diagnosis point, treatment progress, etc. Livercancer can be treated efficiently only when various treatment methodsare properly applied according to its prognosis. For example, withregard to patients who are estimated to have good prognosis, it would benecessary to avoid dangerous treatment methods which have a possibilityto cause severe side effects to the patients such as aggressive chemicaltreatment or operations, radiation treatment, and select treatmentmethods which are relatively moderate, conservative and safe. On theother hand, with regard to patients who are estimated to have badprognosis, chemical treatment or operations, treatment methods such asradiation treatment should be actively conducted in an attempt toincrease the survival period or rate.

According to researchers conducted until now, the prognosis of livercancer that has already progressed is extremely bad, and shows a highfatal rate of dying within 6 months from diagnosis, which leaves anaverage duration of life of only 4 months. However, liver cancer havinga size of less than 3 cm has good prognosis, and is known to have asurvival rate of 90% for a year without any particular treatment andafter surgery, the survival rate of five years is about 40˜50%. However,it is very difficult to estimate the prognosis of liver cancer patientsprecisely with prior art technology. In order to estimate prognosisaccurately, an analysis method which classifies patients into each riskgroup is required. However, until now, prognosis has been determineddepending only on the clinical pathological liver cancer stage at thetime of diagnosis and primary surgical treatment without a means foraccurately estimating prognosis of liver cancer.

The conventional analysis methods include the BCLC (Barcelona-ClinicLiver Cancer) staging system. Said system is a system for classifyingliver cancer patients to determine a treatment method (liver resection,liver transplantation or radiofrequency ablation, etc. according to thestage of the disease) by determining the stage of a patient's livercancer before conducting surgery on the patient (Llovert J M, Bru C,Bruix J. Prognosis of hepatocellular carcinoma: the BCLC stagingclassification. Semin Liver Dis. 1999; 19(3):329-338).

However, unfortunately, the prognosis of each liver cancer patientcannot be precisely determined by the liver cancer stage alone. Thus, itis necessary to develop a technology using gene markers to predictprognosis of liver cancer patients accurately. That is, by selectingpatients expected to respond well to a specific treatment method (forexample, liver resection) based on the stage and the prognosis result ofeach individual patient and providing the treatment to the patients, theoverall treatment outcomes of liver cancer patients can be improved, andsocioeconomic effects such as saving medical cost can be expected.

Meanwhile, with regard to UVRAG, NAMPT, STAT3, CIAP2, BHLHE41, MMP2,SESN2, HMGB1, SIRT1, RPS19BP1, LAMP2, AGER, SESN3, ID2, TCF3, HMGB2,TP63, RAGE, KIAA1967, SATB1, RAPTOR, SESN1, CCNG2, CDH1, FASLG, CASP3,BECN1, CDH2, TWIST1, MMP9, VEGF, ATG12, DIABLO, E2F1, LAMP1, LC3, ATG7,TKT, AIFM1, BNIP3, ATG3, DRAM, ATG5, NNMT, PRKAA1, CASP8, ULK1, BCL2L1,FAS, CSE1L, FRAP1, AKT1, BAX, BCL2, PTEN, CBS, XIAP proteins, it is notknown how their expression level or expression pattern in liver cancertissues changes according to the stage of liver cancer and how they canbe used for predicting prognosis of liver cancer according to stage.Although there have been cases using the above proteins or some of thegenes encoding the above proteins as a marker for prognosis of livercancer, there has not been a case using them as a marker for prognosisof liver cancer according to stage.

As a result of conducting a research on predicting prognosis of livercancer, the present inventors found genes whose expression level andexpression pattern vary significantly (according to the stage of livercancer), and completed the present disclosure.

DETAILED DESCRIPTION Technical Subject

A technical subject matter to be solved by the present disclosure is toprovide a biomarker for predicting prognosis of liver cancer which iscapable of predicting prognosis (according to the stage of the cancer).

Another technical subject matter to be solved by the present disclosureis to provide a composition or kit for predicting prognosis of livercancer which is capable of predicting prognosis (according to the stageof the cancer).

Yet another technical subject matter to be solved by the presentdisclosure is to provide a method for predicting prognosis of livercancer which allows to predict prognosis (according to the stage of thecancer).

Means for Achieving the Subject Matter

The present disclosure provides a biomarker for predicting prognosis ofliver cancer, preferably, a biomarker for predicting prognosis of livercancer according to stage, which is at least one selected from the genesdescribed in the following Table 1 and proteins encoded by the genes.

TABLE 1 Indication of SEQ ID gene Gene name Transcriptome NCBI GI No.UVRAG UV radiation resistance-associated gene protein NM_003369.3111160877 1 NAMPT nicotinamide phosphoribosyltransferase NM_005746.2111161293 2 STAT3 Signal transducer and activator of transcription 3NM_003150.3 47080105 3 CIAP2 baculoviral IAP repeat-containing 3NM_001165.3 33946283 4 BHLHE41 basic helix-loop-helix family, member e41NM_030762.2 209529713 5 MMP2 matrix metallopeptidase 2 NM_004530.4189217851 6 SESN2 Sestrin-2 NM_031459.3 32454742 7 HMGB1 high-mobilitygroup box 1 NM_002128.4 118918424 8 SIRT1 sirtuin 1 NM_012238.4215982795 9 RPS19BP1 ribosomal protein S19 binding protein 1 NM_194326.255775474 10 LAMP2 lysosomal-associated membrane protein 2 NM_002294.2169790830 11 AGER advanced glycosylation end product-specific receptorNM_001136.3 26787960 12 SESN3 Sestrin-3. NM_144665.2 31377590 13 ID2inhibitor of DNA binding 2 NM_002166.4 33946335 14 TCF3 transcriptionfactor 3 NM_003200.2 209915592 15 HMGB2 high-mobility group box 2NM_002129.3 194688131 16 TP63 Tumor protein 63 NM_003722.4 169234655 17RAGE renal tumor antigen NM_014226.1 7657497 18 KIAA1967 Deleted inbreast cancer gene 1 protein NM_021174.4 40548406 19 SATB1 SATB homeobox1 NM_002971.3 196114979 20 RAPTOR Regulatory-associated protein of mTORNM_020761.2 92373520 21 SESN1 Sestrin-1 NM_014454.1 7657436 22 CCNG2Cyclin-G2 NM_004354.2 187608552 23 CDH1 cadherin 1, type 1, E-cadherinNM_004360.3 169790842 24 FASLG Fas ligand (TNF superfamily, member 6)NM_000639.1 4557328 25 CASP3 caspase 3, apoptosis-related cysteinepeptidase NM_004346.3 73622121 26 BECN1 beclin 1, autophagy relatedNM_003766.3 187608304 27 CDH2 cadherin 2, type 1, N-cadherin NM_001792.3215422305 28 TWIST1 twist homolog 1 NM_000474.3 68160957 29 MMP9 matrixmetallopeptidase 9 NM_004994.2 74272286 30 VEGF vascular endothelialgrowth factor A NM_003376.4 71051577 31 ATG12 ATG12 autophagy related 12homolog NM_004707.2 38261968 32 DIABLO Diablo homolog, mitochondrialNM_019887.4 218505810 33 E2F1 E2F transcription factor 1 NM_005225.2168480109 34 LAMP1 Lysosome-associated membrane glycoprotein 1NM_005561.3 112380627 35 LC3 microtubule-associated protein 1 lightchain 3 alpha NM_032514.2 31563519 36 ATG7 ATG7 autophagy related 7homolog NM_006395.1 5453667 37 TKT transketolase NM_001064.2 20527746138 AIFM1 apoptosis-inducing factor, mitochondrion-associated, 1NM_004208.2 22202627 39 BNIP3 BCL2/adenovirus E1B 19 kDa interactingprotein 3 NM_004052.2 7669480 40 ATG3 ATG3 autophagy related 3 homologNM_022488.3 34147490 41 DRAM DNA-damage regulated autophagy modulator 1NM_018370.2 110825977 42 ATG5 ATG5 autophagy related 5 homologNM_004849.2 92859692 43 NNMT nicotinamide N-methyltransferaseNM_006169.2 62953139 44 PRKAA1 protein kinase, AMP-activated, alpha 1catalytic subunit NM_006251.5 94557300 45 CASP8 caspase 8,apoptosis-related cysteine peptidase NM_001228.4 122056470 46 ULK1unc-51-like kinase 1 NM_003565.1 4507830 47 BCL2L1 BCL2-like 1NM_001191.2 20336333 48 FAS Fas (TNF receptor superfamily, member 6)NM_000043.3 23510419 49 CSE1L CSE1 chromosome segregation 1-likeNM_001316.2 29029558 50 FRAP1 mechanistic target of rapamycin(serine/threonine kinase) NM_004958.3 206725550 51 AKT1 v-akt murinethymoma viral oncogene homolog 1 NM_005163.2 62241010 52 BAXBCL2-associated X protein NM_004324.3 34335114 53 BCL2 B-cellCLL/lymphoma 2 NM_000633.2 72198188 54 PTEN phosphatase and tensinhomolog NM_000314.4 110224474 55 CBS cystathionine beta-synthaseNM_000071.2 209862802 56 XIAP X-linked inhibitor of apoptosisNM_001167.2 32528298 57

In the above table, NCBI GI (Geninfo Identifier) refers to a sequenceidentification number given by the National Center for BiotechnologyInformation (NCBI), U.S.A., which consists of accession number andversion number.

In the present disclosure, the “liver cancer” includes hepatocellularcarcinoma, which arises from liver cells themselves, and metastaticliver cancer, which is a cancer from other tissues spread to the liver.Preferably, the “liver cancer” refers to hepatocellular carcinoma.

In the present disclosure, the “marker for predicting prognosis of livercancer” means a gene marker as a criterion for predicting prognosis ofliver cancer after occurrence the disease. This maker has asignificantly low p-value, when the p-value is calculated based on thedifference in its expression in the liver cancer cell and/or tissue ofpatients with different prognosis. Preferably, the p-value of thismarker is less than 0.05.

Also, the present disclosure provides a composition or kit forpredicting prognosis of liver cancer comprising nucleic acids which arespecific to each of one or at least two genes selected from the groupdescribed in the above Table 1, or antibodies which are specific toproteins encoded by said genes, and for predicting prognosis of liveraccording to stage in one or more groups selected from A1 group {a groupof portal vein invasion-negative patients in stage 0 or A of BCLC(Barcelona-Clinic Liver Cancer) staging system, having one tumor whichis 5 cm or less in size, or 3 or less tumors which are 3 cm or less insize}, A2 group {a group of portal vein invasion-negative patients,having a tumor which is more than 5 cm in size}, B group {a group ofportal vein invasion-negative patients in intermediate stage of BCLCstaging system, having plural tumors which are more than 3 cm in size orplural tumors which are more than 3 in number}, or C group {a group ofportal vein invasion-positive patients regardless of tumors size andnumber}.

The at least two genes may be at least three, four, five, six, seven oreight or more genes.

Preferably, the group consisting of genes may be a group consisting ofthe genes described in the following Table 2.

TABLE 2 Indication of SEQ ID gene Gene name Transcriptome NCBI GI No.UVRAG UV radiation resistance-associated gene protein NM_003369.3111160877 1 NAMPT nicotinamide phosphoribosyltransferase NM_005746.2111161293 2 STAT3 Signal transducer and activator of transcription 3NM_003150.3 47080105 3 CIAP2 baculoviral IAP repeat-containing 3NM_001165.3 33946283 4 BHLHE41 basic helix-loop-helix family, member e41NM_030762.2 209529713 5 MMP2 matrix metallopeptidase 2 NM_004530.4189217851 6 SESN2 Sestrin-2 NM_031459.3 32454742 7 HMGB1 high-mobilitygroup box 1 NM_002128.4 118918424 8 SIRT1 sirtuin 1 NM_012238.4215982795 9 RPS19BP1 ribosomal protein S19 binding protein 1 NM_194326.255775474 10 LAMP2 lysosomal-associated membrane protein 2 NM_002294.2169790830 11 AGER advanced glycosylation end product-specific receptorNM_001136.3 26787960 12 SESN3 Sestrin-3. NM_144665.2 31377590 13 ID2inhibitor of DNA binding 2 NM_002166.4 33946335 14 TCF3 transcriptionfactor 3 NM_003200.2 209915592 15 HMGB2 high-mobility group box 2NM_002129.3 194688131 16 TP63 Tumor protein 63 NM_003722.4 169234655 17RAGE renal tumor antigen NM_014226.1 7657497 18 KIAA1967 Deleted inbreast cancer gene 1 protein NM_021174.4 40548406 19 SATB1 SATB homeobox1 NM_002971.3 196114979 20 RAPTOR Regulatory-associated protein of mTORNM_020761.2 92373520 21 SESN1 Sestrin-1 NM_014454.1 7657436 22 CCNG2Cyclin-G2 NM_004354.2 187608552 23 CDH1 cadherin 1, type 1, E-cadherinNM_004360.3 169790842 24 FASLG Fas ligand (TNF superfamily, member 6)NM_000639.1 4557328 25 CASP3 caspase 3, apoptosis-related cysteinepeptidase NM_004346.3 73622121 26 BECN1 beclin 1, autophagy relatedNM_003766.3 187608304 27 CDH2 cadherin 2, type 1, N-cadherin NM_001792.3215422305 28 TWIST1 twist homolog 1 NM_000474.3 68160957 29 MMP9 matrixmetallopeptidase 9 NM_004994.2 74272286 30 VEGF vascular endothelialgrowth factor A NM_003376.4 71051577 31

More preferably, the group consisting of genes may further comprise thegenes described in the following Table 3.

TABLE 3 Indication of SEQ ID gene Gene name Transcriptome NCBI GI No.ATG12 ATG12 autophagy related 12 homolog NM_004707.2 38261968 32 DIABLODiablo homolog, mitochondrial NM_019887.4 218505810 33 E2F1 E2Ftranscription factor 1 NM_005225.2 168480109 34 LAMP1Lysosome-associated membrane glycoprotein 1 NM_005561.3 112380627 35 LC3microtubule-associated protein 1 light chain 3 alpha NM_032514.231563519 36 ATG7 ATG7 autophagy related 7 homolog NM_006395.1 5453667 37TKT transketolase NM_001064.2 205277461 38 AIFM1 apoptosis-inducingfactor, mitochondrion-associated, 1 NM_004208.2 22202627 39 BNIP3BCL2/adenovirus E1B 19 kDa interacting protein 3 NM_004052.2 7669480 40ATG3 ATG3 autophagy related 3 homolog NM_022488.3 34147490 41 DRAMDNA-damage regulated autophagy modulator 1 NM_018370.2 110825977 42 ATG5ATG5 autophagy related 5 homolog NM_004849.2 92859692 43 NNMTnicotinamide N-methyltransferase NM_006169.2 62953139 44 PRKAA1 proteinkinase, AMP-activated, alpha 1 catalytic subunit NM_006251.5 94557300 45CASP8 caspase 8, apoptosis-related cysteine peptidase NM_001228.4122056470 46 ULK1 unc-51-like kinase 1 NM_003565.1 4507830 47 BCL2L1BCL2-like 1 NM_001191.2 20336333 48 FAS Fas (TNF receptor superfamily,member 6) NM_000043.3 23510419 49 CSE1L CSE1 chromosome segregation1-like NM_001316.2 29029558 50 FRAP1 mechanistic target of rapamycin(serine/threonine kinase) NM_004958.3 206725550 51 AKT1 v-akt murinethymoma viral oncogene homolog 1 NM_005163.2 62241010 52 BAXBCL2-associated X protein NM_004324.3 34335114 53 BCL2 B-cellCLL/lymphoma 2 NM_000633.2 72198188 54 PTEN phosphatase and tensinhomolog NM_000314.4 110224474 55 CBS cystathionine beta-synthaseNM_000071.2 209862802 56 XIAP X-linked inhibitor of apoptosisNM_001167.2 32528298 57

Among the genes described in the above Table 2, CDH1, ID2, MMP9, TCF3may be excluded from Table 2, and may be further included in the groupof the genes of Table 3.

The BCLC classification, which is the classification used in FIG. 1, isa system for classifying liver cancer patients to determine thetreatment method (liver resection, liver transplantation orradiofrequency ablation, etc. according to stage) by determining thestage of the disease before conducting surgery on liver cancer patients(see Llovert J M, Bru C, Bruix J. Prognosis of hepatocellular carcinoma:the BCLC staging classification. Semin Liver Dis. 1999; 19(3): 329-338).In FIG. 1, the performance status test (PST) is classified into steps 0to 4. Step 0 means the case where there is no problem in performance;step 1 means the case where the patient can perform light work; step 2means the case where the patient cannot perform work, but can take careof himself; step 3 means the step where the patient can take care ofhimself limitedly, and spend at least 50% of everyday life in bed or ona chair; and step 4 means the case where the patient cannot performactivity at all, cannot take care of himself, and stays in bed or on achair all day. In Okuda stage, stages are determined based on fourcriteria, and the stages are classified as stages I, II, III based onwhether the size of cancer is larger or smaller than 50% of the entireliver; whether there is ascites; and the numerical values for bilirubin(< or >3 mg/dL), and albumin (< or >3 g/dL). Child-Pugh step is an indexevaluating the liver function of patients suffering hepatocirrhosis. Thealbumin value (>3.5 g·dL: 1 point; 2.8-3.5 g/dL: 2 points; <2.8 g/dL: 3points), bilirubin value (<2.0 mg/dL: 1 point; 2.0-3.0 mg/dL: 2points; >3.0 mg/dL: 3 points), prothrombin time value (>50%: 1 point;4050%: 2 points; <40%: 3 points), presence of ascites (none: 1 point;slight: 2 points; moderate: 3 points), encephalopathy step (none: 1point; uncertain temper change, depression, tremor, drowsiness,inarticulate and slow in speech, asterixis, difficulty in walking: 2points; muscle stiffness, loss of orientation, confusion, intermittentmuscle cramp, nystagmus, coma, dilatation of pupil, decerebrate pose: 3points), etc. are evaluated. 6 points or below are classified as classA, 7-9 points are classified as class B, and 10 points or higher areclassified as class C.

The above prognosis can be predicting of recurrence, survival, ordisease-free survival, and can be a prognosis after liver resection forcancer. The “recurrence” means recurrence of liver cancer in those whosurvived after liver resection for cancer. The “survival” means thesurvival rate of five years after liver resection for cancer. Thedisease-free survival means surviving without recurrence after goingthrough liver resection for cancer.

Preferably, the composition or kit is for predicting prognosis ofrecurrence of the A1 group, and the genes are one or more selected fromthe genes or groups of genes described in the following Table 4.

TABLE 4 One type Combinations of two types Combinations of three typesCombinations of four types BCL2L1 FRAP1_SESN1 FRAP1_CASP3_CDH2ID2_NAMPT_RPS19BP1_SESN3 BECN1 FRAP1_TWIST1 ID2_CDH2_SESN3FRAP1_LC3_CASP3_CDH2 BAX FRAP1_CASP3 FRAP1_CDH2_SESN1FRAP1_TKT_CASP3_CDH2 CDH2 FRAP1_CCNG2 FRAP1_LC3_CASP3 BAX_FRAP1_LC3_CDH2NAMPT BAX_FRAP1 FRAP1_LC3_TWIST1 ID2_CDH2_NAMPT_SESN3 TWIST1 FRAP1_NNMTBAX_FRAP1_LC3 CBS_ID2_CDH2_SESN3 RPS19BP1 BCL2L1_FRAP1 FRAP1_CDH2_TWIST1FRAP1_LC3_CDH2_KIAA1967 MMP2 AIFM1_FRAP1 FRAP1_NNMT_CDH2FRAP1_CDH2_SESN1_STAT3 SESN3 FRAP1_RAGE FRAP1_LC3_NNMTFRAP1_LC3_NNMT_CDH2 ID2 FRAP1_VEGF BAX_FRAP1_CDH2 FRAP1_LC3_CDH2_RAPTORAGER ID2_CDH2 FRAP1_SESN1_STAT3 ID2_CDH2_RPS19BP1_SESN3 ATG12 FRAP1_PTENAIFM1_FRAP1_CDH2 FRAP1_LC3_CDH2_TWIST1 NAMPT_SESN3 FRAP1_LC3_VEGFFRAP1_LC3_CDH2_VEGF BCL2_FRAP1 FRAP1_NNMT_MMP2 FRAP1_LC3_SESN1_STAT3CDH2_SESN3 FRAP1_LC3_RAGE FRAP1_LC3_CDH2_RAGE FRAP1_RAPTORFRAP1_CCNG2_CDH2 FRAP1_LC3_NNMT_STAT3 FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2ID2_CDH2_MMP2_SESN3 FRAP1_XIAP FRAP1_CDH2_VEGF FRAP1_LC3_CASP3_STAT3BECN1_SESN3 FRAP1_LC3_CCNG2 AIFM1_FRAP1_LC3_CDH2 HMGB1_TWIST1FRAP1_CASP3_MMP2 BCL2L1_FRAP1_LC3_CDH2 ID2_NAMPT BCL2L1_FRAP1_LC3FRAP1_LC3_PTEN_CDH2 FRAP1_PRKAA1 FRAP1_LC3_SESN1 BAX_FRAP1_LC3_BECN1ID2_RPS19BP1 FRAP1_CDH2_KIAA1967 BAX_FRAP1_LC3_RPS19BP1 BAX_LC3AIFM1_FRAP1_LC3 FRAP1_CASP3_CDH2_STAT3 FRAP1_TP63 FRAP1_LC3_RAPTORLC3_HMGB1_STAT3_TWIST1 ATG12_SESN3 FRAP1_CDH2_RAGE BAX_FRAP1_TKT_CDH2BAX_TWIST1 BAX_FRAP1_MMP2 FRAP1_LC3_CCNG2_CDH2 RPS19BP1_SESN3FRAP1_LC3_PTEN FRAP1_TKT_CDH2_SESN1 BAX_MMP2 FRAP1_TKT_CASP3FRAP1_LC3_HMGB1_TWIST1 SESN1_STAT3 FRAP1_PTEN_CDH2 FRAP1_NNMT_TKT_CDH2LC3_TWIST1 FRAP1_TKT_TWIST1 BAX_FRAP1_LC3_MMP2 MMP2_NAMPTFRAP1_LC3_KIAA1967 FRAP1_LC3_CCNG2_STAT3 ID2_BECN1 BAX_FRAP1_TKTFRAP1_LC3_STAT3_TWIST1 BCL2L1_LC3 BCL2_FRAP1_CDH2 FRAP1_TKT_CDH2_TWIST1MMP2_RPS19BP1 FRAP1_HMGB1_TWIST1 FRAP1_LC3_NNMT_MMP2 ATG7_BCL2L1FRAP1_RPS19BP1_TWIST1 BAX_FRAP1_TKT_MMP2 ID2_TWIST1 FRAP1_CDH2_RAPTORFRAP1_NNMT_CDH2_MMP2 CDH2_HMGB1 FRAP1_TKT_SESN1 FRAP1_LC3_CDH2_SESN1CDH2_MMP2 FRAP1_RPS19BP1_SESN1 BAX_FRAP1_LC3_TKT ATG7_TWIST1BAX_FRAP1_BECN1 FAS_FRAP1_CDH2_SESN1 BAX_SESN3 ID2_NAMPT_SESN3BAX_FAS_FRAP1_LC3 FASLG_NAMPT FRAP1_CCNG2_STAT3 FRAP1_CASP3_CDH2_MMP2ATG7_BAX BCL2L1_FRAP1_MMP2 ID2_FASLG_NAMPT_SESN3 TKT_NAMPTBCL2_FRAP1_LC3 FRAP1_ID2_CDH2_TWIST1 STAT3_TWIST1 FASLG_NAMPT_SESN3FRAP1_CDH2_HMGB1_TWIST1 BCL2L1_MMP2 AIFM1_FRAP1_MMP2BAX_FRAP1_BECN1_CDH2 LC3_KIAA1967 FRAP1_CCNG2_RPS19BP1DRAM_ID2_CDH2_SESN3 BAX_BECN1 BAX_FRAP1_RPS19BP1FRAP1_LC3_RPS19BP1_TWIST1 ATG12_ID2 FAS_FRAP1_SESN1 AIFM1_FRAP1_TKT_CDH2BECN1_MMP2 BCL2L1_FRAP1_TKT FRAP1_TKT_CCNG2_CDH2 AKT1_BAXFRAP1_NNMT_STAT3 BCL2L1_FRAP1_TKT_CDH2 LC3_RAPTOR FRAP1_MMP2_SESN1DIABLO_ID2_CDH2_SESN3 BAX_RPS19BP1 FRAP1_ID2_TWIST1 BCL2_FRAP1_LC3_CDH2BAX_TKT FRAP1_CASP3_STAT3 FRAP1_LC3_CASP3_FASLG BAX_SATB1FRAP1_TKT_CCNG2 FRAP1_CDH2_RPS19BP1_SESN1 LC3_NAMPT FRAP1_MMP2_VEGFFRAP1_LC3_CASP3_MMP2 KIAA1967_MMP2 FRAP1_MMP2_RAPTORID2_CDH2_HMGB2_SESN3 CDH1_ID2_MMP9_TCF3 Combinations of five typesCombinations of six types FRAP1_LC3_CASP3_CDH2_STAT3FRAP1_LC3_BECN1_CASP3_CDH2_STAT3 ID2_MMP2_NAMPT_RPS19BP1_SESN3FRAP1_LC3_NNMT_BECN1_CDH2_STAT3 FRAP1_LC3_CDH2_SESN1_STAT3FRAP1_LC3_TKT_CASP3_CDH2_STAT3 ID2_CDH2_MMP2_RPS19BP1_SESN3ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3 FRAP1_LC3_NNMT_CDH2_STAT3FAS_FRAP1_LC3_CDH2_SESN1_STAT3 BAX_FRAP1_LC3_BECN1_CDH2ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3 ID2_FASLG_NAMPT_RPS19BP1_SESN3FRAP1_LC3_CASP3_CDH2_HMGB1_STAT3 BAX_FRAP1_LC3_TKT_CDH2FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 FRAP1_LC3_BECN1_CDH2_RAPTORFRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 FRAP1_LC3_CDH2_STAT3_TWIST1FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1 FRAP1_LC3_CCNG2_CDH2_STAT3ID2_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3 ID2_CDH2_FASLG_NAMPT_SESN3AIFM1_FRAP1_LC3_BECN1_CDH2_STAT3 LC3_CDH2_HMGB1_STAT3_TWIST1ID2_MMP2_NAMPT_RPS19BP1_SESN3_STAT3 ID2_CDH2_HMGB1_RPS19BP1_SESN3ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3 ID2_CDH2_MMP2_NAMPT_SESN3AKT1_FAS_BECN1_CDH2_STAT3_TP63 FRAP1_LC3_BECN1_CDH2_KIAA1967FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3 BAX_FRAP1_LC3_CDH2_RPS19BP1AKT1_ATG12_BECN1_CDH2_STAT3_TP63 ID2_HMGB2_NAMPT_RPS19BP1_SESN3FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 ID2_NAMPT_RPS19BP1_SESN3_STAT3CSE1L_FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_LC3_CDH2_HMGB1_TWIST1FRAP1_LC3_BECN1_CDH2_RAGE_STAT3 FRAP1_TKT_CDH2_SESN1_STAT3FAS_FRAP1_LC3_NNMT_CDH2_STAT3 CSE1L_ID2_CDH2_RPS19BP1_SESN3ID2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_CASP3_CDH2FRAP1_LC3_TKT_CDH2_SESN1_STAT3 BAX_FAS_FRAP1_LC3_CDH2FRAP1_LC3_NNMT_CDH2_MMP2_STAT3 FAS_FRAP1_LC3_CDH2_RAPTORFRAP1_LC3_NNMT_TKT_CDH2_STAT3 LC3_CASP3_CDH2_HMGB1_STAT3BAX_FRAP1_LC3_BECN1_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_KIAA1967FRAP1_LC3_CASP3_CDH2_SIRT1_STAT3 AIFM1_FRAP1_LC3_CDH2_STAT3FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1 FRAP1_LC3_BECN1_CASP3_STAT3CBS_FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_BECN1_CASP3_CDH2_STAT3FAS_FRAP1_LC3_CASP3_CDH2_STAT3 ID2_CDH2_NAMPT_SESN3_STAT3AKT1_ATG12_FAS_CDH2_STAT3_TP63 LC3_ID2_NAMPT_RPS19BP1_SESN3LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 FRAP1_LC3_NNMT_MMP2_STAT3FRAP1_LC3_BECN1_CDH2_STAT3_TWIST1 BAX_FRAP1_LC3_CASP3_CDH2FRAP1_LC3_CASP3_CDH2_MMP2_STAT3 FRAP1_TKT_CASP3_CDH2_STAT3ID2_MMP9_MMP2_NAMPT_RPS19BP1_SESN3 LC3_HMGB1_RPS19BP1_STAT3_TWIST1CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3 FRAP1_CDH2_RPS19BP1_SESN1_STAT3FRAP1_LC3_BECN1_CDH2_STAT3_VEGF CBS_FRAP1_LC3_CASP3_CDH2BAX_FRAP1_LC3_TKT_BECN1_CDH2 FRAP1_LAMP1_TKT_CASP3_CDH2FRAP1_LC3_NNMT_CASP3_CDH2_STAT3 ID2_CDH2_HMGB1_NAMPT_SESN3FRAP1_TKT_BECN1_CASP3_CDH2_STAT3 ID2_HMGB1_NAMPT_RPS19BP1_SESN3ID2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_ID2_NAMPT_RPS19BP1_SESN3FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1 FRAP1_LC3_TKT_CDH2_KIAA1967FRAP1_LC3_BECN1_CDH2_SESN1_STAT3 FRAP1_LC3_CASP3_CDH2_HMGB1ID2_CDH2_FASLG_NAMPT_SESN3_STAT3 ATG7_FRAP1_LC3_CASP3_CDH2FRAP1_LC3_TKT_CDH2_STAT3_TWIST1 BAX_FRAP1_LC3_TKT_MMP2ATG5_FRAP1_LC3_CASP3_CDH2_STAT3 FRAP1_LC3_CDH2_RAPTOR_RPS19BP1ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3 FRAP1_LC3_RPS19BP1_SESN1_STAT3FAS_LC3_CDH2_HMGB1_STAT3_TWIST1 BAX_FRAP1_LC3_CDH2_MMP2AIFM1_FRAP1_LC3_TKT_CDH2_STAT3 ID2_TCF3_CDH2_RPS19BP1_SESN3FRAP1_LC3_TKT_CASP3_CDH2_FASLG FRAP1_TKT_CASP3_CDH2_FASLGDRAM_ID2_MMP2_NAMPT_RPS19BP1_SESN3 FAS_FRAP1_CDH2_SESN1_STAT3FRAP1_LC3_CASP3_CDH2_NAMPT_STAT3 CBS_ID2_NAMPT_RPS19BP1_SESN3FAS_FRAP1_LC3_CCNG2_CDH2_STAT3 FRAP1_LC3_CDH2_KIAA1967_MMP2BAX_FAS_FRAP1_LC3_CDH2_RPS19BP1 FAS_FRAP1_LC3_CASP3_CDH2BNIP3_FRAP1_LC3_CASP3_CDH2_STAT3 BAX_CBS_FRAP1_LC3_CDH2FRAP1_LC3_CDH2_RPS19BP1_STAT3_TWIST1 FRAP1_LC3_TKT_CDH2_RAPTORFRAP1_LC3_MMP9_CASP3_CDH2_STAT3 CDH1_ID2_MMP9_TCF3_RPS19BP1CDH1_ID2_MMP9_TCF3_RPS19BP1_SESN3 Combinations of seven typesCombinations of eight types AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63ID2_CDH2_FASLG_NAMPT_RPS19BP1_SESN3_STAT3AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63FRAP1_LC3_NNMT_TKT_BECN1_CDH2_STAT3AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3FAS_FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3FAS_FRAP1_LC3_CCNG2_CDH2_RPS19BP1_STAT3AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63FRAP1_LC3_BECN1_CASP3_CDH2_HMGB1_STAT3FRAP1_LC3_TKT_BECN1_CASP3_CDH2_FASLG_STAT3ID2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3CSE1L_FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3FRAP1_LC3_NNMT_BECN1_CASP3_CDH2_STAT3AKT1_ATG12_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63CBS_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3FAS_FRAP1_LC3_NNMT_BECN1_CDH2_RPS19BP1_STAT3FRAP1_LC3_BECN1_CASP3_CDH2_SIRT1_STAT3AKT1_CASP8_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63CSE1L_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3FRAP1_LC3_NNMT_TKT_BECN1_CDH2_FASLG_STAT3FRAP1_LC3_TKT_CASP3_CDH2_HMGB1_STAT3AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63FRAP1_LC3_TKT_CDH2_HMGB1_STAT3_TWIST1AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63ATG5_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63CSE1L_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3ID2_CDH2_FASLG_HMGB1_HMGB2_NAMPT_RPS19BP1_SESN3FRAP1_LC3_BECN1_CASP3_CDH2_HMGB2_STAT3AKT1_ATG12_FAS_BECN1_CDH2_CIAP2_STAT3_TP63AKT1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_CDH2_MMP2_RAPTOR_RPS19BP1ID2_CDH2_FASLG_HMGB2_NAMPT_RPS19BP1_SESN3_STAT3AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_STAT3AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63AKT1_FAS_BECN1_CDH2_RPS19BP1_SESN2_STAT3_TP63FAS_FRAP1_LC3_TKT_CDH2_SESN1_STAT3AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63CBS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3AKT1_LC3_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63FRAP1_LC3_BECN1_CDH2_HMGB1_STAT3_TWIST1FAS_FRAP1_LC3_CASP3_CDH2_FASLG_RPS19BP1_STAT3CSE1L_FRAP1_LC3_TKT_CASP3_CDH2_STAT3AKT1_ATG12_FAS_BECN1_CASP3_CDH2_STAT3_TP63FRAP1_LC3_NNMT_BECN1_CDH2_SIRT1_STAT3AKT1_ATG12_FAS_BECN1_CDH2_HMGB2_STAT3_TP63AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3FRAP1_LC3_TKT_CASP3_CDH2_FASLG_HMGB1_STAT3ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3_STAT3FAS_FRAP1_LC3_NNMT_CDH2_MMP2_RPS19BP1_STAT3FRAP1_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1FAS_FRAP1_LC3_BECN1_CDH2_RPS19BP1_SESN1_STAT3FAS_FRAP1_LC3_CDH2_KIAA1967_MMP2_RPS19BP1FAS_FRAP1_LC3_TKT_CDH2_RPS19BP1_SESN1_STAT3FRAP1_LC3_BECN1_CASP3_CDH2_RPS19BP1_STAT3AKT1_ATG12_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63FRAP1_LC3_TKT_CASP3_CDH2_FASLG_STAT3AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63BNIP3_FRAP1_LC3_BECN1_CASP3_CDH2_STAT3AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63FRAP1_LC3_CASP3_CDH2_HMGB1_MMP2_STAT3FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_SIRT1_STAT3FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1FAS_FRAP1_LC3_CDH2_FASLG_RPS19BP1_SESN1_STAT3ID2_HMGB1_HMGB2_MMP2_NAMPT_RPS19BP1_SESN3AKT1_FAS_NNMT_BECN1_CDH2_RPS19BP1_STAT3_TP63FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTORCSE1L_FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3FRAP1_LC3_NNMT_BECN1_CDH2_FASLG_STAT3FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR_RPS19BP1FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1AKT1_FAS_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63FRAP1_LC3_MMP9_BECN1_CASP3_CDH2_STAT3FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63_TWIST1FAS_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3FAS_FRAP1_LC3_TKT_CASP3_CDH2_RPS19BP1_STAT3AIFM1_FAS_FRAP1_LC3_CDH2_RPS19BP1_STAT3ID2_CDH2_FASLG_HMGB1_NAMPT_RPS19BP1_SESN3_STAT3AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63FAS_FRAP1_LC3_BECN1_CDH2_FASLG_RAPTOR_RPS19BP1AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63CSE1L_FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3ID2_CDH2_HMGB1_MMP2_NAMPT_RPS19BP1_SESN3FRAP1_LC3_TKT_BECN1_CASP3_CDH2_HMGB1_STAT3AKT1_BECN1_CDH2_HMGB1_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_BECN1_CCNG2_CDH2_RPS19BP1_STAT3AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63FAS_FRAP1_LC3_TKT_BECN1_CDH2_FASLG_RAPTORATG5_FRAP1_LC3_NNMT_BECN1_CDH2_STAT3AKT1_ATG12_FAS_TKT_BECN1_CDH2_STAT3_TP63FRAP1_LC3_CASP3_CDH2_HMGB1_RPS19BP1_STAT3FRAP1_LC3_BECN1_CASP3_CDH2_FASLG_HMGB1_STAT3CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3CDH1_ID2_MMP9_TCF3_CDH2_MMP2_RPS19BP1_SESN3

Preferably, the composition or kit is for predicting the prognosis ofsurvival of the A1 group, and the genes are one or more selected fromthe genes or groups of genes described in the following Table 5.

TABLE 5 One type Combinations of two types Combinations of three typesCombinations of four types ID2 CDH1_ID2 ATG12_CDH1_ID2ATG12_CDH1_ID2_HMGB2 CDH1 ATG12_CDH1 CDH1_ID2_HMGB2 CDH1_ID2_AGER_HMGB2LC3 LAMP1_ID2 ATG12_CDH1_HMGB2 ATG12_CDH1_ID2_AGER TKT BNIP3_ID2CDH1_ID2_AGER ATG12_CDH1_TCF3_HMGB2 AKT1 ATG12_ID2 DRAM_CDH1_ID2ATG12_DRAM_CDH1_ID2 AIFM1 CDH1_HMGB2 E2F1_CDH1_ID2 AIFM1_CASP8_LC3_CDH1BNIP3 ID2_HMGB2 CDH1_ID2_LAMP2 ATG12_CDH1_AGER_HMGB2 LAMP1 E2F1_ID2TKT_CDH1_ID2 ATG12_CDH1_ID2_BECN1 FRAP1 TKT_ID2 LAMP1_CDH1_ID2ATG12_DRAM_CDH1_HMGB2 DRAM_ID2 CDH1_ID2_MMP2 DRAM_CDH1_ID2_HMGB2ATG5_ID2 ATG12_DRAM_CDH1 ATG12_CDH1_BHLHE41_HMGB2 ID2_BECN1CSE1L_CDH1_ID2 CDH1_ID2_HMGB2_LAMP2 ID2_AGER CDH1_ID2_MMP9ATG12_CDH1_BECN1_HMGB2 ID2_MMP2 BNIP3_CDH1_ID2 E2F1_CDH1_ID2_HMGB2ATG3_ID2 CDH1_ID2_BECN1 ATG12_DIABLO_CDH1_BHLHE41 ID2_LAMP2ATG12_CDH1_BHLHE41 CDH1_ID2_BECN1_HMGB2 ULK1_CDH1 ULK1_CDH1_ID2ATG12_ATG5_CDH1_HMGB2 CSE1L_ID2 LC3_CDH1_ID2 DRAM_CDH1_ID2_AGER TKT_CDH1ATG12_CDH1_TCF3 LAMP1_CDH1_ID2_HMGB2 LC3_CDH1 ATG5_CDH1_ID2ATG12_BNIP3_CDH1_ID2 ID2_MMP9 ATG3_CDH1_ID2 ATG12_CSE1L_CDH1_ID2 LC3_ID2DIABLO_CDH1_ID2 ATG12_CDH1_ID2_MMP2 FRAP1_ID2 CASP8_CDH1_ID2ATG12_CASP8_CDH1_ID2 CASP8_ID2 ATG12_ULK1_CDH1 ATG12_ATG3_CDH1_HMGB2ID2_CIAP2 ATG12_CDH1_BECN1 ATG12_CDH1_ID2_MMP9 ID2_UVRAG ATG12_BNIP3_ID2CDH1_ID2_HMGB2_MMP2 DIABLO_ID2 CDH1_ID2_CIAP2 ATG12_ATG3_CDH1_ID2DRAM_CDH1 CBS_CDH1_ID2 ATG12_CASP8_CDH1_HMGB2 ID2_SIRT1 CDH1_ID2_HMGB1ATG12_LAMP1_CDH1_ID2 FAS_ID2 CDH1_ID2_SIRT1 CDH1_ID2_AGER_BECN1CDH1_AGER LAMP1_ID2_HMGB2 ATG12_FAS_CDH1_HMGB2 ID2_STAT3 CDH1_ID2_UVRAGATG12_TKT_CDH1_ID2 CBS_ID2 AIFM1_LC3_CDH1 CDH1_ID2_MMP9_HMGB2 CDH1_MMP2ATG12_CDH1_AGER ATG12_CDH1_HMGB1_HMGB2 AKT1_ID2 CDH1_ID2_STAT3ATG12_CDH1_MMP9_HMGB2 ID2_CDH2 ATG12_LAMP1_ID2 ATG12_ATG5_CDH1_ID2ATG7_ID2 ATG12_LC3_CDH1 ATG5_CDH1_ID2_HMGB2 ID2_HMGB1 CDH1_AGER_HMGB2ATG3_CDH1_ID2_HMGB2 ULK1_ID2 FAS_CDH1_ID2 ATG12_DIABLO_CDH1_ID2CDH1_LAMP2 ATG7_CDH1_ID2 CSE1L_CDH1_ID2_HMGB2 ATG5_CDH1 ATG12_CDH1_MMP2ATG12_CDH1_CIAP2_HMGB2 ID2_SATB1 ATG12_CASP8_CDH1 ATG12_CDH1_ID2_UVRAGCDH1_MMP9 ATG12_TKT_CDH1 ATG12_CDH1_HMGB2_SESN3 ID2_RPS19BP1BNIP3_ID2_HMGB2 LC3_CDH1_ID2_AGER ID2_TCF3 E2F1_ID2_HMGB2ATG12_CDH1_HMGB2_SIRT1 CSE1L_CDH1 ATG12_CDH1_MMP9 ATG12_E2F1_CDH1_ID2AIFM1_CDH1 ATG12_CDH1_SESN2 ATG12_FAS_CDH1_ID2 ID2_SESN3 CDH1_ID2_CDH2AIFM1_ATG3_LC3_CDH1 ID2_SESN2 AKT1_CDH1_ID2 ATG12_CDH1_HMGB2_MMP2LAMP1_CDH1 LAMP1_ID2_BECN1 BNIP3_CDH1_ID2_HMGB2 AIFM1_LC3 CDH1_ID2_TCF3ATG12_ULK1_CDH1_HMGB2 E2F1_CDH1 ATG12_CDH1_UVRAG TKT_CDH1_ID2_HMGB2ID2_NAMPT ATG12_FAS_CDH1 ATG12_CDH1_ID2_LAMP2 DIABLO_CDH1 LAMP1_TKT_ID2ATG12_LC3_CDH1_ID2 BNIP3_CDH1 LAMP1_ID2_AGER ATG12_CDH1_HMGB2_UVRAGAKT1_CDH1 DRAM_LAMP1_ID2 CASP8_CDH1_ID2_HMGB2 CASP8_CDH1ATG12_DIABLO_CDH1 DIABLO_CDH1_ID2_HMGB2 CDH1_ID2_MMP9_TCF3 Combinationsof five types Combinations of six types ATG12_CDH1_ID2_AGER_HMGB2ATG12_DRAM_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_HMGB2ATG12_CDH1_ID2_AGER_BECN1_HMGB2 DRAM_CDH1_ID2_AGER_HMGB2ATG12_CSE1L_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_BECN1_HMGB2ATG12_CDH1_ID2_AGER_HMGB2_RPS19BP1 ATG12_LAMP1_CDH1_ID2_HMGB2ATG12_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_ATG5_CDH1_ID2_HMGB2ATG12_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_E2F1_CDH1_ID2_HMGB2ATG12_ATG3_CDH1_ID2_AGER_HMGB2 ATG12_ATG3_CDH1_ID2_HMGB2ATG12_LC3_CDH1_ID2_AGER_HMGB2 CDH1_ID2_AGER_BECN1_HMGB2ATG12_BNIP3_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_HMGB2_MMP2ATG12_CDH1_ID2_AGER_HMGB2_SIRT1 ATG12_CASP8_CDH1_ID2_HMGB2ATG12_CDH1_ID2_AGER_HMGB2_MMP2 ATG12_BNIP3_CDH1_ID2_HMGB2ATG12_CASP8_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_MMP9_HMGB2ATG12_CDH1_ID2_AGER_CIAP2_HMGB2 LAMP1_CDH1_ID2_AGER_HMGB2ATG12_ATG5_CDH1_ID2_AGER_HMGB2 ATG12_CSE1L_CDH1_ID2_HMGB2ATG12_CDH1_ID2_TCF3_AGER_HMGB2 LC3_CDH1_ID2_AGER_HMGB2ATG12_DRAM_CDH1_ID2_BECN1_HMGB2 ATG12_DIABLO_CDH1_ID2_HMGB2ATG12_FAS_CDH1_ID2_AGER_HMGB2 CSE1L_CDH1_ID2_AGER_HMGB2ATG12_CDH1_ID2_AGER_HMGB1_HMGB2 CDH1_ID2_MMP9_AGER_HMGB2ATG12_DRAM_LAMP1_CDH1_ID2_HMGB2 CDH1_ID2_AGER_HMGB2_RPS19BP1ATG12_ATG3_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_CIAP2_HMGB2ATG12_ATG5_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_HMGB2_UVRAGATG12_DIABLO_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_AGERATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2 ATG12_DRAM_CDH1_TCF3_HMGB2ATG12_CASP8_DRAM_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_AGER_BECN1ATG12_DRAM_CDH1_ID2_HMGB2_MMP2 ATG12_DIABLO_CDH1_BHLHE41_HMGB2ATG12_LAMP1_CDH1_ID2_BECN1_HMGB2 ATG12_DIABLO_CDH1_HMGB2_SESN3ATG12_CBS_CDH1_ID2_AGER_HMGB2 ATG12_FAS_CDH1_ID2_HMGB2ATG12_DRAM_CDH1_ID2_MMP9_HMGB2 ATG3_CDH1_ID2_AGER_HMGB2ATG12_CDH1_ID2_AGER_HMGB2_UVRAG CDH1_ID2_AGER_HMGB2_MMP2ATG12_E2F1_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_ID2_TCF3_HMGB2ATG12_ATG5_CDH1_ID2_BECN1_HMGB2 ATG12_CDH1_TCF3_AGER_HMGB2ATG12_DIABLO_CDH1_CIAP2_HMGB2_SESN3 ATG12_CDH1_ID2_HMGB1_HMGB2ATG12_CSE1L_DRAM_CDH1_ID2_HMGB2 AIFM1_ATG3_CASP8_LC3_CDH1ATG12_DRAM_E2F1_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_HMGB2_SIRT1ATG12_DIABLO_CDH1_TCF3_HMGB2_SESN3 ATG12_CDH1_TCF3_BECN1_HMGB2AIFM1_ATG3_ATG5_CASP8_LC3_CDH1 ATG12_DIABLO_CDH1_TCF3_BHLHE41ATG12_BNIP3_DRAM_CDH1_ID2_HMGB2 BNIP3_CDH1_ID2_AGER_HMGB2ATG12_DIABLO_CDH1_ID2_HMGB2_SESN3 AIFM1_CASP8_DRAM_LC3_CDH1AIFM1_ATG3_CASP8_LC3_CDH1_MMP9 ATG12_CDH1_ID2_HMGB2_LAMP2ATG12_ATG3_CDH1_ID2_BECN1_HMGB2 ATG12_ATG3_CDH1_TCF3_HMGB2ATG12_CDH1_ID2_AGER_HMGB2_STAT3 ATG12_LC3_CDH1_ID2_HMGB2ATG12_DIABLO_DRAM_CDH1_ID2_HMGB2 ATG12_TKT_CDH1_ID2_HMGB2ATG12_DRAM_CDH1_ID2_CIAP2_HMGB2 CASP8_CDH1_ID2_AGER_HMGB2DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 ATG12_CDH1_TCF3_BHLHE41_HMGB2DRAM_CDH1_ID2_AGER_BECN1_HMGB2 ATG5_CDH1_ID2_AGER_HMGB2ATG12_BNIP3_CDH1_ID2_HMGB2_MMP2 ATG12_CSE1L_CDH1_ID2_AGERATG12_BNIP3_CDH1_ID2_BECN1_HMGB2 CDH1_ID2_AGER_HMGB2_SIRT1ATG12_CSE1L_CDH1_ID2_BECN1_HMGB2 CDH1_ID2_AGER_CIAP2_HMGB2LAMP1_LC3_CDH1_ID2_AGER_HMGB2 CDH1_ID2_TCF3_AGER_HMGB2ATG12_CDH1_ID2_BECN1_HMGB2_MMP2 AIFM1_CASP8_LC3_CDH1_MMP9DRAM_LC3_CDH1_ID2_AGER_HMGB2 ATG12_DRAM_CDH1_ID2_BECN1ATG12_DIABLO_CDH1_BHLHE41_HMGB2_SIRT1 AIFM1_CASP8_DIABLO_LC3_CDH1ATG12_TKT_CDH1_ID2_AGER_HMGB2 CDH1_ID2_AGER_HMGB1_HMGB2DRAM_CDH1_ID2_MMP9_AGER_HMGB2 ATG12_CDH1_ID2_HMGB2_RPS19BP1ATG12_CDH1_ID2_MMP9_BECN1_HMGB2 ATG12_LC3_CDH1_AGER_HMGB2CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 FAS_CDH1_ID2_AGER_HMGB2ATG12_DRAM_FAS_CDH1_ID2_HMGB2 ATG12_CDH1_ID2_MMP9_TCF3ATG12_CDH1_ID2_MMP9_TCF3_HMGB2 Combinations of seven types Combinationsof eight types ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2ATG12_ATG3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2ATG12_DIABLO_DRAM_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1ATG12_BNIP3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1ATG12_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2ATG12_CSE1L_DRAM_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2ATG12_DIABLO_DRAM_CDH1_TCF3_BHLHE41_HMGB2_SIRT1ATG12_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1ATG12_DIABLO_CDH1_TCF3_BECN1_CIAP2_HMGB2_SESN3ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2ATG12_LAMP1_LC3_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LC3_CDH1_ID2_AGER_BECN1_HMGB2ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1ATG12_DRAM_LC3_CDH1_ID2_AGER_HMGB2ATG12_DRAM_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DRAM_LC3_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DRAM_CDH1_ID2_AGER_HMGB2_SIRT1ATG12_ATG3_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2ATG12_DRAM_CDH1_ID2_MMP9_AGER_BECN1_HMGB2ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_CASP8_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DRAM_LAMP1_LC3_CDH1_ID2_AGER_HMGB2ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2ATG12_DIABLO_CDH1_TCF3_BECN1_BHLHE41_HMGB2_SIRT1ATG12_DRAM_CDH1_ID2_AGER_CIAP2_HMGB2ATG12_CSE1L_LC3_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LAMP1_LC3_CDH1_ID2_AGER_HMGB2ATG12_ATG3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1ATG12_CASP8_DRAM_CDH1_ID2_AGER_HMGB2ATG12_DRAM_CDH1_ID2_TCF3_AGER_BECN1_HMGB2ATG12_CSE1L_CDH1_ID2_AGER_HMGB2_RPS19BP1ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SESN2_SIRT1ATG12_BNIP3_CDH1_ID2_AGER_HMGB2_MMP2ATG12_ATG5_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2ATG12_ATG3_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2ATG12_CDH1_ID2_AGER_BECN1_HMGB2_MMP2ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2_MMP2ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2ATG12_CSE1L_DRAM_CDH1_ID2_MMP9_AGER_HMGB2ATG12_ATG3_CSE1L_CDH1_ID2_AGER_HMGB2ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2_RPS19BP1ATG12_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2ATG12_CSE1L_CDH1_ID2_MMP9_AGER_BECN1_HMGB2ATG12_ATG3_DIABLO_CDH1_TCF3_HMGB2_SESN3ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1ATG12_CSE1IL_LC3_CDH1_ID2_AGER_HMGB2ATG12_DIABLO_FAS_CDH1_TCF3_BECN1_BHLHE41_HMGB2ATG12_CSE1IL_CDH1_ID2_MMP9_AGER_HMGB2ATG12_CSE1L_DRAM_LC3_CDH1_ID2_AGER_HMGB2ATG12_ATG5_DRAM_CDH1_ID2_AGER_HMGB2ATG12_DRAM_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2ATG12_DRAM_CDH1_ID2_AGER_HMGB1_HMGB2ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_MMP2ATG12_DRAM_LAMP1_CDH1_ID2_BECN1_HMGB2ATG12_ATG3_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2ATG12_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1ATG12_CSE1L_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2ATG12_DRAM_FAS_CDH1_ID2_AGER_HMGB2ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1ATG12_DIABLO_DRAM_CDH1_ID2_AGER_HMGB2ATG12_ATG3_DRAM_CDH1_ID2_MMP9_AGER_HMGB2ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_HMGB2ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2ATG12_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2ATG12_DRAM_FAS_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2ATG12_DIABLO_CDH1_TCF3_BECN1_HMGB2_SESN3_SIRT1ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2_MMP2ATG12_ATG3_CDH1_ID2_AGER_HMGB2_RPS19BP1ATG12_LC3_CDH1_ID2_MMP9_AGER_BECN1_HMGB2ATG12_CDH1_ID2_AGER_BECN1_HMGB2_SIRT1AIFM1_CASP8_LAMP1_CDH1_AGER_CIAP2_HMGB2_RPS19BP1ATG12_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1AIFM1_ATG3_CASP8_CSE1L_LC3_CDH1_MMP9ATG12_ATG3_DIABLO_CDH1_BECN1_HMGB2_SESN3_SIRT1ATG12_ATG3_CDH1_ID2_MMP9_AGER_HMGB2ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_HMGB2_SESN3ATG12_LC3_CDH1_ID2_MMP9_AGER_HMGB2ATG12_DIABLO_FAS_CDH1_TCF3_CIAP2_HMGB2_SESN3AIFM1_CASP8_LC3_CDH1_AGER_HMGB2_RPS19BP1ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2_RPS19BP1ATG12_ATG5_CDH1_ID2_AGER_BECN1_HMGB2ATG12_CSE1L_CDH1_ID2_TCF3_AGER_BECN1_HMGB2ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_MMP2ATG12_BNIP3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_RPS19BP1ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1AIFM1_ATG3_ATG5_CASP8_LC3_CDH1_MMP9ATG12_DRAM_LC3_CDH1_ID2_MMP9_AGER_HMGB2ATG12_ATG5_DRAM_CDH1_ID2_BECN1_HMGB2ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_RPS19BP1_SESN3ATG12_BNIP3_CDH1_ID2_MMP9_AGER_HMGB2ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2_RPS19BP1ATG12_BNIP3_CSE1L_CDH1_ID2_AGER_HMGB2ATG12_LAMP1_CDH1_ID2_TCF3_AGER_BECN1_HMGB2ATG12_CDH1_ID2_MMP9_TCF3_AGER_HMGB2ATG12_CDH1_ID2_MMP9_TCF3_AGER_BECN1_HMGB2

Preferably, the composition or kit is for predicting the prognosis ofdisease-free survival of the A1 group, and the genes are one or moreselected from the genes or groups of genes described in the followingTable 6.

TABLE 6 One type Combinations of two types Combinations of three typesCombinations of four types MMP2 ID2_CDH2 FRAP1_CASP3_CDH2FRAP1_TKT_CASP3_CDH2 ID2 FRAP1_TWIST1 ID2_CDH2_SESN3 ID2_CDH2_MMP2_SESN3TWIST1 FRAP1_CASP3 ID2_CDH2_MMP2 CBS_ID2_CDH2_SESN3 BECN1 FRAP1_SESN1_FRAP1_CDH2_TWIST1 FRAP1_TKT_CDH2_TWIST1 BAX BAX_FRAP1 FRAP1_CDH2_SESN1_FRAP1_LC3_CASP3_CDH2 BCL2L1 FRAP1_NNMT FRAP1_NNMT_CDH2FRAP1_NNMT_TKT_CDH2 CDH2 FRAP1_CCNG2 AIFM1_FRAP1_CDH2ID2_CDH2_RPS19BP1_SESN3 FASLG BCL2L1_FRAP1 FRAP1_TKT_TWIST1BAX_FRAP1_TKT_CDH2 AGER FRAP1_RAGE BAX_FRAP1_CDH2 BAX_FRAP1_LC3_CDH2ATG12 AIFM1_FRAP1 FRAP1_LC3_TWIST1 ATG12_ID2_CDH2_SESN3 TKT BCL2_FRAP1AKT1_ID2_CDH2 ATG12_ID2_MMP2_SESN3 FRAP1_VEGF ATG12_ID2_MMP2FRAP1_LC3_CDH2_KIAA1967 FRAP1_PTEN FRAP1_CDH2_KIAA1967AIFM1_FRAP1_TKT_CDH2 HMGB1_TWIST1 FRAP1_CCNG2_CDH2 FRAP1_TKT_CDH2_SESN1_ATG12_ID2 FRAP1_NNMT_MMP2 ID2_MMP2_RPS19BP1_SESN3 FRAP1_RAPTORFRAP1_CDH2_RAGE FRAP1_CDH2_SESN1_STAT3 FRAP1_KIAA1967 BCL2L1_FRAP1_CDH2FRAP1_LC3_CDH2_TWIST1 ID2_BECN1 FRAP1_TKT_CASP3 FRAP1_LC3_NNMT_CDH2BECN1_SESN3 ATG12_MMP2_SESN3 FRAP1_LC3_CDH2_RAPTOR ATG12_MMP2FRAP1_CDH2_VEGF FRAP1_TKT_CCNG2_CDH2 CDH2_SESN3 ID2_CDH2_HMGB1DIABLO_ID2_CDH2_SESN3 ID2_MMP2 FRAP1_PTEN_CDH2 ID2_CDH2_HMGB2_SESN3FRAP1_XIAP CDH1_ID2_CDH2 FRAP1_TKT_CDH2_KIAA1967 AKT1_CDH2FRAP1_CASP3_MMP2 FRAP1_LC3_CDH2_RAGE FRAP1_PRKAA1_ FRAP1_LC3_CASP3BAX_FRAP1_TKT_MMP2 ID2_RPS19BP1 BCL2_FRAP1_CDH2 BCL2L1_FRAP1_TKT_CDH2TKT_MMP2 BAX_FRAP1_TKT FRAP1_CASP3_CDH2_STAT3 BAX_TWIST1FRAP1_CDH2_RAPTOR FRAP1_PTEN_TKT_CDH2 BECN1_FASLG BAX_FRAP1_LC3FRAP1_ID2_CDH2_TWIST1 ATG12_SESN3 BAX_FRAP1_MMP2 ID2_CDH2_NAMPT_SESN3CDH2_MMP2 FAS_ID2_CDH2 FRAP1_TKT_CDH2_VEGF BECN1_MMP2FRAP1_RPS19BP1_TWIST1 FRAP1_LC3_CDH2_VEGF BAX_MMP2 FRAP1_LC3_NNMTFRAP1_NNMT_CDH2_MMP2 ID2_NAMPT FRAP1_LC3_RAGE AIFM1_FRAP1_LC3_CDH2CASP8_ID2 FRAP1_HMGB1_TWIST1 FRAP1_LC3_PTEN_CDH2 ID2_TWIST1FRAP1_SESN1_STAT3 FRAP1_TKT_CDH2_RAGE MMP2_SESN3 FRAP1_TKT_SESN1_FRAP1_CDH2_HMGB1_TWIST1 AKT1_BAX ATG3_ID2_CDH2 FAS_FRAP1_CDH2_SESN1_FRAP1_TP63 FRAP1_ID2_CDH2 FRAP1_CASP3_CDH2_MMP2 BAX_LC3 FRAP1_TKT_CCNG2DRAM_ID2_CDH2_SESN3 ATG12_FASLG FAS_FRAP1_TWIST1 LC3_HMGB1_STAT3_TWIST1LC3_TWIST1 FRAP1_NNMT_TKT CASP8_ID2_CDH2_SESN3 AKT1_TWIST1AIFM1_FRAP1_MMP2 FRAP1_TKT_CDH2_RAPTOR ID2_FASLG ID2_CDH2_CIAP2BCL2L1_FRAP1_LC3_CDH2 STAT3_TWIST1 FRAP1_LC3_VEGFFRAP1_CDH2_KIAA1967_MMP2 TKT_FASLG CDH2_MMP2_SESN3 FRAP1_TKT_CASP3_FASLGAKT1_ATG12 ID2_CDH2_FASLG TKT_ID2_CDH2_MMP2 MMP2_NAMPT CBS_ID2_CDH2FRAP1_NNMT_TKT_MMP2 ID2_SIRT1 FRAP1_LC3_CCNG2 FRAP1_TKT_CASP3_MMP2ID2_AGER BCL2L1_FRAP1_TKT ID2_CDH2_CIAP2_SESN3 ATG7_TWIST1FRAP1_ID2_TWIST1 FRAP1_CDH2_STAT3_TWIST1 AKT1_BCL2L1 AIFM1_FRAP1_LC3CBS_FRAP1_CASP3_CDH2 BAX_TKT AIFM1_FRAP1_TKT BAX_FRAP1_CDH2_MMP2KIAA1967_MMP2 ATG5_ID2_CDH2 ATG12_TKT_MMP2_SESN3 BCL2L1_MMP2FRAP1_TKT_RAGE FRAP1_CDH1_CASP3_CDH2 ATG7_TP63 BCL2L1_FRAP1_MMP2BAX_FRAP1_BECN1_CDH2 LC3_BECN1 FRAP1_CDH2_TP63 ID2_CDH2_HMGB1_MMP2CDH1_ID2_MMP9_TCF3 Combinations of five types Combinations of six typesID2_CDH2_MMP2_RPS19BP1_SESN3 AKT1_ATG12_FAS_CDH2_STAT3_TP63ATG12_ID2_CDH2_MMP2_SESN3 AKT1_FAS_BECN1_CDH2_STAT3_TP63FRAP1_LC3_CASP3_CDH2_STAT3 AKT1_FAS_CDH2_RPS19BP1_STAT3_TP63ATG12_ID2_MMP2_RPS19BP1_SESN3 AKT1_FAS_LC3_CDH2_STAT3_TP63AKT1_FAS_CDH2_STAT3_TP63 ID2_CDH2_HMGB1_MMP2_RPS19BP1_SESN3FRAP1_TKT_CASP3_CDH2_STAT3 AKT1_ATG12_BECN1_CDH2_STAT3_TP63CASP8_ID2_CDH2_MMP2_SESN3 AKT1_ATG7_FAS_CDH2_RPS19BP1_TP63FRAP1_TKT_CASP3_CDH2_FASLG ATG12_ID2_CDH2_HMGB1_MMP2_SESN3BAX_FRAP1_LC3_TKT_CDH2 FRAP1_LC3_BECN1_CASP3_CDH2_STAT3ID2_CDH2_HMGB2_MMP2_SESN3 FRAP1_LC3_TKT_CASP3_CDH2_STAT3DIABLO_ID2_CDH2_MMP2_SESN3 FRAP1_LC3_NNMT_BECN1_CDH2_STAT3FRAP1_LAMP1_TKT_CASP3_CDH2 ID2_CDH2_HMGB2_MMP2_RPS19BP1_SESN3CBS_ID2_CDH2_MMP2_SESN3 ATG12_ID2_CDH2_CIAP2_MMP2_SESN3FRAP1_LC3_NNMT_CDH2_STAT3 FAS_FRAP1_LC3_CDH2_SESN1_STAT3FRAP1_TKT_CDH2_SESN1_STAT3 FRAP1_TKT_BECN1_CASP3_CDH2_STAT3LC3_CDH2_HMGB1_STAT3_TWIST1 ATG12_FRAP1_ID2_CDH2_MMP2_SESN3DRAM_ID2_CDH2_MMP2_SESN3 FAS_LC3_CDH2_HMGB1_STAT3_TWIST1FRAP1_LC3_CDH2_SESN1_STAT3 ATG12_TKT_ID2_CDH2_MMP2_SESN3CBS_FRAP1_TKT_CASP3_CDH2 ID2_CDH2_CIAP2_MMP2_RPS19BP1_SESN3ID2_MMP2_NAMPT_RPS19BP1_SESN3 AKT1_CASP8_FAS_CDH2_STAT3_TP63AKT1_ID2_CDH2_RPS19BP1_SESN3 AKT1_FAS_CASP3_CDH2_STAT3_TP63ID2_CDH2_MMP2_NAMPT_SESN3 FAS_FRAP1_LC3_NNMT_CDH2_STAT3AKT1_BECN1_CDH2_STAT3_TP63 FAS_FRAP1_TKT_CDH2_SESN1_STAT3FAS_FRAP1_LC3_CDH2_RAPTOR ATG12_ID2_CDH2_MMP2_SESN3_STAT3FRAP1_LC3_CDH2_STAT3_TWIST1 FRAP1_NNMT_TKT_BECN1_CDH2_STAT3BAX_FRAP1_TKT_CDH2_MMP2 ATG12_FAS_FRAP1_CDH2_STAT3_TP63FAS_FRAP1_LC3_CDH2_KIAA1967 ATG12_ATG3_ID2_CDH2_MMP2_SESN3AKT1_ATG7_CDH2_RPS19BP1_TP63 DRAM_ID2_CDH2_MMP2_RPS19BP1_SESN3FAS_FRAP1_LC3_CDH2_RAGE ATG12_CBS_ID2_CDH2_MMP2_SESN3FAS_LC3_HMGB1_STAT3_TWIST1 ID2_CDH2_MMP2_RPS19BP1_SESN3_STAT3FRAP1_LC3_TKT_CASP3_CDH2 FRAP1_ID2_CDH2_MMP2_RPS19BP1_SESN3FRAP1_TKT_CASP3_CDH2_CIAP2 AKT1_ID2_CDH2_MMP2_RPS19BP1_SESN3TKT_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CASP3_CDH2_STAT3FRAP1_TKT_CDH2_KIAA1967_MMP2 ATG5_ID2_CDH2_MMP2_RPS19BP1_SESN3FRAP1_IKT_CDH2_HMGB1_TWIST1 AKT1_FAS_CDH2_HMGB1_STAT3_TP63BAX_FRAP1_LC3_BECN1_CDH2 CSE1L_ID2_CDH2_MMP2_RPS19BP1_SESN3FRAP1_TKT_CDH2_STAT3_TWIST1 ATG3_ID2_CDH2_MMP2_RPS19BP1_SESN3AKT1_ATG12_ID2_CDH2_SESN3 FRAP1_LC3_NNMT_TKT_CDH2_STAT3BAX_FAS_FRAP1_LC3_CDH2 CBS_ID2_CDH2_MMP2_RPS19BP1_SESN3ATG12_CBS_ID2_MMP2_SESN3 AKT1_ATG12_CDH2_HMGB1_STAT3_TP63FAS_FRAP1_CDH2_SESN1_STAT3 FAS_FRAP1_LC3_CDH2_RAPTOR_RPS19BP1FRAP1_BECN1_CASP3_CDH2_STAT3 AKT1_ATG12_ID2_CDH2_MMP2_SESN3FAS_FRAP1_TKT_CDH2_SESN1_ ATG12_ATG5_ID2_CDH2_MMP2_SESN3FRAP1_LC3_CCNG2_CDH2_STAT3 AKT1_ATG12_FAS_BECN1_STAT3_TP63ID2_CDH2_MMP2_SESN3_UVRAG AKT1_FAS_BECN1_RPS19BP1_STAT3_TP63ATG7_ID2_CDH2_MMP2_SESN3 FAS_FRAP1_LC3_CDH2_FASLG_RAPTORID2_CDH2_HMGB1_RPS19BP1_SESN3 FAS_ID2_CDH2_MMP2_RPS19BP1_SESN3FRAP1_TKT_CDH2_MMP2_RAPTOR ATG12_CDH1_ID2_CDH2_MMP2_SESN3FRAP1_LC3_BECN1_CDH2_RAPTOR FRAP1_LC3_TKT_CDH2_STAT3_TWIST1ATG12_ID2_CDH2_FASLG_SESN3 CDH1_ID2_CDH2_MMP2_RPS19BP1_SESN3ATG7_FRAP1_TKT_CASP3_CDH2 FAS_FRAP1_LC3_CDH2_KIAA1967_RPS19BP1FRAP1_TKT_CASP3_CDH2_MMP2 FRAP1_LC3_CDH2_HMGB1_STAT3_TWIST1FRAP1_LC3_CDH2_HMGB1_TWIST1 ATG12_ID2_CDH2_HMGB2_MMP2_SESN3FRAP1_LC3_TKT_CDH2_KIAA1967 ATG12_FAS_ID2_CDH2_MMP2_SESN3ATG7_ID2_CDH2_RPS19BP1_TP63 TKT_ID2_CDH2_MMP2_RPS19BP1_SESN3BAX_FRAP1_TKT_BECN1_CDH2 BAX_FAS_FRAP1_LC3_TKT_CDH2ATG3_FRAP1_TKT_CASP3_CDH2 ATG12_ID2_CDH2_MMP2_RPS19BP1_SESN3CDH1_ID2_MMP9_TCF3_CDH2 CDH1_ID2_MMP9_TCF3_CDH2_SESN3 Combinations ofseven types Combinations of eight typesAKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_FAS_CASP3_CDH2_STAT3_TP63AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_LAMP1_CDH2_STAT3_TP63AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_HMGB2_STAT3_TP63AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63AIFM1_AKT1_ATG12_FAS_CDH2_STAT3_TP63AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_CIAP2_STAT3_TP63AKT1_ATG12_FAS_BECN1_CDH2_KIAA1967_STAT3_TP63AKT1_ATG12_FAS_CDH2_SESN2_STAT3_TP63AKT1_FAS_BECN1_CDH2_RAPTOR_RPS19BP1_STAT3_TP36AKT1_ATG12_FAS_NNMT_CDH2_STAT3_TP63AKT1_ATG12_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63AKT1_ATG12_BCL2L1_FAS_BECN1_CDH2_STAT3_TP63AKT1_ATG12_FAS_CDH2_NAMPT_STAT3_TP63AKT1_CASP8_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_FAS_CDH2_SIRT1_STAT3_TP63AKT1_ATG12_FAS_LAMP1_LC3_CDH2_STAT3_TP63AKT1_FAS_LC3_BECN1_CDH2_STAT3_TP63AKT1_ATG12_CASP8_FAS_LC3_CDH2_STAT3_TP63AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63AKT1_ATG12_FAS_CDH2_RAPTOR_RPS19BP1_STAT3_TP63AKT1_ATG12_DRAM_FAS_CDH2_STAT3_TP63AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_NNMT_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_BECN1_RPS19BP1_STAT3_TP63AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63AKT1_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_HMGB1_STAT3_TP63AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63ATG12_FAS_FRAP1_LC3_CDH2_STAT3_TP63AKT1_ATG12_CASP8_FAS_LAMP1_CDH2_STAT3_TP63AKT1_ATG12_FAS_XIAP_CDH2_STAT3_TP63AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63AKT1_ATG12_FAS_CDH2_LAMP2_STAT3_TP63AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63AKT1_ATG12_ATG3_FAS_CDH2_STAT3_TP63AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63AKT1_ATG12_FAS_PTEN_CDH2_STAT3_TP63AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63AKT1_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH1_BECN1_CDH2_STAT3_TP63AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_TP63AKT1_CASP8_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_LC3_CDH2_HMGB1_STAT3_TP63AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_TKT_CDH2_STAT3_TP63AKT1_ATG12_FAS_CDH2_CIAP2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3AKT1_FAS_CDH2_HMGB1_HMGB2_RPS19BP1_STAT3_TP63AKT1_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_LC3_CASP3_CDH2_STAT3_TP63AKT1_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTORAKT1_ATG12_E2F1_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_E2F1_FAS_CDH2_STAT3_TP63AKT1_ATG12_DRAM_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63AKT1_FAS_CASP3_CDH2_RPS19BP1_SESN2_STAT3_TP63AKT1_FAS_NNMT_BECN1_CDH2_STAT3_TP63AKT1_FAS_CDH2_HMGB2_RPS19BP1_SESN2_STAT3_TP63AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63AKT1_FAS_LC3_CASP3_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_BECN1_CDH2_LAMP2_STAT3_TP63AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3AKT1_FAS_TKT_CDH2_RPS19BP1_SESN2_STAT3_TP63FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3AKT1_ATG12_ATG3_FAS_CDH2_RPS19BP1_STAT3_TP63ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3AKT1_ATG12_FAS_XIAP_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_RAPTOR_STAT3_TP63AKT1_ATG12_CASP8_FAS_NNMT_CDH2_STAT3_TP63FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3AKT1_ATG12_CASP8_FAS_CASP3_CDH2_STAT3_TP63FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1AKT1_ATG12_FAS_CDH2_RPS19BP1_SIRT1_STAT3_TP63FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1AKT1_ATG12_BCL2L1_FAS_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_TKT_BECN1_CDH2_STAT3_TP63AKT1_ATG12_CASP8_FAS_CDH2_HMGB2_STAT3_TP63AKT1_CASP8_FAS_LC3_CDH2_STAT3_TP63AKT1_ATG12_FAS_LC3_NNMT_CDH2_STAT3_TP63AKT1_FAS_LC3_CASP3_CDH2_STAT3_TP63AIFM1_AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63AKT1_FAS_LAMP1_BECN1_CDH2_STAT3_TP63AKT1_ATG7_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_TP63AKT1_ATG12_FAS_PTEN_CDH2_RPS19BP1_STAT3_TP63AKT1_ATG12_FAS_TCF3_CDH2_STAT3_TP63AKT1_ATG12_FAS_LAMP1_CDH2_RPS19BP1_STAT3_TP63AKT1_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63AKT1_ATG12_CASP8_FAS_CDH2_CIAP2_STAT3_TP63CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3AKT1_CDH1_ID2_MMP9_TCF3_CDH2_RPS19BP1_SESN3

Preferably, the composition or kit is for predicting the prognosis ofrecurrence of the A2 group, and the genes are one or more selected fromthe genes or groups of genes described in the following Table 7.

TABLE 7 One type Combinations of two types Combinations of three typesCombinations of four types TKT PRKAA1_LAMP2 LC3_SESN2_SIRT1ATG5_LC3_SESN2_SIRT1 SESN2 TKT_SESN2 BNIP3_PRKAA1_LAMP2ATG3_LC3_SESN2_SIRT1 LAMP2 ATG7_LAMP2 ATG5_LC3_SESN2CSE1L_LC3_SESN2_SIRT1 LAMP2_SESN2 BNIP3_LC3_SESN2 ATG5_CSE1L_LC3_SESN2AKT1_PRKAA1_ ATG7_LC3_SESN2 BNIP3_LC3_SESN2_SIRT1 SESN2_SIRT1AKT1_PRKAA1_LAMP2 FRAP1_LC3_SESN2_SIRT1 TKT_VEGF ATG7_TKT_SESN2AKT1_ATG3_PRKAA1_LAMP2 ATG7_TKT DRAM_LC3_SESN2 ATG3_ATG5_LC3_SESN2TKT_LAMP2 PRKAA1_AGER_LAMP2 ATG7_LC3_SESN2_SIRT1 BHLHE41_SESN2PRKAA1_TKT_LAMP2 BNIP3_CSE1L_LC3_SESN2 TKT_BHLHE41 ATG7_TKT_LAMP2TKT_LAMP2_SESN2_SIRT1 ATG5_SESN2 TKT_LAMP2_SESN2 CIAP2_LAMP2_SESN2_SIRT1LAMP1_SESN2 TKT_LAMP2_VEGF ATG12_TKT_LAMP2_SESN2 CSE1L_LAMP2ATG12_LC3_SESN2 ATG7_TKT_LAMP2_SESN2 ATG12_SESN2 ATG7_LAMP2_SESN2AKT1_ATG7_PRKAA1_LAMP2 AKT1_TKT TKT_SESN2_SIRT1 ATG5_BNIP3_LC3_SESN2E2F1_SESN2 E2F1_LC3_SESN2 ATG3_BNIP3_LC3_SESN2 ATG3_LAMP2LC3_SESN2_UVRAG AKT1_PRKAA1_LAMP2_UVRAG BNIP3_SESN2 PRKAA1_CCNG2_LAMP2DRAM_LC3_SESN2_SIRT1 LC3_SESN2 AKT1_ATG7_TKT ATG7_CSE1L_LC3_SESN2TWIST1_VEGF ATG5_PRKAA1_LAMP2 ATG7_FRAP1_LC3_SESN2 ATG7_LC3ATG3_LAMP2_SESN2 BNIP3_PRKAA1_LAMP2_SESN2 CSE1L_SESN2 BNIP3_TKT_SESN2ATG5_ATG7_LC3_SESN2 ATG5_LC3 LAMP2_SESN2_SIRT1 PRKAA1_TKT_LAMP2_SESN2ATG7_SESN2 ATG7_PRKAA1_LAMP2 ATG3_ATG7_LC3_SESN2 LC3_ULK1LAMP1_LC3_SESN2 BNIP3_PRKAA1_AGER_LAMP2 ATG3_TKT ATG12_PRKAA1_LAMP2E2F1_LC3_SESN2_SIRT1 DRAM_SESN2 CASP8_PRKAA1_LAMP2 LC3_ID2_SESN2_SIRT1PRKAA1_TKT AIFM1_TKT_SESN2 LC3_NAMPT_SESN2_SIRT1 BHLHE41_LAMP2FRAP1_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2 LAMP2_VEGF PRKAA1_HMGB1_LAMP2ATG7_BNIP3_LC3_SESN2 AKT1_VEGF LC3_BHLHE41_SESN2LC3_RPS19BP1_SESN2_SIRT1 TKT_CIAP2 ATG12_TKT_SESN2 AKT1_ATG7_TKT_SESN2CSE1L_BHLHE41 CSE1L_LAMP2_SESN2 BCL2L1_BNIP3_PRKAA1_LAMP2 LC3_BHLHE41PRKAA1_CASP3_LAMP2 CSE1L_DRAM_LC3_SESN2 LC3_SIRT1 PRKAA1_LAMP2_RAGEDIABLO_LC3_SESN2_SIRT1 CSE1L_LAMP1 PRKAA1_LAMP2_SESN2LC3_SESN2_SIRT1_STAT3 TKT_RPS19BP1 TKT_CIAP2_SESN2 ATG12_ATG5_LC3_SESN2CBS_TKT BCL2L1_PRKAA1_LAMP2 BNIP3_PRKAA1_TCF3_LAMP2 CSE1L_BECN1DIABLO_PRKAA1_LAMP2 LC3_SESN2_SIRT1_UVRAG TKT_CDH1 PRKAA1_CDH1_LAMP2BNIP3_PRKAA1_MMP9_LAMP2 TKT_HMGB1 CBS_PRKAA1_LAMP2 AKT1_LC3_SESN2_SIRT1TKT_RAGE CSE1L_SESN2_SIRT1 AKT1_PRKAA1_CDH1_LAMP2 AIFM1_SESN2ATG3_PRKAA1_LAMP2 CSE1L_LAMP1_LC3_SESN2 ATG7_TWIST1 PRKAA1_FASLG_LAMP2ATG7_PRKAA1_TKT_LAMP2 BHLHE41_NAMPT PRKAA1_ID2_LAMP2KIAA1967_LAMP2_SESN2_SIRT1 BNIP3_LC3 PRKAA1_LAMP2_SATB1LC3_SESN2_SESN3_SIRT1 PRKAA1_SESN2 PRKAA1_LAMP2_SESN1_BNIP3_PRKAA1_HMGB1_LAMP2 ATG7_NAMPT AKT1_ATG7_PTEN CSE1L_LC3_SESN2_UVRAGBECN1_SESN2 ATG7_TKT_BHLHE41 LC3_MMP9_SESN2_SIRT1 TKT_HMGB2PRKAA1_LAMP2_MMP2 ATG3_LAMP2_SESN2_SIRT1 TKT_SIRT1 CSE1L_LAMP1_SESN2BNIP3_PRKAA1_CCNG2_LAMP2 ATG5_CSE1L PRKAA1_LAMP2_SESN3BNIP3_PRKAA1_LAMP2_SATB1 SESN2_UVRAG ATG3_TKT_SESN2BNIP3_PRKAA1_LAMP2_SESN1_ TKT_CASP3 ATG5_CSE1L_SESN2 ATG5_DRAM_LC3_SESN2TKT_CDH2 ATG5_CSE1L_LC3 BNIP3_PRKAA1_CASP3_LAMP2 TKT_MMP2FRAP1_PRKAA1_LAMP2 BNIP3_FRAP1_LC3_SESN2 Combinations of five typesCombinations of six types CIAP2_FASLG_LAMP2_SESN2_SIRT1LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG5_LC3_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_FRAP1_LC3_SESN2_SIRT1NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_FRAP1_LC3_SESN2_SIRT1CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 TKT_CIAP2_LAMP2_SESN2_SIRT1AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2_SIRT1CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1 ATG5_BNIP3_LC3_SESN2_SIRT1CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 TKT_CDH1_LAMP2_SESN2_SIRT1CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SIRT1AKT1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_BNIP3_LC3_SESN2_SIRT1ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_CSE1L_LC3_SESN2_SIRT1FAS_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_LC3_LAMP2_SESN2_SIRT1CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1 BNIP3_FRAP1_LC3_SESN2_SIRT1TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BNIP3_PRKAA1_TKT_LAMP2_SESN2ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG12_TKT_LAMP2_SESN2_SIRT1ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_ATG7_LC3_SESN2_SIRT1BCL2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_TKT_LAMP2_SESN2CIAP2_FASLG_LAMP2_RAGE_SESN2_SIRT1 AKT1_ATG7_BNIP3_PRKAA1_LAMP2ATG5_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_SESN2_SIRT1CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG5_BNIP3_LC3_SESN2FRAP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 BNIP3_CSE1L_LC3_SESN2_SIRT1MMP9_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_DRAM_LC3_SESN2_SIRT1CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 AIFM1_CIAP2_LAMP2_SESN2_SIRT1ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG7_TKT_LAMP2_SESN2_SIRT1CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LC3_SESN2LAMP1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_LC3_NAMPT_SESN2_SIRT1TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG5_E2F1_LC3_SESN2_SIRT1ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1 BNIP3_CSE1L_FRAP1_LC3_SESN2ATG3_ATG7_LC3_LAMP2_SESN2_SIRT1 ATG7_LC3_LAMP2_SESN2_SIRT1ATG3_BNIP3_FRAP1_LC3_SESN2_SIRT1 AIFM1_BNIP3_PRKAA1_LAMP2_SESN2ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG12_BNIP3_TKT_LAMP2_SESN2ATG3_ATG5_BNIP3_LC3_SESN2_SIRT1 CIAP2_KIAA1967_LAMP2_SESN2_SIRT1E2F1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG12_ATG5_BNIP3_LC3_SESN2ATG3_BNIP3_LC3_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_LAMP2_SESN2ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG12_TKT_CIAP2_LAMP2_SESN2ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_BNIP3_CSE1L_LC3_SESN2TKT_CDH1_CIAP2_LAMP2_SESN2_SIRT1 AKT1_ATG7_PRKAA1_TKT_LAMP2ATG5_BNIP3_E2F1_LC3_SESN2_SIRT1 ATG3_LC3_NAMPT_SESN2_SIRT1ATG3_ATG7_LC3_NAMPT_SESN2_SIRT1 ATG3_CSE1L_LC3_SESN2_SIRT1AIFM1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC3_SESN2ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_LC3_ID2_SESN2_SIRT1CBS_TKT_CIAP2_LAMP2_SESN2_SIRT1 BNIP3_E2F1_LC3_SESN2_SIRT1ATG3_ATG5_LC3_ID2_SESN2_SIRT1 ATG3_LC3_ID2_SESN2_SIRT1AIFM1_TKT_CIAP2_LAMP2_SESN2_SIRT1 ATG7_CSE1L_FRAP1_LC3_SESN2ATG3_DRAM_FRAP1_LC3_SESN2_SIRT1 AIFM1_IKT_LAMP2_SESN2_SIRT1ATG3_ATG5_E2F1_LC3_SESN2_SIRT1 LC3_CIAP2_LAMP2_SESN2_SIRT1ATG7_BNIP3_LC3_LAMP2_SESN2_SIRT1 ATG12_TKT_CDH1_LAMP2_SESN2ATG3_ATG5_LC3_SESN2_SIRT1_STAT3 ATG5_LC3_SESN2_SIRT1_STAT3AIFM1_AKT1_LAMP2_SESN2_SIRT1_UVRAG ATG3_DRAM_LC3_SESN2_SIRT1AKT1_ATG7_TKT_LAMP2_SESN2_SIRT1 ATG5_DIABLO_LC3_SESN2_SIRT1ATG3_ATG5_LC3_NAMPT_SESN2_SIRT1 ATG7_BNIP3_LC3_SESN2_SIRT1ATG3_ATG5_DIABLO_LC3_SESN2_SIRT1 CDH2_CIAP2_LAMP2_SESN2_SIRT1TKT_CDH1_HMGB1_LAMP2_SESN2_SIRT1 ATG3_ATG5_FRAP1_LC3_SESN2ATG3_ATG5_LC3_LAMP2_SESN2_SIRT1 DRAM_TKT_LAMP2_SESN2_SIRT1ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG12_ATG3_TKT_LAMP2_SESN2BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG3_LC3_SESN2_SIRT1_STAT3AKT1_ATG3_ATG5_LC3_SESN2_SIRT1 ATG5_LC3_SESN2_SIRT1_UVRAGAIFM1_BNIP3_PRKAA1_TKT_LAMP2_SESN2 TKT_CDH1_ID2_MMP9_TCF3_SESN2Combinations of seven types Combinations of eight typesATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG7_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1FRAP1_LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1FRAP1_LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1MMP9_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1FRAP1_LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1ATG5_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1FRAP1_LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1LC3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1LC3_NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1FRAP1_LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1FAS_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1LC3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3CIAP2_FASLG_LAMP2_MMP2_SESN1_SESN2_SIRT1NNMT_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1FRAP1_AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1FRAP1_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1LC3_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN1_SESN2_SIRT1ATG5_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1MMP9_CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1TCF3_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1TCF3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SATB1_SESN2_SIRT1AKT1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1FAS_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1NNMT_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1ATG3_ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1NNMT_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1AKT1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1LC3_CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1MMP9_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1FRAP1_LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1AGER_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1FRAP1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1BCL2_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG7_BNIP3_LC3_ID2_FASLG_LAMP2_SESN2_SIRT1BCL2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1_STAT3ULK1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1LC3_TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN_1_SESN2_SIRT1LC3_CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1LC3_CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG7_LC3_BECN1_FASLG_LAMP2_SESN2_SIRT1AKT1_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG7_FRAP1_LC3_FASLG_LAMP2_SESN2_SIRT1FRAP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1NNMT_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1FRAP1_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SESN3_SIRT1CASP3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1FRAP1_LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1CIAP2_FASLG_HMGB1_LAMP2_SESN_1_SESN2_SIRT1FAS_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN_1_SESN2_SIRT1ATG5_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG7_BNIP3_LC3_FASLG_LAMP2_SATB1_SESN2_SIRT1ID2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1BCL2_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1TCF3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1ULK1_MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1FAS_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1LC3_NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1LC3_CIAP2_FASLG_LAMP2_MMP2_NAMPT_SESN2_SIRT1LAMP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1BCL2_FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1AKT1_CCNG2_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1TCF3_CIAP2_FASLG_LAMP2_SESN_1_SESN2_SIRT1ATG7_BNIP3_LC3_MMP9_FASLG_LAMP2_SESN2_SIRT1FRAP1_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1MMP9_AGER_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1FRAP1_LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1AKT1_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1LC3_NNMT_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1NNMT_ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1CASP3_CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1LC3_CDH2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1LC3_NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1MMP9_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1BNIP3_PRKAA1_CDH1_ID2_MMP9_TCF3_LAMP2TKT_CDH1_ID2_MMP9_TCF3_LAMP2_SESN2_SIRT1

Preferably, the composition or kit is for predicting the prognosis ofsurvival of the A2 group, and the genes are one or more selected fromthe genes or groups of genes described in the following Table 8.

TABLE 8 One type Combinations of two types Combinations of three typesCombinations of four types BCL2L1 BCL2L1_NNMT BCL2L1_NNMT_PRKAA1_ATG3_BCL2L1_NNMT_PRKAA1_ FAS BCL2L1_E2F1 BCL2L1_E2F1_PRKAA1_BCL2L1_TKT_CASP3_SESN2 LAMP1 BCL2L1_TKT ATG3_BCL2L1_PRKAA1_BCL2L1_ID2_CASP3_SESN2 BHLHE41 FAS_LAMP1 ATG3_BCL2L1_NNMTATG3_BCL2L1_E2F1_PRKAA1_ TKT BCL2L1_PRKAA1_ ATG3_BCL2L1_E2F1BCL2L1_NNMT_PRKAA1_HMGB1 LC3 FAS_BHLHE41 FAS_BHLHE41_SESN2BCL2L1_NNMT_PRKAA1_MMP2 SESN2 FAS_TKT BCL2L1_PRKAA1_HMGB2BCL2L1_NNMT_PRKAA1_CDH1 BCL2L1_CASP3 BCL2L1_CASP3_SESN2FAS_TKT_CASP3_SESN2 ATG3_BCL2L1 BCL2L1_PRKAA1_TKTBCL2L1_NNMT_PRKAA1_VEGF ATG7_BCL2L1 FAS_CASP3_SESN2ATG7_BCL2L1_NNMT_PRKAA1_ FAS_CASP3 BCL2L1_TKT_CASP3BCL2L1_FRAP1_NNMT_PRKAA1_ TKT_BHLHE41 FAS_TKT_CASP3BCL2L1_NNMT_PRKAA1_ID2 BCL2L1_KIAA1967 BCL2L1_E2F1_TKTAIFM1_BCL2L1_NNMT_PRKAA1_ FAS_PRKAA1_ BCL2L1_NNMT_TKTBCL2L1_TKT_BHLHE41_CASP3 FAS_KIAA1967 FAS_TKT_BHLHE41BCL2L1_NNMT_PRKAA1_CDH2 FAS_SESN2 FAS_TKT_SESN2BCL2L1_CSE1L_NNMT_PRKAA1_ BCL2L1_HMGB2 FAS_LAMP1_BHLHE41BCL2L1_NNMT_PRKAA1_HMGB2 BCL2L1_VEGF FAS_LAMP1_SESN2BCL2L1_CBS_NNMT_PRKAA1_ BNIP3_FAS ATG3_BCL2L1_TKT FAS_TKT_SESN2_TP63FAS_TWIST1 ATG7_BCL2L1_PRKAA1_ BCL2L1_DRAM_NNMT_PRKAA1_ BNIP3_TKTDIABLO_FAS_BHLHE41 BCL2L1_NNMT_PRKAA1_ULK1 BCL2L1_CSE1L TKT_SESN2_TP63BNIP3_TKT_CASP3_SESN2 TKT_SESN2 FAS_PRKAA1_TKT ATG5_BCL2L1_NNMT_PRKAA1_BCL2L1_FRAP1 ATG7_BCL2L1_NNMT BCL2L1_DIABLO_NNMT_PRKAA1_ LAMP1_SESN2BCL2L1_BNIP3_TKT BCL2L1_NNMT_CASP3_SESN2 LC3_BHLHE41 BNIP3_FAS_TKTFAS_TKT_BHLHE41_CASP3 BCL2L1_BNIP3 BCL2L1_NNMT_CASP3BCL2L1_NNMT_PRKAA1_TKT BCL2L1_LC3 TKT_BHLHE41_CASP3 BNIP3_FAS_TKT_CASP3ATG5_BCL2L1 ATG3_BCL2L1_CASP3 ATG3_ATG7_BCL2L1_PRKAA1_ BCL2L1_CBSBCL2L1_PRKAA1_CASP3 FAS_ID2_CASP3_SESN2 CSE1L_LAMP1 BCL2L1_PRKAA1_MMP2BCL2L1_NNMT_PRKAA1_CASP3 E2F1_FAS FAS_BHLHE41_CASP3ATG3_BCL2L1_PRKAA1_HMGB2 AIFM1_BCL2L1 FAS_TKT_KIAA1967FAS_LC3_BHLHE41_SESN2 BHLHE41_SESN2 FAS_TKT_TWIST1ATG3_BCL2L1_BNIP3_NNMT CASP8_FAS BCL2L1_E2F1_NNMTBCL2L1_CASP8_NNMT_PRKAA1_ FAS_NAMPT BCL2L1_FRAP1_NNMTFAS_BHLHE41_CASP3_SESN2 FAS_TP63 BCL2L1_TKT_BHLHE41BCL2L1_BNIP3_NNMT_TKT LAMP1_BHLHE41 BCL2L1_TKT_SESN2DIABLO_FAS_BHLHE41_SESN2 ATG12_FAS FAS_KIAA1967_SESN2ATG3_BCL2L1_PRKAA1_TKT BCL2L1_MMP2 DIABLO_FAS_LAMP1BCL2L1_NNMT_PRKAA1_MMP9 BHLHE41_CASP3 ATG3_BCL2L1_KIAA1967BNIP3_FAS_CASP3_SESN2 FAS_HMGB1 ATG7_BCL2L1_E2F1 FAS_LAMP1_BHLHE41_SESN2FAS_VEGF FAS_BHLHE41_SATB1 BCL2L1_CASP3_SESN1_SESN2 LAMP1_TCF3ATG3_ATG7_BCL2L1 BCL2L1_NNMT_PRKAA1_SIRT1 BCL2L1_ULK1 ATG7_BCL2L1_TKTDIABLO_FAS_LAMP1_BHLHE41 FAS_LC3 BCL2L1_BNIP3_NNMT FAS_TKT_CASP3_SIRT1NNMT_BHLHE41 BCL2L1_PRKAA1_VEGF E2F1_FAS_BHLHE41_SESN2 BCL2L1_FASBCL2L1_BHLHE41_CASP3 FAS_TKT_CASP3_FASLG TKT_TP63 FAS_SESN2_TP63FAS_TKT_HMGB1_SESN2 AKT1_BCL2L1 TKT_BHLHE41_TP63 FAS_CASP3_HMGB1_SESN2ATG12_BCL2L1 AIFM1_BCL2L1_NNMT BAX_BCL2L1_NNMT_PRKAA1_ FAS_HMGB2BCL2L1_CSE1L_NNMT BCL2L1_E2F1_NNMT_PRKAA1_ BCL2L1_ID2 BCL2L1_E2F1_FRAP1ATG3_BCL2L1_PRKAA1_MMP2 BCL2L1_RPS19BP1 BNIP3_FAS_CASP3FAS_TKT_KIAA1967_SESN2 TKT_SATB1 FAS_TKT_SATB1 BNIP3_FAS_TKT_TWIST1FAS_XIAP BCL2L1_CSE1L_PRKAA1_ ATG3_BCL2L1_BNIP3_TKT BCL2_BCL2L1BCL2L1_NNMT_VEGF BCL2L1_NNMT_PRKAA1_PTEN Combinations of five typesCombinations of six types BCL2L1_NNMT_ID2_CASP3_SESN2BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 BCL2L1_PTEN_TKT_CASP3_SESN2BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_HMGB1ATG3_BCL2L1_NNMT_PRKAA1_CASP3_SIRT1 BCL2L1_TKT_XIAP_CASP3_SESN2BCL2L1_NNMT_ID2_CASP3_SESN1_SESN2 BCL2L1_TKT_CASP3_HMGB1_SESN2BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ID2BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2 BCL2L1_BNIP3_TKT_CASP3_SESN2FAS_TKT_CASP3_HMGB1_SESN2_TP63 ATG3_BCL2L1_NNMT_PRKAA1_CDH1ATG3_BCL2L1_NNMT_PRKAA1_KIAA1967_SIRT1 BCL2L1_TKT_CASP3_RAGE_SESN2ATG3_BCL2L1_NNMT_ID2_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_ULK1ATG3_BCL2L1_NNMT_PRKAA1_HMGB1_VEGF FAS_TKT_CASP3_HMGB1_SESN2BCL2L1_PTEN_TKT_CASP3_SESN1_SESN2 FAS_TKT_CASP3_SESN2_TP63BCL2L1_NNMT_ID2_AGER_CASP3_SESN2 ATG3_BCL2L1_FRAP1_NNMT_PRKAA1_BCL2L1_NNMT_ID2_BECN1_CASP3_SESN2 FAS_TKT_HMGB1_SESN2_TP63BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN2 AIFM1_ATG3_BCL2L1_NNMT_PRKAA1_BCL2L1_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_ID2_CASP3_SESN1_SESN2ATG12_BCL2L1_NNMT_ID2_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_MMP2BNIP3_TKT_XIAP_CASP3_RAGE_SESN2 BCL2L1_TKT_CASP3_SESN1_SESN2BCL2L1_NNMT_ID2_CASP3_CCNG2_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_VEGFAIFM1_BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_TKT_ID2_CASP3_SESN2BCL2L1_PTEN_TKT_CASP3_RAGE_SESN2 ATG3_BCL2L1_ID2_CASP3_SESN2BCL2L1_NNMT_ID2_CASP3_CDH2_SESN2 BNIP3_TKT_XIAP_CASP3_SESN2BCL2L1_NNMT_ID2_CASP3_LAMP2_SESN2 BCL2L1_NNMT_PRKAA1_ID2_SESN2ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_FASLG BCL2L1_NNMT_PRKAA1_HMGB1_VEGFBCL2L1_NNMT_ID2_CASP3_SESN2_SESN3 ATG3_BCL2L1_NNMT_PRKAA1_CDH2BCL2L1_CSE1L_NNMT_ID2_CASP3_SESN2 ATG3_BCL2L1_LAMP1_NNMT_PRKAA1_BAX_BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_NNMT_ID2_SESN2_UVRAGBCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2 ATG3_ATG7_BCL2L1_NNMT_PRKAA1_BCL2L1_NNMT_ID2_CASP3_MMP2_SESN2 ATG3_BCL2L1_CBS_NNMT_PRKAA1_BNIP3_PTEN_TKT_XIAP_CASP3_SESN2 BCL2L1_ID2_CASP3_RPS19BP1_SESN2BCL2L1_BNIP3_TKT_ID2_CASP3_SESN2 BNIP3_FAS_TKT_CASP3_SESN2BCL2L1_BNIP3_TKT_CASP3_SESN1_SESN2 ATG3_BCL2L1_DRAM_NNMT_PRKAA1_ATG3_ATG7_BCL2L1_NNMT_PRKAA1_HMGB1 ATG7_BCL2L1_NNMT_PRKAA1_HMGB1BCL2L1_CASP8_NNMT_ID2_CASP3_SESN2 BCL2L1_NNMT_PRKAA1_HMGB1_HMGB2ATG5_BCL2L1_NNMT_ID2_CASP3_SESN2 BCL2L1_FAS_TKT_CASP3_SESN2BCL2L1_NNMT_CDH1_ID2_CASP3_SESN2 ATG3_BCL2L1_CSE1L_NNMT_PRKAA1_ATG3_BCL2L1_NNMT_PRKAA1_ID2_VEGF ATG3_BCL2L1_DIABLO_NNMT_PRKAA1_BCL2L1_NNMT_PRKAA1_ID2_CASP3_SESN2 ATG3_BCL2L1_NNMT_PRKAA1_SIRT1BCL2L1_TKT_XIAP_CASP3_SESN1_SESN2 BCL2L1_CASP8_ID2_CASP3_SESN2BCL2L1_NNMT_XIAP_ID2_CASP3_SESN2 BCL2L1_DIABLO_ID2_CASP3_SESN2BCL2L1_DIABLO_NNMT_ID2_CASP3_SESN2 BCL2L1_TKT_CASP3_SESN2_STAT3BCL2L1_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_ID2_VEGFBCL2L1_BNIP3_TKT_CASP3_RAGE_SESN2 BCL2L1_ID2_CASP3_HMGB2_SESN2BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2 BCL2L1_TKT_CASP3_SESN2_SESN3BCL2L1_TKT_CASP3_HMGB1_RAGE_SESN2 BCL2L1_TKT_CASP3_CCNG2_SESN2BCL2L1_PTEN_TKT_CASP3_CCNG2_SESN2 FAS_TKT_CASP3_FASLG_SESN2BCL2L1_PRKAA1_TKT_XIAP_CASP3_SESN2 FAS_TKT_CASP3_SESN2_SIRT1BCL2L1_TKT_CASP3_HMGB1_SESN1_SESN2 BCL2L1_NNMT_ID2_KIAA1967_SESN2BNIP3_FAS_TKT_CASP3_HMGB1_SESN2 ATG5_BCL2L1_ID2_CASP3_SESN2FAS_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2L1_NNMT_PRKAA1_CASP3_SIRT1BCL2L1_NNMT_ID2_SESN1_SESN2_UVRAG BCL2L1_TKT_XIAP_BHLHE41_CASP3FAS_TKT_HMGB1_KIAA1967_SESN2_TP63 FAS_TKT_XIAP_CASP3_SESN2BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN2 BCL2L1_CDH1_ID2_CASP3_SESN2BCL2L1_PTEN_TKT_ID2_CASP3_SESN2 BCL2L1_TKT_CASP3_SESN2_SIRT1BCL2L1_ID2_CASP3_RAGE_RPS19BP1_SESN2 ATG7_BCL2L1_NNMT_PRKAA1_ID2BNIP3_TKT_XIAP_CASP3_HMGB1_SESN2 BCL2_BCL2L1_TKT_CASP3_SESN2ATG3_ATG7_BCL2L1_NNMT_PRKAA1_ID2 BCL2L1_ID2_CASP3_CDH2_SESN2BCL2L1_BNIP3_NNMT_TKT_CASP3_SESN2 Combinations of seven typesCombinations of eight types BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_NNMT_PRKAA1_PTEN_XIAP_ID2_CASP3_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_SESN3BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2ATG3_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2_SESN3BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2ATG3_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN1_SESN2BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN1_SESN2ATG3_BCL2L1_NNMT_PRKAA1_ID2_CASP3_SIRT1BCL2_BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2BCL2L1_CASP8_NNMT_ID2_CASP3_RAGE_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_RAGE_SESN2BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN2BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN1_SESN2ATG3_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_HMGB1_SESN2BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_ID2_CASP3_SESN2BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_SESN2BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_RAGE_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2_SESN3BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2_SESN3BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN2BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN1_SESN2BNIP3_PTEN_TKT_XIAP_ID2_CASP3_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN_1_SESN2ATG3_BCL2L1_NNMT_PRKAA1_XIAP_CASP3_SIRT1BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_RPS19BP1_SESN2BCL2L1_BNIP3_NNMT_TKT_XIAP_CASP3_SESN2ATG3_BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2BCL2_BCL2L1_TKT_BHLHE41_CASP3_SESN1_SESN2BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLGBCL2L1_NNMT_ID2_BHLHE41_CASP3_HMGB1_SESN1_SESN2ATG3_BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2ATG3_BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2BCL2L1_NNMT_PRKAA1_ID2_CASP3_RAGE_SESN2ATG5_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_PRKAA1_TKT_XIAP_ID2_CASP3_SESN2BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_MMP2_SESN2BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2BCL2L1_BNIP3_TKT_XIAP_CASP3_RAGE_RPS19BP1_SESN2BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN1_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2_SESN3ATG3_BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_MMP2_SESN2BCL2L1_BNIP3_NNMT_TKT_ID2_CASP3_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CCNG2_SESN2BCL2L1_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2BCL2_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BCL2L1_PRKAA1_TKT_XIAP_CASP3_RAGE_SESN2ATG5_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BCL2L1_PRKAA1_TKT_XIAP_CASP3_HMGB1_SESN2BCL2L1_NNMT_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2BCL2L1_NNMT_PRKAA1_XIAP_ID2_AGER_CASP3_SESN2BCL2L1_TKT_BHLHE41_CASP3_RAGE_SESN1_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN1_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_LAMP2_SESN2BCL2L1_NNMT_ID2_BECN1_CASP3_RAGE_SESN2BCL2L1_BNIP3_NNMT_TKT_XIAP_ID2_CASP3_SESN2BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_SESN2ATG12_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BNIP3_TKT_XIAP_ID2_CASP3_RAGE_SESN2BCL2L1_NNMT_PRKAA1_XIAP_ID2_BECN1_CASP3_SESN2BCL2L1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_CDH2_SESN2BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN1_SESN2AIFM1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN2ATG12_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2AIFM1_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2BAX_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_NNMT_ID2_CASP3_CDH2_RAGE_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_LAMP2_SESN2BCL2L1_NNMT_CDH1_ID2_CASP3_RAGE_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_AGER_CASP3_SESN2BCL2L1_NNMT_ID2_AGER_CASP3_RAGE_SESN2AKT1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BNIP3_PTEN_TKT_XIAP_CASP3_SESN1_SESN2BAX_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2BNIP3_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2BCL2L1_PTEN_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2BNIP3_TKT_XIAP_CASP3_HMGB1_RAGE_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_BECN1_CASP3_SESN2BCL2L1_NNMT_ID2_CASP3_MMP2_RAGE_SESN2BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CDH2_SESN2ATG5_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2BCL2L1_CASP8_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2BCL2L1_BNIP3_TKT_ID2_CASP3_RPS19BP1_SESN2BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN1_SESN2BCL2L1_NNMT_ID2_CASP3_RAGE_SESN1_SESN2ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG_KIAA1967BCL2L1_NNMT_TKT_ID2_BHLHE41_CASP3_SESN2BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2_SESN3BCL2L1_PTEN_TKT_BHLHE41_CASP3_SESN1_SESN2BCL2L1_CSE1L_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2BCL2L1_CSE1L_NNMT_ID2_CASP3_RAGE_SESN2BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_STAT3BCL2L1_PTEN_TKT_CASP3_RAGE_SESN1_SESN2BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2BNIP3_TKT_XIAP_CASP3_CCNG2_RAGE_SESN2BCL2L1_NNMT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3ATG3_BCL2L1_BNIP3_TKT_CASP3_FASLG_SESN2BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN1_SESN2BCL2L1_BNIP3_E2F1_TKT_XIAP_CASP3_SESN2BCL2L1_NNMT_PRKAA1_ID2_HMGB1_HMGB2_SESN1_SESN2BCL2L1_CDH1_ID2_MMP9_TCF3_CASP3_SESN2BCL2L1_TKT_CDH1_ID2_MMP9_TCF3_CASP3_SESN2

Preferably, the composition or kit is for predicting the prognosis ofdisease-free survival of the A2 group, and the genes are one or moreselected from the genes or groups of genes described in the followingTable 9.

TABLE 9 One type Combinations of two types Combinations of three typesCombinations of four types SESN2 TKT_SESN2 ATG7_TKT_SESN2ATG5_CSE1L_FRAP1_SESN2 TKT BHLHE41_SESN2 FRAP1_SESN2_SIRT1CSE1L_FRAP1_SESN2_SIRT1 LAMP2_ LAMP2_SESN2 ATG5_LC3_SESN2ATG7_TKT_LAMP2_SESN2 BHLHE41 ATG5_SESN2 ATG5_FRAP1_SESN2ATG5_FRAP1_SESN2_SIRT1 CSE1L LAMP1_SESN2 TKT_LAMP2_SESN2AKT1_ATG7_TKT_SESN2 SESN2_SIRT1 AIFM1_IKT_SESN2 ATG5_CSE1L_LC3_SESN2E2F1_SESN2 ATG5_CSE1L_SESN2 FRAP1_LC3_SESN2_SIRT1 ATG12_SESN2LC3_SESN2_SIRT1 CSE1L_FRAP1_LAMP1_SESN2 TKT_VEGF ATG12_TKT_SESN2ATG7_TKT_SESN2_SESN3 CSE1L_BECN1 CSE1L_LAMP1_SESN2 ATG5_FRAP1_LC3_SESN2CSE1L_SESN2 TKT_HMGB2_SESN2 ATG7_CSE1L_FRAP1_SESN2 ATG7_TKTATG5_TKT_SESN2 CSE1L_LC3_SESN2_SIRT1 FASLG_SESN2 TKT_CDH1_SESN2ATG5_LC3_SESN2_SIRT1 PRKAA1_LAMP2 TKT_SESN2_SESN3 ATG7_TKT_FASLG_SESN2PRKAA1_SESN2 TKT_SESN2_VEGF ATG7_TKT_AGER_SESN2 TKT_BHLHE41CSE1L_BHLHE41_SESN2 ATG7_TKT_HMGB1_SESN2 CSE1L_BHLHE41 PRKAA1_TKT_SESN2ATG7_TKT_MMP2_SESN2 ATG7_SESN2 ATG3_TKT_SESN2 BNIP3_CSE1L_FRAP1_SESN2CSE1L_LAMP2 TKT_RPS19BP1_SESN2 ATG5_ATG7_TKT_SESN2 FAS_SESN2CBS_TKT_SESN2 ATG7_BCL2_TKT_SESN2 HMGB2_SESN2 CSE1L_LAMP2_SESN2ATG7_BNIP3_TKT_SESN2 CSE1L_LAMP1 TKT_SESN2_SIRT1 FAS_FRAP1_SESN2_SIRT1BECN1_SESN2 AKT1_TKT_SESN2 AIFM1_ATG7_TKT_SESN2 NNMT_SESN2CSE1L_SESN2_SIRT1 ATG12_TKT_LAMP2_SESN2 AIFM1_SESN2 TKT_CDH2_SESN2ATG7_TKT_BHLHE41_SESN2 BAX_SESN2 BNIP3_TKT_SESN2 ATG7_TKT_ID2_SESN2DRAM_SESN2 NNMT_TKT_SESN2 CSE1L_DRAM_FRAP1_SESN2 CSE1L_ULK1TKT_AGER_SESN2 CSE1L_FRAP1_SESN2_UVRAG KIAA1967_SESN2 TKT_BHLHE41_SESN2ATG7_LAMP1_TKT_SESN2 SESN2_VEGF TKT_HMGB1_SESN2 ATG7_BCL2L1_TKT_SESN2BNIP3_SESN2 TKT_MMP2_SESN2 ATG7_TKT_CCNG2_SESN2 SESN2_UVRAGE2F1_TKT_SESN2 CSE1L_E2F1_FRAP1_SESN2 TWIST1_VEGF NAMPT_SESN2_SIRT1CSE1L_LAMP1_LC3_SESN2 PRKAA1_FASLG TKT_KIAA1967_SESN2PRKAA1_TKT_LAMP2_SESN2 TKT_RPS19BP1 DRAM_TKT_SESN2 ATG7_CBS_TKT_SESN2PRKAA1_TKT TKT_CIAP2_SESN2 ATG7_LC3_TKT_SESN2 ATG7_LAMP2 TKT_MMP9_SESN2ATG7_NNMT_TKT_SESN2 AGER_SESN2 ATG5_NAMPT_SESN2 ATG7_TKT_CIAP2_SESN2CDH2_SESN2 ATG7_FRAP1_SESN2 ATG7_TKT_SESN2_STAT3 AKT1_PRKAA1_CSE1L_E2F1_SESN2 ATG7_PTEN_TKT_SESN2 ULK1_SESN2 LAMP1_TKT_SESN2ATG7_TKT_CASP3_SESN2 MMP2_SESN2 LC3_TKT_SESN2 ATG7_TKT_CDH2_SESN2ATG5_CSE1L TKT_CASP3_SESN2 ATG7_TKT_HMGB2_SESN2 HMGB1_SESN2TKT_CCNG2_SESN2 ATG7_TKT_NAMPT_SESN2 AKT1_TKT TKT_ID2_SESN2ATG7_TKT_RAPTOR_SESN2 CBS_SESN2 TKT_RAPTOR_SESN2 ATG7_TKT_SESN2_SIRT1FRAP1_SESN2 TKT_XIAP_SESN2 ATG7_FRAP1_LC3_SESN2 CIAP2_SESN2BAX_TKT_SESN2 ATG7_TKT_BECN1_SESN2 BCL2_SESN2 BCL2_TKT_SESN2ATG7_DIABLO_TKT_SESN2 CCNG2_SESN2 ATG12_CSE1L_SESN2ATG7_FRAP1_SESN2_SIRT1 BCL2L1_SESN2 BCL2L1_TKT_SESN2ATG12_CSE1L_FRAP1_SESN2 CSE1L_UVRAG CASP8_TKT_SESN2 ATG7_TKT_XIAP_SESN2RAPTOR_SESN2 DIABLO_TKT_SESN2 ATG7_E2F1_TKT_SESN2 XIAP_SESN2FAS_BHLHE41_SESN2 ATG7_TKT_MMP9_SESN2 CASP3_SESN2 FRAP1_TKT_SESN2ATG7_TKT_RAGE_SESN2 CASP8_SESN2 PTEN_TKT_SESN2 ATG3_ATG7_TKT_SESN2LC3_SESN2 TKT_RAGE_SESN2 ATG7_CSE1L_LC3_SESN2 Combinations of five typesCombinations of six types ATG5_CSE1L_FRAP1_LC3_SESN2ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 ATG5_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_SESN2_SIRT1ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2 ATG7_CSE1L_FRAP1_LC3_SESN2ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG7_FRAP1_LC3_SESN2_SIRT1ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_LAMP1_SESN2ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 AKT1_ATG7_TKT_LAMP2_SESN2ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 ATG5_FRAP1_LAMP1_SESN2_SIRT1ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2 CSE1L_FRAP1LAMP1SESN2_SIRT1CSE1L_FRAP1LC3_SATB1SESN2_SIRT1 ATG3_FRAP1_LC3_SESN2_SIRT1AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2 AKT1_ATG5_CSE1L_FRAP1_SESN2ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 ATG5_CSE1L_DIABLO_FRAP1_SESN2ATG5_CSE1L_FRAP1_LC3_ID2_SESN2 ATG5_CSE1L_LC3_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3 CSE1L_FRAP1SESN2_SIRT1_UVRAGCSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG7_TKT_LAMP2_SESN2_SESN3AKT1_CSE1L_FRAP1_LC3_SESN2_SIRT1 CSE1L_FRAP1SATB1SESN2_SIRT1ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1 CSE1L_FRAP1CDH1_SESN2_SIRT1CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG7_TKT_FASLG_LAMP2_SESN2ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1 ATG5_CSE1L_FRAP1_ID2_SESN2CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 AKT1_ATG7_TKT_SESN2_SESN3CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 ATG7_TKT_LAMP2_MMP2_SESN2CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 AKT1_CSE1L_FRAP1_SESN2_SIRT1AKT1_ATG5_FRAP1_LC3_SESN2_SIRT1 BNIP3_CSE1L_FRAP1LC3_SESN2ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2 ATG5_CSE1L_FRAP1_SESN2_SESN3ATG5_FRAP1_LC3_ID2_SESN2_SIRT1 CSE1L_FRAP1LAMP1LC3_SESN2ATG5_CSE1L_FRAP1LAMP1SESN2_SIRT1 ATG3_ATG5_CSE1L_FRAP1_SESN2ATG3_ATG7_FRAP1_LC3_SESN2_SIRT1 CSE1L_DRAM_FRAP1_LC3_SESN2ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1 ATG3_CSE1L_FRAP1_SESN2_SIRT1ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2 ATG5_ATG7_FRAP1_LC3_SESN2ATG5_BNIP3_CSE1L_FRAP1LC3_SESN2 ATG5_FAS_FRAP1_SESN2_SIRT1CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 CSE1L_FRAP1_SESN2_SESN3_SIRT1BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 CSE1L_DRAM_FRAP1_SESN2_SIRT1ATG5_CSE1L_FRAP1_SESN2_SIRT1_UVRAG CSE1L_DIABLO_FRAP1_SESN2_SIRT1ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2 ATG7_CSE1L_FRAP1_SESN2_SIRT1ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1 ATG5_CSE1L_FRAP1CDH1SESN2ATG5_ATG7_FRAP1_LAMP1_SESN2_SIRT1 ATG7_TKT_FASLG_SESN2_SESN3ATG5_CSE1L_FRAP1CDH1_SESN2_SIRT1 ATG7_TKT_HMGB1_LAMP2_SESN2ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3 ATG7_TKT_AGER_LAMP2_SESN2ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2 ATG3_ATG5_FRAP1_LC3_SESN2ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG ATG3_ATG5_FRAP1_SESN2_SIRT1ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 ATG5_CSE1L_FRAP1_SATB1_SESN2ATG3_ATG5_FRAP1_LAMP1_SESN2_SIRT1 CSE1L_FRAP1_ID2_SESN2_SIRT1CSE1L_FRAP1LC3_CDH1_SESN2_SIRT1 ATG7_BNIP3_TKT_LAMP2_SESN2ATG5_CSE1L_FRAP1_LC3_SESN2_STAT3 ATG5_ATG7_CSE1L_FRAP1_SESN2AIFM1_ATG12_TKT_FASLG_LAMP2_SESN2 ATG5_LC3_NAMPT_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_SESN2_UVRAG ATG12_ATG5_CSE1L_FRAP1_SESN2CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 CSE1L_FRAP1_SESN2_SIRT1_STAT3CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1 CSE1L_FRAP1_LC3_SESN2_UVRAGATG5_CSE1L_FRAP1_LC3_RPS19BP1_SESN2 AKT1_ATG7_TKT_MMP2_SESN2AKT1_ATG5_CSE1L_FRAP1_SESN2_SIRT1 ATG5_BNIP3_CSE1L_FRAP1SESN2ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2 CSE1L_FRAP1_MMP9_SESN2_SIRT1CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1 BNIP3_CSE1L_FRAP1_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2 AKT1_ATG7_TKT_HMGB1_SESN2ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2 AIFM1_AKT1_ATG7_TKT_SESN2ATG5_CSE1L_FRAP1_SATB1_SESN2_SIRT1 AKT1_ATG5_ATG7_TKT_SESN2ATG5_CSE1L_FRAP1_SESN2_SESN3_SIRT1 ATG12_ATG7_TKT_LAMP2_SESN2ATG7_TKT_FASLG_LAMP2_SESN2_SIRT1 CDH1_ID2_MMP9_TCF3_SESN2TKT_CDH1_ID2_MMP9_TCF3_SESN2 Combinations of seven types Combinations ofeight types ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1AIFM1_ATG12_TKT_CDH1_FASLG_HMGB1_LAMP2_SESN2ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAGATG3_ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1AKT1_ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAGATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAGATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAGATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3ATG3_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1ATG3_ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1ATG3_ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1_UVRAGAKT1_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_E2F1_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1ATG3_ATG5_FRAP1_LC3_ID2_SESN2_SIRT1AIFM1_ATG12_TKT_CDH1_CIAP2_FASLG_LAMP2_SESN2ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1AIFM1_ATG12_NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2ATG5_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAGAIFM1_ATG12_TKT_CDH1_FASLG_LAMP2_SESN2ATG3_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1_UVRAGATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3AKT1_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1AKT1_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1AIFM1_ATG12_NNMT_CDH2_CIAP2_FASLG_LAMP2_SESN2ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3ATG3_ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SESN3_SIRT1ATG3_ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1_UVRAGATG3_ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1AIFM1_ATG12_TKT_CDH1_AGER_FASLG_LAMP2_SESN2ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAGATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1_UVRAGATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1_UVRAGATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAGATG3_ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1AIFM1_ATG12_TKT_CIAP2_FASLG_LAMP2_SESN2ATG3_ATG5_ATG7_FRAP1_LAMP1_LC3_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1AKT1_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1AKT1_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1ATG7_TKT_FASLG_LAMP2_SESN2_SESN3_SIRT1AIFM1_DRAM_TKT_CDH1_FASLG_LAMP2_SESN2_SIRT1ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1AKT1_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_DIABLO_FRAP1_LC3_SATB1_SESN2_SIRT1ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2ATG5_CSE1L_FRAP1_LC3_ID2_SATB1_SESN2_SIRT1ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAGATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SESN3_SIRT1ATG12_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SESN3_SIRT1AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT12ATG5_ATG7_FRAP1_LC3_RPS19BP1_SESN2_SIRT1ATG5_CSE1L_DRAM_FRAP1_LC3_SATB1_SESN2_SIRT1ATG3_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1ATG3_ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAGATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2AIFM1_DRAM_TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2ATG5_ATG7_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2ATG3_ATG5_DIABLO_DRAM_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3ATG5_ATG7_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1AKT1_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1AIFM1_ATG12_MMP9_AGER_FASLG_LAMP2_SESN2_SIRT1AKT1_ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1ATG5_ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1ATG7_TKT_CDH1_ID2_MMP9_TCF3_SESN2TKT_CDH1_ID2_MMP9_TCF3_FASLG_SESN2_SIRT1

Preferably, the composition or kit is for predicting the prognosis ofrecurrence of the B group, and the genes are one or more selected fromthe genes or groups of genes described in the following Table 10.

TABLE 10 One type Combinations of two types Combinations of three typesCombinations of four types HMGB1 ATG3_HMGB1 ATG3_BCL2_HMGB1ATG3_BCL2_CDH1_HMGB1 TKT ATG3_BECN1 ATG3_HMGB1_RAGEATG3_CDH1_HMGB1_UVRAG TKT_HMGB1 ATG3_TKT_HMGB1 ATG3_BCL2_TKT_HMGB1BCL2L1_TKT ATG3_CDH1_HMGB1 ATG3_BCL2_HMGB1_RAGE ATG3_NAMPTATG3_HMGB1_HMGB2 ATG3_BCL2_HMGB1_HMGB2 BCL2_HMGB1 ATG3_HMGB1_UVRAGATG3_CDH1_HMGB1_SIRT1 HMGB1_TWIST1 ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_MMP2ATG12_ATG3 ATG3_HMGB1_SIRT1 ATG3_HMGB1_HMGB2_RAGE CSE1L_DIABLOATG3_BECN1_SATB1 ATG3_BCL2_BNIP3_HMGB1 ATG3_TKT ATG3_HMGB1_SATB1ATG3_CDH1_CASP3_HMGB1 LAMP1_HMGB1 ATG3_LC3_BECN1ATG3_CDH1_HMGB1_KIAA1967 TKT_BECN1 ATG3_HMGB1_LAMP2ATG3_HMGB1_RAGE_UVRAG CDH1_HMGB1 ATG3_HMGB1_RAPTOR ATG3_HMGB1_RAGE_SIRT1HMGB1_TP63 ATG3_HMGB1_KIAA1967 ATG3_TKT_HMGB1_HMGB2 TKT_NAMPTBCL2L1_TKT_CASP3 ATG3_TKT_HMGB1_UVRAG BCL2_TKT ATG12_ATG3_HMGB1ATG3_BCL2_LAMP1_HMGB1 CSE1L_TKT BCL2L1_TKT_SIRT1 ATG3_BCL2_HMGB1_RAPTORLC3_TKT ATG3_CIAP2_HMGB1 AIFM1_ATG3_BCL2_HMGB1 TKT_CASP3BCL2L1_TKT_BECN1 ATG3_CASP3_HMGB1_RAGE FASLG_HMGB1 BCL2_TKT_HMGB1ATG12_ATG3_HMGB1_RAGE CDH2_HMGB1 ATG3_BECN1_SESN3 ATG3_TKT_CASP3_HMGB1ATG5_HMGB1 ATG3_CASP8_HMGB1 ATG3_TKT_HMGB1_KIAA1967 HMGB1_SIRT1ATG3_CDH2_HMGB1 ATG3_BCL2L1_TKT_BECN1 ATG12_HMGB1 ATG3_FRAP1_HMGB1ATG12_ATG3_CDH1_HMGB1 HMGB1_RAGE ATG3_BNIP3_HMGB1 ATG3_CDH1_HMGB1_RAGEHMGB1_UVRAG ATG3_BECN1_HMGB1 ATG3_BCL2_FRAP1_HMGB1 BCL2L1_SIRT1ATG3_CBS_HMGB1 ATG3_BCL2_HMGB1_LAMP2 ATG3_TCF3 AIFM1_ATG3_HMGB1ATG3_BCL2_DIABLO_HMGB1 BCL2L1_HMGB1 ATG3_HMGB1_STAT3ATG3_TKT_HMGB1_SIRT1 TKT_SIRT1 ATG3_HMGB1_MMP2 ATG3_BCL2_CBS_HMGB1HMGB1_LAMP2 ATG3_LAMP1_HMGB1 ATG3_BCL2_CASP8_HMGB1 TKT_SESN2BCL2L1_TKT_FASLG ATG3_HMGB1_HMGB2_SATB1 HMGB1_MMP2 ATG3_DIABLO_HMGB1ATG3_BCL2_PTEN_HMGB1 TKT_AGER BCL2_BCL2L1_TKT ATG3_HMGB1_RAGE_RAPTORHMGB1_RAPTOR TKT_HMGB1_TWIST1 ATG3_TKT_HMGB1_RAGE E2F1_HMGB1ATG3_NNMT_HMGB1 ATG3_BCL2_CASP3_HMGB1 CASP8_HMGB1 ATG3_MMP9_HMGB1ATG3_BCL2_HMGB1_SATB1 TKT_ID2 BCL2L1_TKT_HMGB1 ATG3_HMGB1_LAMP2_RAGEAKT1_TKT ATG3_LAMP1_BECN1 ATG3_CDH1_HMGB1_LAMP2 ATG3_SIRT1ATG3_BCL2L1_BECN1 ATG3_HMGB1_HMGB2_UVRAG TKT_RPS19BP1 ATG5_TKT_HMGB1ATG3_BCL2L1_TKT_HMGB1 CSE1L_HMGB1 ATG3_FASLG_HMGB1 CDH1_HMGB1_TP63_UVRAGBCL2L1_BECN1 ATG3_MMP9_BECN1 ATG3_CDH1_HMGB1_HMGB2 CASP3_HMGB1ATG3_ATG7_BECN1 ATG3_BCL2L1_TKT_CASP3 ATG7_HMGB1 ATG3_HMGB1_SESN3ATG3_HMGB1_KIAA1967_RAGE FRAP1_HMGB1 ATG3_E2F1_HMGB1ATG3_BCL2_DRAM_HMGB1 HMGB1_HMGB2 HMGB1_RAPTOR_TWIST1 ATG3_LC3_TKT_HMGB1HMGB1_SATB1 AKT1_ATG3_BECN1 ATG3_BCL2_HMGB1_UVRAG ATG3_ULK1ATG3_FAS_HMGB1 ATG3_CDH1_CDH2_HMGB1 ATG3_SESN1_ ATG3_ULK1_HMGB1BCL2_BCL2L1_TKT_CASP3 CBS_HMGB1 TKT_HMGB1_SIRT1 ATG3_TKT_BECN1_HMGB1TKT_KIAA1967 ATG3_BAX_HMGB1 ATG3_TKT_HMGB1_LAMP2 ATG12_BCL2L1TKT_CDH2_HMGB1 ATG3_BCL2_PRKAA1_HMGB1 DRAM_HMGB1 ATG3_PTEN_HMGB1BCL2L1_TKT_CASP3_SIRT1 LC3_FASLG ATG3_TKT_BECN1 BCL2L1_TKT_CASP3_FASLGHMGB1_KIAA1967 ATG3_HMGB1_TWIST1 BCL2L1_TKT_CASP3_CDH2 TKT_SESN1_BCL2L1_TKT_UVRAG ATG3_BCL2_NNMT_HMGB1 Combinations of five typesCombinations of six types ATG3_BCL2_CDH1_HMGB1_RAGEATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR ATG3_BCL2_CDH1_HMGB1_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE ATG3_BCL2_CDH1_HMGB1_RAPTORATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE ATG3_BCL2_CDH1_HMGB1_HMGB2ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_CDH1_HMGB1_KIAA1967ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_LAMP2ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_CDH1_CDH2_HMGB1ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE ATG3_CDH1_HMGB1_RAGE_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_CASP3_HMGB1ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG ATG12_ATG3_BCL2_CDH1_HMGB1ATG12_ATG3_BCL2_CDH1_HMGB1_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2 ATG3_BCL2_CBS_CDH1_HMGB1ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2 ATG3_CDH1_HMGB1_RAGE_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 ATG3_BCL2_TKT_HMGB1_HMGB2AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_CDH1_HMGB1_MMP2ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967 ATG3_BCL2_NNMT_CDH1_HMGB1ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2 ATG3_BCL2_HMGB1_HMGB2_RAGEATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_CDH1_MMP9_HMGB1ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTOR ATG12_ATG3_CDH1_HMGB1_RAGEATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_LAMP2_SIRT1ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2 ATG3_BCL2_DIABLO_CDH1_HMGB1AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2L1_TKT_BECN1_CASP3ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967 ATG3_BCL2_HMGB1_MMP2_RAGEATG3_BCL2_CDH1_HMGB1_MMP2_RAGE ATG3_CDH1_HMGB1_HMGB2_UVRAGAIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_DRAM_CDH1_HMGB1ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1 ATG3_BCL2_TKT_CDH1_HMGB1ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAG ATG3_BCL2_TKT_CASP3_HMGB1ATG3_BCL2_CASP8_CDH1_HMGB1_RAGE ATG3_CDH1_HMGB1_KIAA1967_UVRAGATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1 ATG3_CDH1_HMGB1_LAMP2_UVRAGATG3_BCL2_DRAM_CDH1_HMGB1_UVRAG ATG3_BCL2_BCL2L1_TKT_HMGB1ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_SATB1ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2L1_TKT_HMGB1_SIRT1ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1 ATG3_BCL2_TKT_ID2_HMGB1ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGE ATG3_CDH1_HMGB1_KIAA1967_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_PTEN_CDH1_HMGB1ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTOR AIFM1_ATG3_CDH1_HMGB1_SIRT1ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_STAT3ATG3_BCL2_CBS_CDH1_HMGB1_RAGE ATG3_CDH1_CASP3_HMGB1_RAGEATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAG ATG3_BCL2_LC3_TKT_HMGB1ATG3_BCL2_CBS_CDH1_HMGB1_UVRAG ATG3_CDH1_CASP3_HMGB1_UVRAGATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1 ATG3_BCL2_CDH1_CIAP2_HMGB1AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_BNIP3_HMGB1_RAGEATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTOR ATG3_CDH1_HMGB1_RAPTOR_SIRT1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3 ATG3_CDH1_HMGB1_SIRT1_UVRAGATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAG ATG3_CDH1_HMGB1_RAPTOR_UVRAGATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2 ATG3_CDH1_HMGB1_KIAA1967_SIRT1ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BAX_BCL2_CDH1_HMGB1ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1 ATG3_BCL2_LAMP1_CDH1_HMGB1ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1 ATG3_ATG5_BCL2_CDH1_HMGB1AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1 ATG3_BCL2_TKT_HMGB1_RAGEATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2 ATG3_CDH1_HMGB1_SATB1_UVRAGATG3_BCL2_CBS_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_SESN3ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAG ATG3_BCL2_FAS_CDH1_HMGB1ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAG CDH1_ID2_MMP9_TCF3_FASLGATG12_ATG3_CDH1_ID2_MMP9_TCF3 Combinations of seven types Combinationsof eight types ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTORATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGEATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAGATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGEATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGEATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGEATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_UVRAGATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAGAIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGEATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGEATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTORATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGEATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTORATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGEAIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGEATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAGATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGEATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_UVRAGATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAGATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGEATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTORATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAGAIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTORATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAGATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTORAIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGEATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAGATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAGAIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTORATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTORATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGEATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAGATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAGATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGEATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGEATG12_ATG3_CDH1_ID2_MMP9_TCF3_SATB1ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG

Preferably, the composition or kit is for predicting the prognosis ofsurvival of the B group, and the genes are one or more selected from thegenes or groups of genes described in the following Table 11.

TABLE 11 One type Combinations of two types Combinations of three typesCombinations of four types ATG12 DIABLO_NAMPT DIABLO_ID2_NAMPTATG12_ID2_MMP9_TCF3 DIABLO ATG12_ID2 DIABLO_FAS_NAMPTDIABLO_FAS_ID2_NAMPT UVRAG ATG12_RPS19BP1 ATG12_ID2_TCF3ATG12_CSE1L_ID2_MMP9 NAMPT ATG12_DIABLO DIABLO_FAS_STAT3DIABLO_ID2_MMP9_NAMPT STAT3 ID2_NAMPT ATG12_ID2_MMP9DIABLO_FAS_MMP9_NAMPT E2F1 DIABLO_STAT3 ATG12_ID2_SATB1DIABLO_ID2_NAMPT_STAT3 BECN1 DIABLO_FAS ATG12_ID2_RPS19BP1ATG12_FAS_ID2_MMP9 FRAP1 ATG12_CSE1L ATG12_CSE1L_ID2ATG12_ID2_MMP9_SATB1 ATG7 ATG12_MMP9 ATG12_DIABLO_FASDIABLO_ID2_NAMPT_SATB1 ID2 ATG12_ATG3 ATG12_ID2_SESN2ATG12_ID2_MMP9_SESN2 SIRT1 ATG12_SATB1 ATG12_ID2_NAMPTATG12_ID2_MMP9_RPS19BP1 BCL2 ATG12_SESN2 ATG12_CSE1L_DIABLOCSE1L_DIABLO_ID2_NAMPT BNIP3 CSE1L_DIABLO ID2_NAMPT_STAT3DIABLO_ID2_TCF3_NAMPT LAMP2 ATG12_TCF3 ATG12_ID2_BHLHE41DIABLO_FAS_NAMPT_SATB1 TKT ATG12_FAS CSE1L_DIABLO_NAMPTATG12_DIABLO_FAS_MMP9 ATG12_STAT3 DIABLO_LC3_NAMPT DIABLO_FAS_ID2_STAT3ATG12_BHLHE41 ATG12_FAS_ID2 ATG12_ATG3_ID2_TCF3 ATG12_NAMPTID2_NAMPT_RPS19BP1 ATG3_DIABLO_ID2_NAMPT ATG12_ATG7 ID2_MMP9_TCF3ATG12_ID2_TCF3_STAT3 ID2_BECN1 DIABLO_NAMPT_SATB1 DIABLO_FAS_NAMPT_STAT3E2F1_FAS ATG12_CSE1L_MMP9 ATG12_CSE1L_DIABLO_MMP9 ATG12_ATG5ATG12_MMP9_RPS19BP1 ATG12_ID2_TCF3_SATB1 ID2_STAT3 ID2_MMP9_BECN1DIABLO_FAS_MMP9_STAT3 ATG12_ULK1 DIABLO_NAMPT_STAT3ATG12_ID2_MMP9_BHLHE41 DIABLO_BECN1 ATG12_DIABLO_MMP9ATG12_BNIP3_ID2_MMP9 ATG12_LAMP1 ATG12_FAS_RPS19BP1DIABLO_FAS_SATB1_STAT3 ATG12_LC3 DIABLO_FAS_MMP9DIABLO_FAS_NAMPT_RPS19BP1 DIABLO_TCF3 ID2_MMP9_NAMPT ATG12_ATG3_ID2_MMP9AKT1_ATG12 ATG12_ID2_STAT3 ATG12_ID2_MMP9_NAMPT ATG12_FRAP1ATG12_DIABLO_TCF3 DIABLO_FAS_NAMPT_SESN2 DIABLO_ID2 ATG12_ATG3_ID2DIABLO_ID2_NAMPT_SESN2 ID2_TCF3 ATG12_DIABLO_ID2 ATG12_ID2_TCF3_RPS19BP1DIABLO_SATB1 CSE1L_DIABLO_STAT3 ATG12_DIABLO_MMP9_TCF3 ATG12_BECN1DIABLO_ID2_STAT3 ATG12_CSE1L_ID2_SATB1 ATG12_SIRT1 ATG12_ATG3_RPS19BP1ATG12_FAS_MMP9_RPS19BP1 NAMPT_STAT3 ATG12_DIABLO_SATB1ID2_MMP9_TCF3_STAT3 ATG12_BNIP3 ATG12_MMP9_TCF3 ATG12_DIABLO_ID2_NAMPTDIABLO_MMP9 ATG3_DIABLO_NAMPT DIABLO_ID2_TCF3_STAT3 ATG12_UVRAGATG12_DIABLO_NAMPT ATG12_ULK1_ID2_TCF3 DIABLO_FRAP1 ATG12_CSE1L_RPS19BP1ATG12_ID2_TCF3_SESN2 NAMPT_RPS19BP1 DIABLO_MMP9_NAMPTBNIP3_CSE1L_DIABLO_MMP9 AKT1_NAMPT ATG12_ATG3_DIABLOATG12_DIABLO_ID2_TCF3 E2F1_UVRAG DIABLO_SATB1_STAT3 ATG12_ATG5_ID2_MMP9ATG3_DIABLO ID2_TCF3_STAT3 ATG12_ID2_SATB1_STAT3 NAMPT_UVRAGATG12_RPS19BP1_SATB1 ATG12_MMP9_TCF3_RPS19BP1 BNIP3_DIABLOATG12_DIABLO_STAT3 ATG12_DIABLO_FAS_ID2 DIABLO_LC3 ATG12_TCF3_RPS19BP1ATG12_CSE1L_ID2_SESN2 DIABLO_SIRT1 DIABLO_NAMPT_SESN2DIABLO_FAS_MMP9_TCF3 LC3_NAMPT ATG12_DIABLO_SESN2 ATG12_ID2_TCF3_BHLHE41DIABLO_SESN2 ATG12_ULK1_ID2 ATG12_FAS_ID2_STAT3 FAS_STAT3 ATG12_ATG5_ID2BNIP3_CSE1L_ID2_MMP9 FAS_NAMPT AKT1_DIABLO_NAMPT CSE1L_DIABLO_FAS_NAMPTE2F1_NAMPT ATG12_ID2_BECN1 ATG12_CSE1L_ID2_TCF3 ATG12_SESN3ATG12_FAS_MMP9 ATG12_ID2_NAMPT_RPS19BP1 BCL2_TKT ATG12_DIABLO_BHLHE41ATG12_ID2_MMP9_BECN1 ATG7_NAMPT ATG12_RPS19BP1_STAT3DIABLO_FAS_LC3_NAMPT ATG7_BECN1 DIABLO_NAMPT_RPS19BP1FAS_ID2_NAMPT_RPS19BP1 CDH1_ID2_MMP9_TCF3 Combinations of five typesCombinations of six types DIABLO_FAS_ID2_MMP9_NAMPTDIABLO_FAS_ID2_MMP9_TCF3_NAMPT ATG12_ATG3_ID2_MMP9_TCF3ATG12_ATG3_BNIP3_ID2_MMP9_TCF3 ATG12_ID2_MMP9_TCF3_SATB1ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1 ATG12_CSE1L_ID2_MMP9_TCF3ATG12_ATG3_ID2_MMP9_TCF3_SATB1 ATG12_BNIP3_ID2_MMP9_TCF3DIABLO_FAS_ID2_MMP9_NAMPT_SATB1 ATG12_ID2_MMP9_TCF3_SESN2ATG12_ATG3_ULK1_ID2_MMP9_TCF3 ATG12_ULK1_ID2_MMP9_TCF3ATG12_BNIP3_CSE1L_ID2_MMP9_SESN2 ATG12_ATG5_ID2_MMP9_TCF3DIABLO_FAS_ID2_MMP9_NAMPT_STAT3 ATG12_FAS_ID2_MMP9_TCF3ATG12_ATG3_FAS_ID2_MMP9_TCF3 DIABLO_FAS_ID2_NAMPT_STAT3ATG12_ATG3_ID2_MMP9_TCF3_SESN2 ATG12_ID2_MMP9_TCF3_RPS19BP1ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3 ATG12_BNIP3_ID2_MMP9_RPS19BP1CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT ATG12_CSE1L_ID2_MMP9_SATB1ATG12_ATG3_CSE1L_ID2_MMP9_TCF3 ATG12_CSE1L_ID2_MMP9_SESN2ATG12_BNIP3_ID2_MMP9_TCF3_SATB1 ATG12_LAMP1_ID2_MMP9_TCF3DIABLO_FAS_ID2_MMP9_NAMPT_SESN2 DIABLO_FAS_ID2_NAMPT_SATB1ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41 ATG12_BNIP3_CSE1L_ID2_MMP9ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1 DIABLO_ID2_MMP9_TCF3_NAMPTDIABLO_FAS_ID2_MMP9_TCF3_STAT3 ATG12_BNIP3_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_FAS_ID2_MMP9 ATG12_ID2_MMP9_TCF3_BHLHE41ATG12_ATG3_BNIP3_ID2_MMP9_SATB1 ATG12_ID2_MMP9_TCF3_STAT3ATG12_BNIP3_CSE1L_ID2_MMP9_RPS19BP1 ATG12_BNIP3_FAS_ID2_MMP9ATG12_BNIP3_DIABLO_FAS_ID2_MMP9 ATG12_BNIP3_ID2_MMP9_SESN2ATG12_BNIP3_FAS_ID2_MMP9_RPS19BP1 ATG12_ATG3_FAS_ID2_MMP9ATG12_CSE1L_ID2_MMP9_TCF3_SATB1 CSE1L_DIABLO_ID2_MMP9_NAMPTATG12_CSE1L_ULK1_ID2_MMP9_TCF3 ATG12_DIABLO_ID2_MMP9_TCF3ATG12_FAS_ID2_MMP9_TCF3_RPS19BP1 DIABLO_ID2_NAMPT_SATB1_STAT3DIABLO_FAS_ID2_NAMPT_SATB1_STAT3 ATG12_ATG3_CSE1L_ID2_MMP9ATG12_ATG5_BNIP3_ID2_MMP9_TCF3 ATG12_FAS_ID2_MMP9_RPS19BP1ATG12_BNIP3_ID2_MMP9_TCF3_SESN2 ATG12_DIABLO_FAS_ID2_MMP9ATG12_CSE1L_ID2_MMP9_TCF3_SESN2 DIABLO_FAS_ID2_MMP9_STAT3ATG12_ID2_MMP9_TCF3_SATB1_SESN2 ATG12_CSE1L_ID2_MMP9_BHLHE41ATG12_ULK1_ID2_MMP9_TCF3_SATB1 DIABLO_ID2_MMP9_NAMPT_STAT3ATG12_ATG3_ATG5_ID2_MMP9_TCF3 DIABLO_FAS_ID2_NAMPT_SESN2ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9 ATG12_CSE1L_FAS_ID2_MMP9ATG12_ATG3_LAMP1_ID2_MMP9_TCF3 DIABLO_FAS_ID2_TCF3_NAMPTATG12_BNIP3_DIABLO_ID2_MMP9_TCF3 ATG12_ATG3_ID2_MMP9_SATB1ATG12_BNIP3_ULK1_ID2_MMP9_TCF3 ATG12_BNIP3_ID2_MMP9_BHLHE41ATG12_DIABLO_FAS_ID2_MMP9_TCF3 ATG3_DIABLO_FAS_ID2_NAMPTATG12_ULK1_ID2_MMP9_TCF3_SESN2 CSE1L_DIABLO_FAS_ID2_NAMPTATG3_DIABLO_FAS_ID2_MMP9_NAMPT ATG12_CSE1L_ID2_MMP9_RPS19BP1ATG12_ATG3_BNIP3_ID2_MMP9_SESN2 ATG12_CSE1L_ULKLID2_MMP9ATG12_ATG3_ID2_MMP9_TCF3_BHLHE41 DIABLO_FAS_ID2_MMP9_TCF3ATG12_BNIP3_CSE1L_FAS_ID2_MMP9 CSE1L_DIABLO_ID2_NAMPT_STAT3DIABLO_ID2_MMP9_TCF3_NAMPT_SATB1 ATG12_ATG3_ID2_MMP9_SESN2ATG12_ATG3_BNIP3_ID2_MMP9_RPS19BP1 DIABLO_ID2_MMP9_TCF3_STAT3ATG12_ATG5_ID2_MMP9_TCF3_SATB1 DIABLO_ID2_TCF3_NAMPT_SATB1ATG12_BNIP3_FAS_ID2_MMP9_TCF3 CSE1L_DIABLO_FAS_MMP9_NAMPTATG12_ATG3_CSE1L_ID2_MMP9_SATB1 DIABLO_FAS_ID2_NAMPT_RPS19BP1ATG12_ATG3_ID2_MMP9_TCF3_STAT3 BNIP3_DIABLO_FAS_ID2_MMP9ATG12_ATG5_BNIP3_ID2_MMP9_SATB1 DIABLO_ID2_MMP9_NAMPT_SATB1ATG12_BNIP3_ID2_MMP9_TCF3_BHLHE41 ATG12_DIABLO_FAS_MMP9_TCF3ATG12_FAS_ID2_MMP9_TCF3_SESN2 ATG12_ATG5_FAS_ID2_MMP9DIABLO_FAS_ID2_MMP9_NAMPT_RPS19BP1 ATG12_LC3_ID2_MMP9_TCF3ATG12_ATG3_CSE1L_ID2_MMP9_SESN2 ATG12_FAS_ID2_MMP9_STAT3ATG12_ATG3_ID2_MMP9_TCF3_RPS19BP1 FAS_ID2_MMP9_NAMPT_RPS19BP1ATG12_ATG5_BNIP3_FAS_ID2_MMP9 ATG12_ID2_MMP9_TCF3_BECN1ATG12_ATG5_ULK1_ID2_MMP9_TCF3 ATG12_CDH1_ID2_MMP9_TCF3E2F1_FAS_CDH1_ID2_MMP9_TCF3 Combinations of seven types Combinations ofeight types DIABLO_FASJD2_MMP9_TCF3_NAMPT_SATB1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SESN2ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_STAT3DIABLO_FASJD2_MMP9_TCF3_NAMPT_SESN2DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_SESN2ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SESN2ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3DIABLO_FASJD2_MMP9_NAMPT_SATB1_STAT3ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2DIABLO_FASJD2_MMP9_TCF3_NAMPT_STAT3ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3ATG3_BCL2_E2F1_LAMP1_TKT_MMP9_CASP3_HMGB1ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SATB1ATG12_ATG3_BNIP3_CSE1L_DIABLO_FASJD2_MMP9ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2ATG12_ATG3_BNIP3_CSE1L_ULK1_02_MMP9_BHLHE41ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SATB1ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SATB1ATG12_ATG3_ID2_MMP9_TCF3_SATB1_SESN2ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_SESN2DIABLO_FASJD2_MMP9_TCF3_SATB1_STAT3ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41_SATB1ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_SESN2ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1_SESN2ATG12_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SATB1ATG12_BNIP3_CSE1L_ULK1_02_MMP9_SESN2ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SATB1CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_STAT3ATG12_BNIP3_FAS_ULK1_ID2_MMP9_TCF3_RPS19BP1ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SATB1ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_TCF3ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SESN2ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_SESN2ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2ATG12_ATG3_ATG5_BNIP3_ULK1_ID2_MMP9_TCF3ATG12_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SATB1ATG12_BNIP3_CSE1L_ULK1_02_MMP9_TCF3ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SESN2ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_SATB1ATG12_ATG3_FAS_ID2_MMP9_TCF3_SATB1ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_SESN2ATG12_ATG3_FAS_ID2_MMP9_TCF3_RPS19BP1ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_RPS19BP1ATG12_ATG3_FAS_ID2_MMP9_TCF3_SESN2ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_TCF3ATG12_ATG3_FAS_ULK1_ID2_MMP9_TCF3ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_SATB1ATG12_ATG5_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_RPS19BP1ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1_SESN2ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SESN2ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3_SATB1ATG12_ATG3_CSE1L_ULK1_ID2_MMP9_TCF3ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_SESN2ATG12_BNIP3_CSE1L_FAS_ID2_MMP9_RPS19BP1ATG12_BNIP3_DIABLO_FAS_ULK1_02_MMP9_TCF3ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_SESN2ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41ATG3_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1ATG12_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2_STAT3ATG12_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2_STAT3DIABLO_FASJD2_MMP9_NAMPT_SESN2_STAT3ATG12_ATG3_ATG5_BNIP3_CSE1L_FAS_ID2_MMP9CSE1L_DIABLO_FAS_ID2_MMP9_TCF3_NAMPTATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_BHLHE41DIABLO_FASJD2_MMP9_NAMPT_SATB1_SESN2ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_TCF3CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_RPS19BP1ATG12_ATG3_BNIP3_DIABLO_ID2_MMP9_TCF3ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_FAS_ID2_MMP9_SATB1ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_SESN2ATG3_TKT_CDH1_ID2_MMP9_TCF3_UVRAG ATG3_TKT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG

Preferably, the composition or kit is for predicting the prognosis ofdisease-free survival of the B group, and the genes are one or moreselected from the genes or groups of genes described in the followingTable 12.

TABLE 12 One type Combinations of two types Combinations of three typesCombinations of four types DIABLO ATG3_BECN1 ATG3_BCL2 HMGB1ATG3_BCL2_CDH1_HMGB1 BECN1 ATG3_HMGB1 ATG3_HMGB1_RAGEATG3_CDH1_HMGB1_UVRAG HMGB1 BCL2L1_TKT ATG3_HMGB1_UVRAGATG3_BCL2_TKT_HMGB1 CSE1L_DIABLO ATG3_CASP3_HMGB1 ATG3_BCL2_HMGB1_RAGEBCL2_HMGB1 ATG3_HMGB1_SIRT1 ATG3_BCL2_HMGB1_HMGB2 ATG12_ATG3ATG3_BECN1_SATB1 ATG3_CDH1_HMGB1_SIRT1 ATG3_NAMPT ATG3_HMGB1_LAMP2ATG3_BCL2_HMGB1_MMP2 HMGB1_TWIST1 ATG3_HMGB1_RAPTORATG3_HMGB1_HMGB2_RAGE TKT_HMGB1 ATG3_LC3_BECN1 ATG3_BCL2_BNIP3_HMGB1LAMP1_HMGB1 ATG3_HMGB1_KIAA1967 ATG3_CDH1_CASP3_HMGB1 TKT_BECN1BCL2L1_TKT_CASP3 ATG3_CDH1_HMGB1_KIAA1967 HMGB1_TP63 ATG12_ATG3_HMGB1ATG3_HMGB1_RAGE_UVRAG BCL2_TKT BCL2L1_TKT_SIRT1 ATG3_HMGB1_RAGE_SIRT1TKT_CASP3 BCL2L1_TKT_BECN1 ATG3_TKT_HMGB1_UVRAG FASLG_HMGB1BCL2_TKT_HMGB1 ATG3_BCL2_LAMP1_HMGB1 TKT_NAMPT ATG3_BECN1_SESN3ATG3_BCL2_HMGB1_RAPTOR ATG5_HMGB1 ATG3_BNIP3_HMGB1 AIFM1_ATG3_BCL2_HMGB1HMGB1_SIRT1 ATG3_BECN1_HMGB1 ATG3_CASP3_HMGB1_RAGE ATG12_HMGB1AIFM1_ATG3_HMGB1 ATG12_ATG3_HMGB1_RAGE HMGB1_RAGE ATG3_LAMP1_HMGB1ATG3_TKT_CASP3_HMGB1 DIABLO_NAMPT BCL2L1_TKT_FASLGATG3_TKT_HMGB1_KIAA1967 HMGB1_UVRAG BCL2_BCL2L1_TKTATG3_BCL2L1_TKT_BECN1 DIABLO_BECN1 TKT_HMGB1_TWIST1ATG12_ATG3_CDH1_HMGB1 BECN1_SATB1 ATG3_NNMT_HMGB1 ATG3_CDH1_HMGB1_RAGEBCL2L1_SIRT1 BCL2L1_TKT_HMGB1 ATG3_BCL2_FRAP1_HMGB1 BCL2L1_HMGB1ATG3_BCL2L1_BECN1 ATG3_BCL2_HMGB1_LAMP2 TKT_SIRT1 ATG5_TKT_HMGB1ATG3_BCL2_DIABLO_HMGB1 DIABLO_TCF3 ATG3_FASLG_HMGB1 ATG3_TKT_HMGB1_SIRT1HMGB1_LAMP2 ATG3_MMP9_BECN1 ATG3_BCL2_CBS_HMGB1 DIABLO_SATB1ATG3_LAMP1_BECN1 ATG3_BCL2_CASP8_HMGB1 HMGB1_RAPTOR ATG3_E2F1_HMGB1ATG3_BCL2_PTEN_HMGB1 E2F1_HMGB1 HMGB1_RAPTOR_TWIST1ATG3_HMGB1_RAGE_RAPTOR ATG5_BECN1 AKT1_ATG3_BECN1 ATG3_TKT_HMGB1_RAGEATG12_SATB1 ATG3_ULK1_HMGB1 ATG3_BCL2_CASP3_HMGB1 BCL2L1_BECN1TKT_HMGB1_SIRT1 ATG3_BCL2_HMGB1_SATB1 CASP3_HMGB1 ATG3_BAX_HMGB1ATG3_HMGB1_LAMP2_RAGE ATG12_CSE1L ATG3_PTEN_HMGB1 ATG3_CDH1_HMGB1_LAMP2ATG7_HMGB1 ATG3_TKT_HMGB1 ATG3_HMGB1_HMGB2_UVRAG ATG3_SIRT1ATG3_TKT_BECN1 ATG3_BCL2L1_TKT_HMGB1 CASP8_HMGB1 ATG3_HMGB1_TWIST1CDH1_HMGB1_TP63_UVRAG ATG3_SESN1 BCL2L1_TKT_UVRAG ATG3_BCL2L1_TKT_CASP3TKT_KIAA1967 TKT_HMGB1_UVRAG ATG3_HMGB1_KIAA1967_RAGE ATG12_BCL2L1BCL2L1_TKT_CDH2 ATG3_BCL2_DRAM_HMGB1 DRAM_HMGB1 BCL2L1_TKT_KIAA1967ATG3_BCL2_HMGB1_UVRAG LC3_FASLG ATG3_BCL2L1_HMGB1 BCL2_BCL2L1_TKT_CASP3HMGB1_KIAA1967 ATG3_ATG5_HMGB1 ATG3_TKT_BECN1_HMGB1 TKT_SESN1ATG3_DRAM_HMGB1 ATG3_TKT_HMGB1_LAMP2 ATG3_DIABLO ATG3_HMGB1_SATB1ATG3_BCL2_PRKAA1_HMGB1 DIABLO_SIRT1 ATG3_BCL2L1_TKTBCL2L1_TKT_CASP3_SIRT1 BECN1_HMGB1 ATG3_PRKAA1_HMGB1BCL2L1_TKT_CASP3_FASLG AlFM1_HMGB1 TKT_CASP3_HMGB1 BCL2L1_TKT_CASP3_CDH2ID2_BECN1 ATG3_XIAP_HMGB1 ATG3_BCL2_NNMT_HMGB1 CSE1L_BECN1TKT_HMGB1_KIAA1967 ATG3_CDH1_HMGB1_RAPTOR TKT_ULK1 TKT_HMGB1_LAMP2ATG3_BNIP3_HMGB1_RAGE BNIP3_HMGB1 HMGB1_RAGE_TWIST1 ATG3_BAX_BCL2_HMGB1TKT_UVRAG ATG12_BCL2L1_TKT ATG3_BCL2_ID2_HMGB1 ATG5_TKT ATG3_PTEN_BECN1ATG3_BCL2_HMGB1_STAT3 Combinations of five types Combinations of sixtypes ATG3_BCL2_CDH1_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_UVRAG ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGEATG3_BCL2_CDH1_HMGB1_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_CDH1_HMGB1_RAPTOR ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGEATG3_BCL2_CDH1_HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_CDH1_HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTORATG3_BCL2_BNIP3_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_RAGEATG3_BCL2_CDH1_HMGB1_LAMP2 ATG3_BCL2_CDH1_HMGB1_RAGE_UVRAGATG3_BCL2_CDH1_CDH2_HMGB1 ATG3_BCL2_CDH1_CASP3_HMGB1_RAGEATG3_CDH1_HMGB1_RAGE_SIRT1 AIFM1_ATG3_BCL2_CDH1_HMGB1_SIRT1ATG3_BCL2_CDH1_CASP3_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAGATG12_ATG3_BCL2_CDH1_HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB1_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_UVRAGATG3_BCL2_CASP8_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAGEATG3_BCL2_FRAP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2ATG3_BCL2_CBS_CDH1_HMGB1 ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2ATG3_CDH1_HMGB1_RAGE_UVRAG ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1ATG3_BCL2_TKT_HMGB1_HMGB2 AIFM1_ATG3_BCL2_CDH1_HMGB1_UVRAGATG3_BCL2_CDH1_HMGB1_MMP2 ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967ATG3_BCL2_NNMT_CDH1_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2ATG3_BCL2_HMGB1_HMGB2_RAGE ATG12_ATG3_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_CDH1_MMP9_HMGB1 ATG3_BCL2_BNIP3_CDH1_HMGB1_RAPTORATG12_ATG3_CDH1_HMGB1_RAGE ATG3_BCL2_DRAM_CDH1_HMGB1_SIRT1ATG3_CDH1_HMGB1_LAMP2_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2ATG3_BCL2_DIABLO_CDH1_HMGB1 AIFMLATG3_BCL2_CDH1_HMGB1_RAGEATG3_BCL2L1_TKT_BECN1_CASP3 ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967ATG3_BCL2_HMGB1_MMP2_RAGE ATG3_BCL2_CDH1_HMGB1_MMP2_RAGEATG3_CDH1_HMGB1_HMGB2_UVRAG AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2ATG3_BCL2_DRAM_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_HMGB2_SIRT1ATG3_BCL2_TKT_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_UVRAGATG3_BCL2_TKT_CASP3_HMGB1 ATG3_BCL2_CASP8_CDH1_HMGB1_RAGEATG3_CDH1_HMGB1_KIAA1967_UVRAG ATG3_CDH1_HMGB1_LAMP2_RAGE_SIRT1ATG3_CDH1_HMGB1_LAMP2_UVRAG ATG3_BCL2_DRAM_CDH1_HMGB1_UVRAGATG3_BCL2_BCL2L1_TKT_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1ATG3_BCL2_CDH1_HMGB1_SATB1 ATG3_BCL2_BCL2L1_TKT_HMGB1_SIRT1ATG3_BCL2L1_TKT_HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_SIRT1ATG3_BCL2_TKT_ID2_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_RAGEATG3_CDH1_HMGB1_KIAA1967_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967ATG3_BCL2_PTEN_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2_RAPTORAIFM1_ATG3_CDH1_HMGB1_SIRT1 ATG3_CDH1_HMGB1_RAGE_SIRT1_UVRAGATG3_BCL2_CDH1_HMGB1_STAT3 ATG3_BCL2_CBS_CDH1_HMGB1_RAGEATG3_CDH1_CASP3_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_UVRAGATG3_BCL2_LC3_TKT_HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1_UVRAGATG3_CDH1_CASP3_HMGB1_UVRAG ATG3_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_CDH1_CIAP2_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_RAPTORATG3_BCL2_BNIP3_HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAPTORATG3_CDH1_HMGB1_RAPTOR_SIRT1 ATG3_BCL2_BCL2L1_TKT_ID2_CASP3ATG3_CDH1_HMGB1_SIRT1_UVRAG ATG3_BCL2_CDH1_HMGB1_RAPTOR_UVRAGATG3_CDH1_HMGB1_RAPTOR_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2ATG3_CDH1_HMGB1_KIAA1967_SIRT1 ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2ATG3_BAX_BCL2_CDH1_HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB1_SIRT1ATG3_BCL2_LAMP1_CDH1_HMGB1 ATG3_BCL2_CDH1_HMGB1_MMP2_SIRT1ATG3_ATG5_BCL2_CDH1_HMGB1 AIFM1_ATG3_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_TKT_HMGB1_RAGE ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2ATG3_CDH1_HMGB1_SATB1_UVRAG ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1ATG3_BCL2_CDH1_HMGB1_SESN3 ATG3_BCL2_CASP8_CDH1_HMGB1_UVRAGATG3_BCL2_FAS_CDH1_HMGB1 ATG3_BCL2_PTEN_CDH1_HMGB1_UVRAGCDH1_ID2_MMP9_TCF3_FASLG ATG12_ATG3_CDH1_ID2_MMP9_TCF3 Combinations ofseven types Combinations of eight typesATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTORATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGEATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAGATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_TWIST1ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGEATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGEATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGEATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_UVRAGATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_TWIST1ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB20000ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAGAIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGEATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGEATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTORATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGEATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTORATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGEAIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGEATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAGATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGEATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_LAMP2ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWISTLUVRAGATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAGATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_KIAA1967AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGEATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTORATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAGAIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTORATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAGATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_UVRAGATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTORAIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGEATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAGATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAGAIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTORATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGEATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTORATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGEATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_UVRAGATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTORATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_UVRAGATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGEATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTORATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGENNMT_CDH1_ID2_MMP9_TCF3_TP63_UVRAGATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG

Preferably, the composition or kit is for predicting the prognosis ofrecurrence of the C group, and the genes are one or more selected fromthe genes or groups of genes described in the following Table 13.

TABLE 13 One type Combinations of two types Combinations of three typesCombinations of four types FASLG CIAP2_FASLG FAS_LC3_FASLGDIABLO_FAS_LC3_FASLG CIAP2 E2F1_FASLG DIABLO_FAS_FASLGFAS_LC3_FASLG_UVRAG CSE1L LC3_FASLG E2F1_LC3_FASLG BNIP3_FAS_LC3_FASLGFAS DIABLO_FASLG FAS_FASLG_RPS19BP1 DRAM_FAS_LC3_FASLG TCF3 FAS_FASLGE2F1_FAS_FASLG E2F1_FAS_LC3_FASLG FASLG_RPS19BP1 FAS_FASLG_UVRAGATG3_FAS_LC3_FASLG PIEN_FASLG DIABL_OLC3_FASLG ATG7_FAS_LC3_FASLGCASP3_FASLG ATG7_FAS_FASLG FAS_LC3_FASLG_STAT3 FASLG_SESN2CIAP2_FASLG_SESN3 FAS_FRAP1_LC3_FASLG FASLG_HMGB1 CIAP2_FASLG_UVRAGFAS_LC3_FASLG_SESN3 CDH2_FASLG BNIP3_LC3_FASLG FAS_LC3_FASLG_SIRT1FRAP1_FASLG LC3_CIAP2_FASLG FAS_LC3_BECN1_FASLG ATG7_FASLGLC3_FASLG_SESN2 ATG5_FAS_LC3_FASLG ATG3_FAS FRAP1_LC3_FASLGFAS_LC3_FASLG_RPS19BP1 FASLG_HMGB2 LC3_FASLG_SESN3 FAS_LAMP1_LC3_FASLGFASLG_UVRAG ATG3_FAS_FASLG FAS_LC3_FASLG_NAMPT DIABLO_FAS ATG7_LC3_FASLGAKT1_FAS_LC3_FASLG FASLG_MMP2 FAS_FRAP1_FASLG FAS_LC3_FASLG_SESN2TKT_FASLG DIABLO_FASLG_SESN2 FAS_LC3_MMP9_FASLG PIEN_CIAP2DRAM_LC3_FASLG FAS_FASLG_RPS19BP1_SESN3 FAS_LC3 CIAP2_FASLG_HMGB1FAS_FASLG_RPS19BP1_UVRAG CBS_FASLG FAS_FASLG_SESN3 FAS_LC3_CDH1_FASLGAIFM1_FASLG LC3_FASLG_UVRAG ATG12_FAS_LC3_FASLG CASP3_CIAP2CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_SESN3 FASLG_SESN3 FAS_FASLG_SESN2DIABLO_FAS_FASLG_UVRAG ATG3_FASLG PTEN_CIAP2_FASLG FAS_LC3_FASLG_LAMP2CASP8_FASLG DIABLO_FASLG_SESN3 FAS_LC3_ID2_FASLG XIAP_FASLGATG7_CIAP2_FASLG DIABLO_FAS_FASLG_SESN2 AGER_FASLG LC3_FASLG_SIRT1FAS_LC3_BHLHE41_FASLG ATG3_ULK1 LC3_FASLG_RPS19BP1 DIABLO_DRAM_FAS_FASLGBNIP3_FASLG FASLG_SESN2_SESN3 DIABLO_FAS_FASLG_STAT3 FAS_UVRAGDRAM_FAS_FASLG DRAM_FAS_FASLG_RPS19BP1 CIAP2_RAGE ID2_CIAP2_FASLGDIABLO_FAS_FRAP1_FASLG ATG3_TCF3 FAS_FASLG_STAT3 FAS_FASLG_SESN2_UVRAGFASLG_RAGE AKT1_CIAP2_FASLG ATG3_FAS_FASLG_SESN2 E2F1_CIAP2DIABLO_FRAP1_FASLG ATG7_DIABLO_FAS_FASLG FASLG_VEGF BNIP3_FAS_FASLGFAS_LC3_TCF3_FASLG E2F1_FAS FAS_LAMP1_FASLG ATG7_FAS_FASLG_UVRAGXIAP_CIAP2 TKT_CIAP2_FASLG DIABLO_FAS_FASLG_NAMPT BCL2L1_FASLGATG7_DIABLO_FASLG DIABLO_FAS_FASLG_SIRT1 BNIP3_FAS FRAP1_FASLG_SESN2DIABLO_FAS_LAMP1_FASLG FASLG_SESN1 E2F1_ULK1_FASLGFAS_FRAP1_FASLG_RPS19BP1 FASLG_KIAA1967 DRAM_CIAP2_FASLGCSE1L_FAS_LC3_FASLG AIFM1_CIAP2 PTEN_CASP3_FASLG DIABLO_FAS_BECN1_FASLGDRAM_FASLG LC3_FASLG_NAMPT E2F1_LC3_ID2_FASLG ATG3_CIAP2 PTEN_CDH1_CIAP2AKT1_DIABLO_FAS_FASLG CSE1L_FASLG ATG12_CIAP2_FASLGATG3_DIABLO_FAS_FASLG FASLG_RAPTOR FASLG_RPS19BP1_SESN3E2F1_FAS_FASLG_SESN3 TCF3_FASLG MMP9_CIAP2_FASLG ATG7_FAS_FASLG_SESN2FASLG_STAT3 LAMP1_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1 ULK1_FASLGLC3_BECN1_FASLG DRAM_FAS_FASLG_UVRAG PRKAA1_CIAP2 CDH1_CIAP2_FASLGLC3_MMP9_FASLG_SESN2 FASLG_SIRT1 BECN1_CIAP2_FASLG FAS_FASLG_SESN3_UVRAGATG12_FASLG CIAP2_FASLG_HMGB2 DIABLO_FAS_FASLG_LAMP2 LAMP1_FASLGE2F1_FASLG_LAMP2 DIABLO_FAS_ID2_FASLG NNMT_FASLG CIAP2_FASLG_SIRT1E2F1_LC3_FASLG_LAMP2 BCL2L1_CIAP2 PTEN_XIAP_FASLG E2F1_LC3_MMP9_FASLGCDH1_ID2_MMP9_TCF3 Combinations of five types Combinations of six typesBNIP3_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2DRAM_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_FASLG_SESN3DIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2ATG3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_MMP9_FASLG_SESN3BNIP3_FAS_LC3_FASLG_SESN3 ATG3_FAS_LC3_FASLG_SESN2_SESN3BNIP3_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLGATG3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_STAT3BNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAGDRAM_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_FASLG_SIRT1DIABLO_FAS_LC3_BECN1_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN2BNIP3_DIABLO_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_BECN1_FASLGATG7_DRAM_FAS_LC3_FASLG DRAM_FAS_LC3_ID2_FASLG_UVRAGDIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAGDRAM_FAS_LC3_FASLG_SIRT1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1DRAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAGDRAM_FAS_LC3_FASLG_SESN3 DRAM_FAS_LC3_FASLG_SIRT1_UVRAGDRAM_FAS_LC3_BECN1_FASLG DRAM_FAS_LC3_MMP9_FASLG_UVRAGBNIP3_FAS_LC3_FASLG_STAT3 BNIP3_DRAM_FAS_LC3_ID2_FASLGBNIP3_FAS_LC3_MMP9_FASLG ATG3_DRAM_FAS_LC3_FASLG_SESN3DIABLO_FAS_LC3_ID2_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN3DIABLO_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2ATG5_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAGATG5_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLGDIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_FASLG_SESN3_SIRT1FAS_LC3_FASLG_SIRT1_UVRAG DRAM_FAS_LC3_BHLHE41_FASLG_UVRAGDRAM_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_LAMP2DIABLO_FAS_LC3_FASLG_SESN3 AKT1_BNIP3_DRAM_FAS_LC3_FASLGFAS_LC3_BECN1_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLGATG3_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SESN3_SIRT1BNIP3_FAS_LC3_FASLG_SIRT1 ATG3_DIABLO_FAS_LC3_MMP9_FASLGBNIP3_FAS_FRAP1_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN3_STAT3DIABLO_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_BECN1_FASLG_SESN2DIABLO_FAS_LC3_FASLG_NAMPT BNIP3_FAS_LC3_FASLG_SESN2_SIRT1FAS_LC3_MMP9_FASLG_RPS19BP1 DIABLO_DRAM_FAS_LC3_MMP9_FASLGBNIP3_FAS_LC3_BECN1_FASLG BNIP3_FAS_LC3_BECN1_FASLG_SESN3E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAGFAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_FASLG_LAMP2_UVRAGATG3_DIABLO_FAS_LC3_FASLG ATG3_FAS_FRAP1_LC3_MMP9_FASLGDIABLO_FAS_LC3_BHLHE41_FASLG DRAM_FAS_LC3_BECN1_FASLG_SESN3FAS_LC3_ID2_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BECN1_FASLGDIABLO_FAS_LC3_FASLG_LAMP2 ATG3_DRAM_FAS_LC3_MMP9_FASLGDRAM_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_CDH1_FASLGDRAM_FAS_LAMP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAGATG3_FAS_FRAP1_LC3_FASLG BNIP3_DRAM_FAS_LC3_BHLHE41_FASLGFAS_LC3_FASLG_STAT3_UVRAG ATG5_DRAM_FAS_LC3_FASLG_SESN3AKT1_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_STAT3FAS_LC3_FASLG_SESN3_UVRAG BNIP3_FAS_LC3_FASLG_SESN2_STAT3ATG3_DRAM_FAS_LC3_FASLG BNIP3_DIABLO_FAS_LC3_MMP9_FASLGAKT1_DRAM_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_SESN2FAS_LC3_FASLG_SESN2_UVRAG ATG5_FAS_LC3_MMP9_FASLG_UVRAGFAS_LC3_BHLHE41_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_BHLHE41_FASLGDRAM_FAS_LC3_FASLG_NAMPT DIABLO_DRAM_FAS_LC3_FASLG_STAT3FAS_LC3_FASLG_LAMP2_UVRAG ATG3_DIABLO_FAS_LC3_FASLG_SESN3ATG7_BNIP3_FAS_LC3_FASLG DRAM_FAS_LC3_TCF3_FASLG_UVRAGAKT1_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1E2F1_FAS_LC3_ID2_FASLG ATG5_DRAM_FAS_LC3_FASLG_STAT3DRAM_FAS_LC3_CDH1_FASLG ATG7_DRAM_FAS_LC3_MMP9_FASLGPTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG Combinations ofseven types Combinations of eight typesATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN3ATG3_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAGBNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_FASLG_SESN3_SIRT1ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAGATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SIRT1ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLGATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAGBNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3_SIRT1ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN3ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2ATG3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2BNIP3_DRAM_FAS_LC3_FASLG_SESN3_STAT3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_SESN2ATG3_FAS_LC3_ID2_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_STAT3ATG3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN3ATG5_DRAM_FAS_LC3_MMP9_FASLG_UVRAGATG3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN3BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAGATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2ATG3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN3ATG3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3ATG3_FAS_LC3_FASLG_SESN2_SESN3_SIRT1AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLGBNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2ATG3_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2ATG3_FAS_LC3_MMP9_BECNI_FASLG_SESN2ATG3_DRAM_FAS_LC3_MMP9_BECNI_FASLG_SESN2BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SIRT1BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN3ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_BECN1_FASLG_SESN2_SESN3ATG3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2ATG7_BNIP3_DRAM_FAS_LC3_MMP9_FASLGATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_STAT3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_STAT3ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGBNIP3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_STAT3ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2BNIP3_DRAM_FAS_LC3_MMP9_BECNl_FASLG_SESN3BNIP3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1BNIP3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN3ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN3ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_MMP9_TCF3_BECNl_FASLGBNIP3_DRAM_FAS_FRAP1_LC3_MMP9_FASLGBNIP3_CSE1L_DRAM_FAS_LC3_MMP9_FASLG_SESN3ATG3_FAS_LC3_FASLG_LAMP2_SESN2_SESN3ATG3_DRAM_FAS_LC3_ULK1_MMP9_FASLG_SESN3BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAGBNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3BNIP3_FAS_LC3_MMP9_BECNI_FASLG_SESN2ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1ATG3_FAS_LC3_MMP9_BECNI_FASLG_SESN3ATG3_FAS_LC3_ULK1_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAGBNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3_SIRT1FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG ATG3_FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG

Preferably, the composition or kit is for predicting the prognosis ofsurvival of the C group, and the genes are one or more selected from thegenes or groups of genes described in the following Table 14.

TABLE 14 One type Combinations of two types Combinations of three typesCombinations of four types CSE1L ID2_CIAP2 ID2_CIAP2_SESN2AIFM1_ID2_CIAP2_SESN2 CIAP2 CASP3_CIAP2 ID2_CASP3_CIAP2PTEN_ID2_CIAP2_SESN2 TCF3 ID2_TCF3 ULK1_ID2_HMGB2 DIABLO_ID2_CASP3_CIAP2CDH2 DIABLO_CDH2 ULK1_ID2_HMGB1 DRAM_FRAP1_CIAP2_TP63 FASLG CSE1L_CDH2DIABLO_ID2_CASP3 BAX_ID2_CIAP2_SESN2 BECN1 CSE1L_TCF3 ULK1_ID2_AGERID2_CIAP2_SESN2_VEGF CASP3 CSE1L_CASP3 ID2_CIAP2_RPS19BP1DRAM_ID2_CIAP2_SESN2 CDH1 CSE1L_RPS19BP1 CASP8_ULK1_ID2ID2_CIAP2_RPS19BP1_SESN2 CDH2_CIAP2 ID2_TCF3_CIAP2 CBS_ID2_CIAP2_SESN2ULK1_ID2 FRAP1_ID2_CIAP2 ATG3_ID2_CIAP2_SESN2 CSE1L_ID2 AIFM1_CDH1_CIAP2NNMT_ID2_CIAP2_SESN2 CDH1_CIAP2 PTEN_CDH1_CIAP2 DIABLO_ID2_CIAP2_SESN2CSE1L_FASLG ULK1_ID2_CIAP2 PRKAA1_ID2_CIAP2_SESN2 NNMT_CIAP2DIABLO_ID2_CDH2 FRAP1_ID2_CIAP2_SESN2 CSE1L_MMP9 CDH1_CIAP2_VEGFDIABLO_DRAM_ID2_CASP3 CSE1L_CDH1 CDH1_CCNG2_CIAP2 XIAP_ID2_CIAP2_SESN2CIAP2_RPS19BP1 BAX_CDH1_CIAP2 ID2_CIAP2_RAGE_SESN2 ID2_CDH2ATG3_ID2_TCF3 DRAM_CIAP2_SESN2_TP63 CDH2_RPS19BP1 ULK1_ID2_MMP2BNIP3_ID2_CIAP2_SESN2 CSE1L_STAT3 CBS_ULK1_ID2 BCL2L1_ID2_CIAP2_SESN2DIABLO_CASP3 DIABLO_ID2_CIAP2 AIFM1_DIABLO_CDH1_CIAP2 CDH1_TCF3LC3_ID2_CIAP2 ID2_CCNG2_CIAP2_SESN2 CSE1L_SIRT1 PTEN_ULK1_ID2LC3_ID2_CIAP2_SESN2 CIAP2_SESN2 BAX_ULK1_ID2 ID2_CASP3_CIAP2_RPS19BP1AIFM1_CIAP2 DIABLO_PTEN_CDH1 AIFM1_CDH1_CIAP2_SESN2 DIABLO_KIAA1967CDH1_CASP3_CIAP2 ATG3_ID2_TCF3_RPS19BP1 CSE1L_KIAA1967 ULK1_ID2_CDH2DIABLO_FRAP1_ID2_CDH2 AKT1_CSE1L CDH1_CIAP2_RAGE E2F1_ID2_CIAP2_SESN2CSE1L_SESN2 ID2_CDH2_CIAP2 ID2_CASP3_CIAP2_SESN2 FRAP1_CDH2NNMT_ID2_CIAP2 DRAM_ID2_CIAP2_RPS19BP1 FRAP1_CIAP2 XIAP_CIAP2_SESN2ID2_CIAP2_HMGB1_SESN2 TCF3_FASLG CSE1L_ID2_CASP3 PTEN_ID2_CASP3_CIAP2FASLG_SESN2 CSE1L_FRAPLCDH2 ATG3_ID2_MMP9_TCF3 CSE1L_DIABLOBCL2_ID2_SESN2 LAMP1_ID2_CIAP2_SESN2 CSE1L_SATB1 AIFM1_ULK1_ID2AIFM1_ID2_CASP3_CIAP2 MMP9_TCF3 ULK1_ID2_RAGE ATG5_ID2_CIAP2_SESN2ATG12_CSE1L DIABLO_CDH1_CCNG2 DIABLO_PTEN_CDH1_CIAP2 ATG7_CSE1LBAX_DIABLO_CDH1 LAMP1_ID2_CASP3_CIAP2 CSE1L_BECN1 CSE1L_ID2_CDH2ID2_CIAP2_HMGB2_SESN2 XIAP_CIAP2 AIFM1_CIAP2_SESN2BCL2L1_CSE1L_ID2_SESN2 CSE1L_FAS NNMT_CDH1_CIAP2 TKT_ID2_CIAP2_SESN2TCF3_RPS19BP1 CBS_ID2_CIAP2 DIABLO_XIAP_ID2_SESN2 XIAP_SESN2DIABLO_CDH1_VEGF FRAP1_LC3_ID2_CIAP2 CIAP2_KIAA1967 ID2_MMP9_TCF3ATG7_ID2_CIAP2_SESN2 TKT_CIAP2 AIFM1_DIABLO_CDH1 ID2_AGER_CIAP2_SESN2PRKAA1_CIAP2 PRKAA1_CIAP2_SESN2 CSE1L_ID2_CASP3_CIAP2 CDH2_FASLGCDH1_ID2_CIAP2 DRAM_CASP3_CIAP2_TP63 CSE1L_FRAP1 CSE1L_CASP3_CIAP2PTEN_CDH1_ID2_CIAP2 CSE1L_CIAP2 ULK1_ID2_VEGF CDHLID2_CIAP2_RPS19BP1CSE1L_ULK1 ID2_CIAP2_HMGB1 ATG3_ULK1_ID2_HMGB1 PTEN_CIAP2BCL2L1_CDH1_CIAP2 FRAP1_ID2_CIAP2_RPS19BP1 BCL2L1_CIAP2 ID2_CIAP2_MMP2DIABLO_PTEN_ID2_CASP3 CIAP2_VEGF CSE1L_ID2_CIAP2 ID2_CIAP2_SESN2_TP63ATG3_TCF3 BCL2L1_CSE1L_CDH1 ID2_TCF3_CIAP2_SESN2 AKT1_TCF3CSE1L_CDH1_CASP3 DIABLO_CDH1_CIAP2_VEGF CSE1L_LC3 CSE1L_XIAP_SESN2ATG3_ULK1_ID2_AGER TKT_CDH2 PRKAA1_CDH1_CIAP2 ID2_CIAP2_MMP2_SESN2CDH1_ID2_MMP9_TCF3 Combinations of five types Combinations of six typesDRAM_ID2_CIAP2_SESN2_TP63 ATG12_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_TKT_CIAP2_SESN2_TP63DRAM_FRAP1_CDH1_CIAP2_TP63 AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63ATG12_DRAM_FRAP1_CIAP2_TP63 AIFM1_DRAM_ID2_CIAP2_SESN2_TP63DRAM_FRAP1_XIAP_CIAP2_TP63 DRAM_TKT_ID2_CIAP2_SESN2_TP63DRAM_TKT_CIAP2_SESN2_TP63 AIFM1_ATG3_DRAM_CIAP2_SESN2_TP63AIFM1_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_CDH1_CIAP2_TP63AIFM1_DRAM_FRAP1_CIAP2_TP63 ATG3_DRAM_ID2_CIAP2_SESN2_TP63DRAM_FRAP1_TKT_CIAP2_TP63 DRAM_PTEN_ID2_CIAP2_SESN2_TP63PTEN_CDH1_ID2_CIAP2_SESN2 DRAM_FRAP1_TKT_XIAP_CIAP2_TP63BAX_CDH1_ID2_CIAP2_SESN2 DRAM_E2F1_FRAP1_CDH1_CIAP2_TP63DRAM_FRAP1_ID2_CIAP2_TP63 ATG3_DRAM_FRAP1_CDH1_CIAP2_TP63DRAM_TKT_CASP3_CIAP2_TP63 ATG7_DRAM_ID2_CIAP2_SESN2_TP63CDH1_ID2_CCNG2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_CDH1_CIAP2_TP63AIFM1_PTEN_ID2_CIAP2_SESN2 ATG5_DRAM_ID2_CIAP2_SESN2_TP63DIABLO_FRAPLCDH1_ID2_CIAP2 AIFM1_DIABLO_CDH1_ID2_CIAP2_SESN2AIFM1_CBS_ID2_CIAP2_SESN2 AIFM1_BNIP3_DRAM_CIAP2_SESN2_TP63AIFM1_LAMP1_ID2_CIAP2_SESN2 BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63DRAM_ID2_CASP3_CIAP2_TP63 DRAM_NNMT_ID2_CIAP2_SESN2_TP63DIABLO_PTEN_CDH1_ID2_CIAP2 CASP8_DRAM_ID2_CIAP2_SESN2_TP63CDH1_ID2_CIAP2_SESN2_VEGF DRAM_ID2_BHLHE41_CIAP2_SESN2_TP63DIABLO_CDH1_ID2_CASP3_CIAP2 DRAM_FRAP1_CDH1_CIAP2_RPS19BP1_TP63AIFM1_ATG3_ID2_CIAP2_SESN2 DRAM_LAMP1_ID2_CIAP2_SESN2_TP63AIFM1_BNIP3_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_ID2_CIAP2_TP63AIFM1_DIABLO_CDH1_ID2_CIAP2 BNIP3_DRAM_ID2_CIAP2_SESN2_TP63ATG3_DRAM_ID2_CIAP2_SESN2 DRAM_ID2_MMP9_CIAP2_SESN2_TP63AIFM1_BAX_ID2_CIAP2_SESN2 AKT1_DRAM_ID2_CIAP2_SESN2_TP63DRAM_E2F1_CASP3_CIAP2_TP63 DRAM_ID2_CIAP2_RAGE_SESN2_TP63AIFM1_ID2_CIAP2_HMGB2_SESN2 ATG12_DRAM_FRAP1_XIAP_CIAP2_TP63AIFM1_ID2_MMP9_CIAP2_SESN2 DRAM_PRKAA1_ID2_CIAP2_SESN2_TP63DIABLO_CDH1_ID2_CIAP2_VEGF DRAM_XIAP_ID2_CIAP2_SESN2_TP63DIABLO_DRAM_XIAP_ID2_SESN2 AIFM1_DRAM_PTEN_CIAP2_SESN2_TP63AIFM1_ATG5_ID2_CIAP2_SESN2 ATG3_DRAM_FRAP1_CASP3_CIAP2_TP63AIFM1_ID2_CIAP2_HMGB1_SESN2 CASP8_DRAM_FRAP1_CDH1_CIAP2_TP63BAX_DIABLO_CDH1_ID2_CIAP2 AIFM1_ATG5_DRAM_CIAP2_SESN2_TP63DRAM_FRAP1_NNMT_CIAP2_TP63 AIFM1_CASP8_DRAM_CIAP2_SESN2_TP63FRAP1_CDH1_ID2_CIAP2_RPS19BP1 BCL2L1_DRAM_FRAPLIKT_CIAP2_TP63DRAM_XIAP_CIAP2_SESN2_TP63 CBS_DRAM_ID2_CIAP2_SESN2_TP63AIFM1_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_NNMT_TKT_CIAP2_TP63AIFM1_DRAM_ID2_CIAP2_SESN2 AIFM1_AKT1_DRAM_CIAP2_SESN2_TP63AIFM1_ID2_CIAP2_SESN2_VEGF DRAM_FRAP1_PTEN_CDH1_CIAP2_TP63AIFM1_TKT_ID2_CIAP2_SESN2 DIABLO_PTEN_CDH1_ID2_CIAP2_SESN2ATG3_ID2_MMP9_TCF3_RPS19BP1 DRAM_ID2_CIAP2_SESN2_TP63_VEGFATG5_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_XIAP_CIAP2_SESN2_TP63CBS_FRAP1_ID2_CIAP2_SESN2 BNIP3_DRAM_FRAP1_CDH1_CIAP2_TP63AIFM1_DIABLO_ID2_CASP3_CIAP2 AIFM1_ATG7_DRAM_CIAP2_SESN2_TP63AIFM1_NNMT_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_NNMT_CIAP2_TP63ATG3_DRAM_CIAP2_SESN2_TP63 AIFM1_DRAM_MMP9_CIAP2_SESN2_TP63ATG3_FRAP1_ID2_CIAP2_SESN2 AIFM1_DRAM_PRKAA1_CIAP2_SESN2_TP63BAX_DIABLO_DRAM_ID2_CASP3 AIFM1_DRAM_CIAP2_RAGE_SESN2_TP63LAMP1_PTEN_ID2_CIAP2_SESN2 AIFM1_DRAM_FRAP1_XIAP_CIAP2_TP63CDH1_ID2_CIAP2_RAGE_SESN2 AIFM1_DRAM_NNMT_CIAP2_SESN2_TP63CBS_DIABLO_ID2_CIAP2_SESN2 DRAM_FRAP1_CDH1_CIAP2_TP63_VEGFDIABLO_CDH1_ID2_CCNG2_CIAP2 AIFM1_DRAM_LAMP1_CIAP2_SESN2_TP63DIABLO_LAMP1_ID2_CASP3_CIAP2 DIABLO_DRAM_FRAP1_XIAP_CASP3_HMGB2AIFM1_DRAM_CASP3_CIAP2_TP63 DRAM_TKT_XIAP_CIAP2_SESN2_TP63BCL2L1_DRAM_FRAPLCIAP2_TP63 AIFM1_BCL2L1_DRAM_CIAP2_SESN2_TP63CDH1_ID2_MMP9_TCF3_CIAP2 BAX_CDH1_ID2_MMP9_TCF3_CIAP2 Combinations ofseven types Combinations of eight typesAIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_PTEN_TKT_XIAP_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFAIFM1_ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_SATBl_TP63ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63AIFM1_AKTLATG12_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63ATG12_BCL2L1_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63AIFM1_ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_PTEN_MMP9_CIAP2_TP63AIFM1_BCL2L1_DRAM_TKT_CIAP2_SESN2_TP63ATG12_DRAM_E2F1_FRAP1_IKT_MMP9_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_PTEN_CIAP2_TP63ATG12_BCL2L1_CBS_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFAIFM1_DRAM_PTEN_ID2_CIAP2_SESN2_TP63ATG12_DIABLO_DRAM_FRAP1_TKT_CDH1_CIAP2_TP63AIFM1_DRAM_TKT_MMP9_CIAP2_SESN2_TP63AIFM1_ATG3_DRAM_ID2_MMP9_CIAP2_SESN2_TP63ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63ATG12_CBS_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_LAMP1_TKT_XIAP_CIAP2_TP63ATG12_DRAM_E2F1_FRAP1_TKT_CIAP2_TP63ATG12_BCL2L1_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_BHLHE41_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_HMGB1_TP63AIFM1_ATG12_DRAM_FRAP1_MMP9_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63AIFM1_ATG3_DRAM_ID2_CIAP2_SESN2_TP63AIFM1_DRAM_PTEN_ID2_MMP9_CIAP2_SESN2_TP63AIFM1_ATG3_DRAM_MMP9_CIAP2_SESN2_TP63ATG12_ATG7_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_CIAP2_HMGB1_TP63ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63_VEGFAIFM1_ATG12_DRAM_TKT_CIAP2_SESN2_TP63AIFM1_ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_BNIP3_DRAM_TKT_CIAP2_SESN2_TP63AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63AIFM1_DRAM_ID2_MMP9_CIAP2_SESN2_TP63ATG12_ATG7_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63AIFM1_DRAM_LAMP1_TKT_CIAP2_SESN2_TP63ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63_VEGFDRAM_FRAP1_TKT_CASP3_CIAP2_HMGB2_TP63ATG12_DRAM_FRAP1_LAMP1_PTEN_TKT_CIAP2_TP63AIFM1_AKT1_ATG12_DRAM_FRAP1_CIAP2_TP63ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63AIFM1_DRAM_PRKAA1_TKT_CIAP2_SESN2_TP63AIFM1_ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_DRAM_TKT_CIAP2_RAGE_SESN2_TP63AIFM1_ATG12_DIABLO_DRAM_FRAP1_CDHl_CIAP2_TP63AIFM1_DRAM_TKT_ID2_CIAP2_SESN2_TP63ATG12_BCL2L1_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63ATG12_CBS_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63AIFM1_AKT1_DRAM_TKT_CIAP2_SESN2_TP63ATG12_DRAM_FRAP1_LAMP1_PRKAA1_TKT_CIAP2_TP63AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63_VEGFATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_RAGE_TP63AIFM1_ATG3_DRAM_NNMT_CIAP2_SESN2_TP63ATG12_ATG7_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63AIFM1_BAX_DRAM_ID2_CIAP2_SESN2_TP63ATG12_BCL2L1_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_DRAM_NNMT_ID2_CIAP2_SESN2_TP63ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFDRAM_FRAP1_NNMT_TKT_XIAP_CIAP2_TP63AIFM1_ATG3_DRAM_NNMTJD2_CIAP2_SESN2_TP63BCL2L1_DRAM_FRAP1_IKT_XIAP_CIAP2_TP63AIFM1_DRAM_NNMT_PTENJD2_CIAP2_SESN2_TP63AIFM1_ATG12_ATG3_DRAM_FRAP1_CIAP2_TP63ATG12_CBS_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63AIFM1_ATG7_DRAM_ID2_CIAP2_SESN2_TP63ATG12_DRAM_FRAP1_PTEN_TKT_MMP9_CIAP2_TP63AIFM1_DRAM_TKT_CIAP2_SESN2_TP63_VEGFAIFM1_ATG12_ATG3_DRAM_FRAP1_MMP9_CIAP2_TP63ATG12_ATG3_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_ATG12_CASP8_DRAM_TKT_CIAP2_SESN2_TP63AIFM1_AKT1_DRAM_ID2_CIAP2_SESN2_TP63ATG12_ATG7_CBS_DRAM_FRAP1_TKT_CIAP2_TP63AIFM1_ATG12_ATG7_DRAM_FRAP1_CIAP2_TP63ATG12_BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63AIFM1_ATG3_BCL2L1_DRAM_CIAP2_SESN2_TP63AIFM1_ATG12_DRAM_PTEN_TKT_CIAP2_SESN2_TP63AIFM1_ATG7_DRAM_TKT_CIAP2_SESN2_TP63AIFM1_BCL2L1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63AIFM1_BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63ATG12_DRAM_E2F1_FRAP1_NNMT_TKT_CIAP2_TP63AIFM1_CBS_DRAM_TKT_CIAP2_SESN2_TP63ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63_VEGFAIFM1_DRAM_PTEN_TKT_CIAP2_SESN2_TP63ATG12_BNIP3_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63AIFM1_DRAM_TKT_BHLHE41_CIAP2_SESN2_TP63ATG12_CBS_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63ATG12_DIABLO_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63BCL2L1_DRAM_TKT_ID2_CIAP2_SESN2_TP63ATG12_DRAM_FRAP1_PRKAA1_TKT_XIAP_CIAP2_TP63BAX_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_RAGE_TP63CBS_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3ATG3_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3_AGER

Preferably, the composition or kit is for predicting the prognosis ofdisease-free survival of the C group, and the genes are one or moreselected from the genes or groups of genes described in the followingTable 15.

TABLE 15 One type Combinations of two types Combinations of three typesCombinations of four types FASLG FAS_FASLG FAS_LC3_FASLGDIABLO_FAS_LC3_FASLG CIAP2 LC3_FASLG DIABLO_FAS_FASLGFAS_LC3_FASLG_UVRAG FAS E2F1_FASLG E2F1_LC3_FASLG E2F1_FAS_LC3_FASLGCSE1L CIAP2_FASLG FAS_FASLG_RPS19BP1 BNIP3_FAS_LC3_FASLG TCF3DIABLO_FASLG E2F1_FAS_FASLG DRAM_FAS_LC3_FASLG FASLG_RPS19BP1FAS_FASLG_UVRAG ATG7_FAS_LC3_FASLG FASLG_SESN2 DIABLO_LC3_FASLGFAS_LAMP1_LC3_FASLG CASP3_FASLG ATG7_FAS_FASLG FAS_FRAP1_LC3_FASLGFASLG_UVRAG FAS_FASLG_SESN2 ATG3_FAS_LC3_FASLG FRAP1_FASLGLC3_FASLG_SESN2 FAS_LC3_FASLG_RPS19BP1 PIEN_FASLG FAS_LAMP1_FASLGFAS_LC3_FASLG_SESN3 FASLG_HMGB1 ATG3_FAS_FASLG FAS_LC3_FASLG_SESN2ATG3_FAS CIAP2_FASLG_SESN3 ATG5_FAS_LC3_FASLG CASP3_CIAP2FAS_FRAP1_FASLG FAS_LC3_FASLG_STAT3 TCF3_FASLG FRAP1_LC3_FASLGFAS_LC3_FASLG_SIRT1 ATG7_FASLG BNIP3_LC3_FASLG AKT1_FAS_LC3_FASLGPIEN_CIAP2 FAS_FASLG_SESN3 FAS_LC3_ID2_FASLG CDH2_FASLG BNIP3_FAS_FASLGFAS_LC3_FASLG_NAMPT FASLG_SESN3 DIABLO_FASLG_SESN2 FAS_LC3_BECN1_FASLGDIABLO_FAS CIAP2_FASLG_UVRAG FAS_LC3_MMP9_FASLG FAS_LC3 LC3_FASLG_UVRAGDIABLO_FAS_FASLG_UVRAG ULK1_FASLG LC3_CIAP2_FASLG ATG12_FAS_LC3_FASLGCSE1L_FASLG DRAM_FAS_FASLG FAS_FASLG_RPS19BP1_UVRAG CBS_FASLGLC3_FASLG_SESN3 DIABLO_FAS_FASLG_SESN2 FASLG_HMGB2 FAS_FASLG_STAT3FAS_LC3_FASLG_LAMP2 FAS_UVRAG ATG7_LC3_FASLG FAS_LC3_CDH1_FASLGLAMP1_FASLG ATG5_FAS_FASLG DIABLO_FAS_FASLG_SESN3 BNIP3_FASLGE2F1_FASLG_SESN2 FAS_LC3_TCF3_FASLG MMP9_FASLG LC3_ID2_FASLGE2F1_LC3_ID2_FASLG TKT_FASLG DRAM_LC3_FASLG FAS_LC3_BHLHE41_FASLGFASLG_STAT3 FAS_TCF3_FASLG DIABLO_FAS_LAMP1_FASLG AKT1_FASLGAKT1_FAS_FASLG DIABLO_DRAM_FAS_FASLG FASLG_MMP2 E2F1_ULK1_FASLGFAS_FASLG_SESN2_UVRAG DRAM_FASLG E2F1_TCF3_FASLGFAS_FASLG_RPS19BP1_SESN3 FASLG_SIRT1 LC3_FASLG_RPS19BP1DIABLO_FAS_FRAP1_FASLG ATG12_FASLG LC3_MMP9_FASLG DIABLO_FAS_FASLG_STAT3CIAP2_RAGE FAS_FASLG_SIRT1 ATG7_DIABLO_FAS_FASLG FAS_LAMP1FAS_ULK1_FASLG CSE1L_FAS_LC3_FASLG ATG5_FASLG FAS_FASLG_NAMPTE2F1_LC3_MMP9_FASLG ATG3_FASLG LC3_FASLG_SIRT1 DRAM_FAS_FASLG_RPS19BP1E2F1_FAS CASP3_CIAP2_FASLG DIABLO_FAS_FASLG_RPS19BP1 BECN1_FASLGATG12_FAS_FASLG FAS_LC3_ULK1_FASLG E2F1_CIAP2 FAS_BECN1_FASLGDIABLO_FAS_FASLG_SIRT1 CASP8_FASLG ATG5_LC3_FASLG DIABLO_FAS_ID2_FASLGXIAP_CIAP2 LC3_BECN1_FASLG AKT1_DIABLO_FAS_FASLG CDH1_FASLGLC3_FASLG_STAT3 DIABLO_FAS_FASLG_NAMPT FASLG_NAMPT E2F1_FASLG_SESN3ATG3_FAS_FASLG_SESN2 BNIP3_FAS AKT1_LC3_FASLG FAS_FASLG_RPS19BP1_SESN2FASLG_LAMP2 FAS_FASLG_LAMP2 DIABLO_FAS_BECNl_FASLG AGER_FASLGLC3_TCF3_FASLG DIABLO_FAS_CDHl_FASLG ID2_FASLG LC3_FASLG_NAMPTATG7_FAS_FASLG_UVRAG AIFM1_FASLG LC3_CDH1_FASLG DIABLO_FAS_FASLG_LAMP2FASLG_SESN1 ATG12_LC3_FASLG FAS_FRAP1_FASLG_RPS19BP1 AIFM1_CIAP2PTEN_CDH1_CIAP2 FAS_LAMP1_FASLG_UVRAG PRKAA1_CIAP2 LC3_FASLG_LAMP2E2F1_FAS_LAMP1_FASLG BCL2L1_CIAP2 DIABLO_FASLG_SESN3ATG7_FAS_FASLG_RPS19BP1 XIAP_FASLG FAS_CDHl_FASLG E2F1_FAS_FASLG_UVRAGCDH1_ID2_MMP9_TCF3 Combinations of five types Combinations of six typesDIABLO_FAS_LC3_ID2_FASLG BNIP3_DRAM_FAS_LC3_FASLG_SESN2DRAM_FAS_LC3_FASLG_UVRAG DIABLO_DRAM_FAS_LC3_ID2_FASLGDIABLO_DRAM_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2BNIP3_FAS_LC3_FASLG_UVRAG DRAM_FAS_LC3_ID2_FASLG_UVRAGBNIP3_FAS_LC3_FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_UVRAGBNIP3_DRAM_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_UVRAGBNIP3_DIABLO_FAS_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_UVRAGFAS_LC3_ID2_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_STAT3DIABLO_FAS_LC3_FASLG_UVRAG DIABLO_FAS_LC3_ID2_FASLG_SESN3DIABLO_FAS_LC3_FASLG_STAT3 BNIP3_FAS_LC3_MMP9_FASLG_UVRAGDIABLO_FAS_LC3_FASLG_SESN3 BNIP3_DRAM_FAS_LC3_FASLG_SESN3DIABLO_FAS_LC3_FASLG_SIRT1 BNIP3_FAS_LC3_ID2_FASLG_UVRAGFAS_LC3_MMP9_FASLG_RPS19BP1 DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1ATG5_FAS_LC3_FASLG_UVRAG BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1BNIP3_FAS_LC3_FASLG_SESN3 BNIP3_FAS_LC3_ID2_FASLG_SESN2DIABLO_FAS_LC3_BECN1_FASLG BNIP3_DIABLO_FAS_LC3_ID2_FASLGDIABLO_FAS_LC3_CDH1_FASLG BNIP3_FAS_LC3_MMP9_FASLG_SESN2ATG3_FAS_LC3_FASLG_SESN2 DIABLO_FAS_LC3_ID2_FASLG_SIRT1DRAM_E2F1_FAS_LC3_FASLG ATG5_DRAM_FAS_LC3_FASLG_UVRAGFAS_LC3_FASLG_SESN2_UVRAG FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAGDIABLO_FAS_LC3_FASLG_LAMP2 ATG3_FAS_LC3_FASLG_SESN2_SESN3E2F1_FAS_LC3_ID2_FASLG DRAM_FAS_LC3_FASLG_SESN2_UVRAGDIABLO_FAS_LC3_FASLG_NAMPT DIABLO_FAS_LC3_ID2_BECN1_FASLGDIABLO_FAS_LC3_MMP9_FASLG DRAM_FAS_LC3_FASLG_SIRT1_UVRAGFAS_LC3_FASLG_SIRT1_UVRAG FAS_LC3_ID2_FASLG_SESN2_UVRAGFAS_LC3_FASLG_SESN3_UVRAG DIABLO_FAS_LC3_CDH1_ID2_FASLGFAS_LAMP1_LC3_FASLG_UVRAG FAS_LC3_ID2_MMP9_FASLG_RPS19BP1AKT1_DIABLO_FAS_LC3_FASLG BNIP3_FAS_LC3_FASLG_SESN2_SESN3DIABLO_FAS_FRAP1_LC3_FASLG DIABLO_FAS_LC3_ID2_FASLG_NAMPTDIABLO_FAS_LC3_BHLHE41_FASLG DIABLO_FAS_LC3_ID2_FASLG_SESN2FAS_LC3_FASLG_STAT3_UVRAG DIABLO_FAS_LC3_ID2_FASLG_LAMP2DIABLO_FAS_LC3_FASLG_SESN2 BNIP3_FAS_LC3_FASLG_SESN2_SIRT1E2F1_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN2_STAT3BNIP3_FAS_FRAP1_LC3_FASLG DRAM_FAS_LC3_FASLG_SESN3_UVRAGDIABLO_FAS_LAMP1_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_STAT3FAS_LC3_BECN1_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_MMP9_FASLGAKT1_FAS_LC3_FASLG_UVRAG ATG5_FAS_LC3_ID2_FASLG_UVRAGBNIP3_FAS_LC3_MMP9_FASLG BNIP3_FAS_LC3_FASLG_SESN3_UVRAGFAS_FRAP1_LC3_FASLG_UVRAG DRAM_FAS_LC3_BECN1_FASLG_UVRAGBNIP3_FAS_LC3_FASLG_STAT3 DIABLO_DRAM_FAS_LC3_CDH1_FASLGFAS_LC3_CDH1_FASLG_UVRAG AKT1_DIABLO_FAS_LC3_ID2_FASLGFAS_LC3_FASLG_LAMP2_UVRAG BNIP3_DIABLO_FAS_LC3_MMP9_FASLGFAS_LC3_MMP9_FASLG_UVRAG DRAM_FAS_LC3_CDH1_FASLG_UVRAGATG7_FAS_LC3_FASLG_UVRAG DIABLO_FAS_FRAP1_LC3_ID2_FASLGATG7_DRAM_FAS_LC3_FASLG BNIP3_DRAM_FAS_LC3_FASLG_STAT3BNIP3_FAS_LC3_FASLG_SIRT1 DIABLO_DRAM_FAS_LC3_FASLG_SESN3DRAM_FAS_LAMP1_LC3_FASLG BNIP3_DIABLO_DRAM_FAS_LC3_FASLGATG7_BNIP3_FAS_LC3_FASLG DIABLO_DRAM_FAS_LC3_FASLG_SIRT1BNIP3_FAS_LAMP1_LC3_FASLG BNIP3_DRAM_FAS_FRAP1_LC3_FASLGATG3_FAS_LC3_MMP9_FASLG DIABLO_DRAM_FAS_LC3_BECN1_FASLGATG5_DIABLO_FAS_LC3_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN3BNIP3_FAS_LC3_ID2_FASLG DIABLO_FAS_LAMP1_LC3_ID2_FASLGATG12_DIABLO_FAS_LC3_FASLG DRAM_FAS_LC3_FASLG_LAMP2_UVRAGE2F1_FAS_LC3_FASLG_SESN3 ATG5_FAS_LC3_FASLG_SESN2_UVRAGAKT1_BNIP3_FAS_LC3_FASLG FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3FAS_LC3_FASLG_NAMPT_UVRAG FAS_LAMP1_LC3_ID2_FASLG_UVRAGATG12_FAS_LC3_FASLG_UVRAG BNIP3_DRAM_FAS_LC3_ID2_FASLGPTEN_CDH1_ID2_MMP9_TCF3 LC3_CDH1_ID2_MMP9_TCF3_FASLG Combinations ofseven types Combinations of eight typesATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAGBNIP3_FAS_LC3_ID2_FASLG_SESN2_UVRAGATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAGFAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAGBNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_ID2_FASLG_UVRAGATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAGDRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAGDRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAGDRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1ATG5_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAGATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAGATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAGATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2BNIP3_FAS_LC3_ID2_MMP9_TCF3_FASLG_UVRAGDIABLO_DRAM_FAS_LC3_ID2_FASLG_STAT3DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN3BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAGATG5_DRAM_FAS_LC3_ID2_FASLG_UVRAGATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1ATG3_DIABLO_FAS_LC3_ID2_MMP9_FASLG_SESN2ATG5_FAS_LC3_ID2_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAGATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGDIABLO_DRAM_FAS_LC3_ID2_FASLG_UVRAGBNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2DIABLO_DRAM_FAS_LC3_CDH1_ID2_FASLGBNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1DRAM_FAS_LC3_ID2_FASLG_SIRT1_UVRAGBNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3DIABLO_DRAM_FAS_LC3_ID2_FASLG_SIRT1ATG3_FAS_LC3_ID2_MMP9_TCF3_FASLG_SESN2BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_FAS_LC3_ID2_MMP9_FASLG_UVRAGBNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN2_UVRAGDIABLO_DRAM_FAS_LC3_ID2_BECN1_FASLGATG5_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAGDRAM_FAS_LC3_ID2_FASLG_SESN3_UVRAGBNIP3_FAS_LC3_CDH1_ID2_FASLG_SESN2_UVRAGATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2BNIP3_FAS_LC3_ID2_FASLG_SESN2_SIRT1_UVRAGBNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3BNIP3_FAS_LC3_ID2_FASLG_SESN2_SESN3BNIP3_DRAM_FAS_LC3_CDH1_ID2_FASLG_SESN2DIABLO_DRAM_FAS_LC3_ID2_FASLG_LAMP2BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN3_UVRAGBNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2AKT1_BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2ATG5_DRAM_FAS_LC3_FASLG_SESN2_UVRAGBNIP3_DRAM_FAS_LC3_ID2_FASLG_LAMP2_SESN2DRAM_FAS_LC3_MMP9_FASLG_RPS19BPLUVRAGATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3DRAM_FAS_LAMP1_LC3_ID2_FASLG_UVRAGBNIP3_DRAM_FAS_LC3_CDHl_FASLG_SESN2_UVRAGDIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN2BNIP3_FAS_LC3_ID2_FASLG_LAMP2_SESN2_UVRAGATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2BNIP3_FAS_LC3_ID2_BECNl_FASLG_SESN2_UVRAGAKT1_BNIP3_DRAM_FAS_LC3_FASLG_SESN2BNIP3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAGDRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3BNIP3_DRAM_FAS_LC3_ID2_TCF3_FASLG_UVRAGATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAGDRAM_FAS_LC3_ID2_FASLG_STAT3_UVRAGATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2BNIP3_DRAM_FAS_LC3_CDH1_FASLG_UVRAGBNIP3_DRAM_FAS_LAMP1_LC3_ID2_FASLG_SESN2ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2ATG3_FAS_FRAP1_LC3_ID2_MMP9_FASLG_SESN2DRAM_FAS_LC3_ID2_BECN1_FASLG_UVRAGBNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2E2F1_LC3_CDH1_ID2_MMP9_TCF3_FASLG FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG_UVRAG

The nucleic acids included in the composition or kit of the presentdisclosure may be primers or probes.

The nucleic acids may have a sequence complementary to genes such as DNAand/or RNA, etc., or may be hybridized. The “primer” means a nucleicacid sequence having free 3′ hydroxyl group that can complementarilybind to a template and that enables the reverse transcriptase or DNApolymerase to initiate reproduction of template. The primer is anucleotide having a sequence complementary to the nucleic acid sequenceof a specific gene, and a primer of a length of about 7 bp˜50 bp,preferably about 10 bp˜30 bp, can be used. The primer may comprise otherbase sequences which do not change the basic feature of the primeracting at the initial point of DNA synthesis. The primer can besynthesized chemically using well known methods, and the nucleic acidsequence can be transformed using many means well known in the pertinentart.

The “probe” refers to a nucleic acid strand partly or completelycomplementary to the target nucleic acid and refers to anoligonucleotide that can bind to the target nucleic acid by a basespecific method. Preferably, it is an oligonucleotide completelycomplementary to the target nucleic acid. The probe includes not onlynucleic acid, but any known nucleic acid derivative capable ofcomplementary binding, including peptide nucleic acid. The binding of aprobe and target nucleic acid (generally, referred to as“hybridization”) is sequence dependent, and can be performed at variousconditions. In general, hybridization reaction takes place at specificion and pH levels at a temperature about 5□ lower than the Tm of aspecific sequence. The “Tm” means a condition where 50% of a probecomplementary to the target sequence has bound to the sequence. Anexample of the reaction condition for hybridization may be pH of 7.0˜8.3and Na+ ion concentration of 0.01˜1.0 M. Also, in order to increase thespecificity between the target nucleic acid and probe, the reaction maybe performed under conditions that do not make the binding between thetarget nucleic acid and probe unstable, for example, under the conditionof not high temperature and in the absence of a high concentration of adestabilizing agent (for example, formamide, etc.). The length of theprobe may be a length where the probe can be specifically bind to thetarget nucleic acid, and includes any length of polynucleotide. Forexample, the length of the probe may be 10˜200 nucleotides, 10˜150nucleotides, 10˜100 nucleotides, 10˜50 nucleotides, or the length of afull gene, but is not limited thereto. The probe may be a labeled by alabel that can be detected. The detectable label may be labeled with afluorescent substance, FAM at the 5′ end of SYBR Green I or variousprobes (TaqMan Probe) and with a quencher, TAMRA, at the 3′ end thereof,but is not limited thereto. The detectable label includes fluorescentlabels such as Cy3 or Cy5, radioactive substance label, enzymetransforming the substrate into a color former, etc., but are notlimited thereto. In the kit of the present disclosure, the probe orprobe set may be fixed to a microarray.

The target nucleic acid in a sample is hybridized with the probe in themicroarray, and the existence and concentration thereof can be measuredby measuring the hybridization result. The target nucleic acid duringthe hybridization process may be labeled by a detectable label.

The “antibody” means a protein that can specifically bind to epitope ofan antigen, and it is a concept including polyclonal antibody,monoclonal antibody and recombinant antibody. The antibody can be easilyprepared by using technology widely known in the art. To be specific,the polyclonal antibodies can be prepared by methods widely known in theart of injecting protein antigen encoded by the marker for prognosis ofliver cancer of the present disclosure into animals and collecting bloodfrom the animals to obtain serum comprising antibodies. These polyclonalantibodies can be prepared from various hosts of species of animals,such as goats, rabbits, sheep, monkeys, horses, pigs, cattle, dogs, etc.

Monoclonal antibodies can be prepared by using a hybridoma method[Kohler and Milstein (1976) European Journal of Immunology 6:511-519] orphage antibody library technology [Clackson et al, Nature, 352:624-628,1991; Marks et al, J. Mol. Biol., 222:58, 1-597, 1991], etc. which arewidely known in the art.

Conventionally, a hybridoma method uses cells obtained from host animalswhich are immunologically suitable, such as a mouse, to which proteinantigen encoded by the marker for prognosis of liver cancer of the firstaspect of the present disclosure has been injected, and a cancer ormyeloma cell line as the other population. The tissues obtained fromthese two populations are fused by a widely known method in the art suchas polyethyleneglycol, and then antibody-producing cells areproliferated by a standard tissue cultivation method. After obtaining ahomogenous cell population by subcloning according to a limited dilutiontechnique, hybridoma that can produce desired antibodies is cultivatedin quantity in vivo or in vitro according to a known technique. A phageantibody library method is a method of producing monoclonal antibodiesby obtaining a gene of the desired antibody, expressing the gene in theform of the fusion protein on the surface of phages, and therebyproducing an antibody library in vitro, and separating the desiredmonoclonal antibodies from the library. The monoclonal antibodiesprepared by the above method may be separated by using known methods,such as gel electrophoresis, dialysis, salts precipitation, ion exchangechromatography, affinity chromatography, etc.

The antibody comprises functional fragments of an antibody molecule inaddition to perfect shapes of two full-length light chains and twofull-length heavy chains. The functional fragments of the antibodymolecule refer to fragments having antigen-binding functions, andinclude Fab, F(ab′), F(ab′)2, Fv, etc.

The predicting prognosis of liver cancer may be predicting prognosisbefore liver resection for cancer or after liver resection for cancer.

In addition to nucleic acids or antibodies, the kit may further compriseone or more types of other ingredients, solutions or apparatus, whichare suitable for methods of analyzing the expression level or theexpression pattern of gene or methods of analyzing the existing level orthe existing patter of protein. For example, in the case of thediagnosis kit for detecting the expression level or the expressionpattern of gene, the diagnosis kit may comprise essential ingredientsrequired for performing RT-PCR, and in addition to respective primersspecific to mRNA of marker genes, this RT-PCR kit may comprise, forexample, test tube or other proper container, reaction buffer solution,deoxynucleotide (dNTPs), enzyme such as Taq-polymerase and reversetranscriptase, DNAse, RNAse inhibitor, DEPC-water (DEPCwater), sterilewater, gene-specific primer pair that is used as a quantitative controlgroup, according to specific embodiments. Meanwhile, in case where thekit is for detecting the existing level or the existing pattern ofprotein, the diagnosis kit may comprise, for example, essentialingredients required for performing ELISA. This ELISA kit may compriseingredients capable of detecting bound antibodies, for example, alabeled secondary antibody, chromopores, enzyme (for example, enzymeconnected to antibody) and its substrate, and an antibody specific toprotein of the quantitative control group. Further, according to thespecific embodiments, the kit may comprise DNA microarray or proteinmicroarray.

Also, the present disclosure provides a composition or kit forpredicting prognosis of liver cancer comprising nucleic acids which arespecific to each of one or at least two genes selected from the groupdescribed in Table 2 (described in the description of the composition orkit for predicting prognosis of liver cancer for predicting theprognosis according to the stage of liver cancer of the presentdisclosure), or antibodies which are specific to proteins encoded bysaid genes.

In the composition or kit, the group of genes may further comprise thegenes described in Table 3 (described in the description of thecomposition or kit for predicting prognosis of liver cancer forpredicting the prognosis according to the stage of liver cancer of thepresent disclosure).

The matters mentioned regarding the composition or kit for predictingprognosis of liver cancer for predicting the prognosis according to thestage of liver cancer of the present disclosure equally apply to thecomposition and the kit unless there is a contradiction.

Also, the present disclosure provides a method for predicting prognosisof liver cancer according to stage comprising: (A) detecting one or moreselected from the expression level or expression pattern of one or atleast two genes selected from the group consisting of the genesdescribed in Table 1 (described in the description of the composition orkit for predicting prognosis of liver cancer for predicting theprognosis according to stage of liver cancer of the present disclosure)in samples obtained from patients of liver cancer; and (B) comparing theresults of the (A) step with the measurement results of the controlgroups to predict prognosis of liver cancer, wherein the patients ofliver cancer are in one or more groups selected from A1 group {a groupof portal vein invasion-negative patients in stage 0 or A of BCLC(Barcelona-Clinic Liver Cancer) staging system, having a tumor which is5 cm or less in size, or 3 or less tumors which are 3 cm or less insize}, A2 group {a group of portal vein invasion-negative patients,having a tumor which is more than 5 cm in size}, B group {a group ofportal vein invasion-negative patients in intermediate stage of BCLCstaging system, having plural tumors which are more than 3 cm in size orplural tumors which are more than 3 in number}, or C group {a group ofportal vein invasion-positive patients regardless of tumors size andnumber}.

Preferably, the group consisting of the genes may be a group consistingof the genes described in Table 2 (described in the description of thecomposition or kit for predicting prognosis of liver cancer forpredicting the prognosis according to the stage of liver cancer of thepresent disclosure), and the group consisting of genes may furthercomprise the genes described in Table 3 (described in the description ofthe composition or kit for predicting prognosis of liver cancer forpredicting the prognosis according to the stage of liver cancer of thepresent disclosure).

Samples harvested from patients of liver cancers mean a cell, tissue,etc. separated from human body where the expression level or expressionpattern of the marker for prognosis of liver cancer, or existing levelor existing pattern of protein encoded by the marker for prognosis ofliver cancer can be detected. It can be exemplified by urine, blood,plasma, serum, etc., but is not particularly limited thereto. The tissuemay be embedded in a paraffin block.

The expression level or expression pattern of the genes can be detectedby general biochemical analysis methods which confirm the level orpattern of mRNA generated by transcription of the corresponding gene. Assuch an analysis method for confirming the level or pattern of mRNA,there are RT-PCR, competitive RT-PCR, real-time RT-PCT, RNase protectionassay, Northern blot, DNA microarray, etc. In addition, any method thatis generally carried out in the pertinent art can be used.

Through the above analysis methods, the level or pattern of mRNA in thebiological sample of liver cancer patient can be compared with thestandard level, and the difference in expression level, expressionpattern or both of the marker for prognosis of liver cancer of thepresent disclosure is detected therefrom. This enables estimating theprognosis of liver cancer patients.

The kit for measuring the level or pattern of mRNA by RT-PCR comprises aprimer specific to mRNA of the marker for prognosis of liver cancer ofthe present disclosure. RT-PCR kits may include a test tube or othersuitable container, reaction buffer solution, deoxynucleotide (dNTPs),enzyme such as Taq-polymerase and reverse transcriptase, DNAse, RNAsesuppresser, DEPC-water, sterile water, etc. according to detailedembodiments. The primer can initiate DNA synthesis in the presence of areagent for polymerization (i.e., DNA polymerase or reversetranscriptase) and four different nucleoside triphosphates in a suitablebuffer solution and temperature.

As a method for measuring the expression level or expression pattern ofa protein by using an antibody, there are western blot, ELISA (enzymelinked immunosorbent assay), radioimmunoassay, radioimmunodiffusion,Ouchterlony immunodiffusion, rocket immunoelectrophoresis, tissueimmunity staining, immunoprecipitation assay, complement fixation assay,FACS, protein chip, etc. In addition, any method that is generallycarried out in the pertinent art can be used.

Through the above analysis methods, the formation level or formationpattern of the antigen-antibody composite in a sample of subject livercancer patients can be compared with the standard level, and theexisting level or existing pattern of the protein encoded by the markerfor prognosis of liver cancer of the present disclosure can bedetermined therefrom, and finally, the prognosis of liver cancerpatients can be estimated. Here, “antigen-antibody composite” means acomposite of protein encoded by a marker for prognosis of liver cancerand an antibody specific thereto. The formation level or formationpattern of the antigen-antibody composite can generally be measured bydetecting the size and pattern of the signal of the detection labelassociated with a secondary antibody. Such detection label can beexemplified by enzyme, fluorescent substance, ligand, luminescentsubstance, nanoparticles, redox molecules, radio isotope, etc., but arenot limited thereto. When enzyme is used as a detection label, asenzymes that can be used, there are β-gluculonidase, β-D-glucosidase,β-D-galacosidase, urease, peroxidase or alkaline phosphatase,acetylcholinesterase, glucose oxidase, hexokinase and GDPase, RNase,glucose oxidase, luciferase, phosphofructokinase, phosphoenolpyruvatecarboxylase, aspartate aminotransferase, phosphenolpyruvatedecarboxylase, β-latamase, etc., but the enzymes are not limitedthereto. When a fluorescent substance is used as a detection label, asfluorescent substances that can be used, there are fluorescein,isothiocyanate, rhodamine, phycoerythrin, phycocyanin, allophycocyanin,o-phthaldehyde, fluorescamine, etc., but the fluorescent substances arenot limited thereto. When a ligand is used as a detection label, as aligand that can be used, there are biotin derivative, etc., but theligand is not limited thereto. When a luminescent substance is used as adetection label, as luminescent substances that can be used, there areacridium ester, luciferin, luciferase, etc., but the luminescentsubstances are not limited thereto. When nanoparticles are used asdetection label, as nanoparticles that can be used, there are colloidalgold, tinted latex, etc., but the nanoparticles are not limited thereto.When redox molecules are used as detection label, as redox moleculesthat can be used, there are ferrocene, ruthenium complex, viologen,quinone, Ti ion, Cs ion, diimide, 1,4-benzoquinone, hydroquinone,K4W(CN)8, [Os(bpy)3]2+, [RU(bpy)3]2+, [MO(CN)8]4−, etc., but the redoxmolecules are not limited thereto. When a radio isotope is used as adetection label, as radio isotopes that can be used, there are 3H, 14C,32P, 35S, 36Cl, 51Cr, 57Co, 58Co, 59Fe, 90Y, 125I, 131I or 186Re, etc.,but the radio isotopes are not limited thereto.

The “measurement results” refers to at least one selected from theexpression level or expression pattern of the genes of the (A) stepcollected from liver cancer tissue, etc., and “the results of thecontrol groups” may refer to the gene expression level having the lowestp-value among the results obtained by subjecting the measurements fromgroups of liver cancer patients (A1 group, A2 group, B group, C group)whose liver cancer prognosis is known to a regression analysis ofcontinuous variables or a risk score obtained from the expression level(see N Engl J. Med 2007; 356: 11-20). The measurement results and theresults of the control groups are expression levels or expressionpatterns (high expression or low expression) obtained according to thesame method, and can be determined based on the average expression levelof the control genes (group of genes) (B2M, GAPDH, HMBS, HPRT1, SDHA,etc.) expressing a constant expression level regardless of whether thepatient is suffering from liver cancer.

The measurement results of liver cancer patients are characterized bybeing compared with the results of the control groups which are obtainedfrom the above groups of patients to allow detection of a differencetherebetween, and any substance allowing detection of such differencecan be used as a substance for specifically detecting the expressionlevel or expression pattern of markers for prognosis of liver cancer, orboth of them. The result of detecting a difference between the resultsof the control group and the measurement results is capable of providinginformation for determining a method for treating liver cancer.

Also, the present disclosure provides a method for predicting prognosisof liver cancer comprising: (A) detecting one or more selected from theexpression level or expression pattern of one or at least two genesselected from the group consisting of the genes described in Table 2above (described in the description of the composition or kit forpredicting prognosis of liver cancer for predicting the prognosisaccording to the stage of liver cancer of the present disclosure) insamples obtained from patients of liver cancer; and (B) comparing theresults of the (A) step with the measurement results of the controlgroups to predict the prognosis of liver cancer.

The group consisting of the genes may further comprise the genesdescribed in Table 3 above (described in the description of thecomposition or kit for predicting prognosis of liver cancer forpredicting the prognosis according to the stage of liver cancer of thepresent disclosure).

The matters mentioned regarding the method for predicting prognosis ofliver cancer for predicting the prognosis according to the stage ofliver cancer of the present disclosure equally apply to the methodunless there is a contradiction.

Also, the matters mentioned regarding the composition or kit of thepresent disclosure equally apply to the method of the present disclosureunless there is a contradiction.

The method for predicting prognosis of liver cancer of the presentdisclosure may be a method for providing information for predictingprognosis of liver cancer.

Also, the present disclosure provides the use of the nucleic acids orantibodies included in the composition of the present disclosure forprediction of the prognosis of liver cancer.

Also, the present disclosure provides nucleic acids or antibodies forpredicting prognosis of liver cancer, and the nucleic acids orantibodies are those included in the composition of the presentdisclosure.

The matters mentioned regarding the marker, composition or kit, methodand use of the present disclosure equally apply unless there is acontradiction.

Effect of the Disclosure

The marker, composition or kit, and method of the present disclosuremake it possible to effectively predict prognosis of liver cancer,preferably, prognosis of liver cancer according to stage.

BRIEF DESCRIPTION OF THE DRAWINGS

FIG. 1 illustrates a BCLC classification table.

FIGS. 2˜106 are Kaplan-Meier curves illustrating the data obtained bymeasuring the markers for prognosis of liver cancer of the presentdisclosure in the aspects of recurrence, survival, and disease-freesurvival.

EMBODIMENTS FOR CARRYING OUT THE DISCLOSURE

Hereinafter, the present disclosure will be explained in detail by meansof examples; however they are described only to help understand thepresent disclosure, but not to limit the scope of the present disclosurein any way.

Example 1 Predicting Prognosis of Liver Cancer

Markers useful for predicting prognosis of liver cancer were found bythe following method, and it was confirmed that it is possible topredict prognosis of liver cancer by using the markers.

1-1. RNA Extraction and cDNA Synthesis

Liver cancer tissue and adjacent normal tissue harvested from 547patients of liver cancer whose liver cancer occurrence was diagnosed andits development was confirmed were obtained. The liver cancer patientswere patients who went through liver resection for cancer withoutreceiving other treatment after diagnosis, and the tissues were tissuesharvested and frozen before the liver resection for cancer.

RNA of each of the tissues was extracted and cDNA was synthesizedaccording to the following methods.

Total RNA was extracted from liver cancer tissue and adjacent normaltissue using RNeasy Minikit (Qiagen, Germany) according to themanufacturer's instructions. The total RNA of the obtained RNA extractwas weighed using Bioanalyzer 2100 (Agilent Technologies, USA). DNase Itreatment was performed in the extraction step to remove contaminatedgenomic DNA from the RNA extract. The sample containing 4 μg of totalRNA was incubated with 2 μl of 10 μM oligo d(T)18 primer (Genotech,Korea) at 70° C. for 7 minutes and cooled down on ice for 5 minutes. Anenzyme mix was separately prepared [in a total volume of 11 μl by adding2 μl of 0.1 M DTT (Duchefa, Netherlands), 2 μl of 10×reverse-transcription buffer, 5 μl of 2 mM dNTP, 1 μl of 200 U/μl MMLVreverse-transcriptase, and 1 μl of 40 U/μl, RNase inhibitor (Enzynomics,Korea)]. After adding the enzyme mix to the samples containing the RNA,they were incubated for 90 minutes at 42° C., and then were incubated at80° C. for 10 minutes to inactivate reverse-transcriptase. The abovesamples were brought up to a final volume of 400 μl by addingdiethylpyrocarbonate (DEPC)-treated water.

1-2: Quantitative Real-Time PCR

Real-time PCR amplifications were carried out for each of the cDNAsamples obtained from Example 1-1, using PRISM 7900HT (AppliedBiosystems, USA) according to the manufacturer's instructions, on thegenetic marks described in the following table:

The real-time PCR analysis was performed in a total volume of 10 μlincluding 5 μl of 2× Taqman gene expression master mix (AppliedBiosystems, USA), 1 μl of each of 5 μM forward and reverse primers, 1 μlof 1 μM probe (Genotech, Korea), and 2 μl of cDNA (in the case of acontrol group, the same amount of water). The amplifications wereperformed with a cycle of a step of dissociation at 95° C. for 10minutes, followed by a step of dissociation at 95° C. for 15 seconds;and a step of synthesis at 60° C. for 1 minute. The primer and probesequences were designed using Primer Express 3.0 (Applied Biosystems,USA) and all the probe sequences were labelled with FAM at the 5′ endand with TAMRA at the 3′ end. The following primer and probe sequencesin the below Table 16 were used for each of the markers:

TABLE 16 Gene Forward Primer (SEQ ID NO.) Reverse Primer (SEQ ID NO.)UVRAG AATGTGCACCCTAGCCAAGAA(58) TGCTCGCTGGGTAGGAGAGT(59) NAMPTCGGCAGAAGCCGAGTTCA(61) GCTTGTGTTGGGTGGATATTGTT(62) STAT3GCCAGAGAGCCAGGAGCAT(64) GGTGTCACACAGATAAACTTGGTCTT(65) CIAP2TGGTTTCCAAGGTGTGAGTACTTG(67) GGGCTGTCTGATGTGGATAGC(68) BHLHE41CAAGCCTACCGTCCCACAGA(70) CCAGTAACTGTCTCTCTTGCAAATG(71) MMP2GGTTGTCTGAAGTCACTGCACAGT(73) CTCGGTAGGGACATGCTAAGTAGAG(74) SESN2TGCCTCCGGGACTGACA(76) TGACCCTGACTTTCACATTGATG(77) HMGB1CGGACAAGGCCCGTTATG(79) AGAGGAAGAAGGCCGAAGGA(80) SIRT1AAAAACCTCCACGAACACAAAAA(82) TGCTTGGTCTAAAAGTGTGACAATC(83) RPS19BP1CGGAAGACGAAGGCAATTCA(85) GCCGACTTGGGCACCTTT(86) LAMP2GCCCCGCCCCTAGTCTTA(88) ACCGACCACAGCCTTGCA(89) AGERCCGAGTCCGTGTCTACCAGATT(91) CACATGTCCCCACCTTATTGG(92) SESN3TCTGCCTGAACTGGTACATGCT(94) TGGATTGATACCACTACCAAAAACA(95) ID2AACGACTGCTACTCCAAGCTCAA(97) GGATTTCCATCTTGCTCACCTT(98) TCF3GCTGCCTTTGGTCTCTGGTTT(100) AGAAATGCAATGCTCAGTCTAGGA(101) HMGB2TGCCGGGAAGAGCACAA(103) TCCATCTCTCCGAACACTTCTTG(104) TP63GCTCCACCTTCGATGCTCTCT(106) TGCTCGACTGCTGGAAGGA(107) RAGECCAATTTGTCCCCACAATGC(109) GGGCGGCGATTCTCTCA(110) KIAA1967CGTTGTTGCATGCTCTTTGTG(112) CCAGCAAAAACTTAATCTGCTTCA(113) SATB1GACCCGGCCACGAACA(115) GTCGAGCTGGGCAGACAGA(116) RAPTORGATGGCACTCAGCGAATGC(118) ATGCGCACATCTCCATTGAC(119) SESN1TCCTGGGTGCATTCAGTCTCT(121) GGAGCTGCACAGCCTTTAAAGT(122) CCNG2TCCCAGTATGATGGCCAGTCA(124) ATAAGGCCAGCCAAAACTCAAG(125) CDH1AAATCTGAAAGCGGCTGATACTG(127) CGGAACCGCTTCCTTCATAG(128) FAS LGGAGATCCAGCTTGCCTCCTCTT(130) CGGTTTTACTTCTTCTCAGTCCTGTA(131) CASP3CAGTGGAGGCCGACTTCTTG(133) ATGAACCAGGAGCCATCCTTT(134) BECN1GATGGTGTCTCTCGCAGATTCA(136) TCAGATGCCTCCCCAATCAG(137) CDH2GCACCCGCCTCAGTCAACT(139) CAACATGGTACCGGCATGAA(140) TWIST1TCCGCGTCCCACTAGCA(142) AGTTATCCAGCTCCAGAGTCTCTAGAC(143) MMP9GGGCTCCCGTCCTGCTT(145) ACTCCTCCCTTTCCTCCAGAAC(146) VEGFGCTTACTCTCACCTGCTTCTGAGTT(148) TGGGCTGCTTCTTCCAACA(149) ATG12CGACAGCTTCGATTTGAATGAC(151) GGGAGCGTCGCAAAGGA(152) DIABLOAATCACATTCAGCTGGTGAAACTG(154) TGCCAGCTTGGTTTCTGCTT(155) E2F1CTGGACCACCTGATGAATATCTGT(157) CAATGCTACGAAGGTCCTGACA(158) LAMP1TGCACTCAGATTTAAGCCTTACAAA(160) TCACCACGAGTGACCTTCATG(161) LC3AACCAGCACAGCATGGTGAGT(163) CCTCGTCTTTCTCCTGCTCGTA(164) ATG7CGGATGAATGAGCCTCCAA(166) GGACATTATCAAACCGTGAAAGAA(167) TKTGAGGCTGTGTCCAGTGCAGTAG(169) CCACTTCTTGGTACCCGGTTA(170) AIFM1TGAAGATCTCAATGAAGTAGCCAAACTAT(172) CTGCAGTGGGTTTGCCAAT(173) BNIP3TTCCCCCCAAGGAGTTCCT(175) CGCTCGTGTTCCTCATGCT(176) ATG3CCATTGAAAATCACCCTCATCTG(178) CACCTCAGCATGCCTGCAT(179) DRAMCAGCCGCCTTCATTATCTCCTA(181) TGGAGGTGTTGTTCCCGTATC(182) ATG5TTTCCTCCACTGCCATCATTAA(184) GGCCAAAGGTTTCAGCTTCA(185) NNMTTTGAGGTGATCTCGCAAAGTTATT(187) CTCGCCACCAGGGAGAAA(188) PRKAA1GGCAGTTGCCTACCATCTCATAA(190) GCCGAGTCAGGTGATGATCA(191) CASP8CCTTCTGATTGATGGTGCTATTTTG(193) GCGGTGAGCCGAGATCAC(194) ULK1TCGCGGCCGCATGT(196) AAGGGTCCAGCACTATCAAGAGA(197) BCL2L1GATTGCCTTTGTTTTGATGTTTGT(199) GGAAAGGGAACCCAGGTTAGTG(200) FASAATGGTGTCAATGAAGCCAAAAT(202) GTCATACGCTTCTTTCTTTCCATGA(203) CSE1LGCATGATCCTGTAGGTCAAATGG(205) CAGGCGGTAGACAACTTGTGAA(206) FRAP1AGGCCGCATTGTCTCTATCAA(208) GCAGTAAATGCAGGTAGTCATCCA(209) AKT1TCTCGGGTGCATTTGAGAGAA(211) ACAGCACAAAAACGTCTTTCCA(212) BAXGGTTGTCGCCCTTTTCTACTTTG(214) CAGTTCCGGCACCTTGGT(215) BCL2CATGTGTGTGGAGAGCGTCAA(217) GCCGGTTCAGGTACTCAGTCA(218) PTENTGGCGGAACTTGCAATCC(220) GCTGAGGGAACTCAAAGTACATGA(221) CBSGTTGGCAAAGTCATCTACAAGCA(223) GGGCGAAGTGGTCCATCTC(224) XIAPGACAGGCCATCTGAGACACATG(226) AGCATAGTCTGGCCAGTTCTGAA(227) GeneProbe (SEQ ID No.) UVRAG AGAAGCCCTCTCCGGGCACCG(60) NAMPTCATCCTCCTGGCCACCGACTCCTAC(63) STAT3 AGCTGACCCAGGCGCTGCCC(66) CIAP2TCATCCGTCAAGTTCAAGCCAGTTACCCTC(69) BHLHE41CCCAAAAATCGAAACAGAGGAAACGAACAG(72) MMP2 CATCTCAGCCCACATAGTGATGGTTCCC(75)SESN2 TGCCTTCTCTCCCCTGTCATTTCCAG(78) HMGB1AAAAGAAGTTCAAGGATCCCAATGCACCC(81) SIRT1 TCAGAGTTGCCACCCACACCTCTTCA(84)RPS19BP1 CCAGAAACTGCGGAACTCGGCCA(87) LAMP2 CTCGCACTGAAGCGCCGATTCC(90)AGER TCTGCCTCTGAACTCACGGCTGGTGT(93) SESN3TGGTCCTCCTGGCACATTATCATGCTTT(96) ID2 TGCCCAGCATCCCCCAGAACAA(99) TCF3AGTCCCGTGTCTCTCGCTATTTCTGCTG(102) HMGB2 ACACCCGGACTCTTCCGTCAATTTCG(105)TP63 ATCACCCGCCATCCCCTCCAAC(108) RAGE CCTCCTGCACGCAATGGTGGC(111)KIAA1967 CCAAGGGAGACGCCAGAGCATCC(114) SATB1TTTCATACAAGACGTGGGCCTGTACCCTG(117) RAPTOR CTCCCTGCAGAAGCGTCCCGAC(120)SESN1 TGCCTCTGCCTGCCTCCTGGTC(123) CCNG2 ATGCTGCTCTTCCCGTCCACAAGTG(126)CDH1 CCCCACAGCCCCGCCTTATGA(129) FAS LG AGCAACAGGGTCCCGTCCTTGACA(132)CASP3 TCCACAGCACCTGGTTATTATTCTTGGCG(135) BECN1ATGTCCACAGAAAGTGCCAACAGCTTCAC(138) CDH2AATGAAAACCCTTATTTTGCCCCCAATCC(141) TWIST1 CACCCCCTCAGCAGGGCCG(144) MMP9TGCCATGTAAATCCCCACTGGGACC(147) VEGF AGACCACTGGCAGATGTCCCGGC(150) ATG12TGTAATTGCGTCCCCCTACTCCGGC(153) DIABLO AAGAGGTGCACCAGCTCTCCCGG(156) E2F1CAGCTGCGCCTGCTCTCCGA(159) LAMP1 AAGCCTCTGGCCGTCACACGTAGG(162) LC3TCCACGCCCATCGCGGACA(165) ATG7 TCTTGGGCTTGTGCCTCACCAGATC(168) TKTCCTGGCATCACTGTCACCCACCTG(171) AIFM1 CAACATTCATGAAGACTGAAGCCCCACA(174)BNIP3 ACCCGAAGCGCACGGCCAC(177) ATG3 CACCACCTCCCATGTGTTCAGTTCACC(180)DRAM TGCTCTCCGGGCACGTCAACC(183) ATG5 CCTCAGCTGTGACATGAAAGACTTACCGG(186)NNMT CCACCATGGCCAACAACGAAGGAC(189) PRKAA1TCTATTTGGCGACAAGCCCACCTGATT(192) CASP8 CAGAATCTCGCTCTGTCGCCCAGG(195)ULK1 AGCAGGTCCTGGGCGCCTCAAC(198) BCL2L1CAGAATTGATCATTTTCCCCCCACTCTCC(201) FASTGACAATGTCCAAGACACAGCAGAACAGAA(204) CSE1LAATAACCCCAAAATTCACCTGGCACAGTCA(207) FRAP1 TGCAATCCAGCTGTTTGGCGCC(210)AKT1 CCACGCTGTCCTCTCGAGCCCA(213) BAX CAGCAAACTGGTGCTCAAGGCCCT(216) BCL2CCTGGTGGACAACATCGCCCTGT(219) PTEN ATATTCCTCCAATTCAGGACCCACACGAC(222) CBSACGCTGGGCAGGCTCTCGCAC(225) XIAP AGACACCATATACCCGAGGAACCCTGCC(228)

Expression of each of the marker genes was measured in triplicate, andthen standardized by subtracting the average expression of 5 types ofreference genes (B2M, GAPDH, HMBS, HPRT1, and SDHA). The primer andprobe sequences in the below Table 17 were used for reference genes.

TABLE 17 Gene forward primer (SEQ ID No.) reverse primer (SEQ ID NO.)B2M(beta-2-microglobulin) CATTCGGGCCGAGATGTCT(229)CTCCAGGCCAGAAAGAGAGAGTAG(230) GAPDH(glyceraldehyde-3- CACATGGCCTCCAAGGAGTAA(232) TGAGGGTCTCTCTCTTCCTCTTGT(233)phosphate dehydrogenase) HMBS(hydroxymethylbilane CCAGGGATTTGCCTCACCTT(235) AAAGAGATGAAGCCCCCACAT(236) synthase)HPRT1(hypoxanthine  GCTCGAGATGTGATGAAGGAGAT(238)CCAGCAGGTCAGCAAAGAATT(239) phosphoribosyltransferase 1) SDHA(succinate  CACCTAGTGGCTGGGAGCTT(241) GCCCAGTTTTATCATCTCACAAGA(242) dehydrogenasecomplex, subunit A) Gene Probe (SEQ ID NO.) B2M(beta-2-microglobulin)CCGTGGCCTTAGCTGTGCTCGC(231) GAPDH(glyceraldehyde-3-phosphate CTGGACCACCAGCCCCAGCAAG(234) dehydrogenase) HMBS(hydroxymethylbilane CCTTGATGACTGCCTTGCCTCCTCAG(237) synthase) HPRT1(hypoxanthine CCATCACATTGTAGCCCTCTGTGTGCTC(240) phosphoribosyltransferase 1)SDHA(succinate dehydrogenase  TGGCACTTACCTTTGTCCCTTGCTTCA(243)complex, subunit A)

CT (the number of cycles required to achieve a threshold) of each of themarkers was measured, and the ΔCT value (CT of each of the markers minusaverage CT of the reference genes) was calculated. The mRNA copy numberwas calculated as 2^(−ΔCT). Standard curves were constructed from theresults of simultaneous amplifications of serial dilutions of the cDNAsamples.

From the above results, it can be found that the expression level andexpression pattern of the markers can be measured by the nucleic acidincluded in the composition of the present disclosure. Also, since mRNA,a transcriptome, is translated into a protein, it can also be known thatthe expression level and expression pattern of the markers can also bemeasured by the antibody included in the composition of the presentdisclosure.

1-3. Statistical Analysis

In consideration of the standardized expression of each of the markersobtained from Examples 1˜2, and the progress of the patients whoprovided liver cancer tissues, Kaplan-Meier curves were completed, andthen significance analysis was performed.

Based on the progress of patients who have provided liver cancertissues, for the respective cases of recurrence, survival, anddisease-free survival, the patients were listed in the ascending orderof the period. The interval survival rate (or interval recurrence rate)was calculated by dividing the number of survivors (or patients withrecurrence) by the number of patients exposed to a risk. The cumulativesurvival rate (or cumulative recurrence rate) is conditionalprobability, which was calculated by multiplying the previous cumulativesurvival rate (or cumulative recurrence rate) by the current intervalsurvival rate (or interval recurrence rate). Kaplan-Meier curves wereconstructed as step functions with the horizontal axis of survival time(or observation period) and the vertical axis of cumulative survivalrate (or cumulative reoccurrence rate).

For each of the markers, Kaplan-Meier curves with regard to recurrence,survival, and disease-free survival were completed. The expression ofeach of the markers that was measured in Example 1˜2 was classified intohigh expression and low expression based on statistically significantreference values that were determined experimentally, and the cases ofhigh expression and low expression for each of the markers wereseparated from each other to complete Kaplan-Meier curves. As thereference values, the gene expression values having the lowest p-valueamong the results of regression analysis of continuous variables (see NEngl J Med 2007; 356: 11-20) were selected. Graphs were prepared byapplying them to the Kaplan-Meier curve (J. Amer. Statist. Assn.53:457481, 1958). The criteria for determining significance in theKaplan-Meier curve was whether the p-value of a single gene or acombination of genes is lower than 0.05.

Kaplan-Meier curves were prepared with regard to prediction ofrecurrence, survival, and disease-free survival for 57 types of singlegenes, 31 types of single genes and gene groups consisting ofcombinations of at least two of them in 547 liver cancer patients whosestage has not been classified. The results for 57 types of single genesare shown in FIGS. 2˜22. Kaplan-Meier curves regarding recurrence for 57types of single genes are shown in FIGS. 2˜8, Kaplan-Meier curvesregarding survival for 57 types of single genes are shown in FIGS. 9˜15,and Kaplan-Meier curves regarding disease-free survival for 57 types ofsingle genes are shown in FIGS. 16˜22.

As can be confirmed in the drawings, in the Kaplan-Meier curvescompleted with respect to recurrence, survival, and disease-freesurvival, each of the markers forms curves where cases of highexpression and low expression are distinctively distinguished from eachother. This means that there is remarkable differences in intervalrecurrence rate or interval survival rate, and cumulative recurrencerate or cumulative survival rate based thereon between the cases whereeach of the markers shows high expression and low expression, and thatconsequently, the expression patterns of each of the markers can be anindex showing recurrence possibility or survival possibility ofpatients.

Also, significance tests were were performed by log-rank test withrespect to each of the markers and their combination by calculatingobservation values and expected values at every point of recurrence ordeath to obtain Chi-square test statistics. The results are shown in thefollowing Tables 18˜21. The results of 57 markers are shown in Table 18,and the results of 31 markers used alone and in combination are shown inTables 19˜21. Among them, Table 19 shows the result of prediction ofrecurrence of 31 markers, Table 20 shows the result of prediction ofsurvival of 31 markers, and Table 21 shows the result of prediction ofdisease-free survival of 31 markers.

TABLE 18 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value FAS 9.36E-06 FAS 1.51E-10 FAS 3.86E-06 TKT1.02E-05 CDH1 2.46E-07 TKT 8.83E-06 FASLG 4.99E-04 FRAP1 5.46E-07 FASLG6.66E-04 CASP8 7.29E-04 NAMPT 8.91E-07 AKT1 9.30E-04 AKT1 2.67E-03 BNIP31.42E-06 CASP8 1.38E-03 ID2 3.17E-03 TKT 1.66E-06 ID2 3.46E-03 DRAM4.17E-03 ID2 4.42E-06 CSE1L 5.42E-03 ULK1 4.48E-03 LC3 5.95E-06 BECN16.19E-03 E2F1 7.03E-03 LAMP2 9.67E-06 ULK1 6.39E-03 RPS19BP1 7.74E-03CSE1L 1.79E-05 HMGB2 8.45E-03 UVRAG 8.77E-03 LAMP1 1.86E-05 UVRAG1.16E-02 AIFM1 9.87E-03 FASLG 2.81E-05 DRAM 1.21E-02 TP63 1.12E-02 AKT13.97E-05 KIAA1967 1.38E-02 TWIST1 1.20E-02 UVRAG 4.45E-05 AGER 1.48E-02BECN1 1.36E-02 BECN1 5.62E-05 TCF3 1.59E-02 BCL2L1 1.94E-02 STAT31.31E-04 RPS19BP1 1.80E-02 KIAA1967 1.95E-02 TCF3 2.39E-04 BCL2 1.86E-02ATG7 2.00E-02 SESN3 7.83E-04 TP63 1.99E-02 AGER 2.05E-02 CIAP2 1.24E-03BNIP3 2.15E-02 HMGB2 2.16E-02 CDH2 1.63E-03 BCL2L1 2.18E-02 TCF32.72E-02 SIRT1 1.91E-03 AIFM1 2.42E-02 CSE1L 2.77E-02 CBS 3.72E-03DIABLO 2.53E-02 DIABLO 2.86E-02 HMGB2 4.96E-03 E2F1 2.72E-02 BCL23.17E-02 VEGF 5.10E-03 MMP2 2.77E-02 BNIP3 3.27E-02 SESN2 8.63E-03 LAMP22.86E-02 SATB1 3.42E-02 BHLHE41 8.83E-03 STAT3 2.88E-02 MMP9 3.62E-02ATG7 1.29E-02 LAMP1 3.38E-02 MMP2 4.51E-02 RPS19BP1 1.55E-02 SESN33.43E-02 STAT3 4.61E-02 SATB1 1.65E-02 CDH1 3.87E-02 LC3 4.96E-02 ATG121.66E-02 SATB1 4.05E-02 RAPTOR 6.38E-02 AIFM1 2.17E-02 LC3 4.47E-02FRAP1 6.43E-02 RAPTOR 2.19E-02 TWIST1 4.94E-02 SESN3 6.70E-02 DIABLO2.51E-02 CDH2 5.28E-02 LAMP1 7.01E-02 TWIST1 2.76E-02 ATG7 6.13E-02LAMP2 7.55E-02 BCL2 3.10E-02 CASP3 6.69E-02 ATG12 8.48E-02 NNMT 3.61E-02NAMPT 6.82E-02 CDH2 8.67E-02 BCL2L1 3.88E-02 SESN2 7.38E-02 ATG59.08E-02 ATG5 3.96E-02 VEGF 7.75E-02 SESN2 9.11E-02 DRAM 4.10E-02 FRAP18.15E-02 BAX 9.26E-02 XIAP 4.21E-02 ATG5 9.29E-02 CASP3 9.40E-02 ATG34.68E-02 BAX 9.60E-02 CDH1 9.49E-02 HMGB1 5.33E-02 PTEN 1.01E-01 VEGF1.11E-01 ULK1 6.22E-02 RAPTOR 1.02E-01 PRKAA1 1.19E-01 PTEN 7.19E-02CIAP2 1.18E-01 BHLHE41 1.23E-01 RAGE 7.30E-02 BHLHE41 1.20E-01 RAGE1.25E-01 PRKAA1 8.26E-02 MMP9 1.26E-01 ATG3 1.31E-01 TP63 8.38E-02 ATG121.53E-01 PTEN 1.33E-01 CASP3 1.26E-01 CCNG2 1.61E-01 CCNG2 1.60E-01 AGER1.59E-01 NNMT 1.69E-01 SIRT1 1.60E-01 CASP8 1.68E-01 RAGE 1.78E-01 NAMPT1.96E-01 BAX 1.92E-01 XIAP 1.99E-01 XIAP 2.09E-01 MMP9 1.93E-01 PRKAA12.34E-01 NNMT 2.46E-01 MMP2 1.93E-01 HMGB1 2.56E-01 CIAP2 2.83E-01KIAA1967 1.99E-01 CBS 2.71E-01 CBS 3.07E-01 CCNG2 2.05E-01 SIRT13.23E-01 HMGB1 3.22E-01 SESN1 2.62E-01 SESN1 3.41E-01 SESN1 4.15E-01E2F1 4.35E-01 ATG3 3.50E-01

TABLE 19 One type Combinations of two types Combinations of three typesMarker p-value Marker p-value Marker p-value FASLG 8.88E-04FASLG_RPS19BP1 2.42E-06 FASLG_ID2_RPS19BP1 8.11E-08 FAS 4.01E-03ULK1_ID2 1.28E-05 DRAM_FASLG_RPS19BP1 2.11E-07 CSE1L 5.58E-03 DRAM_FASLG2.02E-05 LC3_FASLG_RPS19BP1 3.86E-07 ID2 7.13E-03 FASLG_MMP9 2.55E-05FASLG_MMP9_RPS19BP1 4.66E-07 TCF3 1.61E-02 ATG12_FASLG 3.13E-05ATG12_FASLG_RPS19BP1 5.24E-07 LAMP2 2.60E-02 ATG7_FASLG 3.34E-05ULK1_CSE1L_ID2 5.42E-07 RPS19BP1 3.32E-02 RPS19BP1_LAMP2 3.69E-05FASLG_RPS19BP1_SESN3 5.54E-07 ULK1 4.75E-02 CSE1L_ID2 5.33E-05FASLG_STAT3_RPS19BP1 6.07E-07 AKT1 4.92E-02 FASLG_ID2 5.60E-05FASLG_RPS19BP1_TCF3 6.32E-07 DRAM 5.11E-02 LC3_ULK1 5.83E-05FASLG_RPS19BP1_BHLHE41 8.13E-07 SESN2 8.39E-02 ID2_RPS19BP1 7.41E-05FASLG_RPS19BP1_SATB1 8.65E-07 SATB1 8.55E-02 AKT1_CSE1L 8.20E-05ATG7_FASLG_ID2 1.07E-06 SESN3 8.87E-02 FASLG_TCF3 8.70E-05ATG7_FASLG_RPS19BP1 1.10E-06 LC3 9.38E-02 ID2_TCF3 9.33E-05ATG12_FASLG_MMP9 1.20E-06 BECN1 1.54E-01 ID2_SESN2 1.01E-04 AKT1_FASLG1.20E-06 MMP9 1.65E-01 FAS_ID2 1.31E-04 FASLG_FRAPLRPS19BP1 1.24E-06BHLHE41 2.49E-01 CSE1L_FASLG 2.12E-04 ID2_RPS19BP1_LAMP2 1.46E-06 UVRAG3.16E-01 LC3_FASLG 2.16E-04 ATG12_FASLG_ID2 1.60E-06 ATG5 3.43E-01FAS_RPS19BP1 2.31E-04 DRAM_FASLG_TCF3 1.70E-06 STAT3 3.50E-01 E2F1_FASLG2.33E-04 FAS_ID2_RPS19BP1 1.72E-06 E2F1 3.53E-01 ATG3_FASLG 2.53E-04ULK1_FASLG_RPS19BP1 1.84E-06 ATG3 4.00E-01 FASLG_BHLHE41 2.90E-04ATG7_FASLG_MMP9 1.98E-06 CDH1 4.44E-01 DRAM_FAS 3.37E-04 FASLG_RPS19BP12.00E-06 FRAP1 5.30E-01 FASLG_SESN3 3.88E-04 LC3_ULK1_ID2 2.02E-06DIABLO 6.29E-01 DIABLO_FASLG 4.27E-04 DRAM_FASLG_ID2 2.07E-06 ATG126.44E-01 FASLG_SIRT1 4.54E-04 FASLG_RPS19BP1_SESN2 2.14E-06 ATG77.01E-01 CSE1L_FAS 4.67E-04 ULK1_ID2_RPS19BP1 2.14E-06 LAMP1 7.45E-01FASLG_STAT3 5.37E-04 FAS_FASLG_RPS19BP1 2.24E-06 SIRT1 7.77E-01ULKLFASLG 5.90E-04 ATG12_FASLG_TCF3 2.27E-06 NAMPT 7.81E-01 FASLG_SATB16.01E-04 FASLG_CDHLRPS19BP1 2.36E-06 BNIP3 9.40E-01 FASLG_SESN2 7.59E-04FASLG_RPS19BPLNAMPT 2.38E-06 Combinations of four types Combinations offive types Combinations of six types Marker p-value Marker p-valueMarker p-value DRAM_FASLG_ID2_RPS19BP1 6.49E-09 DRAM_FASLG_ID2_STAT3_7.48E-10 DRAM_FASLG_ID2_STAT3_ 1.55E-10 RPS19BP1 RPS19BP1_TCF3ATG12_FASLG_ID2_RPS19BP1 1.07E-08 DRAM_FASLG_ID2_RPS19BP1_ 1.02E-09ATG12_FASLG_ID2_STAT3_ 1.72E-10 TCF3 RPS19BP1_TCF3FASLG_ID2_RPS19BP1_TCF3 1.09E-08 ATG12_FASLG_ID2_STAT3_ 1.08E-09ATG7_DRAM_FASLG_ID2_ 1.94E-10 RPS19BP1 STAT3_RPS19BP1ATG7_FASLG_ID2_RPS19BP1 1.30E-08 ATG7_FASLG_ID2_STAT3_ 1.43E-09DRAM_FASLG_ID2_ 2.19E-10 RPS19BP1 RPS19BP1_SATB1_TCF3DRAM_FASLG_STAT3_RPS19BP1 1.70E-08 ATG12_FASLG_ID2_RPS19BP1_ 1.52E-09DRAM_ATG12_FASLG_ID2_ 2.70E-10 TCF3 STAT3_RPS19BP1FASLG_ID2_MMP9_RPS19BP1 2.12E-08 DRAM_FASLG_ID2_RPS19BP1_ 2.14E-09ATG12_FASLG_ID2_MMP9_ 3.18E-10 SATB1 STAT3_RPS19BP1FASLG_ID2_STAT3_RPS19BP1 2.78E-08 DRAM_FASLG_ID2_RPS19BP1_ 2.16E-09DRAM_FASLG_ID2_ 3.37E-10 SESN3 STAT3_RPS19BP1_SATB1 LC3_ULK1_CSE1L_ID22.85E-08 ATG7_FASLG_ID2_RPS19BP1_ 2.66E-09 DRAM_ULK1_FASLG_ID2_ 3.54E-10TCF3 STAT3_RPS19BP1 DRAM_FASLG_RPS19BP1_SESN3 3.03E-08DRAM_FAS_FASLG_ID2_ 2.76E-09 DRAM_FASLG_ID2_STAT3_ 3.66E-10 RPS19BP1RPS19BP1_SESN2 DRAM_LC3_FASLG_RPS19BP1 3.58E-08 DRAM_ULK1_FASLG_ID2_3.11E-09 DRAM_FASLG_ID2_STAT3_ 3.87E-10 RPS19BP1 RPS19BP1_SESN3FASLG_ID2_RPS19BP1_SESN3 3.68E-08 ATG7_FASLG_ID2_RPS19BP1_ 3.18E-09ATG7_FASLG_ID2_STAT3_ 4.01E-10 SATB1 RPS19BP1_TCF3FASLG_ID2_RPS19BP1_SATB1 4.01E-08 DRAM_FASLG_ID2_RPS19BP1_ 3.25E-09ATG12_FASLG_ID2_STAT3_ 4.19E-10 SESN2 RPS19BP1_SESN3ULK1_FASLG_ID2_RPS19BP1 4.36E-08 ATG12_FASLG_ID2_RPS19BP1_ 3.29E-09DRAM_FAS_FASLG_ID2_ 4.19E-10 SESN3 STAT3_RPS19BP1FASLG_ID2_RPS19BP1_SESN2 4.51E-08 DRAM_LC3_FASLG_STAT3_ 3.34E-09ATG7_FASLG_ID2_ 4.23E-10 RPS19BP1 RPS19BP1_SATB1_TCF3ATG12_FASLG_STAT3_RPS19BP1 4.72E-08 ATG12_FASLG_ID2_MMP9_ 3.53E-09ATG7_FASLG_ID2_STAT3_ 4.68E-10 RPS19BP1 RPS19BP1_SATB1DRAM_FASLG_RPS19BP1_SATB1 5.03E-08 DRAM_FASLG_STAT3_RPS19BP1_ 3.56E-09DRAM_FASLG_ID2_ 4.97E-10 SESN3 RPS19BP1_SESN3_TCF3FASLG_ID2_SIRT1_RPS19BP1 5.34E-08 FASLG_ID2_RPS19BP1_SATB1_ 3.87E-09ATG12_FASLG_ID2_STAT3_ 4.98E-10 TCF3 RPS19BP1_SESN2FASLG_ID2_RPS19BP1_BHLHE41 5.49E-08 ATG7_FASLG_ID2_RPS19BP1_ 3.90E-09DRAM_FASLG_ID2_MMP9_ 5.21E-10 SESN3 STAT3_RPS19BP1LC3_FASLG_ID2_RPS19BP1 6.13E-08 ATG7_DRAM_FASLG_ID2_ 4.10E-09ATG12_FASLG_ID2_ 5.22E-10 RPS19BP1 RPS19BP1_SATB1_TCF3FASLG_ID2_RPS19BP1_UVRAG 6.21E-08 DRAM_FASLG_ID2_MMP9_ 4.34E-09ULK1_ATG12_FASLG_ID2_ 5.40E-10 RPS19BP1 STAT3_RPS19BP1DRAM_AKT1_FASLG_RPS19BP1 6.38E-08 ATG12_FAS_FASLG_ID2_ 4.75E-09DRAM_FASLG_ID2_STAT3_ 5.59E-10 RPS19BP1 RPS19BP1_BHLHE41E2F1_FASLG_ID2_RPS19BP1 6.45E-08 DRAM_ATG12_FASLG_ID2_ 4.86E-09DRAM_FAS_FASLG_ID2_ 5.70E-10 RPS19BP1 RPS19BP1_TCF3DRAM_FASLG_RPS19BP1_TCF3 6.83E-08 ATG12_FASLG_FRAP1_ID2_ 4.89E-09ATG12_FASLG_FRAP1_ID2_ 5.79E-10 RPS19BP1 RPS19BP1_TCF3FAS_FASLG_ID2_RPS19BP1 7.00E-08 ATG12_FASLG_ID2_ 4.93E-09ATG12_FASLG_ID2_ 5.88E-10 RPS19BP1_SATB1 RPS19BP1_SESN3_TCF3DIABLO_FASLG_ID2_RPS19BP1 7.16E-08 ATG12_FASLG_ID2_RPS19BP1_ 5.11E-09ATG12_FAS_FASLG_ID2_ 5.97E-10 SESN2 STAT3_RPS19BP1ATG12_FASLG_MMP9_STAT3 7.44E-08 FASLG_ID2_STAT3_RPS19BP1_ 5.26E-09ATG7_FASLG_ID2_MMP9_ 6.05E-10 TCF3 STAT3_RPS19BP1FASLG_ID2_RPS19BP1_NAMPT 7.49E-08 FASLG_ID2_SIRT1_RPS19BP1_ 5.29E-09ATG7_ATG12_FASLG_ID2_ 6.08E-10 TCF3 STAT3_RPS19BP1LC3_ATG12_FASLG_RPS19BP1 7.87E-08 DRAM_LC3_FASLG_ID2_ 5.35E-09ATG7_DRAM_FASLG_ID2_ 6.29E-10 RPS19BP1 RPS19BP1_SATB1ATG12_FASLG_RPS19BP1_SESN 8.09E-08 ATG7_LC3_FASLG_ID2_ 5.54E-09ATG12_FASLG_ID2_STAT3_ 6.30E-10 RPS19BP1 RPS19BP1_BHLHE41LC3_FASLG_RPS19BP1_TCF3 8.15E-08 DRAM_FASLG_FRAP1_ID2_ 5.54E-09ATG12_FASLG_FRAP1_ID2_ 6.34E-10 RPS19BP1 STAT3_RPS19BP1DRAM_FASLG_FRAP1_RPS19BP1 8.22E-08 DRAM_AKT1_FASLG_ID2_ 5.55E-09ATG7_DRAM_FASLG_ID2_ 6.38E-10 RPS19BP1 RPS19BP1_SESN3 CDH1_ID2_MMP9_TCF31.61E-03 IFASLG_CDH1_ID2_MMP9_TCF3 2.18E-06 IFASLG_CDH1_ID2_MMP9_6.28E-09 RPS19BP1_TCF3

TABLE 20 One type Combinations of two types Combinations of three typesCombinations of four types Marker p-value Marker p-value Marker p-valueMarker p-value CDH1 7.27E-08 CSE1L_ID2 6.55E-15 BNIP3_CSE1L_ID2 <1.0E-16AKT1_CSE1L_ <1.0E-16 ID2_BHLHE41 FAS 2.08E-07 ID2_TCF3 1.74E-13CSE1L_ID2_BECN1 <1.0E-16 AKT1_CSE1L_ <1.0E-16 ID2_TCF3 ID2 4.37E-07AKT1_CSE1L 4.49E-13 ULK1_CSE1L_ID2 1.11E-16 ATG5_BNIP3_ <1.0E-16CSE1L_ID2 CSE1L 9.09E-07 FAS_CDH1 2.52E-12 AKT1_CSE1L_ID2 5.55E-16ATG5_CSE1L_ <1.0E-16 ID2_BECN1 LAMP2 2.13E-06 FAS_ID2 6.73E-12ATG7_CSE1L_ID2 5.55E-16 ATG7_BNIP3_ <1.0E-16 CSE1L_ID2 NAMPT 7.54E-06ID2_BECN1 1.19E-11 LAMP1_CSE1L_ID2 7.77E-16 ATG7_CSE1L_ <1.0E-16ID2_BHLHE41 BNIP3 1.05E-05 CDH1_ 1.37E-11 CSE1L_FAS_ID2 8.88E-16ATG7_CSE1L_ <1.0E-16 BHLHE41 ID2_TCF3 BECN1 1.56E-05 DRAM_CDH1 1.89E-11CSE1L_ID2_TCF3 1.33E-15 ATG7_LC3_ <1.0E-16 CSE1L_ID2 TCF3 2.26E-05CSE1L_CDH1 3.44E-11 CSE1L_DIABLO_ID2 1.67E-15 ATG7_ULK1_ <1.0E-16CSE1L_ID2 AKT1 2.86E-05 BNIP3_ID2 1.01E-10 LC3_CSE1L_ID2 1.78E-15BNIP3_AKT1_ <1.0E-16 CSE1L_ID2 LC3 5.44E-05 BNIP3_CDH1 1.02E-10CSE1L_ID2_BHLHE41 1.89E-15 BNIP3_CSE1L_ <1.0E-16 DIABLO_ID2 STAT39.10E-05 BNIP3_ 1.48E-10 CSE1L_ID2_STAT3 1.89E-15 BNIP3_CSE1L_ <1.0E-16CSE1L FAS_ID2 FRAP1 9.85E-05 LC3_CSE1L 1.82E-10 FAS_CDH1_BHLHE411.89E-15 BNIP3_CSE1L_ <1.0E-16 FRAP1_ID2 FASLG 3.34E-04 BHLHE41_2.32E-10 ATG5_CSE1L_ID2 2.33E-15 BNIP3_CSE1L_ <1.0E-16 NAMPT ID2_BECN1UVRAG 8.20E-04 ULK1_CDH1 3.30E-10 CSE1L_ID2_SESN2 2.33E-15 BNIP3_CSE1L_<1.0E-16 ID2_RPS19BP1 LAMP1 1.36E-03 CSE1L_FAS 3.60E-10 ATG3_CSE1L_ID22.78E-15 BNIP3_CSE1L_ <1.0E-16 ID2_SATB1 BHLHE41 7.24E-03 AKT1_TCF33.74E-10 FAS_ID2_TCF3 3.00E-15 BNIP3_CSE1L_ <1.0E-16 ID2_SESN2 SIRT18.95E-03 BNIP3_FAS 4.67E-10 DRAM_FAS_CDH1 3.11E-15 BNIP3_CSE1L_ <1.0E-16ID2_STAT3 SESN3 1.15E-02 ATG5_CDH1 5.82E-10 BNIP3_AKTLCSE1L 5.00E-15BNIP3_LC3_ <1.0E-16 CSE1L_ID2 ATG7 1.61E-02 FAS_LAMP2 6.81E-10CSE1L_ID2_SIRT1 5.44E-15 BNIP3_ULK1_ <1.0E-16 CSE1L_ID2 ATG12 1.79E-02LC3_BECN1 7.00E-10 CSE1L_ID2_RPS19BP1 5.88E-15 CSE1L_DIABLO_ <1.0E-16ID2_BECN1 SESN2 6.68E-02 FAS_FRAP1 8.30E-10 ATG12_CSE1L_ID2 8.33E-15CSE1L_FRAP1_ <1.0E-16 ID2_BHLHE41 SATB1 8.42E-02 CSE1L_ 8.49E-10LC3_ID2_TCF3 1.28E-14 CSE1L_ID2_ <1.0E-16 FRAP1 BHLHE41_BECN1 ULK11.22E-01 CDH1_ID2 8.93E-10 BNIP3_LC3_CSE1L 1.37E-14 CSE1L_ID2_ <1.0E-16BHLHE41_NAMPT DRAM 1.63E-01 FRAP1_ 9.98E-10 CSE1L_ID2_MMP9 1.61E-14CSE1L_ID2_ <1.0E-16 BHLHE41 RPS19BP1_SESN2 DIABLO 2.90E-01 FAS_NAMPT1.00E-09 LC3_AKT1 2.31E-14 CSE1L_ID2_ <1.0E-16 SESN2_BECN1 ATG3 2.93E-01LC3_TCF3 1.22E-09 ATG7_ID2_TCF3 2.32E-14 CSE1L_ID2_ <1.0E-16STAT3_BHLHE41 RPS19BP1 3.00E-01 ULK1_ID2 1.53E-09 ID2_RPS19BP1_TCF32.36E-14 LC3_CSE1L_ <1.0E-16 ID2_BECN1 ATG5 3.56E-01 FAS_TCF3 1.70E-09CSE1L_FRAP1_ID2 3.18E-14 LC3_CSE1L_ <1.0E-16 ID2_BHLHE41 MMP9 3.63E-01ID2_NAMPT 1.93E-09 AKT1_ID2_TCF3 3.50E-14 LC3_CSE1L_ <1.0E-16 ID2_SIRT1E2F1 4.93E-01 DRAM_ 2.01E-09 LC3_BHLHE41_NAMPT 4.36E-14 LC3_CSE1L_<1.0E-16 NAMPT CDH1_ID2_MMP9_TCF3 4.73E-12 ID2_TCF3 Combinations of fivetypes Combinations of six types Marker p-value Marker p-valueAKT1_ATG12_CSE1L_ID2_TCF3 <1.0E-16 AKT1_ATG12_DIABLO_ <1.0E-16 ID2_TCF3AKT1_ATG3_CSE1_LID2_TCF3 <1.0E-16 AKT1_ATG12_CSE1L_FAS_ <1.0E-16ID2_TCF3 AKT1_CSE1L_DIABLO_ID2_ <1.0E-16 AKT1_ATG12_CSE1L_ <1.0E-16BHLHE41 ID2_BHLHE41_SESN2 AKT1_CSE1L_DIABLO_ID2_TCF3 <1.0E-16AKT1_ATG12_CSE1L_ <1.0E-16 ID2_BHLHE41_TCF3 AKT1_CSE1L_FAS_ID2_BECN1<1.0E-16 AKT1_ATG12_CSE1L_ <1.0E-16 ID2_RPS19BP1_TCF3AKT1_CSE1L_FAS_ID2_TCF3 <1.0E-16 AKT1_ATG12_CSE1L_ <1.0E-16ID2_SATB1_TCF3 AKT1_CSE1L_FRAP1_ID2_ <1.0E-16 AKT1_ATG12_CSE1L_ <1.0E-16BHLHE41 ID2_SESN2_TCF3 AKT1_CSE1L_FRAP1_ID2_TCF3 <1.0E-16AKT1_ATG3_CSE1L_ <1.0E-16 DIABLO_ID2_BHLHE41AKT1_CSE1L_ID2_BHLHE41_BECN1 <1.0E-16 AKT1_ATG3_CSE1L_DIABLO_ <1.0E-16ID2_TCF3 AKT1_CSE1L_ID2_BHLHE41_NAMPT <1.0E-16 AKT1_ATG3_CSE1L_FAS_<1.0E-16 ID2_TCF3 AKT1_CSE1L_ID2_BHLHE41_SESN2 <1.0E-16 AKT1_ATG3_CSE1L_<1.0E-16 FRAP1_ID2_BHLHE41 AKT1_CSE1L_ID2_BHLHE41_TCF3 <1.0E-16AKT1_ATG3_CSE1L_ <1.0E-16 ID2_BHLHE41_BECN1 AKT1_CSE1L_ID2_MMP9_TCF3<1.0E-16 AKT1_ATG3_CSE1L_ <1.0E-16 ID2_BHLHE41_NAMPTAKT1_CSE1L_ID2_NAMPT_TCF3 <1.0E-16 AKT1_ATG3_CSE1L_ <1.0E-16ID2_BHLHE41_SESN2 AKT1_CSE1L_ID2_RPS19BP1_ <1.0E-16 AKT1_ATG3_CSE1L_<1.0E-16 BHLHE41 ID2_BHLHE41_TCF3 AKT1_CSE1L_ID2_RPS19BP1_SESN2 <1.0E-16AKT1_ATG3_CSE1L_ <1.0E-16 ID2_MMP9_TCF3 AKT1_CSE1L_ID2_RPS19BP1_TCF3<1.0E-16 AKT1_ATG3_CSE1L_ <1.0E-16 ID2_RPS19BP1_BHLHE41AKT1_CSE1L_ID2_SATB1_TCF3 <1.0E-16 AKT1_ATG3_CSE1L_ <1.0E-16ID2_RPS19BP1_TCF3 AKT1_CSE1L_ID2_SESN2_BECN1 <1.0E-16 AKT1_ATG3_CSE1L_<1.0E-16 ID2_SATB1_TCF3 AKT1_CSE1L_ID2_SESN2_TCF3 <1.0E-16AKT1_ATG3_CSE1L_ <1.0E-16 ID2_SESN2_TCF3 AKT1_CSE1L_ID2_SIRT1_TCF3<1.0E-16 AKT1_ATG3_CSE1L_ <1.0E-16 ID2_SIRT1_ICF3AKT1_CSE1L_ID2_STAT3_BHLHE41 <1.0E-16 AKT1_ATG3_CSE1L_ID2_ <1.0E-16STAT3_BHLHE41 AKT1_CSE1L_ID2_STAT3_TCF3 <1.0E-16 AKT1_ATG3_CSE1L_ID2_<1.0E-16 STAT3_TCF3 AKT1_CSE1L_ID2_TCF3_BECN1 <1.0E-16AKT1_ATG3_CSE1L_ID2_ <1.0E-16 TCF3_BECN1 ATG3_CSE1L_FRAP1_ID2_ <1.0E-16AKT1_CSE1L_DIABLO_FAS_ <1.0E-16 BHLHE41 CDH1_BHLHE41ATG3_CSE1L_ID2_RPS19BP1_TCF3 <1.0E-16 AKT1_CSE1L_DIABLO_FAS_ <1.0E-16ID2_BECN1 ATG3_CSE1L_ID2_STAT3_BHLHE41 <1.0E-16 AKT1_CSE1L_DIABLO_FAS_<1.0E-16 ID2_TCF3 ATG5_AKT1_CSE1L_ID2_TCF3 <1.0E-16 AKT1_CSE1L_DIABLO_<1.0E-16 FRAP1_ID2_BHLHE41 ATG5_ATG7_CSE1L_ID2_TCF3 <1.0E-16AKT1_CSE1L_DIABLO_ID2_ <1.0E-16 BHLHE41_BECN1 ATG5_ATG7_ULK1_CSE1L_ID2<1.0E-16 AKT1_CSE1L_DIABLO_ID2_ <1.0E-16 BHLHE41_NAMPTATG5_BNIP3_AKT1_CSE1L_ID2 <1.0E-16 AKT1_CSE1L_DIABLO_ID2_ <1.0E-16BHLHE41_SATB1 FAS_CDH1_ID2_MMP9_TCF3 4.00E-15 DRAM_FAS_CDH1_ID2_MMP9_<1.0E-16 TCF3

TABLE 21 One type Combinations of two types Combinations of three typesCombinations of four types Marker p-value Marker p-value Marker p-valueMarker p-value FASLG 2.12E-04 FASLG_ 9.60E-07 FASLG_ID2_RPS19BP15.41E-08 FASLG_ID2_ 2.39E-09 RPS19BP1 RPS19BP1_TCF3 CSE1L 1.85E-03FASLG_ 4.89E-06 FASLG_RPS19BP1_TCF3 9.51E-08 DRAM_FASLG_ 7.50E-09 TCF3ID2_RPS19BP1 FAS 3.01E-03 DRAM_ 1.03E-05 DRAM_FASLG_RPS19BP1 1.44E-07ATG12_FASLG_ 9.10E-09 FASLG ID2_RPS19BP1 ID2 4.85E-03 ATG12_ 1.05E-05ATG12_FASLG_TCF3 1.57E-07 DRAM_FASLG_ 1.04E-08 FASLG STATS_RPS19BP1 TCF38.81E-03 AKT1_ 1.17E-05 DRAM_FASLG_TCF3 1.94E-07 ATG12_FASLG_ 1.14E-08CSE1L ID2_TCF3 LAMP2 1.17E-02 CSE1L_ID2 1.23E-05 FASLG_STATS_RPS19BP12.04E-07 ATG7_FASLG_ 1.22E-08 ID2_RPS19BP1 AKT1 2.35E-02 FASLG_ 1.57E-05LC3_FASLG_RPS19BP1 2.41E-07 ATG12_FASLG_ 1.48E-08 MMP9 STATS_TCF3 ULK16.69E-02 ATG7_ 1.78E-05 ATG12_FASLG_RPS19BP1 2.56E-07 ATG7_FASLG_1.56E-08 FASLG ID2_TCF3 SESN2 7.32E-02 FASLG_ID2 2.19E-05FASLG_MMP9_RPS19BP1 2.58E-07 FASLG_ID2_ 1.61E-08 STATS_RPS19BP1 BECN18.16E-02 ULK1_ID2 2.52E-05 FASLG_RPS19BP1_SESN3 2.93E-07 ATG12_FASLG_1.76E-08 STATS_RPS19BP1 SESN3 8.49E-02 ID2_TCF3 2.97E-05 ULK1_CSE1L_ID23.55E-07 LC3_FASLG_ 1.86E-08 RPS19BP1_TCF3 LC3 1.02E-01 CSE1L_ 3.13E-05ATG7_FASLG_TCF3 4.06E-07 DRAM_FASLG_ 1.86E-08 FASLG RPS19BP1_TCF3 SATB11.10E-01 RPS19BP1_ 3.54E-05 AKT1_FASLG_RPS19BP1 4.18E-07 FASLG_ID2_1.87E-08 LAMP2 MMP9_RPS19BP1 DRAM 1.11E-01 ID2_SESN2 5.44E-05FASLG_RPS19BP1_SATB1 4.42E-07 FASLG_ID2_ 1.97E-08 RPS19BP1_SESN2RPS19BP1 1.24E-01 E2F1_ 7.03E-05 FASLG_FRAP1_RPS19BP1 4.76E-07FASLG_ID2_ 2.69E-08 FASLG RPS19BP1_SESN3 STAT3 1.90E-01 FAS_ID2 7.41E-05ATG7_FASLG_RPS19BP1 5.24E-07 FASLG_RPS19BP1_ 2.87E-08 SATB1_TCF3 CDH11.94E-01 LC3_FASLG 8.16E-05 FASLG_RPS19BP1_BHLHE41 6.12E-07 ATG12_FASLG_2.90E-08 RPS19BP1_TCF3 FRAP1 2.26E-01 DIABLO_ 8.86E-05FASLG_RPS19BP1_SESN2 6.56E-07 AKT1_FASLG_ 2.98E-08 FASLG RPS19BP1_TCF3UVRAG 2.61E-01 FASLG_ 1.00E-04 FASLG_ID2_TCF3 6.59E-07 DRAM_FASLG_3.15E-08 SESN2 ID2_TCF3 BHLHE41 2.70E-01 FASLG_ 1.02E-04ATG12_FASLG_MMP9 7.89E-07 FASLG_STAT3_ 3.19E-08 SESN3 RPS19BP1_TCF3 ATG53.41E-01 ATG3_ 1.03E-04 FASLG_CDH1_RPS19BP1 8.31E-07 FASLG_ID2_ 3.20E-08FASLG RPS19BP1_SATB1 MMP9 3.73E-01 FASLG_ 1.18E-04 FASLG_RPS19BP1_NAMPT9.01E-07 DRAM_FASLG_ 3.25E-08 STAT3 RPS19BP1_SESN3 E2F1 4.76E-01 FASLG_1.22E-04 ATG12_FASLG_ID2 9.27E-07 DRAM_AKT1_ 3.70E-08 BHLHE41FASLG_RPS19BP1 BNIP3 4.92E-01 FASLG_ 1.54E-04 FASLG_RPS19BP1_LAMP29.34E-07 DRAM_LC3_ 3.73E-08 SATB1 FASLG_RPS19BP1 LAMP1 4.96E-01 FASLG_1.58E-04 FASLG_RPS19BP1_UVRAG 9.61E-07 LC3_ULK1_ 3.84E-08 SIRT1CSE1L_ID2 NAMPT 7.13E-01 CSE1L_FAS 1.59E-04 FASLG_RPS19BP1_BECN19.63E-07 ATG12_FASLG_ 3.99E-08 MMP9_TCF3 ATG3 7.51E-01 AKT1_ 1.91E-04ULK1_FASLG_RPS19BP1 9.87E-07 AKT1_ATG12_ 4.05E-08 FASLG FASLG_TCF3DIABLO 7.99E-01 ULK1_ 1.95E-04 FASLG_MMP9_TCF3 1.01E-06 FASLG_ID2_4.12E-08 FASLG RPS19BP1_UVRAG ATG12 8.89E-01 FASLG_ 2.06E-04CSE1L_ID2_SESN2 1.08E-06 CSE1L_FASLG_ 4.19E-08 UVRAG ID2_RPS19BP1 SIRT19.53E-01 ATG5_ 2.36E-04 FAS_FASLG_RPS19BP1 1.12E-06 DIABLO_FASLG_4.19E-08 FASLG ID2_RPS19BP1 ATG7 9.86E-01 FASLG_ 2.37E-04FASLG_SIRT1_RPS19BP1 1.12E-06 FASLG_FRAP1_ 4.28E-08 BECN1 RPS19BP1_TCF3CDH1_ID2_(—) 7.94E-04 MMP9_TCF3 Combinations of five types Combinationsof six types Marker p-value Marker p-value DRAM_FASLG_ID2_RPS19BP1_TCF33.98E-10 ATG12_FASLG_ID2_STAT3_ 4.12E-11 RPS19BP1_TCF3ATG12_FASLG_ID2_RPS19BP1_TCF3 4.16E-10 DRAM_FASLG_ID2_STAT3_ 6.35E-11RPS19BP1_TCF3 ATG12_FASLG_ID2_STAT3_RPS19BP1 7.74E-10DRAM_FASLG_ID2_RPS19BP1_ 1.02E-10 SATB1_TCF3DRAM_FASLG_ID2_STAT3_RPS19BP1 8.29E-10 ATG7_FASLG_ID2_STAT3_ 1.26E-10RPS19BP1_TCF3 ATG7_FASLG_ID2_RPS19BP1_TCF3 8.31E-10ATG12_FASLG_FRAP1_ID2_ 1.42E-10 RPS19BP1_TCF3FASLG_ID2_RPS19BP1_SATB1_TCF3 9.81E-10 ATG7_ATG12_FASLG_ID2_ 1.57E-10STAT3_TCF3 FASLG_ID2_STAT3_RPS19BP1_TCF3 1.13E-09ATG12_FASLG_ID2_RPS19BP1_ 1.68E-10 SATB1_TCF3ATG7_FASLG_ID2_STAT3_RPS19BP1 1.24E-09 ATG7_FASLG_ID2_RPS19BP1_ 1.72E-10SATB1_TCF3 FASLG_ID2_RPS19BP1_SESN2_TCF3 1.30E-09ATG12_FASLG_ID2_RPS19BP1_ 1.89E-10 SESN2_TCF3FASLG_ID2_MMP9_RPS19BP1_TCF3 1.59E-09 DRAM_FASLG_ID2_RPS19BP1_ 1.95E-10SESN2_TCF3 FASLG_ID2_SIRT1_RPS19BP1_TCF3 1.61E-09 ATG7_DRAM_FASLG_ID2_1.95E-10 STAT3_RPS19BP1 FASLG_ID2_RPS19BP1_TCF3_UVRAG 1.65E-09AKT1_ATG12_FASLG_ID2_ 2.08E-10 RPS19BP1_TCF3 ATG12_FASLG_ID2_SESN2_TCF31.65E-09 ATG12_FASLG_ID2_STAT3_ 2.20E-10 RPS19BP1_SESN2LC3_FASLG_ID2_RPS19BP1_TCF3 2.15E-09 DRAM_ATG12_FASLG_ID2_ 2.23E-10STAT3_RPS19BP1 FASLG_ID2_RPS19BP1_TCF3_BECN1 2.19E-09ATG12_FASLG_ID2_RPS19BP1_ 2.29E-10 SESN3_TCF3 DRAM_FASLG_STAT3_RPS19BP1_2.20E-09 DRAM_FASLG_ID2_STAT3_ 2.58E-10 TCF3 RPS19BP1_SESN2ATG12_FASLG_ID2_STAT3_TCF3 2.24E-09 ATG7_DRAM_FASLG_ID2_ 2.63E-10STAT3_TCF3 DRAM_FASLG_ID2_RPS19BP1_SESN2 2.39E-09 DRAM_AKT1_FASLG_ID2_2.68E-10 RPS19BP1_TCF3 ULK1_FASLG_ID2_RPS19BP1_TCF3 2.47E-09ATG12_FASLG_ID2_MMP9_ 2.70E-10 STAT3_RPS19BP1FASLG_ID2_RPS19BP1_SESN3_TCF3 2.55E-09 DRAM_FASLG_ID2_RPS19BP1_ 2.94E-10SESN3_TCF3 ATG12_FASLG_STAT3_RPS19BP1_ 2.62E-09 DRAM_ATG12_FASLG_ID2_3.16E-10 TCF3 STAT3_TCF3 AKT1_FASLG_ID2_RPS19BP1_TCF3 2.70E-09LC3_ATG12_FASLG_ID2_ 3.20E-10 RPS19BP1_TCF3 ATG12_FASLG_ID2_RPS19BP1_2.72E-09 ATG12_FASLG_ID2_MMP9_ 3.24E-10 SESN2 RPS19BP1_TCF3FASLG_FRAP1_ID2_RPS19BP1_TCF3 2.91E-09 ATG12_FASLG_ID2_RPS19BP1_3.30E-10 TCF3_LAMP2 DIABLO_FASLG_ID2_RPS19BP1_TCF3 2.98E-09DRAM_FASLG_FRAP1_ID2_ 3.38E-10 RPS19BP1_TCF3 DRAM_ATG12_FASLG_STAT3_TCF32.99E-09 DRAM_FAS_FASLG_ID2_ 3.39E-10 RPS19BP1_TCF3BNIP3_FASLG_ID2_RPS19BP1_TCF3 3.00E-09 ATG12_FAS_FASLG_ID2_ 3.40E-10RPS19BP1_TCF3 DRAM_LC3_FASLG_STAT3_ 3.15E-09 ATG12_FASLG_ID2_STAT3_3.46E-10 RPS19BP1 SESN2_TCF3 ATG7_DRAM_FASLG_ID2_TCF3 3.17E-09ATG12_FASLG_CDH1_ID2_ 3.57E-10 RPS19BP1_TCF3DRAM_FASLG_ID2_RPS19BP1_SATB1 3.17E-09 DRAM_ATG12_FASLG_ID2_ 3.63E-10RPS19BP1_TCF3 ATG12_FASLG_MMP9_STAT3_TCF3 3.18E-09ATG12_FASLG_ID2_STAT3_ 3.71E-10 RPS19BP1_SESN3 FASLG_CDH1JD2_MMP9_TCF35.07E-07 FASLG_CDH1_ID2_MMP9_ 2.21E-09 RPS19BP1_TCF3

Each of the markers or their combination shows p-values low enough to beconsidered significant in terms of all of recurrence, survival, anddisease-free survival. In particular, in the case of the combination ofthe two or more markers, all the p-values for recurrence, survival, anddisease-free survival were less than 0.05, which is desirable. As ap-value becomes lower, the statistical significance becomes higher.Thus, the low p-values suggest that the estimation for prognosis ofliver cancer by each of the markers or their combination is highlyaccurate.

From the above results, it can be found that as more markers of thepresent disclosure are combined, the p-value is lower. This means thatthe more markers of the present disclosure are combined, the lowerp-values, which means higher significance, are shown, which means thatthe more improved accuracy would be achieved in the estimation forprognosis based on the combinations of the markers.

Also, it can be found that the prognosis of liver cancer of the A2 groupcan be predicted effectively by the method for predicting prognosis ofliver cancer of the present disclosure, which is targeted at themarkers.

Further, cross-validation was performed for 31 genes. In thecross-validation, patients not classified according to stage wererandomly divided into two groups (positive group: 274 patients; testgroup: 273 patients). With the reference value which was consideredstatistically significant for the positive group fixed, for the testgroup, the accuracy of estimation was calculated to be the level ofp<0.05 or p<0.001 with respect to recurrence, survival and disease-freesurvival.

Among the results of cross-validation of the prediction of recurrence,survival and disease-free survival for a combination of two or more ofthe 31 genes in all patients not classified according to stage,representative examples showing the excellent accuracy of prognosis ineach aspect are as follows:

Recurrence: ATG3_FASLG_ID2_RPS19BP1_SESN3_TCF3 (94% at the level ofp<0.05)

Survival: CSE1L_FAS_FRAP1_CDH1_BHLHE41_SESN2 (95% at the level ofp<0.0001)

Disease-free survival: ATG12_FASLG_ID2_STAT3_RPS19BP1_TCF3 (95.0% at thelevel of p<0.05)

Example 2 Predicting Prognosis of Liver Cancer in the A1 Group

An experiment was performed in the same manner as in Example 1, exceptfor experimenting on a patient group determined as the A1 group {a groupof portal vein invasion-negative patients in stage 0 or A of BCLC(Barcelona-Clinic Liver Cancer) staging system, having a tumor which is5 cm or less in size, or 3 or less tumors which are 3 cm or less insize} (277 patients). Kaplan-Meier curves were prepared with respect tothe prediction of recurrence, survival, and disease-free survival andthe results are shown in FIGS. 23˜43. Kaplan-Meier curves for recurrenceare shown in FIGS. 23˜29, Kaplan-Meier curves for survival are shown inFIGS. 30˜36, and Kaplan-Meier curves for disease-free survival are shownin FIGS. 37˜43.

As can be seen from the drawings, in Kaplan-Meier curves completed withrespect to recurrence, survival, and disease-free survival, the abovemarkers form curves where cases of high expression and low expressionare distinctively distinguished from each other. This means that thereare remarkable differences in interval recurrence rate or intervalsurvival rate and cumulative recurrence rate or cumulative survival ratebased thereon between the cases where the marker is in high expressionand low expression, and that consequently, the expression pattern of themarker can be an index showing recurrence possibility or survivalpossibility of patients.

Also, significance tests were performed by log-rank test with respect toeach of the markers and their combination by calculating observationvalues and expected values at every point of recurrence or death toobtain p-values. The results are shown in the following Tables 22˜29.The results of using a marker alone are shown in Table 22, the resultsof a combination of two markers are shown in Table 23, the results of acombination of three markers are shown in Table 24, the results of acombination of four markers are shown in Table 25, the results of acombination of five markers are shown in Table 26, the results of acombination of six markers are shown in Table 27, the results of acombination of seven markers are shown in Table 28, and the results of acombination of eight markers are shown in Table 29.

TABLE 22 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value BCL2L1 1.38E-02 ID2 5.13E-06 MMP2 1.13E-02 BECN11.50E-02 CDH1 2.19E-05 ID2 1.37E-02 BAX 1.60E-02 LC3 1.09E-02 TWIST11.53E-02 CDH2 1.67E-02 TKT 1.29E-02 BECN1 1.76E-02 NAMPT 1.71E-02 AKT11.54E-02 BAX 2.47E-02 TWIST1 2.19E-02 AIFM1 2.16E-02 BCL2L1 2.61E-02RPS19BP1 2.77E-02 BNIP3 3.10E-02 CDH2 2.77E-02 MMP2 2.88E-02 LAMP13.57E-02 FASLG 3.64E-02 SESN3 3.89E-02 FRAP1 3.86E-02 AGER 3.70E-02 ID23.92E-02 FASLG 6.14E-02 ATG12 3.72E-02 AGER 4.00E-02 SESN3 7.42E-02 TKT3.91E-02 ATG12 4.67E-02 NAMPT 8.01E-02 NAMPT 6.77E-02 KIAA1967 5.73E-02E2F1 9.08E-02 SESN3 7.09E-02 FASLG 6.51E-02 MMP2 9.50E-02 TCF3 7.71E-02TCF3 7.55E-02 SESN1 9.58E-02 KIAA1967 8.14E-02 TKT 7.85E-02 ATG51.11E-01 LC3 1.15E-01 RAPTOR 8.57E-02 LAMP2 1.14E-01 AKT1 1.29E-01PRKAA1 1.07E-01 HMGB2 1.81E-01 BCL2 1.35E-01 SIRT1 1.15E-01 ULK11.96E-01 PRKAA1 1.36E-01 CCNG2 1.17E-01 SATB1 2.07E-01 RAGE 1.36E-01CSE1L 1.17E-01 SIRT1 2.12E-01 RAPTOR 1.39E-01 CASP8 1.32E-01 TWIST12.36E-01 CCNG2 1.41E-01 BNIP3 1.40E-01 ATG12 2.46E-01 CASP8 1.56E-01SESN1 1.56E-01 CDH2 2.62E-01 RPS19BP1 1.65E-01 BCL2 1.65E-01 CIAP23.66E-01 SIRT1 1.73E-01 LC3 1.79E-01 FAS 3.97E-01 BHLHE41 1.94E-01 RAGE1.84E-01 RPS19BP1 4.40E-01 HMGB2 2.01E-01 PTEN 1.84E-01 CBS 4.45E-01CSE1L 2.43E-01 BHLHE41 2.06E-01 ATG7 4.76E-01 SESN1 2.46E-01 LAMP12.36E-01 STAT3 4.76E-01 BNIP3 2.64E-01 HMGB1 2.59E-01 HMGB1 5.14E-01HMGB1 2.66E-01 DRAM 2.74E-01 ATG3 5.18E-01 XIAP 2.70E-01 XIAP 2.94E-01TCF3 6.06E-01 DRAM 2.99E-01 TP63 3.11E-01 DRAM 6.07E-01 PTEN 3.10E-01AKT1 3.66E-01 BAX 6.19E-01 ULK1 3.65E-01 CBS 3.74E-01 KIAA1967 6.38E-01UVRAG 4.00E-01 HMGB2 3.75E-01 BCL2 6.46E-01 CBS 4.27E-01 LAMP2 3.85E-01SESN2 6.73E-01 SATB1 4.52E-01 SATB1 3.90E-01 CCNG2 6.93E-01 LAMP14.72E-01 UVRAG 4.60E-01 VEGF 7.04E-01 NNMT 5.37E-01 DIABLO 4.65E-01 NNMT7.15E-01 TP63 5.47E-01 E2F1 4.78E-01 XIAP 7.17E-01 MMP9 5.64E-01 ATG74.83E-01 AGER 7.37E-01 ATG7 5.80E-01 NNMT 5.04E-01 CSE1L 7.51E-01 ATG35.99E-01 AIFM1 5.60E-01 RAGE 7.69E-01 DIABLO 6.01E-01 CDH1 6.66E-01 MMP98.11E-01 AIFM1 6.11E-01 ULK1 6.68E-01 BCL2L1 8.29E-01 VEGF 6.84E-01STAT3 7.17E-01 DIABLO 8.59E-01 CDH1 6.87E-01 FAS 7.34E-01 RAPTOR8.62E-01 ATG5 7.08E-01 FRAP1 7.36E-01 CASP3 8.69E-01 E2F1 7.46E-01 VEGF7.64E-01 BHLHE41 8.77E-01 STAT3 7.47E-01 ATG5 7.79E-01 CASP8 9.03E-01SESN2 8.00E-01 CASP3 7.93E-01 PTEN 9.31E-01 CASP3 8.05E-01 ATG3 8.36E-01BECN1 9.42E-01 CIAP2 8.12E-01 CIAP2 9.33E-01 TP63 9.68E-01 LAMP28.19E-01 SESN2 9.35E-01 PRKAA1 9.85E-01 FRAP1 8.43E-01 MMP9 9.53E-01UVRAG 9.90E-01 FAS 9.39E-01

TABLE 23 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value FRAP1_SESN1 5.25E-05 CDH1_ID2 3.21E-08 ID2_CDH24.81E-05 FRAP1_TWIST1 5.74E-05 ATG12_CDH1 1.73E-07 FRAP1_TWIST1 9.28E-05FRAP1_CASP3 6.05E-05 LAMP1_ID2 5.08E-07 FRAP1_CASP3 1.56E-04 FRAP1_CCNG28.19E-05 BNIP3_ID2 7.33E-07 FRAP1_SESN1 1.64E-04 BAX_FRAP1 8.19E-05ATG12_ID2 1.08E-06 BAX_FRAP1 2.04E-04 FRAPLNNMT 8.59E-05 CDI-11_HMGB21.19E-06 FRAPLNNMT 2.08E-04 BCL2L1_FRAP1 8.75E-05 ID2_HMGB2 1.38E-06FRAP1_CCNG2 2.09E-04 AlFM1_FRAP1 1.04E-04 E2F1_ID2 1.56E-06 BCL2L1_FRAP12.47E-04 FRAPLRAGE 1.21E-04 TKT_ID2 2.54E-06 FRAPLRAGE 2.47E-04FRAPLVEGF 1.21E-04 DRAM_ID2 2.72E-06 AlFM1_FRAP1 2.48E-04 ID2_CDH21.27E-04 ATG5_ID2 2.80E-06 BCL2_FRAP1 3.14E-04 FRAPLPTEN 1.43E-04ID2_BECN1 3.13E-06 FRAPLVEGF 3.35E-04 NAMPT_SESN3 1.45E-04 ID2_AGER3.32E-06 FRAPLPTEN 3.46E-04 BCL2_FRAP1 1.50E-04 ID2_MMP2 3.56E-06HMGB1_TWIST1 4.38E-04 CDH2_SESN3 1.96E-04 ATG3_ID2 3.82E-06 ATG12_ID24.68E-04 FRAPLRAPTOR 2.02E-04 ID2_LAMP2 4.03E-06 FRAPLRAPTOR 4.80E-04FRAP1_KIAA1967 2.25E-04 ULK1_CDH1 4.24E-06 FRAP1_KIAA1967 5.28E-04FRAPLXIAP 3.24E-04 CSE1L_ID2 4.25E-06 ID2_BECN1 5.71E-04 BECN1_SESN33.45E-04 TKT_CDH1 4.29E-06 BECN1_SESN3 6.61E-04 HMGB1_TWIST1 4.29E-04LC3_CDH1 4.77E-06 ATG12_MMP2 6.71E-04 ID2_NAMPT 4.55E-04 ID2_MMP94.89E-06 CDH2_SESN3 6.88E-04 FRAP1_PRKAA1 4.65E-04 LC3_ID2 5.03E-06ID2_MMP2 6.88E-04 ID2_RPS19BP1 4.97E-04 FRAP1_ID2 5.51E-06 FRAPLXIAP7.02E-04 BAX_LC3 6.40E-04 CASP8_ID2 6.05E-06 AKT1_CDH2 8.14E-04FRAP1_TP63 7.32E-04 ID2_CIAP2 6.10E-06 FRAP1_PRKAA1 9.50E-04 ATG12_SESN38.72E-04 ID2_UVRAG 6.34E-06 ID2_RPS19BP1 9.90E-04 BAX_TWIST1 9.07E-04DIABLO_ID2 6.59E-06 TKT_MMP2 9.99E-04 RPS19BP1_SESN3 1.04E-03 DRAM_CDH16.97E-06 BAX_TWIST1 1.01E-03 BAX_MMP2 1.06E-03 ID2_SIRT1 6.99E-06BECNI_FASLG 1.03E-03 SESN1_STAT3 1.15E-03 FAS_ID2 7.15E-06 ATG12_SESN31.05E-03 LC3_TWIST1 1.36E-03 CDH_LAGER 7.80E-06 CDH2_MMP2 1.08E-03MMP2_NAMPT 1.37E-03 ID2_STAT3 7.83E-06 BECNLMMP2 1.10E-03 ID2_BECN11.40E-03 CBS_ID2 8.12E-06 BAX_MMP2 1.12E-03 BCL2L1_LC3 1.42E-03CDH1_MMP2 9.00E-06 ID2_NAMPT 1.15E-03 MMP2_RPS19BP1 1.47E-03 AKT1_ID29.11E-06 CASP8_ID2 1.15E-03 ATG7_BCL2L1 1.55E-03 ID2_CDH2 1.03E-05ID2_TWIST1 1.21E-03 ID2_TWIST1 1.55E-03 ATG7_ID2 1.05E-05 MMP2_SESN31.26E-03 CDH2_HMGB1 1.60E-03 ID2_HMGB1 1.21E-05 AKTLBAX 1.31E-03CDH2_MMP2 1.61E-03 ULK1_ID2 1.25E-05 FRAP1_TP63 1.31E-03 ATG7_TWIST11.71E-03 CDH1_LAMP2 1.32E-05 BAX_LC3 1.33E-03 BAX_SESN3 1.73E-03ATG5_CDH1 1.89E-05 ATG12_FASLG 1.33E-03 FASLG_NAMPT 1.79E-03 ID2_SATB11.95E-05 LC3_TWIST1 1.36E-03 ATG7_BAX 1.83E-03 CDH1_MMP9 2.14E-05AKT1_TWIST1 1.41E-03 TKT_NAMPT 1.84E-03 ID2_RPS19BP1 2.31E-05 ID2_FASLG1.46E-03 STAT3_TWIST_1 1.85E-03 ID2_TCF3 2.32E-05 STAT3_TWIST1 1.59E-03BCL2L1_MMP2 1.92E-03 CSE1L_CDH1 2.42E-05 TKT_FASLG 1.61E-03 LC3_KIAA19671.96E-03 Al_FM1_CDH1 2.48E-05 AKT1_ATG12 1.64E-03 BAX_BECN1 1.99E-03ID2_SESN3 2.49E-05 MMP2_NAMPT 1.68E-03 ATG12_ID2 2.08E-03 ID2_SESN22.83E-05 ID2_SIRT1 1.70E-03 BECNLM_MP2 2.10E-03 LAM_PLCDH1 2.88E-05ID2_AGER 1.73E-03 AKT1_BAX 2.22E-03 AIFM1_LC3 2.99E-05 ATG7_TWIST11.83E-03 LC3_RAPTOR 2.25E-03 E2F1_CDH1 3.08E-05 AKT1_BCL2L1 1.95E-03BAX_RPS19BP1 2.26E-03 ID2_NAMPT 3.23E-05 BAX_TKT 2.00E-03 BAX_TKT2.27E-03 DIABLO_CDH1 3.24E-05 KIAA1967_MMP2 2.24E-03 BAX_SATB1 2.31E-03BNIP3_CDH1 3.29E-05 BCL2L1_MMP2 2.26E-03 LC3_NAMPT 2.34E-03 AKT1_CDH13.31E-05 ATG7_TP63 2.29E-03 KIAA1967_MMP2 2.35E-03 CASP8_CDH1 3.34E-05LC3_BECN1 2.33E-03

TABLE 24 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value FRAP1_CASP3_CDH2 3.52E-06 ATG12_CDH1_ID2 2.54E-09FRAP1_CASP3_CDH2 5.47E-06 ID2_CDH2_SESN3 4.61E-06 CDH1_ID2_HMGB23.03E-09 ID2_CDH2_SESN3 5.70E-06 FRAP1_CDH2_SESN1 5.74E-06ATG12_CDH1_HMGB2 3.32E-09 ID2_CDH2_MMP2 8.25E-06 FRAP1_LC3_CASP36.25E-06 CDH1_ID2_AGER 5.59E-09 FRAP1_CDH2_TWIST1 9.04E-06FRAP1_LC3_TWIST1 6.56E-06 DRAM_CDHLID2 1.18E-08 FRAP1_CDH2_SESN11.10E-05 BAX_FRAPLLC3 7.41E-06 E2F1_CDH1_ID2 1.82E-08 FRAP1_NNMT_CDH21.10E-05 FRAP1_CDH2_TWIST1 7.58E-06 CDH1_ID2_LAMP2 1.95E-08AlFM1_FRAP1_CDH2 1.32E-05 FRAP1_NNMT_CDH2 7.85E-06 TKT_CDHLID2 2.47E-08FRAP1_TKT_TWIST1 1.34E-05 FRAP1_LC3_NNMT 8.70E-06 LAMPLCDHLID2 2.58E-08BAX_FRAPLCDH2 1.44E-05 BAX_FRAPLCDH2 9.08E-06 CDH1_ID2_MMP2 2.61E-08FRAP1_LC3_TWIST1 1.45E-05 FRAPLSESN1_STAT3 9.21E-06 ATG12_DRAM_CDH12.66E-08 AKT1_ID2_CDH2 1.54E-05 AIFM1_FRAP1_CDH2 9.30E-06 CSE1L_CDH1_ID23.01E-08 ATG12_ID2_MMP2 1.66E-05 FRAP1_LC3_VEGF 9.92E-06 CDH1_ID2_MMP93.13E-08 FRAP1_CDH2_KIAA1967 1.68E-05 FRAP1_NNMT_MMP2 9.99E-06BNIP3_CDH1_ID2 3.16E-08 FRAP1_CCNG2_CDH2 1.68E-05 FRAP1_LC3_RAGE1.01E-05 CDH1_ID2_BECN1 3.21E-08 FRAPLNNMT_MMP2 1.71E-05FRAP1_CCNG2_CDH2 1.02E-05 ATG12_CDH1_BHLHE41 3.44E-08 FRAP1_CDH2_RAGE1.71E-05 BCL2L1_FRAP1_CDH2 1.04E-05 ULK1_CDH1_ID2 3.60E-08BCL2L1_FRAP1_CDH2 1.80E-05 FRAP1_CDH2_VEGF 1.09E-05 LC3_CDH1_ID23.74E-08 FRAP1_TKT_CASP3 1.85E-05 FRAP1_LC3_CCNG2 1.12E-05ATG12_CDH1_TCF3 3.87E-08 ATG12_MMP2_SESN3 1.89E-05 FRAP1_CASP3_MMP21.18E-05 ATG5_CDH1_ID2 3.90E-08 FRAP1_CDH2_VEGF 1.90E-05BCL2L1_FRAP1_LC3 1.21E-05 ATG3_CDH1_ID2 3.97E-08 ID2_CDF12_(—+L1MGB1)1.92E-05 FRAP1_LC3_SESN1 1.22E-05 DIABLO_CDHLID2 4.47E-08FRAP1_PTEN_CDH2 2.01E-05 FRAP1_CDH2_KIAA1967 1.25E-05 CASP8_CDHID24.50E-08 CDH1_ID2_CDH2 2.03E-05 AIFM1_FRAP1_LC3 1.28E-05 ATG12_ULK1_CDH14.71E-08 FRAP1_CASP3_MMP2 2.03E-05 FRAP1_LC3_RAPTOR 1.29E-05ATG12_CDH1_BECN1 4.84E-08 FRAP1_LC3_CASP3 2.07E-05 FRAP1_CDH2_RAGE1.30E-05 ATG12_BNIP3_ID2 5.54E-08 BCL2_FRAP1_CDH2 2.38E-05 BAX_FRAPLMMP21.32E-05 CDH1_ID2_CIAP2 6.23E-08 BAX_FRAPLTKT 2.39E-05 FRAP1_LC3_PTEN1.36E-05 CBS_CDHLID2 6.43E-08 FRAP1_CDH2_RAPTOR 2.40E-05 FRAP1_TKT_CASP31.38E-05 CDHLI_D2_HMGB1 7.57E-08 BAX_FRAPLLC3 2.41E-05 FRAP1_PTEN_CDH21.49E-05 CDH1_ID2_SIRT1 8.34E-08 BAX_FRAPLMMP2 2.41E-05 FRAP1_TKT_TWIST11.51E-05 LAMPLID2_HMGB2 8.59E-08 FAS_ID2_CDH2 2.57E-05FRAP1_LC3_KIAA1967 1.60E-05 CDH1_ID2_UVRAG 8.93E-08FRAP1_RPS19BP1_TWIST1 2.74E-05 BAX_FRAP1_TKT 1.70E-05 AlFM1_LC3_CDH19.09E-08 FRAP1_LC3_NNMT 2.75E-05 BCL2_FRAP1_CDH2 1.72E-05ATG12_CDH_LAGER 9.55E-08 FRAP1_LC3_RAGE 2.75E-05 FRAPLHMGB1_TWIST11.72E-05 CDH1_ID2_STAT3 9.74E-08 FRAP1_HMGB1_TWIST1 2.96E-05FRAP1_RPS19BP1_TWIST1 1.74E-05 ATG12_LAMP1_ID2 9.98E-08 FRAPLSESN1_STAT33.07E-05 FRAP1_CDH2_RAPTOR 1.80E-05 ATG12_LC3_CDH1 1.01E-07FRAPLTKT_SESN1 3.14E-05 FRAP1_TKT_SESN1 1.81E-05 CDH1_AGER_HMGB21.05E-07 ATG3_ID2_CDH2 3.31E-05 FRAP1_RPS19BP1_SESN1 1.91E-05FAS_CDHLID2 1.19E-07 FRAP1_ID2_CDH2 3.42E-05 BAX_FRAPLBECN1 1.94E-05ATG7_CDH1_ID2 1.21E-07 FRAP1_TKT_CCNG2 3.43E-05 ID2_NAMPT_SESN3 1.96E-05ATG12_CDH1_MMP2 1.28E-07 FAS_FRAP1_TWIST1 3.43E-05 FRAP1_CCNG2_STAT32.02E-05 ATG12_CASP8_CDH1 1.32E-07 FRAPLNNMT_TKT 3.45E-05BCL2L1_FRAP1_MMP2 2.02E-05 ATG12_TKT_CDH1 1.32E-07 AlFM1_FRAP1_MMP23.50E-05 BCL2_FRAP1_LC3 2.05E-05 BNIP3_ID2_HMGB2 1.37E-07 ID2CDH2CIAP23.53E-05 FASLG_NAMPT_SESN3 2.09E-05 E2F1_ID2_1MGB2 1.44E-07FRAP1_LC3VEGF 3.53E-05 AIFM1_FRAPLMMP2 2.10E-05 ATG12CDH1_MMP9 1.69E-07CDH2_MMP2_SESN3 3.54E-05 FRAP1_CCNG2RPS19BP1 2.14E-05 ATG12CDH1_SESN21.73E-07 ID2_CDH2_FASLG 3.63E-05 BAXFRAPLRPS19BP1 2.15E-05 CDH1_ID2_CDH21.84E-07 CBS_ID2_CDH2 3.69E-05 FASFRAPLSESN1 2.18E-05 AKTLCDH1_ID21.84E-07 FRAPLLC3CCNG2 3.70E-05 BCL2L1_FRAP1_TKT 2.23E-05 LAMPLID2BECN11.93E-07 BCL2L1_FRAPLTKT 3.72E-05 FRAPLNNMTSTAT3 2.28E-05 CDH1_ID2_TCF31.94E-07 FRAPLID2_TWIST1 3.77E-05 FRAP1_MMP2_SESN1 2.38E-05ATG12_CDHLUVRAG 1.99E-07 AlFM1_FRAP1_LC3 3.82E-05 FRAP1_ID2_TWIST12.39E-05 ATG12_FAS_CDH1 1.99E-07 AlFMLFRAPLTKT 3.82E-05FRAP1_CASP3_STAT3 2.39E-05 LAMP1_TKT_ID2 2.09E-07 ATG5_ID2_CDH2 3.94E-05FRAP1_TKT_CCNG2 2.47E-05 LAMP1_ID2_AGER 2.41E-07 FRAPLTKT_RAGE 4.03E-05FRAP1_MMP2_VEGF 2.47E-05 DRAM_LAMPLID2 2.42E-07 BCL2L1_FRAP1_MMP24.04E-05 FRAP1_MMP2_RAPTOR 2.56E-05 ATG12_DIABLO_CDH1 2.43E-07FRAP1_CDH2_TP63 4.05E-05

TABLE 25 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ID2_NAMPT_RPS19BP1_SESN3 5.76E-07ATG12_CDH1_ID2_HMGB2 1.06E-10 FRAP1_TKT_CASP3_CDH2 5.04E-07FRAP1_LC3_CASP3_CDH2 5.78E-07 CDH1_ID2_AGER_HMGB2 1.45E-10ID2_CDH2_MMP2_SESN3 6.57E-07 FRAP1_TKT_CASP3_CDH2 6.32E-07ATG12_CDH1_ID2_AGER 4.15E-10 CBS_ID2_CDH2_SESN3 1.15E-06BAX_FRAPLLC3_CDH2 6.71E-07 ATG12_CDH1_TCF3_HMGB2 5.35E-10FRAP1_TKT_CDH2_TWIST1 1.24E-06 ID2_CDH2_NAMPT_SESN3 7.55E-07ATG12_DRAM_CDH1_ID2 6.42E-10 FRAP1_LC3_CASP3_CDH2 1.27E-06CBS_ID2CDH2SESN3 8.34E-07 AlFM1_CASP8LC3CDH1 7.92E-10 FRAP1_NNMTTKTCDH21.28E-06 FRAP1_LC3_CDH2_KIAA1967 8.40E-07 ATG12CDHLAGERHMGB2 8.22E-10ID2CDH2RPS19BP1_SESN3 1.35E-06 FRAPLCDH2SESN1_STAT3 9.25E-07ATG12CDH1_ID2_BECN1 9.07E-10 BAXFRAPLTKTCDH2 1.37E-06 FRAPLLC3NNMTCDH29.26E-07 ATG12DRAMCDH1_HMGB2 1.11E-09 BAXFRAPLLC3CDH2 1.47E-06FRAP1LC3CDH2RAPTOR 9.80E-07 DRAM_CDHLID2_HMGB2 1.12E-09ATG12_ID2CDH2SESN3 1.62E-06 ID2_CDH2_RPS19BP1_SESN3 1.03E-06ATG12CDHLBHLHE41_HMGB2 1.24E-09 ATG12_ID2MMP2SESN3 1.67E-06FRAP1_LC3CDH2TWIST1 1.10E-06 CDH1_ID2_HMGB2_LAMP2 1.34E-09FRAP1_LC3_CDH2_KIAA1967 1.68E-06 FRAPLLC3CDH2VEGF 1.12E-06ATG12CDHLBECN1_HMGB2 1.36E-09 AlFMLFRAPLTKTCDH2 1.75E-06FRAPLLC3SESN1_STAT3 1.15E-06 E2F1_CDH1_ID2_HMGB2 1.37E-09FRAPLTKTCDH2SESN1 1.75E-06 FRAP1_LC3CDH2RAGE 1.20E-06ATG12DIABLOCDH1_BHLHE41 1.89E-09 ID2_MMP2_RPS19BP1_SESN3 1.83E-06FRAPLLC3NNMTSTAT3 1.37E-06 CDH1_ID2_BECN1_HMGB2 1.93E-09FRAPLCDH2SESN1_STAT3 1.87E-06 ID2CDH2MMP2SESN3 1.37E-06ATG12ATG5CDH1_HMGB2 1.95E-09 FRAP1_LC3CDH2TWIST1 1.87E-06FRAP1_LC3CASP3STAT3 1.38E-06 DRAM_CDHLID2_AGER 2.00E-09 FRAPLLC3NNMTCDH21.91E-06 AlFMLFRAPLLC3CDH2 1.39E-06 LAMPLCDH1_ID2_HMGB2 2.03E-09FRAP1LC3CDH2RAPTOR 1.94E-06 BCL2L1_FRAP1_LC3CDH2 1.40E-06ATG12BNIP3CDH1_ID2 2.04E-09 FRAPLTKTCCNG2CDH2 2.00E-06 FRAPLLC3PTENCDH21.43E-06 ATG12_CSE1L_CDH1_ID2 2.04E-09 DIABLO_ID2CDH2SESN3 2.02E-06BAXFRAP1_LC3BECN1 1.46E-06 ATG12CDH1_ID2_MMP2 2.05E-09 ID2CDH2HMGB2SESN32.09E-06 BAXFRAPLLC3RPS19BP1 1.54E-06 ATG12CASP8CDH1_ID2 2.20E-09FRAP1TKTCDH2KIAA1967 2.19E-06 FRAPLCASP3CDH2STAT3 1.58E-06ATG12ATG3CDH1_HMGB2 2.43E-09 FRAP1_LC3CDH2RAGE 2.20E-06LC3HMGB1_STAT3TWIST1 1.69E-06 ATG12CDH1_ID2_MMP9 2.51E-09BAXFRAPLTKTMMP2 2.24E-06 BAXFRAPLTKTCDH2 1.71E-06 CDH1_ID2_HMGB2_MMP22.61E-09 BCL2L1_FRAPLTKTCDH2 2.24E-06 FRAP1_LC3CCNG2CDH2 1.71E-06ATG12ATG3CDH1_ID2 2.61E-09 FRAPLCASP3CDH2STAT3 2.30E-06FRAPLTKTCDH2SESN1 1.72E-06 ATG12CASP8CDH1_HMGB2 2.62E-09FRAPLPTENTKTCDH2 2.33E-06 FRAP1_LC3HMGB1_TWIST1 1.78E-06ATG12LAMPLCDH1_ID2 2.74E-09 FRAP1_ID2CDH2TWIST1 2.43E-06FRAP1_NNMTTKTCDH2 1.78E-06 CDH1_ID2_AGER_BECN1 2.80E-09ID2CDH2NAMPTSESN3 2.50E-06 BAXFRAPLLC3MMP2 1.80E-06 ATG12FASCDH1_HMGB22.80E-09 FRAP1_TKTCDH2VEGF 2.55E-06 FRAPLLC3CCNG2STAT3 1.83E-06ATG12TKTCDH1_ID2 2.84E-09 FRAPLLC3CDH2VEGF 2.65E-06 FRAP1_LC3STAT3TWIST11.85E-06 CDH1_ID2_MMP9_HMGB2 2.88E-09 FRAP1_NNMTCDH2MMP2 2.73E-06FRAP1_TKTCDH2TWIST1 1.91E-06 ATG12CDHLHMGB1_HMGB2 2.98E-09AlFMLFRAPLLC3CDH2 2.73E-06 FRAPLLC3_NNMT_MMP2 1.92E-06ATG12_CDHLMMP9_HMGB2 3.05E-09 FRAPLLC3_PTEN_CDH2 2.86E-06BAX_FRAPLTKT_MMP2 2.09E-06 ATG12_ATG5_CDH1_ID2 3.06E-09FRAP1_TKT_CDH2_RAGE 2.90E-06 FRAPLNNMT_CDH2_MMP2 2.10E-06ATG5_CDH1_ID2_HMGB2 3.07E-09 FRAP1_CDH2_HMGB1_TWIST1 2.91E-06FRAP1_LC3_CDH2_SESN1 2.10E-06 ATG3_CDH1_ID2_HMGB2 3.08E-09FAS_FRAPLCDH2_SESN1 2.95E-06 BAX_FRAPLLC3_TKT 2.14E-06ATG12_DIABLO_CDHLID2 3.09E-09 FRAP1_CASP3_CDH2_MMP2 3.01E-06FAS_FRAP1_CDH2_SESN1 2.16E-06 CSE1L_CDH1_ID2_HMGB2 3.13E-09DRAWD2CDH2SESN3 3.09E-06 BAXFASFRAP1_LC3 2.18E-06 ATG12CDH1_CIAP2HMGB23.16E-09 LC3_HMGB1_STAT3_TWIST1 3.10E-06 FRAPLCASP3CDH2MMP2 2.21E-06ATG12CDH1_ID2_UVRAG 3.35E-09 CASP8_ID2_CDH2_SESN3 3.10E-06ID2FASLGNAMPTSESN3 2.22E-06 ATG12CDHLHMGB2SESN3 3.37E-09FRAP1_TKTCDH2RAPTOR 3.10E-06 FRAP1_ID2CDH2TWIST1 2.33E-06LC3CDH1_ID2AGER 3.42E-09 BCL2L1_FRAP1_LC3CDH2 3.25E-06FRAPLCDH2HMGB1_TWIST1 2.38E-06 ATG12CDH1_HMGB2_SIRT1 3.58E-09FRAP1_CDH2KIAA1967MMP2 3.35E-06 BAXFRAPLBECNI_CDH2 2.38E-06ATG12_E2F1_CDH1_ID2 3.64E-09 FRAPLTKTCASP3FASLG 3.42E-06DRAM_ID2CDH2SESN3 2.38E-06 ATG12FASCDH1_ID2 3.65E-09 TKT_ID2_CDH2_MMP23.42E-06 FRAP1_LC3_RPS19BP1_TWIST1 2.39E-06 AlFMLATG3LC3CDH1 3.70E-09FRAP1NNMTTKTMMP2 3.43E-06 AlFMLFRAP1_TKTCDH2 2.45E-06 ATG12CDHLHMGB2MMP23.77E-09 FRAP1_TKTCASP3MMP2 3.52E-06 FRAPLTKTCCNG2CDH2 2.45E-06BNIP3_CDHLID2_HMGB2 3.78E-09 ID2CDH2CIAP2SESN3 3.59E-06BCL2L1_FRAPLTKTCDH2 2.50E-06 ATG12ULK1_CDH1_HMGB2 4.01E-09FRAP1_CDH2STAT3TWIST1 3.61E-06 DIABLO_ID2CDH2SESN3 2.50E-06TKTCDH1_ID2HMGB2 4.06E-09 CBSFRAP1_CASP3CDH2 3.71E-06 BCL2FRAP1LC3CDH22.51E-06 ATG12CDH1_ID2_LAMP2 4.07E-09 BAXFRAPLCDH2MMP2 3.74E-06FRAPLLC3CASP3FASLG 2.52E-06 ATG12LC3CDH1_ID2 4.14E-09ATG12_TKT_MMP2_SESN3 3.75E-06 FRAPLCDH2RPS19BP1_SESN1 2.53E-06ATG12CDHLHMGB2UVRAG 4.16E-09 FRAP1_CDHLCASP3CDH2 3.81E-06FRAPLLC3CASP3MMP2 2.56E-06 CASP8_CDH1_ID2_HMGB2 4.30E-09BAXFRAPLBECN1_CDH2 3.92E-06 ID2CDH2HMGB2SESN3 2.60E-06DIABLOCDHLID2_HMGB2 4.40E-09 ID2CDH2HMGBLMMP2 3.94E-06CDH1_ID2_MMP9_TCF3 8.98E-03 CDH1_ID2_MMP9_TCF3 1.86E-07CDH1_ID2_MMP9_TCF3 5.11E-03

TABLE 26 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value FRAP1_LC3_CASP3_CDH2_STAT3 8.29E-08ATG12_CDH1_ID2_AGER_HMGB2 9.20E-12 ID2_CDH2_MMP2_ 8.23E-08RPS19BP1_SESN3 ID2_MMP2_NAMPT_RPS19BP1_ 9.47E-08ATG12_DRAM_CDH1_ID2_HMGB2 3.10E-11 ATG12_ID2_CDH2_ 8.47E-08 SESN3MMP2_SESN3 FRAP1_LC3_CDH2_SESN1_STAT3 1.26E-07 DRAM_CDH1_ID2_AGER_HMGB25.16E-11 FRAP1_LC3_CASP3_ 1.62E-07 CDH2_STAT3 ID2_CDH2_MMP2_RPS19BP1_1.44E-07 ATG12_CDH1_ID2_BECN1_HMGB2 5.30E-11 ATG12_ID2_MMP2_ 1.67E-07SESN3 RPS19BP1_SESN3 FRAP1_LC3_NNMT_CDH2_STAT3 1.46E-07ATG12_LAMP1_CDH1_ID2_HMGB2 7.40E-11 AKT1_FAS_CDH2_ 1.86E-07 STAT3_TP63BAX_FRAP1_LC3_BECN1_CDH2 1.75E-07 ATG12_ATG5_CDH1_ID2_HMGB2 7.70E-11FRAP1_TKT_CASP3_ 2.31E-07 CDH2_STAT3 ID2_FASLG_NAMPT_RPS19BP1_ 1.83E-07ATG12_E2F1_CDH1_ID2_HMGB2 7.80E-11 CASP8_ID2_CDH2_ 2.43E-07 SESN3MMP2_SESN3 BAX_FRAP1_LC3_TKT_CDH2 1.91E-07 ATG12_ATG3_CDH1_ID2_HMGB27.90E-11 FRAP1_TKT_CASP3_ 2.44E-07 CDH2_FASLG FRAP1_LC3_BECN1_CDH2_2.06E-07 CDH1_ID2_AGER_BECN1_HMGB2 8.92E-11 BAX_FRAP1_LC3_ 2.53E-07RAPTOR TKT_CDH2 FRAP1_LC3_CDH2_STAT3_ 2.12E-07 ATG12_CDH1_ID2_HMGB2_MMP29.10E-11 ID2_CDH2_HMGB2_ 2.55E-07 TWIST1 MMP2_SESN3FRAP1_LC3_CCNG2_CDH2_STAT3 2.14E-07 ATG12_CASP8_CDH1_ID2_HMGB2 9.30E-11DIABLO_ID2_CDH2_ 2.57E-07 MMP2_SESN3 ID2_CDH2_FASLG_NAMPT_SESN3 2.14E-07ATG12_BNIP3_CDH1_ID2_HMGB2 1.00E-10 FRAP1_LAMP1_TKT_ 2.61E-07 CASP3_CDH2LC3_CDH2_HMGB1_STAT3_ 2.18E-07 ATG12_CDH1_ID2_MMP9_HMGB2 1.00E-10CBS_ID2_CDH2_ 2.64E-07 TWIST1 MMP2_SESN3 ID2_CDH2_HMGB1_RPS19BP1_2.24E-07 LAMP1_CDH1_ID2_AGER_HMGB2 1.06E-10 FRAP1_LC3_NNMT_ 2.78E-07SESN3 CDH2_STAT3 ID2_CDH2_MMP2_NAMPT_SESN3 2.36E-07ATG12_CSE1L_CDH1_ID2_HMGB2 1.10E-10 FRAP1_TKT_CDH2_ 2.89E-07 SESN1_STAT3FRAP1_LC3_BECN1_CDH2_ 2.45E-07 LC3_CDH1_ID2_AGER_HMGB2 1.21E-10LC3_CDH2_HMGB1_ 2.93E-07 KIAA1967 STAT3_TWIST1 BAX_FRAP1_LC3_CDH2_2.48E-07 ATG12_DIABLO_CDH1_ID2_HMGB2 1.30E-10 DRAM_ID2_CDH2_ 2.96E-07RPS19BP1 MMP2_SESN3 ID2_HMGB2_NAMPT_RPS19BP1_ 2.54E-07CSE1L_CDH1_ID2_AGER_HMGB2 1.40E-10 FRAP1_LC3_CDH2_ 3.00E-07 SESN3SESN1_STAT3 ID2_NAMPT_RPS19BP1_SESN3_ 2.56E-07 CDH1_ID2_MMP9_AGER_HMGB21.43E-10 CBS_FRAP1_TKT_ 3.07E-07 STAT3 CASP3_CDH2 FRAP1_LC3_CDH2_HMGB1_2.68E-07 CDH1_ID2_AGER_HMGB2_RPS19BP1 1.54E-10 ID2_MMP2_NAMPT_ 3.10E-07TWIST1 RPS19BP1_SESN3 FRAP1_TKT_CDH2_SESN1_STAT3 2.78E-07ATG12_CDH1_ID2_CIAP2_HMGB2 1.60E-10 AKT1_ID2_CDH2_ 3.16E-07RPS19BP1_SESN3 CSE1L_ID2_CDH2_RPS19BP1_ 2.79E-07ATG12_CDH1_ID2_HMGB2_UVRAG 1.60E-10 ID2_CDH2_MMP2_ 3.32E-07 SESN3NAMPT_SESN3 FRAP1_LC3_TKT_CASP3_CDH2 2.83E-07 ATG12_DRAM_CDH1_ID2_AGER1.60E-10 AKT1_BECN1_CDH2_ 3.37E-07 STAT3_TP63 BAX_FAS_FRAP1_LC3_CDH22.91E-07 ATG12_DRAM_CDH1_TCF3_HMGB2 1.70E-10 FAS_FRAP1_LC3_ 3.42E-07CDH2_RAPTOR FAS_FRAP1_LC3_CDH2_RAPTOR 2.97E-07 ATG12_CDH1_ID2_AGER_BECN11.80E-10 FRAP1_LC3_CDH2_ 3.44E-07 STAT3_TWIST1 LC3_CASP3_CDH2_HMGB1_3.07E-07 ATG12_DIABLO_CDH1_BHLHE41_HMGB2 1.80E-10 BAX_FRAP1_TKT_3.51E-07 STAT3 CDH2_MMP2 FAS_FRAP1_LC3_CDH2_ 3.24E-07ATG12_DIABLO_CDH1_HMGB2_SESN3 1.80E-10 FAS_FRAP1_LC3_ 3.53E-07 KIAA1967CDH2_KIAA1967 AlFM1_FRAP1_LC3_CDH2_STAT3 3.25E-07ATG12_FAS_CDH1_ID2_HMGB2 1.80E-10 AKT1_ATG7_CDH2_ 3.56E-07 RPS19BP1_TP63FRAP1_LC3_BECN1_CASP3_ 3.27E-07 ATG3_CDH1_ID2_AGER_HMGB2 1.80E-10FAS_FRAP1_LC3_ 3.79E-07 STAT3 CDH2_RAGE FRAP1_BECN1_CASP3_CDH2_ 3.27E-07CDH1_ID2_AGER_HMGB2_MMP2 1.82E-10 FAS_LC3_HMGB1_ 3.93E-07 STAT3STAT3_TWIST1 ID2_CDH2_NAMPT_SESN3_STAT3 3.31E-07ATG12_CDH1_ID2_TCF3_HMGB2 1.90E-10 FRAP1_LC3_TKT_ 3.94E-07 CASP3_CDH2LC3_ID2_NAMPT_RPS19BP1_ 3.34E-07 ATG12_CDH1_TCF3_AGER_HMGB2 1.90E-10FRAP1_TKT_CASP3_ 3.98E-07 SESN3 CDH2_CIAP2 FRAP1_LC3_NNMT_MMP2_STAT33.35E-07 ATG12_CDH1_ID2_HMGB1_HMGB2 2.00E-10 TKT_ID2_CDH2_ 3.99E-07MMP2_SESN3 BAX_FRAP1_LC3_CASP3_CDH2 3.37E-07 AlFM1_ATG3_CASP8_LC3_CDH12.10E-10 FRAP1_TKT_CDH2_ 4.02E-07 KIAA1967_MMP2FRAP1_TKT_CASP3_CDH2_STAT3 3.37E-07 ATG12_CDH1_ID2_HMGB2_SIRT1 2.10E-10FRAP1_TKT_CDH2_ 4.07E-07 HMGB1_TWIST1 LC3_HMGB1_RPS19BP1_STAT3_ 3.49E-07ATG12_CDH1_TCF3_BECN1_HMGB2 2.10E-10 BAX_FRAP1_LC3_ 4.15E-07 TWIST1BECN1_CDH2 FRAP1_CDH2_RPS19BP1_SESN1_ 3.50E-07ATG12_DIABLO_CDH1_TCF3_BHLHE41 2.20E-10 FRAP1_TKT_CDH2_ 4.17E-07 STAT3STAT3_TWIST1 CBS_FRAP1_LC3_CASP3_CDH2 3.56E-07 BNIP3_CDH1_ID2_AGER_HMGB22.24E-10 AKT1_ATG12_ID2_ 4.20E-07 CDH2_SESN3 FRAP1_LAMP1_TKT_CASP3_3.58E-07 AlFM1_CASP8_DRAM_LC3_CDH1 2.30E-10 BAX_FAS_FRAP1_ 4.24E-07 CDH2LC3_CDH2 ID2_CDH2_HMGB1_NAMPT_ 3.64E-07 ATG12_CDH1_ID2_HMGB2_LAMP22.30E-10 ATG12_CBS_ID2_ 4.28E-07 SESN3 MMP2_SESN3ID2_HMGB1_NAMPT_RPS19BP1_ 3.78E-07 ATG12_ATG3_CDH1_TCF3_HMGB2 2.50E-10FAS_FRAP1_CDH2_ 4.33E-07 SESN3 SESN1_STAT3 AKT1_ID2_NAMPT_RPS19BP1_3.78E-07 ATG12_LC3_CDH1_ID2_HMGB2 2.50E-10 FRAP1_BECN1_CASP3_ 4.35E-07SESN3 CDH2_STAT3 FRAP1_LC3_TKT_CDH2_ 3.83E-07 ATG12_TKT_CDH1_ID2_HMGB22.60E-10 FAS_FRAP1_TKT_ 4.37E-07 KIAA1967 CDH2_SESN1FRAP1_LC3_CASP3_CDH2_ 3.84E-07 CASP8_CDH1_ID2_AGER_HMGB2 2.64E-10FRAP1_LC3_CCNG2_ 4.41E-07 HMGB1 CDH2_STAT3 ATG7_FRAP1_LC3_CASP3_CDH23.85E-07 ATG12_CDH1_TCF3_BHLHE41_HMGB2 2.70E-10 ID2_CDH2_MMP2_ 4.42E-07SESN3_UVRAG BAX_FRAP1_LC3_TKT_MMP2 3.89E-07 ATG5_CDH1_ID2_AGER_HMGB22.70E-10 ATG7_ID2_CDH2_ 4.45E-07 MMP2_SESN3 FRAP1_LC3_CDH2_RAPTOR_3.90E-07 ATG12_CSE1L_CDH1_ID2_AGER 2.80E-10 ID2_CDH2_HMGB1_ 4.51E-07RPS19BP1 RPS19BP1_SESN3 FRAP1_LC3_RPS19BP1_SESN1_ 3.94E-07CDH1_ID2_AGER_HMGB2_SIRT1 2.84E-10 FRAP1_TKT_CDH2_ 4.57E-07 STAT3MMP2_RAPTOR BAX_FRAP1_LC3_CDH2_MMP2 3.95E-07 CDH1_ID2_AGER_CIAP2_HMGB22.91E-10 FRAP1_LC3_BECN1_ 4.61E-07 CDH2_RAPTOR ID2_TCF3_CDH2_RPS19BP1_3.95E-07 CDH1_ID2_TCF3_AGER_HMGB2 2.91E-10 ATG12_ID2_CDH2_ 4.64E-07SESN3 FASLG_SESN3 FRAP1_TKT_CASP3_CDH2_ 3.95E-07AlFM1_CASP8_LC3_CDH1_MMP9 3.00E-10 ATG7_FRAP1_TKT_ 4.65E-07 FASLGCASP3_CDH2 FAS_FRAP1_CDH2_SESN1_ 3.96E-07 ATG12_DRAM_CDH1_ID2_BECN13.00E-10 FRAP1_TKT_CASP3_ 4.66E-07 STAT3 CDH2_MMP2CBS_ID2_NAMPT_RPS19BP1_ 3.97E-07 AlFM1_CASP8_DIABLO_LC3_CDH1 3.10E-10FRAP1_LC3_CDH2_ 4.66E-07 SESN3 HMGB1_TWIST1 FRAP1_LC3_CDH2_KIAA1967_4.00E-07 CDH1_ID2_AGER_HMGB1_HMGB2 3.12E-10 FRAP1_LC3_TKT_ 4.72E-07 MMP2CDH2_KIAA1967 FAS_FRAP1_LC3_CASP3_CDH2 4.04E-07ATG12_CDH1_ID2_HMGB2_RPS19BP1 3.20E-10 ATG7_ID2_CDH2_ 4.72E-07RPS19BP1_TP63 BAX_CBS_FRAP1_LC3_CDH2 4.07E-07 ATG12_LC3_CDH1_AGER_HMGB23.20E-10 BAX_FRAP1_TKT_ 4.73E-07 BECN1_CDH2 FRAP1_LC3_TKT_CDH2_RAPTOR4.10E-07 FAS_CDH1_ID2_AGER_HMGB2 3.35E-10 ATG3_FRAP1_TKT_ 4.76E-07CASP3_CDH2 CDH1_ID2_MMP9_TCF3_ 1.84E-04 ATG12_CDH1_ID2_MMP9_TCF35.60E-09 CDH1_ID2_MMP9_ 1.17E-04 RPS19BP1 TCF3_CDH2

TABLE 27 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value FRAP1_LC3_BECN1_CASP3_CDH2_ 1.90E-08ATG12_DRAM_CDH1_ID2_AGER_ 3.90E-12 AKT1_ATG12_FAS_ 5.94E-09 STAT3 HMGB2CDH2_STAT3_TP63 FRAP1_LC3_NNMT_BECN1_ 2.38E-08ATG12_CDH1_ID2_AGER_BECN1_ 5.00E-12 AKT1_FAS_BECN1_ 1.41E-08 CDH2_STAT3HMGB2 CDH2_STAT3_TP63 FRAP1_LC3_TKT_CASP3_CDH2_ 3.39E-08ATG12_CSE1L_CD1_ID2_AGER_ 8.30E-12 AKT1_FAS_CDH2_ 1.86E-08 STAT3 HMGB2RPS19BP1_STAT3_TP63 ID2_CDH2_HMG131_MMP2_ 3.43E-08 ATG12_CDH1_ID2_AGER_8.90E-12 AKT1_FAS_LC3_ 2.97E-08 RPS19BP1_SESN3 HMGB2_RPS19BP1CDH2_STAT3_TP63 FAS_FRAP1_LC3_CDH2_SESN1_ 4.04E-08ATG12_LAMP1_CDH1_ID2_AGER_ 9.00E-12 ID2_CDH2_HMG131_ 3.01E-08 STAT3HMGB2 MMP2_RPS19BP1_SESN3 ID2_CDH2_FASLG_NAMPT_ 4.30E-08ATG12_CDH1_ID2_MMP9_AGER_ 9.30E-12 AKT1_ATG12_BECN1_ 3.23E-08RPS19BP1_SESN3 HMGB2 CDH2_STAT3_TP63 FRAP1_LC3_CASP3_CDH2_HMG131_4.31E-08 ATG12_ATG3_CDH1_ID2_AGER_ 9.80E-12 AKT1_ATG7_FAS_ 3.33E-08STAT3 HMGB2 CDH2_RPS19BP1_TP63 FRAP1_LC3_CDH2_RPS19BP1_ 4.41E-08ATG12_LC3_CDH1_ID2_AGER_ 1.00E-11 ATG12_ID2_CDH2_ 3.48E-08 SESN1_STAT3HMGB2 HMGB1_MMP2_SESN3 FRAP1_LC3_CASP3_CDH2_RPS19BP1_ 4.45E-08ATG12_BNIP3_CDH1_ID2_AGER_ 1.10E-11 FRAP1_LC3_BECN1_ 3.58E-08 STAT3HMGB2 CASP3_CDH2_STAT3 FRAP1_LC3_CDH2_HMGI31_STAT3_ 4.53E-08ATG12_CDH1_ID2_AGER_ 1.30E-11 FRAP1_LC3_TKT_ 3.93E-08 TWIST1 HMGB2_31RT1CASP3_CDH2_STAT3 ID2_HMGB2_MMP2_NAMPT_ 4.81E-08 ATG12_CDH1_ID2_AGER_1.40E-11 FRAP1_LC3_NNMT_ 4.23E-08 RPS1913P1_SESN3 HMGB2_MMP2BECN1_CDH2_STAT3 AIFM1_FRAP1_LC3_BECN1_CDH2_ 4.86E-08ATG12_CASP8_CDH1_ID2_AGER_ 1.60E-11 ID2_CDH2_HMGB2_ 4.26E-08 STAT3 HMGB2MMP2_RPS1913P1_SESN3 ID2_MMP2_NAMPT_RPS1913P1_ 4.92E-08ATG12_CDH1_ID2_AGER_CIAP2_ 1.60E-11 ATG12_ID2_CDH2_ 4.44E-08 SESN3_STAT3HMGB2 CIAP2_MMP2_SESN3 ID2_FASLG_HMGB2_NAMPT_ 4.93E-08ATG12_ATG5_CDH1_ID2_AGER_ 1.90E-11 FAS_FRAP1_LC3_ 4.57E-08RPS1913P1_SESN3 HMGB2 CDH2_SESN1_STAT3 AKT1_FAS_BECN1_CDH2_STAT3_5.40E-08 ATG12_CDH1_ID2_TCF3_AGER_ 1.90E-11 FRAP1_TKT_BECN1_ 4.71E-08TP63 HMGB2 CASP3_CDH2_STAT3 FRAP1_LC3_CCNG2_CDH2_ 5.43E-08ATG12_DRAM_CDH1_ID2_ 1.90E-11 ATG12_FRAP1_ID2_ 4.88E-08 RPS1913P1_STAT3BECN1_HMGB2 CDH2_MMP2_SESN3 AKT1_ATG12_BECN1_CDH2_ 5.69E-08ATG12_FAS_CDH1_ID2_AGER_ 1.90E-11 FAS_LC3_CDH2_ 5.21E-08 STAT3_TP63HMGB2 HMGB1_STAT3_TWIST1 FRAP1_LC3_NNMT_CDH2_RPS1913P1_ 5.80E-08ATG12_CDH1_ID2_AGER_ 2.00E-11 ATG12_TKT_ID2_ 5.23E-08 STAT3 HMGB1_HMGB2CDH2_MMP2_SESN3 CSE1L_FRAP1_LC3_CASP3_CDH2_ 5.93E-08ATG12_DRAM_LAMP1_CDH1_ 2.00E-11 ID2_CDH2_CIAP2_ 5.31E-08 STAT3 ID2_HMGB2MMP2_RPS1913P1_SESN3 FRAP1_LC3_BECN1_CDH2_RAGE_ 5.94E-08ATG12_ATG3_DRAM_CDH1_ 2.10E-11 AKT1_CASP8_FAS_ 5.49E-08 STAT3 ID2_HMGB2CDH2_STAT3_TP63 FAS_FRAP1_LC3_NNMT_CDH2_STAT3 5.97E-08ATG12_ATG5_DRAM_CDH1_ 2.20E-11 AKT1_FAS_CASP3_ 5.76E-08 ID2_HMGB2CDH2_STAT3_TP63 ID2_HMGB1_MMP2_NAMPT_ 5.98E-08 ATG12_DIABLO_CDH1_ID2_2.30E-11 FAS_FRAP1_LC3_ 5.85E-08 RPS1913P1_SESN3 AGER_HMGB2NNMT_CDH2_STAT3 FRAP1_LC3_TKT_CDH2_SESNLSTAT3 6.02E-08ATG12_DIABLO_CDH1_TCF3_ 2.50E-11 FAS_FRAP1_TKT_ 5.91E-08 BHLHE41_HMGB2CDH2_SESN1_STAT3 FRAP1_LC3_NNMT_CDH2_MMP2_ 6.07E-08ATG12_CASP8_DRAM_CDH1_ 2.70E-11 ATG12_ID2_CDH2_ 6.09E-08 STAT3 ID2_HMGB2MMP2_SESN3_STAT3 FRAP1_LC3_NNMT_TKT_CDH2_ 6.10E-08 ATG12_DRAM_CDH1_ID2_2.70E-11 FRAPLNNMT_TKT_ 6.10E-08 STAT3 HMGB2_MMP2 BECN1_CDH2_STAT3BAX_FRAP1_LC3_BECNLCDH2_ 6.30E-08 ATG12_LAMP1_CDH1_ID2_ 2.70E-11ATG12_FAS_FRAP1_ 6.16E-08 STAT3 BECN1_HMGB2 CDH2_STAT3_TP63FRAP1_LC3_CASP3_CDH2_ 6.41E-08 ATG12_CBS_CDH1_ID2_AGER_ 2.90E-11ATG12_ATG3_ID2_ 6.17E-08 31RT1_STAT3 HMGB2 CDH2_MMP2_SESN3FAS_FRAP1_LC3_CDH2_RAPTOR_ 6.48E-08 ATG12_DRAM_CDH1_ID2_ 2.90E-11DRAM_ID2_CDH2_ 6.22E-08 RPS1913P1 MMP9_HMGB2 MMP2_RPS1913P1_SESN3CBS_FRAP1_LC3_CASP3_CDH2_ 6.53E-08 ATG12_CDH1_ID2_AGER_ 3.00E-11ATG12_CBS_ID2_ 6.22E-08 STAT3 HMGB2_UVRAG CDH2_MMP2_SESN3FAS_FRAP1_LC3_CASP3_CDH2_ 6.53E-08 ATG12_E2F1_CDH1_ID2_ 3.00E-11ID2_CDH2_MMP2_ 6.31E-08 STAT3 AGER_HMGB2 RPS1913P1_SESN3_STAT3AKT1_ATG12_FAS_CDH2_STAT3_ 6.67E-08 ATG12_ATG5_CDH1_ID2_ 3.20E-11FRAP1_ID2_CDH2_ 6.33E-08 TP63 BECN1_HMGB2 MMP2_RPS1913P1_SESN3LC3_CDH2_HMGB1_RPS1913P1_ 6.69E-08 ATG12_DIABLO_CDH1_ 3.20E-11AKT1_02_CDH2_ 6.36E-08 STAT3_TWIST1 CIAP2_HMGB2_SESN3MMP2_RPS1913P1_SESN3 FRAP1_LC3_BECN1_CDH2_STAT3_ 6.71E-08ATG12_CSE1L_DRAM_CDH1_ 3.30E-11 FAS_FRAP1_LC3_ 6.57E-08 TWIST1 ID2_HMGB2CASP3_CDH2_STAT3 FRAP1_LC3_CASP3_CDH2_MMP2_ 6.77E-08ATG12_DRAM_E2F1_CDH1_ 3.30E-11 ATG5_ID2_CDH2_ 6.57E-08 STAT3 ID2_HMGB2MMP2_RPS1913P1_SESN3 ID2_MMP9_MMP2_NAMPT_ 6.97E-08 ATG12_DIABLO_CDH1_3.50E-11 AKT1_FAS_CDH2_ 6.60E-08 RPS1913P1_SESN3 TCF3_HMGB2_SESN3HMGB1_STAT3_TP63 CSE1L_ID2_CDH2_MMP2_RPS1913P1_ 6.97E-08AIFM1_ATG3_ATG5_CASP8_ 3.60E-11 CSE1L_ID2_CDH2_ 6.70E-08 SESN3 LC3_CDH1MMP2_RPS1913P1_SESN3 FRAP1_LC3_BECN1_CDH2_STAT3_ 7.00E-08ATG12_BNIP3_DRAM_CDH1_ 3.60E-11 ATG3_ID2_CDH2_ 6.76E-08 VEGF ID2_HMGB2MMP2_RPS1913P1_SESN3 BAX_FRAP1_LC3_TKT_BECN1_CDH2 7.10E-08ATG12_DIABLO_CDH1_ID2_ 3.60E-11 FRAP1_LC3_NNMT_ 6.90E-08 HMGB2_SESN3TKT_CDH2_STAT3 FRAP1_LC3_NNMT_CASP3_CDH2_ 7.38E-08 AIFMLATG3_CASP8_LC3_3.70E-11 CBS_ID2_CDH2_ 7.00E-08 STAT3 CDH1_MMP9 MMP2_RPS1913P1_SESN3FRAP1_TKT_BECN1_CASP3_CDH2_ 7.40E-08 ATG12_ATG3_CDH1_ID2_ 3.70E-11AKT1_ATG12_CDH2_ 7.01E-08 STAT3 BECN1_HMGB2 HMGB1_STAT3_TP63ID2_FASLG_NAMPT_RPS1913P1_ 7.57E-08 ATG12_CDH1_ID2_AGER_ 3.70E-11FAS_FRAP1_LC3_CDH2_ 7.17E-08 SESN3_STAT3 HMGB2_STAT3 RAPTOR_RPS1913P1FAS_FRAP1_LC3_CDH2_KIAA1967_ 7.62E-08 ATG12_DIABLO_DRAM_ 3.80E-11AKT1_ATG12_02_CDH2_ 7.23E-08 RPS1913P1 CDH1_ID2_HMGB2 MMP2_SESN3FRAP1_LC3_BECN1_CDH2_SESN1_ 7.73E-08 ATG12_DRAM_CDH1_ID2_ 3.80E-11ATG12_ATG5_ID2_CDH2_ 7.25E-08 STAT3 CIAP2_HMGB2 MMP2_SESN3ID2_CDH2_FASLG_NAMPT_SESN3_ 7.81E-08 DRAM_LAMPLCDHLID2_ 3.95E-11AKT1_ATG12_FAS_BECN1_ 7.25E-08 STAT3 AGER_HMGB2 STAT3_TP63FRAP1_LC3_TKT_CDH2_STAT3_ 7.91E-08 DRAM_CDHLID2_AGER_ 3.97E-11AKT1_FAS_BECN1_ 7.27E-08 TWIST1 BECN1_HMGB2 RPS1913P1_STAT3_TP63ATG5_FRAP1_LC3_CASP3_CDH2_ 7.93E-08 ATG12_BNIP3_CDH1_ID2_ 4.00E-11FAS_FRAP1_LC3_CDH2_ 7.34E-08 STAT3 HMGB2_MMP2 FASLG_RAPTORID2_CDH2_MMP2_RPS1913P1_SESN3_ 7.96E-08 ATG12_BNIP3_CDH1_ID2_ 4.60E-11FAS_ID2_CDH2_MMP2_ 7.34E-08 STAT3 BECN1_HMGB2 RPS1913P1_SESN3FAS_LC3_CDH2_HMGB1_STAT3_ 8.02E-08 ATG12_CSE1L_CDH1_ID2_ 4.60E-11ATG12_CDH1_ID2_CDH2_ 7.49E-08 TWIST1 BECN1_HMGB2 MMP2_SESN3AIFM1_FRAP1_LC3_TKT_CDH2_ 8.09E-08 LAMP1_LC3_CDH1_ID2_ 4.75E-11FRAP1_LC3_TKT_CDH2_ 7.55E-08 STAT3 AGER_HMGB2 STAT3_TWIST1FRAP1_LC3_TKT_CASP3_CDH2_ 8.17E-08 ATG12_CDH1_ID2_BECN1_ 4.80E-11CDH1_ID2_CDH2_MMP2_ 7.66E-08 FASLG HMGB2_MMP2 RPS19BP1_SESN3DRAM_ID2_MMP2_NAMPT_ 8.35E-08 DRAM_LC3_CDH1_ID2_ 4.83E-11FAS_FRAP1_LC3_CDH2_ 7.69E-08 RPS19BP1_SESN3 AGER_HMGB2 KIAA1967_RPS19BP1FRAP1_LC3_CASP3_CDH2_NAMPT_ 8.40E-08 ATG12_DIABLO_CDH1_ 4.90E-11FRAP1_LC3_CDH2_HMGB1_ 7.87E-08 STAT3 BHLHE41_HMGB2_SIRT1 STAT3_TWIST1FAS_FRAP1_LC3_CCNG2_CDH2_ 8.40E-08 ATG12_TKT_CDH1_ID2_ 4.90E-11ATG12_ID2_CDH2_HMGB2_ 7.98E-08 STAT3 AGER_HMGB2 MMP2_SESN3BAX_FAS_FRAP1_LC3_CDH2_ 8.40E-08 DRAM_CDH1_ID2_MMP9_ 4.94E-11ATG12_FAS_ID2_CDH2_ 7.98E-08 RPS19BP1 AGER_HMGB2 MMP2_SESN3BNIP3_FRAP1_LC3_CASP3_CDH2_ 8.59E-08 ATG12_CDH1_ID2_MMP9_ 5.10E-11TKT_ID2_CDH2_MMP2_ 8.12E-08 STAT3 BECN1_HMGB2 RPS19BP1_SESN3FRAP1_LC3_CDH2_RPS19BP1_STAT3_ 8.60E-08 CSE1L_DRAM_CDH1_ID2_ 5.13E-11BAX_FAS_FRAP1_LC3_ 8.37E-08 TWIST1 AGER_HMGB2 TKT_CDH2FRAP1_LC3_MMP9_CASP3_CDH2_ 8.66E-08 ATG12_DRAM_FAS_ 5.30E-11ATG12_ID2_CDH2_MMP2_ 8.37E-08 STAT3 CDH1_ID2_HMGB2 RPS19BP1_SESN3CDH1_ID2_MMP9_TCF3_RPS19BP1_ 4.58E-06 ATG12_CDH1_ID2_ 1.80E-10CDH1_ID2_MMP9_TCF3_ 8.42E-06 SESN3 MMP9_TCF3_HMGB2 CDH2_SESN3

TABLE 28 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value AKT1_ATG12_FAS_BECN1_CDH- 5.95E-09ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 2.60E-12AKT1_ATG12_FAS_CDH2_RPS19BP1_STAT3_TP63 1.25E-09 2_STAT3_TP63FRAP1_LC3_TKT_BECN1_CASP- 9.04E-09 ATG12_CSE1L_DRAM_CDH1_ID2_AGER_HMGB23.62E-12 AKT1_ATG12_FAS_BECN1_CDH2_STAT3_TP63 1.62E-09 3_CDH2_STAT3FAS_FRAP1_LC3_CASP3_CDH- 9.51E-09ATG12_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 3.70E-12AKT1_ATG12_FAS_LC3_CDH2_STAT3_TP63 1.77E-09 2_RPS19BP1_STAT3FAS_FRAP1_LC3_CDH2_RPS- 9.55E-09 ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB23.76E-12 AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 1.89E-09 19BP1_SESN1_STAT3AKT1_FAS_BECN1_CDH2_RPS- 9.89E-09 ATG12_DRAM_LAMP1_CDH1_ID2_AGER_HMGB23.77E-12 AKT1_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 2.32E-0919BP1_STAT3_TP63 ID2_CDH2_FASLG_NAMPT_RPS- 1.11E-08ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 3.85E-12AKT1_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 2.46E-09 19BP1_SESN3_STAT3FRAP1_LC3_NNMT_TKT_BECN- 1.15E-08ATG12_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 3.92E-12AKT1_ATG12_FAS_CASP3_CDH2_STAT3_TP63 3.14E-09 1_CDH2_STAT3AKT1_ATG12_FAS_CDH2_RPS- 1.15E-08ATG12_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 3.92E-12AKT1_ATG12_FAS_CASP3_CDH2_STAT3_TP63 3.14E-09 19BP1_STAT3_TP63AKT1_ATG12_FAS_CDH2_RPS- 1.17E-08 ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB24.10E-12 AKT1_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 3.17E-0919BP1_STAT3_TP63 FAS_FRAP1_LC3_NNMT_CDH- 1.23E-08ATG12_LC3_CDH1_ID2_AGER_BECN1_HMGB2 4.34E-12AKT1_LATG12_FAS_LAMP1_CDH2_STAT3_TP63 3.43E-09 2_RPS19BP1_STAT3FAS_FRAP1_LC3_CCNG2_CDH- 1.39E-08 ATG12_DRAM_LC3_CDH1_ID2_AGER_HMGB24.68E-12 AKT1_ATG12_FAS_CDH2_HMGB2_STAT3_TP63 3.66E-09 2_RPS19BP1_STAT3FRAP1_LC3_BECN1_CASP3_CDH- 1.44E-08ATG12_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 4.72E-12AIFM1_AKT1_ATG12_FAS_CDH2_STAT3_TP63 4.18E-09 2_HMGB1_STAT3ID2_FASLG_HMGB2_NAMPT_RPS- 1.50E-08 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_SIRT14.96E-12 AKT1_ATG12_FAS_CDH2_CIAP2_STAT3_TP63 4.33E-09 19BP1_SESN3_STAT3FRAP1_LC3_NNMT_BECN1_CASP- 1.52E-08 ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB25.00E-12 AKT1_ATG12_FAS_CDH2_SESN2_STAT3_TP63 4.34E-09 3_CDH2_STAT3CBS_FRAP1_LC3_BECN1_CASP- 1.52E-08ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 5.29E-12AKT1_ATG12_FAS_NNMT_CDH2_STAT3_TP63 4.41E-09 3_CDH2_STAT3FRAP1_LC3_BECN1_CASP3_CDH- 1.62E-08 ATG12_DIABLO_CDH1_TCF3_BHLHE41_SIRT15.86E-12 AKT1_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 4.69E-09 2_SIRT1_STAT3CSE1L_FRAP1_LC3_CASP3_CDH- 1.63E-08 ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB25.70E-12 AKT1_ATG12_FAS_CDH2_NAMPT_STAT3_TP63 5.00E-09 2_RPS19BP1_STAT3FRAP1_LC3_TKT_CASP3_HMGB- 1.70E-08 ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB25.90E-12 AKT1_ATG12_FAS_CDH2_SIRT1_STAT3_TP63 5.09E-09 1_TAT3FRAP1_LC3_TKT_CDH2_HMGB- 1.71E-08 ATG12_DRAM_CDH1_ID2_AGER_CIAP2_HMGB26.12E-12 AKT1_FAS_LC3_BECN1_CDH2_STAT3_TP63 5.11E-09 1_STAT3_TWIST1ATG5_FRAP1_LC3_BECN1_CASP- 1.76E-08 ATG12_LAMP1_LC3_CDH1_ID2_AGER_HMGB26.14E-12 AKT1_CASP8_FAS_BECN1_CDH2_STAT3_TP63 5.38E-09 3_CDH2_STAT3CSE1L_FRAP1_LC3_BECN1_CASP- 1.77E-08 ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP26.19E-12 AKT1_ATG12_DRAM_FAS_CDH2_STAT3_TP63 5.54E-09 3_CDH2_STAT3FRAP1_LC3_BECN1_CASP3_CDH- 1.81E-08 ATG12_CASP8_DRAM_CDH1_ID2_AGER_HMGB26.50E-12 AKT1_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63 6.04E-09 2_HMGB2_STAT3AKT1_LC3_CDH2_HMGB1_RPS- 1.81E-08ATG12_CSE1L_CDH1_ID2_AGER_HMGB2_RPS19BP1 6.69E-12AKT1_ATG12_FAS_BECN1_RPS19BP1_STAT3_TP63 6.22E-09 19BP1_STAT3_TP63FAS_FRAP1_LC3_CDH2_MMP- 1.81E-08 ATG12_BNIP3_CDH1_ID2_AGER_HMGB2_MMP26.80E-12 AKT1_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 6.23E-092_RAPTOR_RPS19BP1 AKT1_FAS_CDH2_RPS19BP- 1.86E-08ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 6.90E-12AKT1_ATG12_FAS_CDH2_HMGB1_STAT3_TP63 6.53E-09 1_SESN2_STAT3_TP63FRAP1_LC3_BECN1_CASP- 1.87E-08 ATG12_CDH1_ID2_AGER_BECN1_HMGB2_MMP27.10E-12 ATG12_FAS_FRAP1_LC3_CDH2_STAT3_TP63 6.78E-09 3_CDH2_FASLG_STAT3ID2_CDH2_HMGB1_HMGB- 1.88E-08 ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB27.20E-12 AKT1_ATG12_FAS_XIAP_CDH2_STAT3_TP63 6.99E-092_MMP2_RPS19BP1_SESN3 AKT1_CASP8_FAS_BECN- 1.90E-08ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2 7.28E-12AKT1_ATG12_FAS_CDH2_LAMP2_STAT3_TP63 7.29E-09 1_CDH2_STAT3_TP63FAS_FRAP1_LC3_TKT_CDH- 1.91E-08 ATG12_ATG3_CSE1L_CDH1_ID2_AGER_HMGB28.00E-12 AKT1_ATG12_ATG3_FAS_CDH2_STAT3_TP63 7.32E-09 2_SESN1_STAT3CBS_FRAP1_LC3_NNMT_BECN- 1.91E-08ATG12_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3 8.02E-12AKT1_ATG12_FAS_PTEN_CDH2_STAT3_TP63 7.70E-09 1_CDH2_STAT3AKT1_FAS_LC3_CDH2_RPS- 1.91E-08 ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB28.06E-12 AKT1_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 7.80E-0919BP1_STAT3_TP63 FRAP1_LC3_BECN1_CDH- 1.91E-08ATG12_ATG3_DIABLO_CDH1_TCF3_HMGB2_SESN3 8.10E-12AKT1_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 7.81E-09 2_HMGB1_STAT3_TWIST1CSE1L_FRAP1_LC3_TKT_CASP- 1.91E-08 ATG12_CSE1L_LC3_CDH1_ID2_AGER_HMGB28.13E-12 AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_TP63 7.97E-09 3_CDH2_STAT3FRAP1_LC3_NNMT_BECN- 1.95E-08 ATG12_CSE1L_CDH1_ID2_MMP9_AGER_HMGB28.26E-12 AKT1_FAS_LC3_CDH2_HMGB1_STAT3_TP63 8.01E-09 1_CDH2_SIRT1_STAT3AKT1_ATG12_CDH2_HMGB- 1.96E-08 ATG12_ATG5_DRAM_CDH1_ID2_AGER_HMGB28.40E-12 AKT1_ATG12_FAS_TKT_CDH2_STAT3_TP63 8.05E-091_RPS19BP1_STAT3_TP63 ID2_CDH2_FASLG_HMGB- 1.96E-08ATG12_DRAM_CDH1_ID2_AGER_HMGB1_HMGB2 8.48E-12FAS_FRAP1_LC3_CASP3_CDH2_RPS19BP1_STAT3 8.20E-09 1_NAMPT_RPS19BP1_SESN3ID2_CDH2_HMGB1_MMP- 1.99E-08 ATG12_DRAM_LAMP1_CDH1_ID2_BECN1_HMGB28.67E-12 AKT1_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63 8.20E-092_RPS19BP1_SESN3_STAT3 FRAP1_LC3_CDH2_HMGB- 2.00E-08ATG12_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1 8.80E-12AKT1_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 8.24E-09 1_RPS19BP1_STAT3_TWIST1FAS_FRAP1_LC3_CDH2_KIAA- 2.01E-08 ATG12_DRAM_FAS_CDH1_ID2_AGER_HMGB28.86E-12 FAS_FRAP1_LC3_TKT_CDH2_FASLG_RAPTOR 8.41E-09 1967_MMP2_RPS19BP1FRAP1_LC3_BECN1_CASP- 2.02E-08 ATG12_DIABLO_DRAM_CDH1_ID2_AGER_HMGB28.99E-12 AKT1_ATG12_E2F1_FAS_CDH2_STAT3_TP63 8.55E-093_CDH2_RPS19BP1_STAT3 FRAP1_LC3_TKT_CASP- 2.04E-08ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_HMGB2 8.99E-12AKT1_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 8.57E-09 3_CDH2_FASLG_STAT3BNIP3_FRAP1_LC3_BECN- 2.05E-08 ATG12_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB29.11E-12 AKT1_FAS_NNMT_BECN1_CDH2_STAT3_TP63 9.44E-09 1_CASP3_CDH2_STAT3FRAP1_LC3_CASP3_CDH- 2.05E-08 ATG12_LAMP1_CDH1_ID2_MMP9_AGER_HMGB29.14E-12 AKT1_ATG12_CDH2_HMGB1_RPS19BP1_STAT3_TP63 9.58E-092_HMGB1_MMP_STAT3 FAS_LC3_CDH2_HMGB1_RPS- 2.05E-08ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2 9.20E-12AKT1_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 9.77E-09 19BP1_STAT3_TWIST1ID2_HMGB1_HMGB2_MMP- 2.06E-08 ATG12_ATG3_CDH1_ID2_AGER_HMGB2_RPS19BP19.40E-12 FAS_FRAP1_LC3_CDH2_RPS19BP1_SESN1_STAT3 9.79E-092_NAMPT_RPS19BP1_SESN3 FRAP1_LC3_TKT_BECN- 2.07E-08ATG12_CDH1_ID2_AGER_BECN1_HMGB2_SIRT1 9.40E-12FAS_FRAP1_LC3_NNMT_CDH2_RPS19BP1_STAT3 9.88E-09 1_CDH2_FASLG_RAPTORFRAP1_LC3_NNMT_BECN- 2.12E-08 ATG12_CDH1_ID2_AGER_HMGB2_MMP2_SIRT19.60E-12 ID2_CDH2_HMGB1_HMGB2_MMP2_RPS19BP1_SESN3 9.90E-091_CDH2_FASLG_STAT3 FAS_FRAP1_LC3_CDH- 2.13E-08AIFM1_ATG3_CASP8_CSE1L_LC3_CDH1_MMP9 9.70E-12AKT1_ATG12_FAS_CDH2_RAPTOR_STAT3_TP63 1.03E-08 2_FASLG_RAPTOR_RPS19BP1FRAP1_LC3_MMP9_BECN- 2.15E-08 ATG12_ATG3_CDH1_ID2_MMP9_AGER_HMGB29.70E-12 FRAP1_LC3_TKT_BECN1_CASP3_CDH2_STAT3 1.06E-081_CASP3_CDH2_STAT3 FAS_FRAP1_LC3_NNMT_BECN- 2.17E-08ATG12_LC3_CDH1_ID2_MMP9_AGER_HMGB2 9.86E-12FAS_FRAP1_LC3_CDH2_FASLG_RAPTOR_RPS19BP1 1.07E-08 1_CDH2_STAT3AIFM1_FAS_FRAP1_LC- 2.18E-08 AIFM1_CASP8_LC3_CDH1_AGER_HMGB2_RPS19BP11.00E-11 FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TWIST1 1.07E-083_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_LC- 2.18E-08ATG12_ATG5_CDH1_ID2_AGER_BECN1_HMGB2 1.00E-11AKT1_FAS_TKT_BECN1_CDH2_STAT3_TP63 1.10E-08 3_CDH2_STAT3_TP63AKT1_FAS_CDH2_HMGB- 2.18E-08 ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_MMP21.06E-11 AKT1_CASP8_FAS_LC3_CDH2_STAT3_TP63 1.10E-081_RPS19BP1_STAT3_TP63 ID2_CDH2_HMGB1_MMP- 2.22E-08ATG12_LAMP1_CDH1_ID2_AGER_HMGB2_RPS19BP1 1.07E-11AKT1_FAS_LC3_CASP3_CDH2_STAT3_TP63 1.10E-08 2_NAMPT_RPS19BP1_SESN3AKT1_BECN1_CDH2_HMGB- 2.23E-08 AIFM1_ATG3_ATG5_CASP8_LC3_CDH1_MMP91.10E-11 AKT1_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 1.13E-081_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP- 2.24E-08ATG12_ATG5_DRAM_CDH21_ID2_BECN1_HMGB2 1.10E-11AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_TP63 1.15E-08 8_FAS_CDH2_STAT3_TP63ATG5_FRAP1_LC- 2.25E-08 ATG12_BNIP3_CDH1_ID2_MMP9_AGER_HMGB2 1.10E-11AKT1_ATG12_FAS_TCF3_CDH2_STAT3_TP63 1.16E-08 3_NNMT_BECN1_CDH2_STAT3FRAP1_LC3_CASP3_CDH- 2.27E-08 ATG12_BNIP3_CSE1L_CDH1_ID2_AGER_HMGB21.10E-11 AKT1_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 1.17E-082_HMGB1_RPS19BP1_STAT3 CDH1_ID2_MMP9_TCF- 6.86E-07ATG12_CDH1_ID2_MMP9_TCF3_AGER_HMGB2 1.90E-11CDH1_ID2_MMP9_TCF23_CDH2_RPS19BP1_SESN3 7.02E-07 3_CDH2_RPS19BP1_SESN3AKT1_ATG12_FAS_CDH- 2.03E-09ATG12_ATG3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 1.60E-12AKT1_ATG12_FAS_CDH2_RPS19BP1_SESN2_STAT3_TP63 1.76E-102_RPS19BP1_SESN2_STAT3_TP63 AKT1_FAS_LC3_CDH- 2.06E-09ATG12_DIABLO_DRAM_CDH1_TCF3_CIAP2_HMGB2_SESN3 1.68E-12AKT1_ATG12_FAS_BECN1_CDH2_RAPTOR_STAT3_TP63 1.84E-102_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_BECN- 2.35E-09ATG12_BNIP3_DIABLO_CDH1_TCF3_CIAP2_HMGB2_SESN3 1.71E-12AKT1_ATG12_FAS_BECN1_CDH2_LAMP2_STAT3_TP63 2.81E-101_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_CASP8_FAS_BECN- 2.49E-09ATG12_DRAM_CDH1_AGER_BECN1_HMGB2_RPS19BP1 1.76E-12AKT1_ATG12_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 2.84E-10 1_CDH2_STAT3_TP63AKT1_ATG12_FAS_LC3_CDH- 3.36E-09ATG12_CSE1L_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 2.00E-12AKT1_FAS_LC3_CDH2_HMGB1_RPS19BP1_STAT3_TP63 4.35E-102_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_NNMT_BECN- 3.42E-09ATG12_DIABLO_DRAM_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 2.01E-12AKT1_FAS_LC3_CDH2_RPS19BP1_SESN2_STAT3_TP63 4.86E-10 1_CDH2_STAT3_TP63AKT1_ATG12_FAS_BECN- 3.50E-09ATG12_DIABLO_CDH1_TCF3_BECN1_CIAP2_HMGB2_SESN3 2.17E-12AKT1_ATG12_ATG7_FAS_CDH2_RPS19BP1_STAT3_TP63 5.42E-101_CDH2_RAPTOR_STAT3_TP63 AKT1_FAS_LC3_BECN1_CDH- 3.74E-09ATG12_LAMP1_LC3_CDH1_ID2_AGER_BECN1_HMGB2 2.31E-12AKT1_ATG7_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 5.54E-102_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_BECN1_CASP- 3.80E-09ATG12_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 2.31E-12AKT1_ATG12_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 5.65E-103_CDH2_RPS19BP1_STAT3 AKT1_ATG12_FAS_CDH2_HMGB- 3.80E-09ATG12_DRAM_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 2.37E-12AKT1_ATG12_FAS_CDH2_HMGB1_RPS19BP1_STAT3_TP63 5.69E-101_RPS19BP1_STAT3_TP63 FRAP1_LC3_—BECN1_CASP- 3.83E-09ATG12_DRAM_LC3_CDH1_ID2_AGER_BECN1_HMGB2 2.40E-12AKT1_ATG12_FAS_TCF3_CDH2_RPS19BP1_STAT3_TP63 6.64E-10 3_CDH2_FASLG_STAT3CSE1L_FAS_FRAP1_LC3_CASP- 3.94E-09ATG12_ATG3_DIABLO_CDH1_BECN1_CIAP2_HMGB2_SESN3 2.50E-12AKT1_ATG12_FAS_BECN1_CDH2_KIAA1967_STAT3_TP63 6.89E-103_CDH2_RPS19BP1_STAT3 AKT1_ATG12_LC3_CDH2_HMGB- 4.06E-09ATG12_DRAM_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 2.54E-12AKT1_FAS_BECN1_CDH2_RAPTOR_RPS19BP1_STAT3_TP63 7.14E-101_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_NNMT_BECN- 4.36E-09ATG12_CASP8_DIABLO_CDH1_TCF3_HMGB2_SESN3 2.59E-12AKT1_ATG12_FAS_CDH2_HMGB2_RPS19BP1_STAT3_TP63 7.18E-101_CDH2_RPS19BP1_STAT3 AKT1_CASP8_FAS_BECN1_CDH- 4.39E-09ATG12_ATG3_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 2.70E-12AKT1_ATG12_BCL2L1_FAS_BECN1_CDH2_STAT3_TP63 7.38E-102_RPS19BP1_STAT3_TP63 FRAP1_LC3_NNMT_TKT_BECN- 4.42E-09ATG12_DRAM_LAMP1_LC3_CDH21_ID2_AGER_HMGB2 2.71E-12AKT1_CASP8_FAS_CDH2_RPS19BP1_STAT3_TP63 7.42E-10 1_CDH2_FASLG_STAT3AKT1_ATG12_FAS_BECN1_CDH- 4.50E-09ATG12_DIABLO_CDH1_TCF3_BECN1_BHLHE41_HMGB2_SIRT1 2.73E-12AKT1_ATG12_FAS_LAMP1_LC3_CDH2_STAT3_TP63 7.69E-10 2_LAMP2_STAT3_TP63AKT1_FAS_LC3_CDH2_RPS- 4.53E-09ATG12_CSE1L_LC3_CDH1_ID2_AGER_BECN1_HMGB2 2.88E-12AKT1_ATG12_CASP8_FAS_LC3_CDH2_STAT3_TP63 7.83E-10 19BP1_SESN2_STAT3_TP63AKT1_ATG12_FAS_LAMP- 4.56E-09 ATG12_ATG3_DRAM_CDH1_ID2_AGER_BECN1_HMGB22.90E-12 AKT1_ATG12_FAS_CDH2_RAPTOR_RPS19BP1_STAT3_TP63 7.90E-101_BECN1_CDH2_STAT3_TP63 ID2_CDH2_FASLG_HMGB- 4.69E-09ATG12_CSE1L_CRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 3.04E-12AKT1_FAS_LC3_BECN1_CDH2_RPS19BP1_STAT3_TP63 8.27E-101_HMGB2_NAMPT_RPS19BP1_SESN3 AKT1_ATG12_FAS_BECN- 4.77E-09ATG12_DRAM_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 3.11E-12AKT1_ATG12_FAS_NNMT_CDH2_RPS19BP1_STAT3_TP63 8.45E-101_CDH2_CIAP2_STAT3_TP63 AKT1_ATG12_CASP8_FAS_CDH- 4.88E-09ATG12_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SESN2_SIRT1 3.17E-12AKT1_ATG12_CASP8_FAS_BECN1_CDH2_STAT3_TP63 8.83E-102_RPS19BP1_STAT3_TP63 ID2_CDH2_FASLG_HMGB- 5.10E-09ATG12_ATG5_DIABLO_CDH1_TCF3_BHLHE41_HMGB2_SIRT1 3.20E-12AKT1_ATG7_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 8.96E-102_NAMPT_RPS19BP1_SESN3_STAT3 AKT1_ATG12_FAS_TCF3_CDH- 5.17E-09ATG12_ATG3_CSE1L_DRAM_CDH1_ID2_AGER_HMGB2 3.40E-12AKT1_ATG12_FAS_CDH2_NAMPT_RPS19BP1_STAT3_TP63 9.10E-102_RPS19BP1_STAT3_TP63 AKT1_ATG12_E2F1_FAS_BECN- 5.17E-09ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_BHLHE41_HMGB2 3.40E-12AKT1_ATG12_CASP8_FAS_LAMP1_CDH2_STAT3_TP63 9.24E-10 1_CDH2_STAT3_TP63AKT1_ATG7_FAS_BECN1_CDH- 5.22E-09ATG12_BNIP3_DRAM_CDH1_ID2_AGER_HMGB2_MMP2 3.51E-12AKT1_ATG12_FAS_NNMT_BECN1_CDH2_STAT3_TP63 9.33E-10 2_RPS19BP1_STAT3_TP63AKT1_FAS_BECN1_CDH2_RPS- 5.26E-09ATG12_CSE1L_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 3.55E-12AKT1_ATG12_FAS_LC3_BECN1_CDH2_STAT3_TP63 9.38E-10 19BP1_SESN2_STAT3_TP63AKT1_ATG12_FAS_LC3_BECN- 5.29E-09ATG12_CDH1_ID2_MMP9_AGER_BECN1_HMGB2_RPS19BP1 3.61E-12AKT1_ATG12_FAS_LC3_CDH2_HMGB1_STAT3_TP63 9.72E-10 1_CDH2_STAT3_TP63AKT1_LC3_BECN1_CDH2_HMGB- 5.33E-09ATG12_DRAM_CDH1_ID2_MMP9_AGER_HMGB2_RPS19BP1 3.64E-12AKT1_ATG12_FAS_BECN1_CDH2_RPS19BP1_STAT3_TP63 9.81E-101_RPS19BP1_STAT3_TP63 AKT1_ATG12_ATG7_BECN- 5.39E-09ATG12_CSE1L_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 3.75E-12AKT1_ATG12_E2F1_FAS_BECN1_CDH2_STAT3_TP63 9.82E-101_CDH2_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_CASP3_CDH- 5.55E-09ATG12_DRAM_CDH1_ID2_AGER_HMGB2_MMP2_SIRT1 3.79E-12AKT1_ATG12_GAS_CDH1_BECN1_CDH2_STAT3_TP63 9.88E-102_FASLG_RPS19BP1_STAT3 AKT1_ATG12_FAS_BECN- 5.62E-09ATG12_DIABLO_FAS_CDH1_TF3_BECN1_BHLHE41_HMGB2 3.80E-12AKT1_CASP8_FAS_LC3_CDH2_RPS19BP1_STAT3_TP63 9.98E-101_CASP3_CDH2_STAT3_TP63 AKT1_ATG12_FAS_BECN- 5.68E-09ATG12_CSE1L_DRAM_LC3_CDH1_ID2_AGER_HMGB2 3.81E-12AKT1_ATG12_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 1.08E-091_CDH2_HMGB2_STAT3_TP63 AKT1_ATG12_FAS_LC3_CDH- 5.75E-09ATG12_DRAM_LAMP1_CDH1_ID2_MMP9_AGER_HMGB2 3.87E-12AKT1_ATG12_FAS_CDH2_CIAP2_RPS19BP1_STAT3_TP63 1.12E-092_HMGB1_STAT3_TP63 FRAP1_LC_TKT_CASP3_CDH- 5.85E-09ATG12_DRAM_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 3.90E-12AKT1_FAS_CDH2_HMGB1_HMGB2_RPS19BP1_STAT3_TP63 1.12E-092_FASLG_HMGB1_STAT3 FAS_FRAP1_LC3_NNMT_CDH- 5.93E-09ATG12_ATG3_CSE1L_CDH1_ID2_AGER_BECN1_HMGB2 3.90E-12AKT1_ATG12_FAS_LC3_CASP3_CDH2_STAT3_TP63 1.12E-09 2_MMP2_RPS19BP1_STAT3FAS_FRAP1_LC3_BECN1_CDH- 5.93E-09ATG12_CSE1L_DRAM_LAMP1_CDH1_ID2_AGER_HMGB2 3.93E-12AKT1_ATG12_ATG7_BECN1_CDH2_RPS19BP1_STAT3_TP63 1.15E-092_RPS19BP1_SESN1_STAT3 FAS_FRAP1_LC3_TKT_CDH- 5.97E-09ATG12_ATG3_DRAM_CDH1_ID2_AGER_HMGB2_RPS19BP1 4.00E-12AKT1_ATG12_E2F1_FAS_CDH2_RPS19BP1_STAT3_TP63 1.18E-092_RPS19BP1_SESN1_STAT3 AKT1_ATG12_BECN1_CDH- 5.98E-09ATG12_ATG3_DRAM_CDH1_ID2_MMP9_AGER_HMGB2 4.00E-12AKT1_ATG12_DRAM_FAS_CDH2_RPS19BP1_STAT3_TP63 1.19E-092_HMGB1_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CASP- 6.02E-09ATG12_CSE1L_LAMP1_CDH1_ID2_AGER_BECN1_HMGB2 4.03E-12AKT1_FAS_CASP3_CDH2_RPS19BP1_SESN2_STAT3_TP63 1.19E-093_CDH2_RPS19BP1_STAT3_TP63 AKT1_ATG12_FAS_CDH- 6.04E-09ATG12_DRAM_FAS_CDH1_ID2_AGER_BECN1_HMGB2 4.06E-12AKT1_FAS_CDH2_HMGB2_RPS19BP1_SESN2_STAT3_TP63 1.23E-092_NAMPT_RPS19BP1_STAT3_TP63 FAS_FRAP1_LC3_CASP- 6.06E-09ATG12_DIABLO_CDH1_TCF3_BECN1_HMGB2_SESN3_SIRT1 4.09E-12AKT1_FAS_LC3_CASP3_CDH2_RPS19BP1_STAT3_TP63 1.24E-093_CDH2_RPS19BP1_SIRT1_STAT3 FAS_FRAP1_LC3_CDH- 6.10E-09ATG12_BNIP3_CDH1_ID2_AGER_BECN1_HMGB2_MMP2 4.09E-12AKT1_ATG12_FAS_LAMP1_BECN1_CDH2_STAT3_TP63 1.29E-092_FASLG_RPS19BP1_SESN1_STAT3 AKT1_FAS_NNMT_BECN- 6.17E-09ATG12_LC3_CDH1_ID2_MMP9_AGER_BECN1_HMGB2 4.09E-12AKT1_FAS_TKT_CDH2_RPS19BP1_SESN2_STAT3_TP63 1.31E-091_CDH2_RPS19BP1_STAT3_TP63 CSE1L_FAS_FRAP1_LC- 6.17E-09AIFM1_CASP8_LAMP1_CDH1_AGER_CIAP2_HMGB2_RPS19BP1 4.10E-12AKT1_ATG12_ATG3_FAS_CDH2_RPS19BP1_STAT3_TP63 1.34E-093_NNMT_CDH2_RPS19BL1_STAT3 FAS_FRAP1_LC3_TKT_CDH- 6.23E-09ATG12_ATG3_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 4.10E-12AKT1_ATG12_FAS_XIAP_CDH2_RPS19BP1_STAT3_TP63 1.36E-092_FASLG_RAPTOR_RPS19BL1 AKT1_FAS_BECN1_CDH- 6.28E-09ATG12_ATG3_DIABLO_CDH1_BECN1_HMGB2_SESN3_SIRT1 4.10E-12AKT1_ATG12_CASP8_FAS_NNMT_CDH2_STAT3_TP63 1.36E-092_HMGB1_RPS19BP1_STAT3_TP63 FAS_LC3_CDH2_HMGB1_RPS- 6.29E-09ATG12_ATG3_DIABLO_FAS_CDH1_TCF3_HMGB2_SESN3 4.20E-12AKT1_ATG12_CASP8_FAS_CASP3_CDH2_STAT3_TP63 1.38E-0919BP1_STAT3_TP62_TWIST1 FAS_FRAP1_LC3_TKT_CASP- 6.35E-09ATG12_DIABLO_FAS_CDH1_TCF3_CIAP2_HMGB2_SESN3 4.22E-12AKT1_ATG12_FAS_CDH2_RPS19BP1_SIRT1_STAT3_TP63 1.39E-093_CDH2_RPS19BP1_STAT3 ID2_CDH2_FASLG_HMGB- 6.36E-09ATG12_CDH1_ID2_TCF3_AGER_BECN1_HMGB2_RPS19BP1 4.23E-12AKT1_ATG12_BCL2L1_FAS_CDH2_RPS19BP1_STAT3_TP63 1.40E-091_NAMPT_RPS19BP1_SESN3_STAT3 FAS_FRAP1_LC3_BECN- 6.40E-09ATG12_CSE1L_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 4.25E-12AKT1_ATG12_CASP8_FAS_CDH2_HMGB2_STAT3_TP63 1.41E-091_CDH2_FASLG_RAPTOR_RPS19BP1 VSE1L_FRAP1_LC3_TKT_BECN- 6.45E-09ATG12_BNIP3_DRAM_CDH1_ID2_AGER_BECN1_HMGB2 4.37E-12AKT1_ATG12_FAS_LC3_NNMT_CDH2_STAT3_TP63 1.41E-09 1_CASP3_CDH2_STAT3FRAP1_LC3_TKT_BECN1_CASP- 6.46E-09ATG12_FAS_CDH1_ID2_AGER_BECN1_HMGB2_RPS19BP1 4.39E-12AIFM1_AKT1_ATG12_CASP8_FAS_CDH2_STAT3_TP63 1.43E-09 3_CDH2_HMGB1_STAT3FAS_FRAP1_LC3_BECN1_CCNG- 6.47E-09ATG12_DRAM_LC3_CDH1_ID2_MMP9_AGER_HMGB2 4.47E-12AKT1_ATG7_FAS_CASP3_CDH2_RPS19BP1_STAT3_TP63 1.44E-092_CDH2_RPS19BP1_STAT3 FAS_FRAP1_LC3_TKT_BECN- 6.49E-09ATG12_DIABLO_CDH1_TCF3_CIAP2_HMGB2_RPS19BP1_SESN3 4.56E-12AKT1_ATG12_FAS_PTEN_CDH2_RPS19BP1_STAT3_TP63 1.45E-091_CDH2_FASLG_RAPTOR AKT1_ATG12_FAS_TKT_BECN- 6.56E-09ATG12_DRAM_CDH1_ID2_TCF3_AGER_HMGB2_RPS19BP1 4.59E-12AKT1_ATG12_FAS_LAMP1_CDH2_RPS19BP1_STAT3_TP63 1.45E-09 1_CDH2_STAT3_TP63FRAP1_LC3_BECN1_CASP3_CDH- 6.58E-09ATG12_LAMP1_CDH1_ID2_TCF3_AGER_BECN1_HMGB2 4.63E-12AKT1_ATG12_CASP8_FAS_CDH2_CIAP2_STAT3_TP63 1.46E-09 2_FASLG_HMGB1_STAT3CDH1_ID2_MMP9_TCF3_CDH- 2.57E-07ATG12_CDH1_ID2_MMP9_TCF3_AGER_BECN1_HMGB2 7.12E-12AKT1_CDH1_MMP9_TCF3_CDH2_RPS19BP1_SESN3 2.37E-07 2_MMP2_RPS19BP1_SESN3

As can be confirmed from the above tables, each of the markers or theircombination shows p-values low enough to be considered significant interms of all of recurrence, survival, and disease-free survival. Inparticular, in the case of the combination of the two or more markers,all the p-values for recurrence, survival, and disease-free survivalwere low. In particular, it was found that there were cases where thep-value for a single marker was relatively high but the p-valuedecreased when the marker was used in combination with other marker. Asa p-value becomes lower, the statistical significance becomes higher.Thus, the low p-values suggest that the estimation for prognosis ofliver cancer by each of the markers or their combination is highlyaccurate.

This means that the more markers of the present disclosure are combined,the lower p-values, which means higher significance, are shown, whichmeans that the more improved accuracy would be achieved in theestimation for prognosis based on the combinations of the markers.

Thus, it was found that the markers and/or the combinations of markersof Tables 22˜29 are effective in predicting prognosis of liver cancer ofthe A1 group (recurrence, survival, disease-free survival), and that theprognosis of liver cancer of the A1 group can be predicted effectivelyby nucleic acids and antibodies targeted at the markers.

Also, it can be found that the prognosis of liver cancer of the A1 groupcan be predicted effectively by the method for predicting prognosis ofliver cancer of the present disclosure, which is targeted at themarkers.

Further, cross-validation was performed for combinations of markerswhich were considered statistically significant. Patients of eachpatient group were randomly divided into two groups (positive group: 139patients; test group: 138 patients). With the reference value which wasconsidered statistically significant in the results of the positivegroup obtained in the same manner as Example 1 fixed, for the testgroup, the accuracy of estimation was calculated to be the level ofp<0.05 or p<0.001 with respect to recurrence, survival and disease-freesurvival.

Among the results of cross-validation of the prediction of therecurrence, survival and disease-free survival of the A1 group,representative examples showing the excellent accuracy of prognosis ineach aspect are as follows:

Recurrence: ATG7_FRAP1_LC3_NNMT_STAT3 (95% at the level of p<0.05)

Survival: AKT1_CDH1_ID2 (98.7% at the level of p<0.05)

Disease-free survival: FRAP1_LC3_TKT_HMGB1_STAT3_TWIST1 (84.0% at thelevel of p<0.05)

Example 3 Predicting Prognosis of Liver Cancer in the A2 Group

An experiment was performed in the same manner as in Example 1, exceptfor experimenting on a patient group determined as the A2 group {a groupof portal vein invasion-negative patients, having a tumor which is morethan 5 cm in size} (123 patients), an experiment was performed in thesame manner as in Example 1. Kaplan-Meier curves were prepared withrespect to the prediction of recurrence, survival, and disease-freesurvival and the results are shown in FIGS. 44˜46. Kaplan-Meier curvesfor recurrence are shown in FIGS. 44˜50, Kaplan-Meier curves forsurvival are shown in FIGS. 51˜57, and Kaplan-Meier curves fordisease-free survival are shown in FIGS. 58˜64.

As can be seen from the drawings, in Kaplan-Meier curves completed withrespect to recurrence, survival, and disease-free survival, the abovemarkers form curves where cases of high expression and low expressionare distinctively distinguished from each other. This means that thereare remarkable differences in interval recurrence rate or intervalsurvival rate and cumulative recurrence rate or cumulative survival ratebased thereon between the cases where the marker is in high expressionand low expression, and that consequently, the expression pattern of themarker can be an index showing recurrence possibility or survivalpossibility of patients.

Also, significance tests were performed by log-rank test with respect toeach of the markers and their combination by calculating observationvalues and expected values at every point of recurrence or death toobtain p-values. The results are shown in the following Tables 30˜37.The results of using a marker alone are shown in Table 30, the resultsof a combination of two markers are shown in Table 31, the results of acombination of three markers are shown in Table 32, the results of acombination of four markers are shown in Table 33, the results of acombination of five markers are shown in Table 34, the results of acombination of six markers are shown in Table 35, the results of acombination of seven markers are shown in Table 36, and the results of acombination of eight markers are shown in Table 37.

TABLE 30 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value TKT 2.09E-02 BCL2L1 1.18E-03 SESN2 1.18E-02 SESN2.63E-02 FAS 3.84E-03 TKT 1.51E-02 LAMP2 3.49E-02 LAMP1 9.31E-03 LAMP23.89E-02 BHLHE41 5.45E-02 BHLHE41 1.08E-02 BHLHE41 4.38E-02 CSE1L8.20E-02 TKT 1.62E-02 CSE21L 4.51E-02 LC3 1.14E-01 LC3 2.80E-02 FAS6.76E-02 VEGF 1.68E-01 SESN2 4.22E-02 BECN1 6.85E-02 PRKAA1 1.70E-01NAMPT 5.17E-02 TCF3 1.13E-01 BECN1 1.86E-01 BNIP3 6.09E-02 PRKAA11.28E-01 LAMP1 2.14E-01 CSE1L 6.82E-02 VEGF 1.37E-01 FAS 2.80E-01 TCF37.17E-02 ULK1 1.42E-01 ATG5 3.07E-01 STS3 9.89E-02 LAMP1 1.44E-01 ATG33.66E-01 NNMT 1.03E-01 FASLG 2.09E-01 ULK1 3.48E-01 TP63 1.12E-01 ATG52.30E-01 FASLG 3.88E-01 RAGE 1.21E-01 NAMPT 2.58E-01 RAGE 4.04E-01 XIAP1.38E-01 BCL2L1 2.84E-01 NAMPT 4.46E-01 BCL2 1.38E-01 LC3 3.08E-01 SESN34.48E-01 RAPTOR 1.65E-01 BCL2 3.81E-01 ATG7 4.57E-01 LAMP2 2.06E-01STAB1 4.47E-01 CBS 4.80E-01 E2F1 2.16E-01 STAT3 4.59E-01 AKT1 4.81E-01FRAP1 2.30E-01 FRAP1 4.70E-01 BCL2L1 4.82E-01 CDH1 2.34E-01 ATG124.72E-01 BCL2 4.84E-01 CASP3 2.54E-01 HMGB2 4.95E-01 CIAP2 4.85E-01STAB1 2.66E-01 ATG3 5.13E-01 TP63 4.93E-01 BECN1 3.08E-01 MMP9 5.25E-01TCF3 5.09E-01 PTEN 3.47E-01 MMP2 5.28E-01 CASP8 5.36E-01 PRKAA1 3.70E-01SESN1 5.39E-01 HMGB2 5.51E-01 KIAA1967 4.07E-01 AKT1 5.55E-01 SIRT15.52E-01 HMGB1 4.07E-01 RPS19BP1 5.65E-01 AIFM1 5.72E-01 ATG5 4.12E-01TP63 5.72E-01 PTEN 5.78E-01 HMGB2 4.15E-01 CBS 5.76E-01 DRAM 6.00E-01ULK1 4.50E-01 NNMT 5.82E-01 DIABLO 6.33E-01 AKT1 4.50E-01 UVRAG 5.84E-01BNIP3 6.43E-01 CIAP2 4.66E-01 CDH1 5.89E-01 CDH1 6.55E-01 BAX 4.83E-01ATG7 5.98E-01 FRAP1 6.84E-01 SESN1 5.32E-01 TWIST1 6.16E-01 HMGB16.85E-01 VEGF 5.48E-01 SIRT1 6.25E-01 CDH2 6.89E-01 FASLG 5.79E-01 CASP86.42E-01 CASP3 6.94E-01 RPS19BP1 5.81E-01 SESN3 6.72E-01 SATB1 7.11E-01MMP9 5.92E-01 BAX 6.80E-01 MMP9 7.13E-01 CASP8 5.97E-01 AIFM1 7.29E-01RPS19BP1 7.16E-01 MMP2 6.02E-01 HMGB1 7.40E-01 KIAA1967 7.34E-01 TWIST16.04E-01 DIABLO 7.57E-01 TWIST1 7.38E-01 CDH2 6.51E-01 KIAA1967 7.85E-01ID2 7.63E-01 ATG12 6.91E-01 CASP3 8.03E-01 STAT3 7.79E-01 CCNG2 7.26E-01CDH2 8.09E-01 AGER 7.84E-01 CBS 7.53E-01 BNIP3 8.46E-01 UVRAG 7.97E-01ATG3 7.61E-01 RAGE 8.63E-01 CCNG2 8.32E-01 ATG7 7.63E-01 AGER 8.67E-01MMP2 8.38E-01 UVRAG 8.15E-01 PTEN 8.79E-01 BAX 8.66E-01 SIRT1 8.23E-01RAPTOR 9.04E-01 XIAP 8.89E-01 SESN3 8.58E-01 CCNG2 9.23E-01 RAPTOR9.12E-01 DRAM 8.68E-01 E2F1 9.23E-01 ATG12 9.21E-01 DIABLO 8.80E-01 XIAP9.27E-01 E2F1 9.39E-01 AIFM1 9.34E-01 DRAM 9.27E-01 NNMT 9.67E-01 AGER9.81E-01 CIAP2 9.35E-01 SESN1 9.98E-01 ID2 9.97E-01 ID2 9.90E-01

TABLE 31 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value PRKAA1_LAMP2 5.60E-04 BCL2L1_NNMT 5.30E-05TKT_SESN2 1.60E-04 TKT_SESN2 1.30E-03 BCL2L1_E2F1 7.40E-05 BHLHE41_SESN28.00E-04 ATG7_LAMP2 2.10E-03 BCL2L1_TKT 8.10E-05 LAMP2_SESN2 8.80E-04LAMP2_SESN2 2.30E-03 FAS_LAMP1 9.10E-05 ATG5_SESN2 9.50E-04 AKT1_PRKAA12.90E-03 BCL2L1_PRKAA1 9.50E-05 LAMP1_SESN2 1.30E-03 SESN2_SIRT13.40E-03 FAS_BHLHE41 1.10E-04 SESN2_SIRT1 1.30E-03 TKT_VEGF 3.80E-03FAS_TKT 1.30E-04 E2F1_SESN2 1.70E-03 ATG7_TKT 4.10E-03 BCL2L1_CASP31.60E-04 ATG12_SESN2 1.80E-03 TKT_LAMP2 4.20E-03 ATG3_BCL2L1 1.70E-04TKT_VEGF 2.10E-03 BHLHE41_SESN2 4.30E-03 ATG7_BCL2L1 2.30E-04CSE1L_BECN1 2.20E-03 TKT_BHLHE41 4.30E-03 FAS_CASP3 2.50E-04 CSE1L_SESN22.20E-03 ATG5_SESN2 4.50E-03 TKT_BHLHE41 3.70E-04 ATG7_TKT 2.40E-03LAMP1_SESN2 5.00E-03 BCL2L1_KIAA1967 3.90E-04 FASLG_SESN2 2.40E-03CSE1L_LAMP2 5.30E-03 FAS_PRKIAA1 4.40E-04 PRKAA1_LAMP2 2.50E-03ATG12_SESN2 5.50E-03 FAS_KIAA1967 5.00E-04 PRKAA1_SESN2 2.50E-03AKT1_TKT 5.60E-03 FAS_SESN2 5.50E-04 TKT_BHLHE41 2.50E-03 E2F1_SESN25.60E-03 BCL2L1_HMGB2 6.30E-04 CSE1L_BHLHE41 2.90E-03 ATG3_LAMP26.30E-03 BCL2L1_VEGF 6.40E-04 ATG7_SESN2 3.00E-03 BNIP3_SESN2 6.30E-03BNIP3_FAS 6.70E-04 CSE1L_LAMP2 3.00E-03 LC3_SESN2 6.70E-03 FAS_TWIST16.70E-04 FAS_SESN2 3.10E-03 TWIST1_VEGF 6.80E-03 BNIP3_TKT 7.30E-04HMGB2_SESN2 3.10E-03 ATG7_LC3 7.10E-03 BCL2L1_CSE1L 7.50E-04 CSE1L_LAMP13.40E-03 CSE1L_SESN2 7.40E-03 TKT_SESN2 7.90E-04 BECN1_SESN2 3.50E-03ATG5_LC3 7.60E-03 BCL2L1_FRAP1 8.00E-04 NNMT_SESN2 3.50E-03 ATG7_SESN27.70E-03 LAMP1_SESN2 8.10E-04 AIFM1_SESN2 3.70E-03 LC3_ULK1 8.00E-03LC3_BHLHE41 9.40E-04 BAX_SESN2 3.70E-03 ATG3_TKT 8.10E-03 BCL2L1_BNIP39.70E-04 DRAM_SESN2 3.90E-03 DRAM_SESN2 8.10E-03 BCL2L1_LC3 1.00E-03CSE1L_ULK1 4.00E-03 PRKAA1_TKT 8.30E-03 ATG5_BCL2L1 1.10E-03KIAA1967_SESN2 4.00E-03 BHLHE41_LAMP2 8.60E-03 BCL2L1_CBS 1.10E-03SESN2_VEGF 4.00E-03 LAMP2_VEGF 9.10E-03 CSE1L_LAMP1 1.10E-03 BNIP3_SESN24.10E-03 AKT1_VEGF 9.20E-03 E2F1_FAS 1.10E-03 SESN2_UVRAG 4.30E-03TKT_CIAP2 9.20E-03 AIFM1_BCL2L1 1.20E-03 TWIST1_VEGF 4.40E-03CSE1L_NHLHE41 9.30E-03 BHLHE41_SESN2 1.20E-03 PRKAA1_FASLG 4.50E-03LC3_BHLHE41 9.30E-03 BASP8_FAS 1.30E-03 TKT_RPS19BP1 4.80E-03 LC3_SIRT19.30E-03 FAS_NAMPT 1.30E-03 PRKAA1_TKT 4.90E-03 CSE1L_LAMP1 1.00E-02FAS_TP63 1.30E-03 ATG7_LAMP2 5.10E-03 TKT_RPS19BP1 1.00E-02LAMP1_BHLHE41 1.30E-03 AGER_SESN2 5.20E-03 CBS_TKT 1.10E-02 ATG12_FAS1.40E-03 CDH2_SESN2 5.30E-03 CSE1L_BECN1 1.10E-02 BCL2L1_MMP2 1.40E-03AKT1_PRKAA1 5.40E-03 TKT_CDH1 1.10E-02 BHLHE41_CASP3 1.40E-03 ULK1_SESN25.40E-03 TKT_HMGB1 1.10E-02 FAS_HMGB1 1.40E-03 MMP2_SESN2 5.80E-03TKT_RAGE 1.10E-02 FAS_VEGF 1.40E-03 ATG5_CSE1L 6.20E-03 AIFM1_SESN21.20E-02 LAMP1_TCF3 1.40E-03 HMGB1_SESN2 6.20E-03 ATG7_TWIST1 1.20E-02BCL2L1_ULK1 1.50E-03 AKT1_TKT 6.30E-03 BHLHE41_NAMPT 1.20E-02 FAS_LC31.50E-03 CBS_SESN2 6.30E-03 BNIP3_LC3 1.20E-02 NNMT_BHLHE41 1.50E-03FRAP1_SESN2 6.30E-03 PRKAA1_SESN2 1.20E-02 BCL2L1_FAS 1.60E-03CIAP2_SESN2 6.40E-03 ATG7_NAMPT 1.30E-02 TKT_TP63 1.60E-03 BCL2_SESN26.50E-03 BECN1_SESN2 1.30E-02 AKT1_BCL2L1 1.70E-03 CCNG2_SESN2 6.50E-03TKT_HMGB2 1.30E-02 ATG12_BCL2L1 1.70E-03 BCL2L1_SESN2 6.60E-03 TKT_SIRT11.30E-02 FAS_HMGB2 1.70E-03 CSE1L_UVRAG 6.60E-03 ATG5_CSE1L 1.40E-02BCL2L1_ID2 1.80E-03 RAPTOR_SESN2 6.60E-03 SESN2_UVRAG 1.40E-02BCL2L1_RPS19BP1 1.80E-03 XIAP_SESN2 6.70E-03 TKT_CASP3 1.40E-02TKT_SATB1 1.80E-03 CASP3_SESN2 6.80E-03 TKT_CDH2 1.40E-02 FAS_XIAP1.90E-03 CASP8_SESN2 6.80E-03 TKT_MMP2 1.40E-02 BCL2_NCL2L1 2.00E-03LC3_SESN2 6.80E-03

TABLE 32 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value LC3_SESN2_SIRT1 3.80E-05 BCL2L1_NNMT_PRKAA11.30E-06 ATG7_TKT_SESN2 1.90E-05 BNIP3_PRKAA1_LAMP2 6.30E-05BCL2L1_E2F1_PRKAA1 7.50E-06 FRAP1_SESN2_SIRT1 4.60E-05 ATG5_LC3_SESN26.60E-05 ATG3_BCL2L1_PRKAA1 8.10E-06 ATG5_LC3_SESN2 5.60E-05BNIP3_LC3_SESN2 9.40E-05 ATG3_BCL2L1_NNMT 8.70E-06 ATG5_FRAP1_SESN25.80E-05 ATG7_LC3_SESN2 1.00E-04 ATG3_BCL2L1_E2F1 9.40E-06TKT_LAMP2_SESN2 7.20E-05 AKT1_PRKAA1_LAMP2 1.70E-04 FAS_BHLHE41_SESN21.20E-05 AIFM1_TKT_SESN2 7.40E-05 ATG7_TKT_SESN2 1.80E-04BCL2L1_PRKAA1_HMGB2 1.30E-05 ATG5_CSE1L_SESN2 7.90E-05 DRAM_LC3_SESN21.90E-04 BCL2L1_CASP3_SESN2 1.40E-05 LC3_SESN2_SIRT1 8.00E-05PRKAA1_AGER_LAMP2 1.90E-04 BCL2L1_PRKAA1_TKT 1.40E-05 ATG12_TKT_SESN28.20E-05 PRKAA1_TKT_LAMP2 1.90E-04 FAS_CASP3_SESN2 1.40E-05CSE1L_LAMP1_SESN2 8.20E-05 ATG7_TKT_LAMP2 2.00E-04 BCL2L1_TKT_CASP31.60E-05 TKT_HNGB2_SESN2 8.40E-05 TKT_LAMP2_SESN2 2.80E-04 FAS_TKT_CASP31.60E-05 ATG5_TKT_SESN2 8.90E-05 TKT_LAMP2_VEGF 3.00E-04 BCL2L1_E2F1_TKT1.80E-05 TKT_CDH1_SESN2 9.10E-05 ATG12_LC3_SESN2 3.10E-04 BCL21_NNMT_TKT1.80E-05 TKT_SESN2_SESN3 9.20E-05 ATG7_LAMP2_SESN2 3.20E-04FAS_TKT_BHLHE41 1.80E-05 TKT_SESN2_VEGF 9.40E-05 TKT_SESN2_SIRT13.20E-04 FAS_TKT_SESN2 1.80E-05 CSE1L_NHLHE41_SESN2 9.50E-05E2F1_LC3_SESN2 3.30E-04 FAS_LAMP1_BHLHE41 1.90E-05 PRKAA1_TKT_SESN29.60E-05 LC3_SESN2_UVRAG 3.30E-04 FAS_LAMP1_SESN2 2.00E-05ATG3_TKT_SESN2 9.90E-05 PRKAA1_CCNG2_LAMP2 3.30E-04 ATG3_BCL2L1_TKT2.20E-05 TKT_RPS19BP1_SESN2 9.90E-05 AKT1_ATG7_TKT 3.40E-04ATG7_BCL2L1_PRKAA1 2.20E-05 CBS_TKT_SESN2 1.00E-04 ATG5_PRKAA1_LAMP23.70E-04 DIABLO_FAS_BHLHE41 2.20E-05 CSE1L_LAMP2_SESN2 1.00E-04ATG3_LAMP2_SESN2 3.80E-04 TKT_SESN2_TP63 2.20E-05 TKT_SESN2_SIRT11.00E-04 BNIP3_TKT_SESN2 3.80E-04 FAS_PRKAA1_TKT 2.30E-05 AKT1_TKT_SESN21.10E-04 LAMP2_SESN2_SIRT1 3.80E-04 ATG7_BCL21_NNMT 2.40E-05CSE1L_SESN2_SIRT1 1.10E-04 ATG7_PRKAA1_LAMP2 3.90E-04 BCL2L1_BNIP3_TKT2.70E-05 TKT_CDH2_SESN2 1.10E-04 LAMP1_LC3_SESN2 3.90E-04 BNIP3_FAS_TKT2.80E-05 BNIP3_TKT_SESN2 1.20E-04 ATG12_PRKAA1_LAMP2 4.00E-04BCL2L1_NNMT_CASP3 2.90E-05 NNMT_TKT_SESN2 1.20E-04 CASP8_PRKAA1_LAMP24.00E-04 TKT_BHLHE41_CASP3 3.00E-05 TKT_AGER_SESN2 1.20E-04AIFM1_TKT_SESN2 4.10E-04 ATG3_BCL2L1_CASP3 3.30E-05 TKT_BHLHE41_SESN21.20E-04 FRAP1_SESN2_SIRT1 4.10E-04 BCL2L1_PRKAA1_CASP3 3.30E-05TKT_HMGB1_SESN2 1.20E-04 PRKAA1_HMGB1_LAMP2 4.30E-04 BCL2L1_PRKAA1_MMP23.30E-05 TKT_MMP2_SESN2 1.20E-04 LC3_BHLHE41_SESN2 4.50E-04FAS_BHLHE41_CASP3 3.30E-05 E2F1_TKT_SESN2 1.30E-04 ATG12_TKT_SESN24.70E-04 FAS_TKT_KIAA1967 3.30E-05 NAMPT_SESN2_SIRT1 1.30E-04CSE1L_LAMP2_SESN2 4.80E-04 FAS_TKT_TWIST1 3.40E-05 TKT_KIAA1967_SESN21.30E-04 PRKAA1_CASP3_LAMP2 4.90E-04 BCL2L1_E2F1_NNMT 3.60E-05DRAM_TKT_SESN2 1.40E-04 PRKAA1_LAMP2_RAGE 4.90E-04 BCL2L1_FRAP1_NNMT3.60E-05 TKT_CIAP2_SESN2 1.40E-04 PRKAA1_LAMP2_SESN2 4.90E-04BCL2L1_TKT_BHLHE41 3.60E-05 TKT_MMP9_SESN2 1.40E-04 TKT_CIAP2_SESN24.90E-04 BCL2L1_TKT_SESN2 3.60E-05 ATG5_NAMPT_SESN2 1.50E-04BCL2L1_PRKAA1_LAMP2 5.00E-04 FAS_KIAA1967_SESN2 3.60E-05ATG7_FRAP1_SESN2 1.50E-04 DIABLO_PRKAA1_LAMP2 5.00E-04 DIABLO_FAS_LAMP13.80E-05 CSE1L_E2F1_SESN2 1.50E-04 PRKAA1_CDH1_LAMP2 5.00E-04ATG3_BCL2L1_KIAA1967 3.90E-05 LAMP1_TKT_SESN2 1.50E-04 CBS_PRKAA1_LAMP25.10E-04 ATG7_BCL2L1_E2F1 3.90E-05 LC3_TKT_SESN2 1.50E-04CSE1L_SESN2_SIRT1 5.10E-04 FAS_BHLHE41_SATB1 3.90E-05 TKT_CASP3_SESN21.50E-04 ATG3_PRKAA1_LAMP2 5.20E-04 ATG3_ATG7_BCL2L1 4.00E-05TKT_CCNG2_SESN2 1.50E-04 PRKAA1_FASLG_LAMP2 5.20E-04 ATG7_BCL2L1_TKT4.00E-05 TKT_IS2_SESN2 1.50E-04 PRKAA1_ID2_LAMP2 5.20E-04BCL2L1_BNIP3_NNMT 4.10E-05 TKT_RAPTOR_SESN2 1.50E-04 PRKAA1_LAMP2_SATB15.40E-04 BCL2L1_PRKAA1_VEGF 4.10E-05 TKT_XIAP_SESN2 1.50E-04PRKAA1_LAMP2_SESN1 5.40E-04 BCL2L1_BHLHE41_CASP3 4.30E-05 BAX_TKT_SESN21.60E-04 AKT1_ATG7_PTEN 5.70E-04 FAS_SESN2_TP63 4.30E-05 BCL2_TKT_SESN21.60E-04 ATG7_TKT_BHLHE41 5.70E-04 TKT_BHLHE41_TP63 4.50E-05ATG12_CSE1L_SESN2 1.70E-04 PRKAA1_LAMP2_MMP2 5.70E-04 AIFM1_BCL2L1_NNMT4.70E-05 BCL2L1_TKT_SESN2 1.70E-04 CSE1L_LAMP1_SESN2 5.80E-04BCL2L1_CSE1L_NNMT 4.90E-05 CASP8_TKT_SESN2 1.70E-04 PRKAA1_LAMP2_SESN35.90E-04 BCL2L1_E2F1_FRAP1 5.00E-05 DIABLO_TKT_SESN2 1.70E-04ATG3_TKT_SESN2 6.00E-04 BNIP3_FAS_CASP3 5.00E-05 FAS_BHLHE41_SESN21.70E-04 ATG5_CSE1L_SESN2 6.00E-04 FAS_TKT_SATB1 5.00E-05FRAP1_TKT_SESN2 1.70E-04 ATG5_CSE1L_LC3 6.10E-04 BCL2L1_CSE1L_PRKAA15.10E-05 PTEN_TKT_SESN2 1.70E-04 FRAP1_PRKAA1_LAMP2 6.10E-04BCL2L1_NNMT_VEGF 5.10E-05 TKT_RAGE_SESN2 1.70E-04

TABLE 33 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ATG5_LC3_SESN2_SIRT1 6.90E-06 ATG3_BCL2L-1.80E-07 ATG5_CSE1L_FRAP- 3.00E-06 1_NNMT_PRKAA1 1_SESN2ATG3_LC3_SESN2_SIRT1 7.60E-06 BCL2L1_TKT_CASP- 4.10E-07CSE1L_FRAP1_SESN- 3.10E-06 3_SESN2 2_SIRT1 CSE1L_LC3_SESN2_SIRT18.80E-06 BCL2L1_ID2_CASP3_SESN2 4.20E-07 ATG7_TKT_LAMP2_SESN2 5.10E-06ATG5_CSE1L_LC3_SESN2 1.30E-05 ATG3_BCL2L1_E2F- 5.80E-07 ATG5_FRAP1_SESN-5.40E-06 1_PRKAA1 2_SIRT1 BNIP3_LC3_SESN2_SIRT1 1.30E-05BCL2L1_NNMT_PRKAA- 6.40E-07 AKT1_ATG7_TKT_SESN2 5.70E-06 1_HMGB1FRAP1_LC3_SESN2_SIRT1 1.30E-05 BCL2L1_NNMT_PRKAA- 7.40E-07ATG5_CSE1L_LC3_SESN2 6.30E-06 1_MMP2 AKT1_ATG3_PRKAA- 1.40E-05BCL2L1_NNMT_PRKAA- 8.20E-07 FRAP1_LC3_SESN2_SIRT1 7.30E-06 1_LAMP21_CDH1 ATG3_ATG5_LC3_SESN2 1.50E-05 FAS_TKT_CASP3_SESN2 9.00E-07CSE1L_FRAP1_LAMP- 7.40E-06 1_SESN2 ATG7_LC3_SESN2_SIRT1 1.50E-05BCL2L1_NNMT_PRKAA- 9.30E-07 ATG7_TKT_SESN2_SESN3 8.20E-06 1_VEGFBNIP3_CSE1L_LC3_SESN2 1.50E-05 ATG7_BCL2L- 1.00E-06 ATG5_FRAP1_LC3_SESN28.40E-06 1_NNMT_PRKAA1 TKT_LAMP2_SESN2_SIRT1 1.50E-05 BCL2L1_FRAP-1.00E-06 ATG7_CSE1L_FRAP- 8.40E-06 1_NNMT_PRKAA1 1_SESN2CIAP2_LAMP2_SESN2_SIRT1 1.80E-05 BCL2L1_NNMT_PRKAA- 1.00E-06CSE1L_LC3_SESN2_SIRT1 8.60E-06 1_ID2 ATG12_TKT_LAMP2_SESN2 1.90E-05AIFM1_BCL2L- 1.10E-06 ATG5_LC3_SESN2_SIRT1 8.80E-06 1_NNMT_PRKAA1ATG7_TKT_LAMP2_SESN2 1.90E-05 BCL2L1_TKT_BHLHE- 1.10E-06ATG7_TKT_FASLG_SESN2 9.70E-06 41_CASP3 AKT1_ATG7_PRKAA- 2.00E-05BCL2L1_NNMT_PRKAA- 1.20E-06 ATG7_TKT_AGER_SESN2 1.30E-05 1_LAMP2 1_CDH2ATG5_BNIP3_LC3_SESN2 2.00E-05 BCL2L1_CSE- 1.30E-06 ATG7_TKT_HMGB-1.30E-05 1L_NNMT_PRKAA1 1_SESN2 ATG3_BNIP3_LC3_SESN2 2.30E-05BCL2L1_NNMT_PRKAA- 1.30E-06 ATG7_TKT_MMP2_SESN2 1.30E-05 1_HMGB2AKT1_PRKAA1_LAMP- 2.50E-05 BCL2L- 1.40E-06 BNIP3_CSE1L_FRAP- 1.30E-052_UVRAG 1_CBS_NNMT_PRKAA1 1_SESN2 DRAM_LC3_SESN2_SIRT1 2.60E-05FAS_TKT_SESN2_TP63 1.40E-06 ATG5_ATG7_TKT_SESN2 1.40E-06ATG7_CSE1L_LC3_SESN2 2.70E-05 BCL2L- 1.70E-06 ATG7_BCL2_TKT_SESN21.40E-05 1_DRAM_NNMT_PRKAA1 ATG7_FRAP1_LC3_SESN2 2.70E-05BCL2L1_NNMT_PRKAA- 1.70E-06 ATG7_BNIP3_TKT_SESN2 1.40E-05 1_ULK1BNIP3_PRKAA1_LAMP- 2.70E-05 BNIP3_TKT_CASP3_SESN2 1.90E-06FAS_FRAP1_SESN2_SIRT1 1.40E-05 2_SESN2 ATG5_ATG7_LC3_SESN2 3.10E-05ATG5_BCL2L- 2.00E-06 AIFM1_ATG7_TKT_SESN2 1.50E-05 1_NNMT_PRKAA1PRKAA1_TKT_LAMP- 3.20E-05 BCL2L- 2.00E-06 ATG12_TKT_LAMP- 1.50E-052_SESN2 1_DIABLO_NNMT_PRKAA1 2_SESN2 ATG3_ATG7_LC3_SESN2 3.30E-05BCL2L1_NNMT_CASP- 2.10E-06 ATG7_TKT_BHLHE- 1.50E-05 3_SESN2 41_SESN2BNIP3_PRKAA- 3.40E-05 FAS_TKT_BHLHE- 2.10E-06 ATG7_TKT_ID2_SESN21.50E-05 1_AGER_LAMP2 41_CASP3 E2F1_LC3_SESN2_SIRT1 3.40E-05BCL2L1_NNMT_PRKAA- 2.20E-06 CSE1L_DRAM_FRAP- 1.50E-05 1_TKT 1_SESN2LC3_ID2_SESN2_SIRT1 3.50E-05 BNIP3_FAS_TKT_CASP3 2.20E-06CSE1L_FRAP1_SESN- 1.50E-05 2_UVRAG LC3_NAMPT_SESN2_SIRT1 3.50E-05ATG3_ATG7_BCL2L- 2.30E-06 ATG7_LAMP1_TKT_SESN2 1.60E-05 1_PRKAA1ATG5_FRAP1_LC3_SESN2 3.60E-05 FAS_ID2_CASP3_SESN2 2.30E-06 ATG7_BCL2L-1.70E-05 1_TKT_SESN2 ATG7_BNIP3_LC3_SESN2 3.60E-05 BCL2L1_NNMT_PRKAA-2.60E-06 ATG7_TKT_CCNG- 1.70E-05 1_CASP3 2_SESN2 LC3_RPS19BP1_SESN-3.60E-05 ATG3_BCL2L1_PRKAA- 2.70E-06 CSE1L_E2F1_FRAP- 1.70E-05 2_SIRT11_HMGB2 1_SESN2 AKT1_ATG7_TKT_SESN2 3.70E-05 FAS_LC3_BHLHE41_SESN22.80E-06 CSE1L_LAMP1_LC- 1.70E-05 3_SESN2 BCL2L1_BNIP3_PRKAA- 3.70E-05ATG3_BCL2L1_BNIP- 2.90E-06 PRKAA1_TKT_LAMP- 1.70E-05 1_LAMP2 3_NNMT2_SESN2 CSE1L_DRAM_LC3_SESN2 3.70E-05 BCL2L1_CASP- 3.00E-06ATG7_CBS_TKT_SESN2 1.80E-05 8_NNMT_PRKAA1 DIABLO_LC3_SESN2_SIRT13.70E-05 FAS_BHLHE41_CASP- 3.00E-06 ATG7_LC3_TKT_SESN2 1.80E-05 3_SESN2LC3_SESN2_SIRT1_STAT3 3.70E-05 BCL2L1_BNIP3_NNMT_TKT 3.10E-06ATG7_NNMT_TKT_SESN2 1.80E-05 ATG12_ATG5_LC3_SESN2 3.80E-05DIABLO_FAS_BHLHE- 3.10E-06 ATG7_TKT_CIAP2_SESN2 1.80E-05 41_SESN2BNIP3_PRKAA1_TCF- 3.80E-05 ATG3_BCL2L1_PRKAA- 3.20E-06ATG7_TKT_SESN2_STAT3 1.80E-05 3_LAMP2 1_TKT LC3_SESN2_SIRT1_UVRAG3.80E-05 BCL2L1_NNMT_PRKAA- 3.20E-06 ATG7_PTEN_TKT_SESN2 1.90E-05 1_MMP9BNIP3_PRKAA1_MMP- 3.90E-05 BNIP3_FAS_CASP3_SESN2 3.20E-06ATG7_TKT_CASP3_SESN2 1.90E-05 9_LAMP2 AKT1_LC3_SESN2_SIRT1 4.00E-05FAS_LAMP1_BHLHE- 3.30E-06 ATG7_TKT_CDH2_SESN2 1.90E-05 41_SESN2AKT1_PRKAA1_CDH- 4.00E-05 BCL2L1_CASP3_SESN- 3.50E-06 ATG- 1.90E-051_LAMP2 1_SESN2 7_TKT_HMGB2-SESN2 CSE1L_LAMP1_LC3_SESN2 4.00E-05BCL2L1_NNMT_PRKAA- 3.50E-06 ATG- 1.90E-05 1_SIRT1 7_TKT_NAMPT_SESN2ATG7_PRKAA- 4.10E-05 DIABLO_FAS_LAMP- 3.50E-06 ATG- 1.90E-05 1_TKT_LAMP21_BHLHE41 7_TKT_RAPTOR_SESN2 KIAA1967_LAMP2_SESN- 4.10E-05FAS_TKT_CASP3_SIRT1 3.50E-05 ATG7_TKT_SESN2_SIRT1 1.90E-05 2_SIRT1LC3_SESN2_SESN3_SIRT1 4.20E-05 E2F1_FAS_BHLHE41_SESN2 3.60E-06ATG7_FRAP1_LC3_SESN2 2.00E-05 BNIP3_PRKAA1_HMGB- 4.30E-05FAS_TKT_CASP3_FASLG 3.60E-06 ATG7_TKT_BECN1_SESN2 2.00E-06 1_LAMP2CSE1l-LC3_SESN2_UVRAG 4.30E-05 FAS_TKT_HMGB1_SESN2 3.60E-06 ATG-2.10E-05 7_DIABLO_TKT_SESN2 LC3_MMP9_SESN2_SIRT1 4.30E-05FAS_CASP3_HMGB1_SESN2 3.70E-06 ATG7_FRAP1_SESN- 2.10E-05 2_SIRT1ATG3_LAMP2_SESN2_SIRT1 4.40E-05 BAX_BCL2L- 3.80E-06 ATG12_CSE1L_FRAP-2.20E-05 1_NNMT_PRKAA1 1_SESN2 BNIP3_PRKAA1_CCNG- 4.40E-05 BCL2L1_E2F-3.90E-06 ATG7_TKT_XIAP_SESN2 2.20E-05 2_LAMP2 1_NNMT_PRKAA1BNIP3_PRKAA1_LAMP- 4.40E-05 ATG3_BCL2L1_PRKAA- 4.00E-06ATG7_E2F1_TKT_SESN2 2.30E-05 2_SATB1 1_MMP2 BNIP3_PRKAA1_LAMP- 4.40E-05FAS_TKT_KIAA1967_SESN2 4.00E-06 ATG7_TKT_MMP9_SESN2 2.30E-05 2_SESN1ATG5_DRAM_LC3_SESN2 4.50E-05 BNIP3FAS_TKT_TWIST1 4.20E-06ATG7_TKT_RAGE_SESN2 2.30E-05 BNIP3_PRKAA1_CASP- 4.50E-05ATG3_BCL2L1_BNIP3_TKT 4.30E-06 ATG3_ATG7_TKT_SESN2 2.40E-05 3_LAMP2BNIP3_FRAP1_LC3_SESN2 4.60E-05 BCL2L1_NNMT_PRKAA- 4.40E-06ATG7_CSE1L_LC3_SESN2 2.40E-05 1_PTEN

TABLE 34 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value CIAP2_FASLG_LAMP- 2.90E-07BCL2L1_NNMT_ID2_CASP3_SESN2 3.40E-08 ATG5_CSE1L_FRAP1_LC- 5.20E-072_SESN2_SIRT1 3_SESN2 ATG3_ATG5_LC3_SESN- 1.32E-06BCL2L1_PTEN_TKT_CASP3_SESN2 8.42E-08 CSE1-lFRAP1_LC3_SESN2_SIRT15.51E-07 2_SIRT1 ATG3_FRAP1_LC3_SESN- 1.61E-06 ATG3_BCL2L1_NNMT_PRKAA-1.00E-07 ATG5_FRAP1_LC3_SESN2_SIRT1 5.70E-07 2_SIRT1 1_HMGB1ATG7_FRAP1_LC3_SESN- 2.13E-06 BCL2L1_TKT_XIAP_CASP3_SESN2 1.19E-07ATG5_CSE1L_FRAP1_SESN- 1.00E-06 2_SIRT1 2_SIRT1 TKT_CIAP2_LAMP2_SESN-2.30E-06 BCL2L1_TKT_CASP3_HMGB1_SESN2 1.20E-07 ATG7_CSE1L_FRAP1_LC-1.39E-06 2_SIRT1 3_SESN2 ATG5_FRAP1_LC3_SESN- 2.32E-06ATG3_BCL2L1_NNMT_PRKAA1_ID2 1.30E-07 ATG7_FRAP1_LC3_SESN- 1.82E-062_SIRT1 2_SIRT1 ATG5_BNIP3_LC3_SESN- 2.47E-06BCL2L1_BNIP3_TKT_CASP3_SESN2 1.32E-07 ATG5_CSE1L_FRAP1_LAMP- 1.90E-062_SIRT1 1_SESN2 TKT_CDH1_LAMP2_SESN- 2.50E-06 ATG3_BCL2L1_NNMT_PRKAA-1.35E-07 AKT1_ATG7_TKT_LAMP- 2.12E-06 2_SIRT1 1_CDH1 2_SESN2CSE1L_FRAP1_LC3_SESN 2.70E-06 BCL2L1_TKT_CASP3_RAGE_SESN2 1.38E-07ATG5_FRAP1_LAMP1_SESN- 2.30E-06 2_SIRT1 2_SIRT1 ATG3_BNIP3_LC3_SESN-3.03E-06 ATG3_BCL2L1_NNMT_PRKAA- 1.43E-07 CSE1L_FRAP1_LAMP1_SESN-2.38E-06 2_SIRT1 1_ULK1 2_SIRT1 ATG5_CSE1L_LC3_SESN- 3.35E-06FAS_TKT_CASP3_HMGB1_SESN2 1.45E-07 ATG3_FRAP1_LC3_SESN2_SIRT1 2.40E-062_SIRT1 ATG3_LC3_LAMP2_SESN- 3.56E-06 FAS_TKT_CASP3_SESN2_TP63 1.49E-07AKT1_ATG5_CSE1L_FRAP- 2.47E-06 2_SIRT1 1_SESN2 BNIP3_FRAP1_LC3_SESN-3.80E-06 ATG3_BCL2L1_FRAP- 1.53E-07 ATG5_CSE1L_DIABLO_FRAP- 2.50E-062_SIRT1 1_NNMT_PRKAA1 1_SESN2 BNIP3_PRKAA- 3.80E-06FAS_TKT_HMGB1_SESN2_TP63 1.55E-07 ATG5_CSE1L_LC3_SESN2_SIRT1 2.50E-061_TKT_LAMP2_SESN2 ATG12_TKT_LAMP2_SESN- 3.90E-06 AIFM1_ATG3_BCL2L-1.58E-07 CSE1L_FRAP1_SESN2_SIRT- 2.54E-06 2_SIRT1 1_NNMT_PRKAA1 1_UVRAGATG5_ATG7_LC3_SESN- 4.29E-06 BCL2L1_ID2_CASP3_SESN1_SESN2 1.63E-07ATG7_TKT_LAMP2_SESN- 2.56E-06 2_SIRT1 2_SESN3 ATG7_BNIP3_TKT_LAMP-4.50E-06 ATG3_BCL2L1_NNMT_PRKAA- 1.73E-07 CSE1L_FRAP1_SATB1_SESN-2.72E-06 2_SESN2 1_MMP2 2_SIRT1 AKT1_ATG7_BNIP- 4.51E-06BCL2L1_TKT_CASP3_SESN1_SESN2 1.74E-07 CSE1L_FRAP1_CDH1_SESN- 2.82E-063_PRKAA1_LAMP2 2_SIRT1 ATG3_ATG7_LC3_SESN- 4.66E-06ATG3_BCL2L1_NNMT_PRKAA- 1.79E-07 ATG6_TKT_FASLG_LAMP- 2.90E-06 2_SIRT11_VEGF 2_SESN2 ATG3_ATG5_BNIP3_LC- 4.67E-06 BCL2L1_TKT_ID2_CASP3_SESN21.81E-07 ATG5_CSE1L_FRAP1_ID2_SESN2 2.90E-06 3_SESN2BNIP3_CSE1L_LC3_SESN- 4.70E-06 ATG3_BCL2L1_ID2_CASP3_SESN2 1.88E-07AKT1_ATG7_TKT_SESN2_SESN3 2.92E-06 2_SIRT1 ATG5_DRAM_LC3_SESN- 4.84E-06BNIP3_TKT_XIAP_CASP3_SESN2 2.07E-07 ATG7_TKT_LAMP2_MMP- 2.92E-06 2_SIRT12_SESN2 AIFM1_CIAP2_LAMP- 4.84E-06 BCL2L1_NNMT_PRKAA1_ID2_SESN2 2.12E-07AKT1_CSE1L_FRAP1_SESN- 2.98E-06 2_SESN2_SIRT1 2_SIRT1ATG7_TKT_LAMP2_SESN- 4.90E-06 BCL2L1_NNMT_PRKAA1_HMGB- 2.16E-07BNIP3_CSE1L_FRAP1_LC- 2.99E-06 2_SIRT1 1_VEGF 3_SESN2ATG5_CSE1L_FRAP1_LC- 4.96E-06 ATG3_BCL2L1_NNMT_PRKAA- 2.25E-07ATG5_CSE1L_FRAP1_SESN- 3.00E-06 3_SESN2 1_CDH2 2_SESN3ATG7_LC3_NAMPT_SESN- 5.05E-06 ATG3_BCL2L1_LAMP- 2.32E-07CSE1L_FRAP1_LAMP1_LC- 3.10E-06 2_SIRT1 1_NNMT_PRKAA1 3_SESN2ATG5_E2F1_LC3_SESN- 5.06E-06 BCL2L1_NNMT_ID2_SESN2_UVRAG 2.34E-07ATG3_ATG5_CSE1L_FRAP- 3.10E-06 2_SIRT1 1_SESN2 BNIP3_CSE1L_FRAP1_LC-5.20E-06 ATG3_ATG7_BCL2L- 2.41E-07 CSE1L_DRAM_FRAP1_LC- 3.16E-06 3_SESN21_NNMT_PRKAA1 3_SESN2 ATG7_LC3_LAMP2_SESN- 5.26E-06ATG3_BCL2L1_CBS_NNMT_PRKAA1 2.43E-07 ATG3_CSE1L_FRAP1_SESN- 3.20E-062_SIRT1 2_SIRT1 AIFM1_BNIP3_PRKAA- 5.26E-06 BCL2L1_ID2_CASP3_RPS-2.44E-07 ATG5_ATG7_FRAP1_LC3_SESN2 3.20E-06 1_LAMP2_SESN2 19BP1_SESN2ATG12_BNIP3_TKT_LAMP- 5.41E-06 BNIP3_FAS_TKT_CASP3_SESN2 2.48E-07ATG5_FAS_FRAP1_SESN- 3.20E-06 2_SESN2 2_SIRT1 CIAP2_KIAA1967_LAMP-5.50E-06 ATG3_BCL2L- 2.49E-07 CSE1L_FRAP1_SESN2_SESN- 3.23E-062_SESN2_SIRT1 1_DRAM_NNMT_PRKAA1 3_SIRT1 ATG12_ATG5_BNIP3_LC- 5.51E-06ATG7_BCL2L1_NNMT_PRKAA- 2.52E-07 CSE1L_DRAM_FRAP1_SESN- 3.31E-06 3_SESN21_HMGB1 2_SIRT1 ATG3_ATG7_LC3_LAMP- 5.57E-06 BCL2L1_NNMT_PRKAA1_HMGB-2.54E-07 CSE1L_DIABLO_FRAP1_SESN- 3.38E-06 2_SESN2 1_HMGB2 2_SIRT1ATG12_TKT_CIAP2_LAMP- 5.59E-06 BCL2L1_FAS_TKT_CASP3_SESN2 2.65E-07ATG7_CSE1L_FRAP1_SESN- 3.39E-06 2_SESN2 2_SIRT1 ATG5_BNIP3_CSE1L_LC-5.71E-06 ATG3_BCL2L1_CSE- 2.68E-07 ATG5_CSE1L_FRAP1_CDH- 3.40E-063_SESN2 1L_NNMT_PRKAA1 1_SESN2 AKT1_ATG7_PRKAA- 5.85E-06 ATG3_BCL2L-2.80E-07 ATG7_TKT_FASLG_SESN- 3.44E-06 1_TKT_LAMP2 1_DIABLO_NNMT_PRKAA12_SESN3 ATG3_LC3_NAMPT_SESN- 5.86E-06 ATG3_BCL2L1_NNMT_PRKAA- 2.92E-07ATG7_TKT_HMGB1_LAMP- 3.44E-06 2_SIRT1 1_SIRT1 2_SESN2ATG3_CSE1L_LC3_SESN- 5.90E-06 BCL2L1_CASP8_ID2_CASP3_SESN2 2.93E-07ATG7_TKT_AGER_LAMP- 3.47E-06 2_SIRT1 2_SESN2 ATG3_ATG7_FRAP1_LC-5.93E-06 BCL2L1_DIABLO_ID2_CASP3_SESN2 2.96E-07ATG3_ATG5_FRAP1_LC3_SESN2 3.50E-06 3_SESN2 ATG5_LC3_ID2_SESN- 5.95E-06BCL2L1_TKT_CASP3_SESN2_STAT3 2.98E-07 ATG3_ATG5_FRAP1_SESN- 3.50E-062_SIRT1 2_SIRT1 BNIP3_E2F1_LC3_SESN- 6.00E-06BCL2L1_NNMT_PRKAA1_ID2_VEGF 3.09E-07 ATG5_CSE1L_FRAP1_SATB- 3.50E-062_SIRT1 1_SESN2 ATG3_LC3_ID2_SESN- 6.35E-06 BCL2L1_ID2_CASP3_HMGB2_SESN23.14E-07 CSE1L_FRAP1_ID2_SESN2_SIRT1 3.56E-06 2_SIRT1ATG7_CSE1L_FRAP1_LC- 6.37E-06 BCL2L1_TKT_CASP3_SESN2_SESN3 3.15E-07ATG7_BNIP3_TKT_LAMP- 3.57E-06 3_SESN2 2_SESN2 AIFM1_TKT_LAMP2_SESN-6.38E-06 BCL2L1_TKT_CASP3_CCNG2_SESN2 3.16E-07 ATG5_ATG7_CSE1L_FRAP-3.60E-06 2_SIRT1 1_SESN2 LC3_CIAP2_LAMP2_SESN- 6.50E-06FAS_TKT_CASP3_FASLG_SESN2 3.20E-07 ATG5_LC3_NAMPT_SESN- 3.60E-06 2_SIRT12_SIRT1 ATG12_TKT_CDH1_LAMP- 6.51E-06 FAS_TKT_CASP3_SESN2_SIRT1 3.22E-07ATG12_ATG5_CSE1L_FRAP- 3.60E-06 2_SESN2 1_SESN2 ATG5_LC3_SESN2_SIRT-6.58E-06 BCL2L1_NNMT_ID2_KIAA- 3.26E-07 CSE1L_FRAP1_SESN2_SIRT- 3.67E-061_STAT3 1967_SESN2 1_STAT3 ATG3_DRAM_LC3_SESN- 6.63E-06ATG5_BCL2L1_ID2_CASP3_SESN2 3.28E-07 CSE1L_FRAP1_LC3_SESN- 3.67E-062_SIRT1 2_UVRAG ATG5_DIABLO_LC3_SESN- 6.63E-06 BCL2L1_NNMT_PRKAA-3.35E-07 AKT1_ATG7_TKT_MMP2_SESN2 3.80E-06 2_SIRT1 1_CASP3_SIRT1ATG7_BNIP3_LC3_SESN- 6.67E-06 BCL2L1_TKT_XIAP_BHLHE- 3.36E-07ATG5_BNIP3_CSE1L_FRAP- 3.80E-06 2_SIRT1 41_CASP3 1_SESN2CDH2_CIAP2_LAMP- 6.70E-06 FAS_TKT_XIAP_CASP3_SESN2 3.40E-07CSE1L_FRAP1_MMP9_SESN- 3.89E-06 2_SESN2_SIRT1 2_SIRT1ATG3_ATG5_FRAP1_LC- 6.73E-06 BCL2L1_CDH1_ID2_CASP3_SESN2 3.41E-07BNIP3_CSE1L_FRAP1_SESN- 3.90E-06 3_SESN2 2_SIRT1 DRAM_TKT_LAMP- 6.80E-06BCL2L1_TKT_CASP3_SESN2_SIRT1 3.44E-07 AKT1_ATG7_TKT_HMGB- 3.93E-062_SESN2_SIRT1 1_SESN2 ATG12_ATG3_TKT_LAMP- 6.84E-06ATG7_BCL2L1_NNMT_PRKAA1_ID2 3.44E-07 AIFM1_AKT1_ATG7_TKT_SESN2 4.07E-062_SESN2 ATG3_LC3_SESN2_SIRT- 6.93E-06 BCL2_BCL2L1_TKT_CASP3_SESN23.44E-07 AKT1_ATG5_ATG7_KT_SESN2 4.10E-06 1_STAT3 ATG5_LC3_SESN2_SIRT-6.94E-06 BCL2L1_ID2_CASP3_CDH2_SESN2 3.54E-07 ATG12_ATG7_TKT_LAMP-4.14E-06 1_UVRAG 2_SESN2 CDH1_ID2_MMP9_TCF3_SESN2 8.41E-03

TABLE 35 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value LC3_CIAP2_FASLG_LAMP- 1.29E-07BCL2L1_NNMT_ID2_CASP- 1.46E-08 ATG5_CSE1L_FRAP1_LC- 1.28E-072_SESN2_SIRT1 3_RAGE_SESN2 3_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP-1.43E-07 BCL2L1_NNMT_ID2_CASP- 1.89E-08 ATG3_ATG5_FRAP1_LC- 1.81E-072_SESN2_SIRT1 3_HMGB1_SESN2 3_SESN2_SIRT1 NNMT_CIAP2_FASLG_LAMP-2.07E-07 ATG3_BCL2L1_NNMT_PRKAA- 2.30E-08 ATG5_ATG7_FRAP1_LC- 2.26E-072_SESN2_SIRT1 1_CASP3_SIRT1 3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_MMP-2.23E-07 BCL2L1_NNMT_ID2_CASP- 2.42E-08 ATG3_ATG5_CSE1L_FRAP- 3.87E-072_SESN2_SIRT1 3_SESN1_SESN2 1_LC3_SESN2 AGER_CIAP2_FASLG_LAMP- 2.27E-07BCL2L1_NNMT_PRKAA1_ID- 2.46E-08 ATG3_CSE1L_FRAP1_LC- 4.03E-072_SESN2_SIRT1 2_SESN1_SESN2 3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SESN-2.29E-07 BCL2L1_BNIP- 2.60E-08 ATG7_CSE1L_FRAP1_LC- 4.05E-071_SESN2_SIRT1 3_TKT_XIAP_CASP3_SESN2 3_SESN2_SIRT1CIAP2_FASLG_HMGB1_LAMP- 2.31E-07 FAS_TKT_CASP3_HMGB- 2.64E-08ATG5_ATG7_CSE1L_FRAP- 4.31E-07 2_SESN2_SIRT1 1_SESN2_TP63 1_LC3_SESN2CIAP2_FASLG_LAMP- 2.31E-07 ATG3_BCL2L1_NNMT_PRKAA- 2.80E-08ATG5_DRAM_FRAP1_LC- 4.39E-07 2_NAMPT_SESN2_SIRT1 1_KIAA1967_SIRT13_SESN2_SIRT1 AKT1_CIAP2_FASLG_LAMP- 2.35E-07 ATG3_BCL2L1_NNMT_ID-3.00E-08 ATG5_CSE1L_DIABLO_FRAP- 4.66E-07 2_SESN2_SIRT1 2_CASP3_SESN21_LC3_SESN2 ID2_CIAP2_FASLG_LAMP 2.55E-07 ATG3_BCL2L1_NNMT_PRKAA-3.10E-08 CSE1L_FRAP1_LC3_SATB- 4.80E-07 2_SESN2_SIRT1 1_HMGB1_VEGF1_SESN2_SIRT1 FAS_CIAP2_FASLG_LAMP- 2.62E-07 BCL2L1_PTEN_TKT_CASP-3.17E-08 AKT1_ATG5_CSE1L_FRAP- 4.80E-07 2_SESN2_SIRT1 3_SESN1_SESN21_LC3_SESN2 CIAP2_FASLG_LAMP2_SESN- 2.69E-07 BCL2L1_NNMT_ID- 3.22E-08ATG5_FRAP1_LC3_RPS- 4.87E-07 2_SESN3_SIRT1 2_AGER_CASP3_SESN219BP1_SESN2_SIRT1 TCF3_CIAP2_FASLG_LAMP- 2.77E-07 BCL2L1_NNMT_ID2_BECN-3.29E-08 ATG5_CSE1L_FRAP1_LC- 5.13E-07 2_SESN2_SIRT1 1_CASP3_SESN23_ID2_SESN2 ATG3_ATG5_FRAP1_LC- 2.84E-07 BCL2L1_PTEN_TKT_CASP- 3.31E-08ATG5_CSE1L_FRAP1_LC- 5.14E-07 3_SESN2_SIRT1 3_HMGB1_SESN2 3_SESN2_SESN3ULK1_CIAP2_FASLG_LAMP- 2.85E-07 BCL2L1_PTEN_TKT_XIAP_CASP- 3.34E-08CSE1L_FRAP1_LC3_SESN- 5.36E-07 2_SESN2_SIRT1 3_SESN2 2_SIRT1_UVRAGBCL2_CIAP2_FASLG_LAMP- 2.89E-07 ATG12_BCL2L1_NNMT_ID- 3.40E-08AKT1_CSE1L_FRAP1_LC- 5.44E-07 2_SESN2_SIRT1 2_CASP3_SESN2 3_SESN2_SIRT1CIAP2_FASLG_LAMP- 2.97E-07 BNIP3_TKT_XIAP_CASP- 3.42E-08ATG5_DIABLO_FRAP1_LC- 5.49E-07 2_RAGE_SESN2_SIRT1 3_RAGE_SESN23_SESN2_SIRT1 ATG5_CIAP2_FASLG_LAMP- 3.04E-07 BCL2L1_NNMT_ID2_CASP-3.46E-08 CSE1L_FRAP1_LC3_SESN- 5.50E-07 2_SESN2_SIRT1 3_CCNG2_SESN22_SESN3_SIRT1 CASP3_CIAP2_FASLG_LAMP- 3.16E-07 AIFM1_BCL2L1_NNMT_ID-3.50E-08 ATG5_FRAP1_LC3_SESN- 5.66E-07 2_SESN2_SIRT1 2_CASP3_SESN22_SESN3_SIRT1 FRAP1_CIAP2_FASLG_LAMP- 3.24E-07 BCL2L1_PTEN_TKT_CASP-3.55E-08 CSE1L_DRAM_FRAP- 5.70E-07 2_SESN2_SIRT1 3_RAGE_SESN21_LC3_SESN2_SIRT1 MMP9_CIAP2_FASLG_LAMP- 3.44E-07 BCL2L1_NNMT_ID2_CASP-3.61E-08 CSE1L_DIABLO_FRAP- 5.76E-07 2_SESN2_SIRT1 3_CDH2_SESN21_LC3_SESN2_SIRT1 CIAP2_FASLG_LAMP2_SATB- 3.51E-07 BCL2L1_NNMT_ID2_CASP-3.66E-08 CSE1L_FRAP1_LC3_ID- 5.76E-07 1_SESN2_SIRT1 3_LAMP2_SESN22_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC- 3.70E-07 ATG3_BCL2L1_BNIP- 3.70E-06AKT1_ATG5_FRAP1_LC- 5.85E-07 3_SESN2_SIRT1 3_NNMT_PRKAA1_FASLG3_SESN2_SIRT1 CDH2_CIAP2_FASLG_LAMP- 3.78E-07 BCL2L1_NNMT_ID2_CASP-3.78E-08 ATG5_CSE1L_FRAP1_LC- 5.95E-07 2_SESN2_SIRT1 3_SESN2_SESN33_SATB1_SESN2 LAMP1_CIAP2_FASLG_LAMP- 3.93E-07 BCL2L1_CSE1L_NNMT_ID-3.87E-08 ATG5_FRAP1_LC3_ID- 5.96E-07 2_SESN2_SIRT1 2_CASP2_SESN22_SESN2_SIRT1 TKT_CIAP2_FASLG_LAMP- 4.02E-07 BAX_BCL2L1_NNMT_ID-3.90E-08 ATG5_CSE1L_FRAP1_LAMP- 6.20E-07 2_SESN2_SIRT1 2_CASP3_SESN21_SESN2_SIRT1 ATG7_LC3_FASLG_LAMP- 4.51E-07 BCL2L1_NNMT_ID2_BHLHE-3.93E-08 ATG3_ATG7_FRAP1_LC- 6.50E-07 2_SESN2_SIRT1 41_CASP3_SESN23_SESN2_SIRT1 ATG3_ATG7_LC3_LAMP- 4.68E-07 BCL2L1_NNMT_ID2_VASP-3.93E-08 ATG5_E2F1_FRAP1_LC- 6.69E-07 2_SESN2_SIRT1 3_MMP2_SESN23_SESN2_SIRT1 ATG3_BNIP3_FRAP1_LC- 5.23E-07 BNIP3_PTEN_TKT_XIAP_CASP-3.97E-08 ATG5_CSE1L_FRAP1_LAMP- 6.97E-07 3_SESN2_SIRT1 3_SESN21_LC3_SESN2 ATG5_ATG7_FRAP1_LC- 5.89E-07 BCL2L1_BNIP3_TKT_ID- 4.10E-08ATG5_BNIP3_CSE1L_FRAP- 7.03E-07 3_SESN2_SIRT1 2_CASP3_SESN2 1_LC3_SESN2ATG3_ATG5_BNIP3_LC- 6.24E-07 BCL2L1_BNIP3_TKT_CASP- 4.20E-08CSE1L_FRAP1_LC3_SESN- 7.19E-07 3_SESN2_SIRT1 3_SESN1_SESM2 2_SIRT1_STAT3E2F1_CIAP2_FASLG_LAMP- 6.56E-07 ATG3_ATG7_BCL2L- 4.30E-08BNIP3_CSE1L_FRAP1_LC- 7.24E-07 2_SESN2_SIRT1 1_NNMT_PRKAA1_HMGB13_SESN2_SIRT1 ATG3_BNIP3_LC3_LAMP- 6.99E-07 BCL2L1_CASP8_NNMT_ID-4.30E-08 ATG5_CSE1L_FRAP1_SESN- 7.96E-07 2_SESN2_SIRT1 2_CASP3_SESN22_SIRT1_UVRAG ATG5_BNIP3_FRAP1_LC- 7.20E-07 ATG5_BCL2L1_NNMT_ID-4.40E-08 ATG5_CSE1L_FRAP1_LC- 8.10E-07 3_SESN2_SIRT1 2_CASP3_SESN23_SESN2 ATG7_BNIP3_FRAP1_LC- 7.32E-07 BCL2L1_NNMT_CDH1_CASP- 4.52E-08ATG5_FRAP1_LC3_MMP- 8.11E-07 3_SESN2_SIRT1 3_SESN2 9_SESN2_SIRT1TKT_CDH1_CIAP2_LAMP- 8.77E-07 ATG3_BCL2L1_NNMT_PRKAA- 4.60E-08ATG5_ATG7_FRAP1_LAMP- 8.50E-07 2_SESN2_SIRT1 1_ID2_VEGF 1_SESN2_SIRT1ATG5_BNIP3_E2F1_LC- 9.14E-07 BCL2L1_NNMT_PRKAA1_ID- 4.65E-08ATG5_CSE1L_FRAP1_CDH- 8.54E-07 3_SESN2_SIRT1 2_CASP3_SESN221_SESN2_SIRT1 ATG3_ATG7_LC- 9.24E-07 BCL2L1_TKT_XIAP_CASP- 4.74E-08ATG5_FRAP1_LC3_SESN- 8.67E-07 3_NAMPT_SESN2_SIRT1 3_SESN1_SESN22_SIRT1_STAT3 AIFM1_CIAP2_FASLG_LAMP- 9.84E-07BCL2L1_NNMT_XIAP_ID2_CASP- 4.75E-08 ATG12_ATG5_CSE1L_FRAP- 8.73E-072_SESN2_SIRT1 3_SESN2 1_LC3_SESN2 ATG5_CSE1L_FRAP1_LC- 1.01E-06BCL2L1_DIABLO_NNMT_ID- 5.03E-08 ATG5_FRAP1_LC3_SESN- 8.73E-073_SESN2_SIRT1 2_CASP3_SESN2 2_SIRT1_UVRAG CBS_TKT_CIAP2_LAMP- 1.02E-06BCL2L1_TKT_XIAP_CASP- 5.21E-08 ATG5_BNIP3_FRAP1_LC- 8.83E-072_SESN2_SIRT1 3_HMGB1_SESN2 3_SESN2_SIRT1 ATG3_ATG5_LC3_ID- 1.04E-06BCL2L1_BNIP3_TKT_CASP- 5.30E-08 ATG3_ATG5_FRAP1_LAMP- 8.85E-072_SESN2_SIRT1 3_RAGE_SESN2 1_SESN2_SIRT1 AIFM1_TKT_CIAP2_LAMP- 1.06E-06BCL2L1_TKT_BHLHE41_CASP- 5.35E-08 CSE1L_FRAP1_LC3_CDH- 8.90E-072_SESN2_SIRT1 3_SESN1_SESN2 1_SESN2_SIRT1 ATG3_DRAM_FRAP1_LC- 1.06E-06BCL2L1_TKT_CASP3_HMGB- 5.36E-08 ATG5_CSE1L_FRAP1_LC- 8.97E-073_SESN2_SIRT1 1_RAGE_SESN2 3_SESN2_STAT3 ATG3_ATG5_E2F1_LC- 1.11E-06BCL2L1_PTEN_TKT_CASP- 5.37E-08 AIFM1_ATG12_TKT_FASLG_LAMP- 9.06E-073_SESN2_SIRT1 3_CCNG2_SESN2 2_SESN2 ATG7_BNIP3_LC3_LAMP- 1.12E-06BCL2L1_PRKAA- 5.38E-08 ATG5_CSE1L_FRAP1_LC3_SESN- 9.14E-07 2_SESN2_SIRT11_TKT_XIAP_CASP3_SESN2 2_UVRAG ATG3_ATG5_LC3_SESN- 1.16E-06BCL2L1_TKT_CASP3_HMGB- 5.41E-08 CSE1L_FRAP1_LAMP1_LC3_SESN- 9.28E-072_SIRT1_STAT3 1_SESN1_SESN2 2_SIRT1 AIFM1_AKT1_LAMP2_SESN- 1.16E-06BNIP3_FAS_TKT_CASP3_HMGB- 5.47E-08 CSE1L_FRAP1_LC3_MMP9_SESN- 9.50E-072_SIRT1_UVRAG 1_SESN2 2_SIRT1 AKT1_ATG7_TKT_LAMP- 1.18E-06FAS_TKT_XIAP_CASP3_HMGB- 5.47E-08 ATG5_CSE1L_FRAP1_LC3_RPS- 9.53E-072_SESN2_SIRT1 1_SESN2 19BP1_SESN2 ATG3_ATG5_CS- 1.20E-06BCL2L1_NNMT_ID2_SESN- 5.49E-08 AKT1_ATG5_CSE1L_FRAP1_SESN- 9.55E-0731L_NAMPT_SESN2_SIRT1 1_SESN2_UVRAG 2_SIRT1 ATG3_ATG5_DIABLO_LC-1.20E-06 FAS_TKT_HMGB1_KIAA- 5.60E-08 ATG5_CSE1L_E2F1_FRAP1_LC- 9.62E-073_SESN2_SIRT1 1967_SESN2_TP63 3_SESN2 TKT_CDH1_HMGB1_LAMP- 1.20E-06BCL2L1_TKT_ID2_BHLHE- 5.63E-08 CSE1L_E2F1_FRAP1_SESN2_SIRT1 9.90E-072_SESN2_SIRT1 41_CASP3_SESN2 ATG3_ATG5_LC3_LAMP- 1.20E-06BCL2L1_PTAN_TKT_ID2_CASP- 5.75E-08 ATG5_CSE1L_FRAP1_LC3_CDH- 1.03E-062_SESN2_SIRT1 3_SESN2 1_SESN2 ATG5_DRAM_FRAP1_LC- 1.23E-06BCL2L1_ID2_CASP3_RAGE_RPS- 5.87E-08 ATG3_ATG7_CSE1L_FRAP1_LC- 1.05E-063_SESN2_SIRT1 19BP1_SESN2 3_SESN2 BNIP3_CSE1L_FRAP1_LC- 1.23E-06BNIP3_TKT_XIAP_CASP3_HMGB- 5.89E-08 ATG5_CSE1L_FRAP1_SATB- 1.06E-063_SESN2_SIRT1 1_SESN2 1_SESN2_SIRT1 AKT1_ATG3_ATG5_LC- 1.24E-06ATG3_ATG7_BCL2L- 5.90E-08 ATG5_CSE1L_FRAP1_SESN- 1.06E-06 3_SESN2_SIRT11_NNMT_PRKAA1_ID2 2_SESN3_SIRT1 AIFM1_BNIP3_PRKAA- 1.24E-06 BCL2L1_BNIP-5.90E-08 ATG7_TKT_FASLG_LAMP- 1.07E-06 1_TKT_LAMP2_SESN23_NNMT_TKT_CASP3_SESN2 2_SESN2_SIRT1 TKT_CDH1_ID2_MMP- 7.98E-04TKT_CDH1_ID2_MMP9_TCF- 1.65E-04 9_TCF3_SESN2 3_SESN2

TABLE 36 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ATG3_ATG7_LC3_FASLG_LAMP2_SESN2_SIRT1 6.31E-08BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 2.95E-09ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 9.03E-08MMP9_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 7.01E-08BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 3.28E-09ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 1.06E-07FRAP1_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 7.33E-08BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2 4.78E-09ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG 1.21E-07ATG7_BNIP3_LC3_FASLG_LAMP2_SESN2_SIRT1 7.57E-08BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2 7.10E-09AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 1.24E-07CCNG2_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 7.71E-08ATG3_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 7.30E-09ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 1.26E-07LC3_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 8.40E-08BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2 7.39E-09ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 1.27E-07CCNG2_CIAP2_FASLG_MMP2_SESN2_SIRT1 8.60E-08BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN1_SESN2 7.50E-09ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 1.31E-07LC3_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 8.97E-08ATG3_BCL2L1_NNMT_PRKAA1_ID2_CASP3_SIRT1 7.60E-09ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 1.37E-07LC3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 9.20E-08BCL2L1_CASP8_NNMT_ID2_CASP3_RAGE_SESN2 7.80E-09ATG5_CSE1L_RAP1_LC3_ID2_SESN2_SIRT1 1.37E-07TCF3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 9.26E-08BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN2 7.83E-09ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 1.39E-07LC3_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 1.01E-07ATG3_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 8.10E-09ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SIRT1 1.45E-07FAS_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.09E-07BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN2 8.10E-09ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 1.64E-07CIAP2_FASLG_LAMP2_NAMPT_SESN1_SESN2_SIRT1 1.10E-07BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_SESN2 8.45E-09ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 1.76E-07CIAP2_FASLG_LAMP2_MMP2_SESN1_SESN2_SIRT1 1.18E-07BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN2_SESN3 8.80E-09ATG3_ATG5_DIABLO_FRAP1_LC3_SESN2_SIRT1 1.78E-07ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 1.18E-07BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN2 8.90E-09ATG3_ATG5_FRAP1_LC3_SESN2_SESN3_SIRT1 1.80E-07NNMT_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.19E-07BNIP3_PTEN_TKT_XIAP_ID2_CASP3_SESN2 9.68E-09AKT1_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 1.84E-07LC3_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 1.20E-07ATG3_BCL2L1_NNMT_PRKAA1_XIAP_CASP3_SIRT1 1.00E-08ATG5_CSE1L_E2F1_LC3_SESN2_SIRT1 1.86E-07ATG5_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.20E-07BCL2L1_BNIP3_NNMT_TKT_XIAP_CASP3_SESN2 1.00E-08ATG3_ATG5_FRAP1_LC3_ID2_SESN2_SIRT1 1.94E-07LC3_TCF3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.23E-07BCL2_BCL2L1_BHLHE41_CASP3_SESN1_SESN2 1.05E-08ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1 1.96E-07AGER_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 1.25E-07ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG 1.10E-08ATG5_CSE1L_FRAP1_LAMP1_SESN2_SIRT1 2.01E-07CCNG2_CIAP2_FASLG_LAMP2_SATB1_SESN2_SIRT1 1.27E-07ATG3_BCL2L1_NNMT_ID2_CASP3_HMGB1_SESN2 1.10E-08AIFM1_ATG12_TKT_CDH1_FASLG_LAMP2_SESN2 2.13E-07AKT1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.28E-07BCL2L1_NNMT_PRKAA1_ID2_CASP3_RAGE_SESN2 1.12E-08ATG5_CSE1L_FRAP1_LC3_CDH1_SESN2_SIRT1 2.16E-07LC3_ULK1_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.29E-07BCL2L1_PRKAA1_TKT_XIAP_ID2_CASP3_SESN2 1.16E-08ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3 2.25E-07CCNG2_CIAP2_FASLG_LAMP2_SESN2_SESN3_SIRT1 1.29E-07BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2 1.16E-08AKT1_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 2.25E-07NNMT_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 1.31E-07BCL2L1_TKT_ID2_BHLHE41_CASP3_SESN1_SESN2 1.17E-08ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1 2.26E-07ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 1.33E-07ATG3_BCL2L1_BNIP3_TKT_XIAP_CASP3_SESN2 1.20E-08ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1 2.28E-07NNMT_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 1.35E-07BCL2L1_BNIP3_NNMT_TKT_ID2_CASP3_SESN2 1.20E-08ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_STAT3 2.47E-07LC3_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 1.35E-07BCL2L1_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2 1.23E-08ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1 2.50E-07AGER_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 1.36E-07BCL2L1_PRKAA1_TKT_XIAP_CASP3_RAGE_SESN2 1.24E-08ATG3_ATG5_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 2.59E-07BCL2_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.36E-07BCL2L1_PRKAA1_TKT_XIAP_CASP3_HMGB1_SESN2 1.25E-08ATG3_ATG5_E2F1_FRAP1_LC3_SESN2_SIRT1 2.60E-07BCL2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.42E-07BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2 1.26E-08ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1_UVRAG 2.61E-07ULK1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.44E-07BCL2L1_TKT_BHLHE4`1_CASP3_RAGE_SESN1_SESN2 1.26E-08ATG12_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 2.61E-07CCNG2_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 1.44E-07BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2 1.29E-08ATG3_ATG5_BNIP3_FRAP1_LC3_SESN2_SIRT1 2.73E-07LC3_CDH2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.48E-07BCL2L1_NNMT_BECN1_CASP3_RAGE_SESN2 1.29E-08ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG 2.77E-07LC3_CASP3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.48E-07BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_SESN2 1.30E-08ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1 2.86E-07AKT1_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.49E-07BNIP3_TKT_XIAP_ID2_CASP3_RAGE_SESN2 1.33E-08AIFM1_ATG12_TKT_CIAP2_FASLG_LAMP2_SESN2 2.89E-07FRAP1_CCNG2_CIAP2_FASLG)LAMP2_SESN2_SIRT1 1.50E-07BCL2L1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 1.36E-08ATG5_CSE1L_FRAP1_LC3_MMP9_SESN2_SIRT1 2.94E-07FRAP1_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.51E-07BCL2L1_PTEN_TKT_CASP3_HMGB1_SESN1_SESN2 1.39E-08ATG3_ATG5_FRAP1_LC3_MMP9_SESN2_SIRT1 3.12E-07CASP3_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.58E-07BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN2 1.40E-08ATG7_TKT_FASLG_LAMP2_SESN2_SESN3_SIRT1 3.20E-07CIAP2_FASLG_HMGB1_LAMP2_SESN1_SESN2_SIRT1 1.56E-07BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN2 1.40E-08ATG7_TKT_FASLG_LAMP2_SESN2_SESN3_SIRT1 3.20E-07CIAP2_FASLG_HMGB1_LAMP2_SESN1_SESN2_SIRT1 1.57E-07AIFM1_BCL2L1_NNMT_ID2_CASP3_RAGE_SESN2 1.40E-08ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 3.31E-07LC3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.57E-07BCL2L1_NNMT_ID2_CASP3_CDH2_RAGE_SESN2 1.41E-08ATG3_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 3.32E-07CIAP2_FASLG_HMGB1_LAMP2_NAMPT_SESN2_SIRT1 1.58E-07BCL2L1_NNMT_CDH1_ID2_CASP3_RAGE_SESN2 1.44E-08ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2 3.35E-07ATG5_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.58E-07BCL2L1_NNMT_ID2_AGER_CASP3_RAGE_SESN2 1.44E-08ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG 3.39E-07ID2_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.60E-07BNIP3_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 1.45E-08AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2 3.46E-07TCF3_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.60E-07BNIP3_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 1.47E-08ATG12_ATG3_ATG5_FRAP1_LC3_SESN2_SIRT1 3.46E-07FAS_LC3_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.60E-07BNIP3_TKT_XIAP_CASP3_HMGB1_RAGE_SESN2 1.48E-08AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2 3.48E-07NNMT_CIAP2_FASLG_LAMP2_NAMPT_SESN2_SIRT1 1.62E-07BCL2L1_NNMT_ID2_CASP3_MMP2_RAGE_SESN2 1.49E-08ATG5_ATG7_FRAP1_LC3_RPS19BP1_SESN2_SIRT1 3.52E-07LAMP1_CCNG2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.63E-07ATG5_BCL2L1_NNMT_PRKAA1_ID2_SESN1_SESN2 1.50E-08ATG3_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 3.54E-07CIAP2_FASLG_LAMP2_MMP2_SESN2_SESN3_SIRT1 1.66E-07BCL2L1_BNIP3_TKT_ID2_CASP3_RPS19BP1_SESN2 1.50E-08ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2 3.59E-07TCF3_CIAP2_FASLG_LAMP2_SESN1_SESN2_SIRT1 1.68E-07BCL2L1_NNMT_ID2_CASP3_RAGE_SESN1_SESN2 1.50E-08ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG 3.63E-07FRAP1_CIAP2_FASLG_HMGB1_LAMP2_SESN2_SIRT1 1.69E-07BCL2L1_NNMT_TKT_ID2_BHLHE41_CASP3_SESN2 1.53E-08ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 3.64E-07ATG3_ATG7_BNIP3_FRAP1_LC3_SESN2_SIRT1 1.72E-07BCL2L1_PTEN_TKT_BHLHE41_CASP3_SESN1_SESN2 1.53E-08AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2 3.75E-07AKT1_CIAP2_FASLG_LAMP2_MMP2_SESN2_SIRT1 1.73E-07BCL2L1_CSE1L_NNMT_ID2_CASP3_RAGE_SESN2 1.57E-08ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2 3.81E-07NNMT_ID2_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.78E-07BCL2L1_PTEN_TKT_CASP3_RAGE_SESN1_SESN2 1.57E-08ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3 3.84E-07NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.79E-07BNIP3_TKT_XIAP_CASP3_CCNG2_RAGE_SESN2 1.59E-08AKT1_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 3.92E-07ATG7_LC3_CDH1_FASLG_LAMP2_SESN2_SIRT1 1.81E-07ATG3_BCL2L1_BNIP3_TKT_CASP3_FASLG_SESN2 1.60E-08AKT1_ATG3_CSE1L_FRAP1_LC3_SESN2_SIRT1 3.93E-07MMP9_AGER_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.83E-07BCL2L1_BNIP3_E2F1_TKT_XIAP_CASP3_SESN2 1.60E-08ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 3.94E-07BNIP3_PRKAA1_CDH1_ID2_MMP9_TCF3_LAMP2 4.64E-05BCL2L1_CDH1_ID2_MMP9_TCF3_CASP3_SESN2 4.96E-08ATG7_TKT_CDH1_ID2_MMP9_TCF3_SESN2 5.56E-05

TABLE 37 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ATG3_ATG7_LC3_ID- 3.42E-08BCL2L1_NNMT_PRKAA1_PTEN_XIAP_ID2_CASP3_SESN2 4.96E-10ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_STAT3 7.38E-082_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP- 4.14E-08BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_SESN3 9.32E-10AIFM1_ATG12_TKT_CDH1_FASLG_HMGB1_LAMP2_SESN2 8.07E-082_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_CIAP- 4.37E-08BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN2 1.02E-09ATG3_ATG5_ATG7_DRAM_FRAP1_LC3_SESN2_SIRT1 8.31E-082_FASLG_LAMP2_MMP2_SESN2_SIRT1 MMP9_CCNG2_CIAP- 4.52E-08BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 1.07E-09AKT1_ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1 8.83E-082_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_LC3_CCNG2_CIAP- 4.53E-08BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2_SESN3 1.17E-09ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SESN3_SIRT1 9.09E-082_FASLG_LAMP2_SESN2_SIRT1 ATG5_FRAP1_LC3_CIAP- 4.58E-08ATG3_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 1.20E-09ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG 9.20E-082_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_CIAP- 4.90E-08BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN1_SESN2 1.22E-09ATG3_ATG5_ATG7_DIABLO_FRAP1_LC3_SESN2_SIRT1 9.25E-082_FASLG_HMGB1_LAMP2_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP- 4.94E-08BCL2_BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2 1.32E-09ATG3_ATG5_ATG7_FRAP1_LC3_SESN2_SIRT1_UVRAG 9.91E-082_MMP2_NAMPT_SESN2_SIRT1 LC3_CCNG2_CIAP- 4.98E-08BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_RAGE_SESN2 1.35E-09AKT1_ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1 1.01E-072_FASLG_LAMP2_MMP2_SESN2_SIRT1 LC3_NNMT_CIAP- 5.07E-08BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN1_SESN2 1.36E-09ATG3_ATG5_ATG7_FRAP1_LC3_ID2_SESN2_SIRT1 1.02E-072_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_LC3_AGER_CIAP- 5.20E-08BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_HMGB1_SESN2 1.36E-09ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 1.05E-072_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP- 5.31E-08BCL2L1_PRKAA1_PTEN_TKT_XIAP_ID2_CASP3_SESN2 1.47E-09ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG 1.05E-072_FASLG_LAMP2_NAMPT_SESN2_SIRT1 ATG3_ATG7_LC3_FASLG_LAMP- 5.51E-08BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_RAGE_SESN2 1.56E-09ATG3_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 1.07E-07 2_SESN2_SIRT1_STAT3NNMT_MMP9_CCNG- 5.52E-08 BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2_SESN31.84E-09 AIFM1_ATG12_NNMT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.08E-072_CIAP2_FASLG_LAMP2_SESN2_SIRT1 FRAP1_AGER_CIAP- 5.78E-08BCL2L1_BNIP3_TKT_XIAP_CASP3_RPS19BP1_SESN1_SESN2 1.86E-09ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1_UVRAG 1.14E-072_FASLG_LAMP2_NAMPT_SESN2_SIRT1 FRAP1_CCNG2_CIAP- 5.85E-08BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN1_SESN2 1.92E-09ATG3_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 1.14E-072_FASLG_LAMP2_NAMPT_SESN2_SIRT1 CIAP2_FASLG_LAMP- 5.86E-08BCL2L1_BNIP3_TKT_XIAP_ID2_CASP3_RPS19BP1_SESN2 2.05E-09ATG3_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 1.15E-072_MMP2_NAMPT_SESN1_SESN2_SIRT1 MMP9_CCNG2_CIAP- 5.98E-08ATG3_BCL2L1_NNMT_PRKAA1_ID2_HMGB1_SESN1_SESN2 2.10E-09AIFM1_ATG12_TKT_CDH1_CIAP2_FASLG_LAMP2_SESN2 1.17E-072_FASLG_HMGB1_LAMP2_SESN2_SIRT1 TCF3_CCNG2_CIAP- 6.03E-08BCL2L1_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3 2.20E-09AIFM1_ATG12_NNMT_AGER_CIAP2_FASLG_LAMP2_SESN2 1.17E-072_FASLG_LAMP2_MMP2_SESN2_SIRT1 TCF3_CCNG2_CIAP- 6.04E-08BCL2L1_NNMT_ID2_BHLHE41_CASP3_HMGB1_SESN1_SESN2 2.24E-09AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_UVRAG 1.18E-072_FASLG_LAMP2_NAMPT_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP- 6.05E-08ATG3_BCL2L1_CASP8_NNMT_XIAP_ID2_CASP3_SESN2 2.30E-09ATG3_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 1.19E-072_NAMPT_SATB1_SESN2_SIRT1 FAS_CCNG2_CIAP- 6.08E-08ATG5_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 2.40E-09ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1_UVRAG 1.20E-072_FASLG_LAMP2_NAMPT_SESN2_SIRT1 NNMT_CCNG2_CIAP- 6.08E-08BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_MMP2_SESN2 2.41E-09AKT1_ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 1.20E-072_FASLG_LAMP2_MMP2_SESN2_SIRT1 ATG3_ATG7_BNIP3_LC- 6.10E-08BCL2L1_BNIP3_TKT_XIAP_CASP3_RAGE_RPS19BP1_SESN2 2.46E-09AKT1_ATG5_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 1.23E-073_FASLG_LAMP2_SESN2_SIRT1 AKT1_MMP9_CCNG2_CIAP- 6.11E-08BCL2L1_NNMT_ID2_BHLHE41_CASP3_CCNG2_SESN2_SESN3 2.50E-09AKT1_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 1.24E-072_FASLG_LAMP2_SESN2_SIRT1 LC3_CCNG2_CIAP- 6.12E-08BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_MMP2_SESN2 2.52E-09AIFM1_ATG12_NNMT_CDH2_CIAP2_FASLG_LAMP2_SESN2 1.25E-072_FASLG_LAMP2_SATB1_SESN2_SIRT1 MMP9_CCNG2_CIAP- 6.15E-08BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CCNG2_SESN2 2.52E-09ATG3_ATG5_ATG7_BNIP3_FRAP1_LC3_SESN2_CIRT1 1.25E-072_FASLG_LAMP2_MMP2_SESN2_SIRT1 FRAP1_LC3_NNMT_CIAP- 6.16E-08BCL2_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 2.54E-09ATG5_CSE1L_FRAP1_LC3_SATB1_SESN2_SESN3_SIRT1 1.26E-072_FASLG_LAMP2_SESN2_SIRT1 FRAP1_MMP9_CCNG- 6.19E-08ATG5_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 2.60E-09ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1_UVRAG 1.27E-072_CIAP2_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_ID- 6.22E-08BCL2L1_NNMT_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 2.61E-09AIFM1_ATG12_TKT_CDH1_AGER_FASLG_LAMP2_SESN2 1.27E-072_FASLG_LAMP2_SESN2_SIRT1 ATG7_BNIP3_LC- 6.24E-08BCL2L1_NNMT_PRKAA1_CIAP_ID2_AGER_CASP3_SESN2 2.65E-09ATG3_ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1 1.27E-073_FASLG_LAMP2_SESN2_SIRT1_STAT3 LC3_TCF3_CCNG2_CIAP- 6.25E-08BCL2L1_NNMT_ID2_BHLHE41_CASP3_RAGE_SESN1_SESN2 2.67E-09ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1_UVRAG 1.27E-072_FASLG_LAMP2_SESN2_SIRT1 CIAP2_FASLG_HMGB- 6.30E-08BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_LAMP2_SESN2 2.67E-09ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1_UVRAG 1.27E-071_LAMP2_NAMPT_SESN1_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP- 6.34E-08BCL2L1_BNIP3_NNMT_TKT_XIAP_ID2_CASP3_SESN2 2.71E-09ATG3_ATG5_BNIP3_CSE1L_FRAP1_LC3_SESN2_SIRT1 1.30E-072_MMP2_SESN2_SESN3_SIRT1 ATG3_ATG7_LC3_BECN- 6.36E-08ATG12_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 2.80E-09ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SESN3_SIRT1 1.31E-071_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_FRAP1_LC- 6.36E-08BCL2L1_NNMT_PRKAA1_XIAP_ID2_BECN1_CASP3_SESN2 2.85E-09ATG3_ATG5_ATG7_FRAP1_LAMP1_LC3_SESN2_SIRT1 1.32E-073_FASLG_LAMP2_SESN2_SIRT1 NNMT_CCNG2_CIAP- 6.37E-08BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_CDH2_SESN2 2.95E-09AKT1_ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 1.32E-072_FASLG_LAMP2_NAMPT_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP- 6.47E-08AIFM1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 3.00E-09AKT1_ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 1.32E-07 2_SESN2_SESN3_SIRT1FRAP1_LC3_TCF3_CIAP- 6.49E-08ATG12_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 3.00E-09AIFM1_DRAM_TKT_CDH1_FASLG_LAMP2_SESN2_SIRT1 1.33E-072_FASLG_LAMP2_SESN2_SIRT1 FAS_CCNG2_CIAP2_FASLG_LAMP- 6.53E-08BAX_BCL1L2_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 3.00E-09AKT1_ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SIRT1 1.34E-07 2_MMP2_SESN2_SIRT1CCNG2_CIAP2_FASLG_HMGB- 6.57E-08BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_LAMP2_SESN2 3.02E-09ATG5_CSE1L_DIABLO_FRAP1_LC3_SATB1_SESN2_SIRT1 1.34E-071_LAMP2_NAMPT_SESN2_SIRT1 CCNG2_CIAP2_FASLG_LAMP- 6.68E-08BCL2L1_PRKAA1_PTEN_TKT_XIAP_AGER_CASP3_SESN2 3.03E-09ATG5_CSE1L_FRAP1_LC3_ID2_SATB1_SESN2_SIRT1 1.35E-072_NAMPT_SESN1_SESN2_SIRT1 ATG7_BNIP3_LC3_FASLG_LAMP- 6.70E-08AKT1_BCL2L1_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 3.10E-09ATG3_ATG5_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 1.35E-07 2_SATB1_SESN2_SIRT1BCL2_MMP9_CCNG2_CIAP- 6.93E-08BAX_BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_SESN2 3.10E-09ATG5_CSE1L_DIABLO_FRAP1_LC3_SESN2_SESN3_SIRT1 1.36E-072_FASLG_LAMP2_SESN2_SIRT1 ULK1_MMP9_CCNG2_CIAP- 6.88E-08BCL2L1_PTEN_TKT_XIAP_BHLHE41_CASP3_SESN1_SESN2 3.11E-09ATG5_CSE1L_FRAP1_LC3_ID2_SESN2_SESN3_SIRT1 1.36E-072_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP- 7.02E-08BCL2L1_PRKAA1_PTEN_TKT_XIAP_BECN1_CASP3_SESN2 3.15E-09ATG5_CSE1L_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1 1.38E-07 2_NAMPT_SESN2_SIRT1LC3_CIAP2_FASLG_LAMP2_MMP- 7.13E-08BCL2L1_PRKAA1_PTEN_TKT_XIAP_CASP3_CDH2_SESN2 3.17E-09ATG5_CSE1L_DRAM_FRAP1_LC3_SATB1_SESN2_SIRT1 1.40E-07 2_NAMPT_SESN2_SIRT1BCL2_FRAP1_LC3_CIAP- 7.25E-08BCL2L1_CASP8_NNMT_ID2_CASP3_HMGB1_RAGE_SESN2 3.17E-09ATG3_ATG5_ATG7_E2F1_FRAP1_LC3_SESN2_SIRT1 1.42E-072_FASLG_LAMP2_SESN2_SIRT1 AKT1_CCNG2_CIAP- 7.27E-08BCL2L1_CASP8_PTEN_TKT_XIAP_CASP3_SESN1_SESN2 3.18E-09ATG5_ATG7_CSE1L_FRAP1_LC3_SESN2_SIRT1_STAT3 1.43E-072_FASLG_LAMP2_MMP2_SESN2_SIRT1 ATG7_BNIP3_LC3_MMP- 7.32E-08ATG3_BCL2L1_BNIP3_NNMT_PRKAA1_ID2_FASLG_KIAA1967 3.20E-09ATG5_ATG7_CSE1L_DIABLO_FRAP1_LC3_SESN2_SIRT1 1.43E-079_FASLG_LAMP2_SESN2_SIRT1 MMP9_AGER_CCNG2_CIAP- 7.33E-08BCL2L1_NNMT_XIAP_ID2_BHLHE41_CASP3_SESN2_SESN3 3.20E-09AIFM1_DRAM_TKT_CIAP2_FASLG_LAMP2_SESN2_SIRT1 1.43E-072_FASLG_LAMP2_SESN2_SIRT1 FRAP1_LC3_ULK1_CIAP- 7.38E-08BCL2L1_CSE1L_NNMT_PRKAA1_XIAP_ID2_CASP3_SESN2 3.21E-09ATG5_ATG7_CSE1L_FRAP1_LAMP1_LC3_SESN2_SIRT1 1.43E-072_FASLG_LAMP2_SESN2_SIRT1 LC3_NNMT_CIAP2_FASLG_LAMP- 7.51E-08BCL2L1_NNMT_ID2_BHLHE41_CASP3_SESN1_SESN2_STAT3 3.22E-09ATG3_ATG5_DIABLO_DRAM_FRAP1_LC3_SESN2_SIRT1 1.44E-07 2_SATB1_SESN2_SIRT1CASP3_CCNG2_CIAP- 7.52E-08 BCL2L1_FRAP1_PTEN_TKT_XIAP_CASP3_HMGB1_SESN23.30E-09 ATG5_ATG7_CSE1L_FRAP1_LC3_ID2_SESN2_SIRT1 1.44E-072_FASLG_LAMP2_NAMPT_SESN2_SIRT1 LC3_CDH2_CIAP2_FASLG_LAMP- 7.54E-08BCL2L1_NNMT_XIAP_BHLHE41_CASP3_SESN1_SESN2_SESN3 3.31E-09AIFM1_ATG12_MMP9_AGER_FASLG_LAMP2_SESN2_SIRT1 1.44E-072_NAMPT_SESN2_SIRT1 LC3_NNMT_CCNG2_CIAP- 7.56E-08BNIP3_PTEN_TKT_XIAP_CASP3_RAGE_SESN1_SESN2 3.33E-09ATG3_ATG5_DRAM_FRAP1_LC3_SESN2_SESN3_SIRT1 1.45E-072_FASLG_LAMP2_SESN2_SIRT1 ATG3_ATG7_LC3_CDH- 7.57E-08BCL2L1_NNMT_PRKAA1_ID2_HMGB1_HMGB2_SESN1_SESN2 3.34E-09ATG5_ATG7_CSE1L_FRAP1_LC3_SATB1_SESN2_SIRT1 1.45E-071_FASLG_LAMP2_SESN2_SIRT1 TKT_CDH1_ID2_MMP9_TCF- .43E-06BCL2L1_TKT_CDH1_ID2_MMP9_TCF3_CASP3_SESN2 6.82E-07TKT_CDH1_ID2_MMP9_TCF3_FASLG_SESN2_SIRT1 1.20E-05 3_LAMP2_SESN2_SIRT1

As can be confirmed from the above tables, each of the markers or theircombination shows p-values low enough to be considered significant interms of all of recurrence, survival, and disease-free survival. Inparticular, in the case of the combination of the two or more markers,all the p-values for recurrence, survival, and disease-free survivalwere low. In particular, it was found that there were cases where thep-value for a single marker was relatively high but the p-valuedecreased when the marker was used in combination with other marker. Asa p-value becomes lower, the statistical significance becomes higher.Thus, the low p-values suggest that the estimation for prognosis ofliver cancer by each of the markers or their combination is highlyaccurate.

This means that the more markers of the present disclosure are combined,the lower p-values, which means higher significance, are shown, whichmeans that the more improved accuracy would be achieved in theestimation for prognosis based on the combinations of the markers.

Thus, it was found that the markers and/or the combinations of markersof Tables 30˜37 are effective in predicting prognosis of liver cancer ofthe A2 group (recurrence, survival, disease-free survival), and that theprognosis of liver cancer of the A2 group can be predicted effectivelyby nucleic acids and antibodies targeted at the markers.

Also, it can be found that the prognosis of liver cancer of the A2 groupcan be predicted effectively by the method for predicting prognosis ofliver cancer of the present disclosure, which is targeted at themarkers.

Further, cross-validation was performed for combinations of markerswhich were considered statistically significant. Patients of eachpatient group were randomly divided into two groups (positive group: 62patients; test group: 61 patients). With the reference value which wasconsidered statistically significant in the results of the positivegroup obtained in the same manner as Example 1 fixed, for the testgroup, the accuracy of estimation was calculated to be the level ofp<0.05 or p<0.001 with respect to recurrence, survival and disease-freesurvival.

Among the results of cross-validation of the prediction of therecurrence, survival and disease-free survival of the A2 group,representative examples showing the excellent accuracy of prognosis ineach aspect are as follows:

Recurrence: TKT_SESN2_VEGF (65.0% at the level of p<0.05)

Survival: DIABLO_FAS_LAMP1_BHLHE41_SESN2 (83.3% at the level of p<0.05)

Disease-free survival: TKT_SESN2_VEGF (82.0% at the level of p<0.05)

Example 4 Predicting Prognosis of Liver Cancer in the B Group

An experiment was performed in the same manner as in Example 1, exceptfor experimenting on a patient group determined as the B group {a groupof portal vein invasion-negative patients in intermediate stage of BCLCstaging system, having plural tumors which are more than 3 cm in size orplural tumors which are more than 3 in number} (78 patients).Kaplan-Meier curves were prepared with respect to the prediction ofrecurrence, survival, and disease-free survival and the results areshown in FIGS. 65˜85. Kaplan-Meier curves for recurrence are shown inFIGS. 65˜71, Kaplan-Meier curves for survival are shown in FIGS. 72˜78,and Kaplan-Meier curves for disease-free survival are shown in FIGS.79˜85.

As can be seen from the drawings, in Kaplan-Meier curves completed withrespect to recurrence, survival, and disease-free survival, the abovemarkers form curves where cases of high expression and low expressionare distinctively distinguished from each other. This means that thereare remarkable differences in interval recurrence rate or intervalsurvival rate and cumulative recurrence rate or cumulative survival ratebased thereon between the cases where the marker is in high expressionand low expression, and that consequently, the expression pattern of themarker can be an index showing recurrence possibility or survivalpossibility of patients.

Also, significance tests were performed by log-rank test with respect toeach of the markers and their combination by calculating observationvalues and expected values at every point of recurrence or death toobtain p-values. The results are shown in the following Tables 38˜45.The results of using a marker alone are shown in Table 38, the resultsof a combination of two markers are shown in Table 39, the results of acombination of three markers are shown in Table 40, the results of acombination of four markers are shown in Table 41, the results of acombination of five markers are shown in Table 42, the results of acombination of six markers are shown in Table 43, the results of acombination of seven markers are shown in Table 44, and the results of acombination of eight markers are shown in Table 45.

TABLE 38 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value HMGB1 2.22E-02 ATG12 2.08E-04 DIABLO 4.18E-02 TKT3.71E-02 DIABLO 3.97E-04 BECN1 4.32E-02 BECN1 6.59E-02 UVRAG 1.53E-03HMGB1 4.69E-02 DIABLO 7.11E-02 NAMPT 1.91E-03 ATG12 6.32E-02 TCF38.67E-02 STAT3 3.43E-03 TKT 7.58E-02 ATG12 9.30E-02 E2F1 5.12E-03 SIRT17.74E-02 CSE1L 9.76E-02 BECN1 5.88E-03 NAMPT 8.06E-02 SIRT1 9.92E-02FRAP1 7.79E-03 TCF3 9.30E-02 BCL2L1 1.15E-01 ATG7 1.09E-02 CSE1L9.39E-02 NAMPT 1.26E-01 ID2 1.18E-02 BCL2L1 1.15E-01 ATG3 1.47E-01 SIRT12.47E-02 STAT3 1.45E-01 ATG5 2.163-01 BCL2 2.56E-02 UVRAG 1.98E-01 STAT32.52E-01 BNIP3 2.56E-02 FRAP1 2.31E-01 UVRAG 2.70E-01 LAMP2 2.97E-02ATG3 2.46E-01 BCL2 2.81E-01 TKT 3.95E-02 ATG5 2.51E-01 BNIP3 2.96E-01RPS19BP1 5.62E-02 SATB1 2.60E-01 STAB1 3.11E-01 AKT1 5.72E-02 BNIP32.65E-01 FASLG 3.17E-01 FAS 5.98E-02 BCL2 2.81E-01 ULK1 3.23E-01 FASLG6.50E-02 CIAP2 3.00E-01 CASP3 3.39E-01 TCF3 8.11E-02 FASLG 3.17E-01FRAP1 3.61E-01 CIAP2 8.51E-02 CASP3 3.39E-01 CCNG2 3.66E-01 RAPTOR9.96E-02 ULK1 3.64E-01 PTEN 3.67E-01 LC3 1.02E-01 CCNG2 3.66E-01 SESN13.69E-01 CASP8 1.07E-01 PTEN 3.67E-01 AGER 4.09E-01 CSE1L 1.48E-01 SESN13.69E-01 FAS 4.15E-01 MMP9 1.49E-01 ID2 3.77E-01 CIAP2 4.23E-01 TWIST11.57E-01 AGER 3.89E-01 ID2 4.28E-01 CDH2 1.63E-01 CDH2 4.08E-01 TWIST14.50E-01 CDH1 1.94E-01 FAS 4.20E-01 CDH2 4.57E-01 XIAP 2.50E-01 TWIST14.50E-01 LC3 5.41E-01 DRAM 3.11E-01 RPS19BP1 4.59E-01 LAMP1 5.61E-01SESN3 3.35E-01 LAMP2 4.82E-01 RPS19BP1 5.67E-01 PRKAA1 3.53E-01 CASP85.31E-01 KIAA1967 5.68E-01 LAMP1 4.67E-01 MMP2 5.53E-01 SESN3 5.83E-01HMGB1 4.70E-01 SESN3 5.55E-01 PRKAA1 5.93E-01 NNMT 4.96E-01 KIAA19675.68E-01 MMP2 6.00E-01 CASP3 5.01E-01 PRKAA1 5.93E-01 XIAP 6.17E-01 PTEN5.30E-01 XIAP 6.17E-01 VEGF 6.25E-01 SATB1 5.36E-01 VEGF 6.25E-01 LAMP26.29E-01 CCNG2 5.89E-01 RAGE 6.67E-01 RAGE 6.67E-01 ATG5 5.94E-01 MMP97.01E-01 HMGB2 6.82E-01 BAX 6.21E-01 TP63 7.29E-01 MMP9 7.26E-01 TP636.40E-01 RAPTOR 7.33E-01 TP63 7.29E-01 RAGE 6.77E-01 LC3 7.35E-01 RAPTOR7.33E-01 KIAA1967 7.83E-01 E2F1 7.45E-01 DRAM 7.87E-01 CBS 7.85E-01SESN2 7.76E-01 CDH1 7.91E-01 BHLHE41 8.44E-01 CDH1 7.83E-01 BAX 7.94E-01SESN2 8.76E-01 HMGB2 7.88E-01 AIFM1 8.17E-01 ULK1 8.82E-01 BAX 7.94E-01E2F1 8.46E-01 MMP2 8.91E-01 LAMP1 7.98E-01 NNMT 8.71E-01 HMGB2 8.97E-01ATG7 8.14E-01 CASP8 8.73E-01 BCL2L1 9.37E-01 AIFM1 8.17E-01 AKT18.74E-01 SESN1 9.40E-01 CBS 8.42E-01 SESN2 8.80E-01 AIFM1 9.67E-01 NNMT8.71E-01 ATG7 9.31E-01 AGER 9.70E-01 DRAM 9.18E-01 BHLHE41 9.76E-01 ATG39.89E-01 BHLHE41 9.40E-01 CBS 9.98E-01 VEGF 9.97E-01 AKT1 9.88E-01

TABLE 39 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ATG3_HMGB1 1.03E-03 DIABLO_NAMPT 3.60E-05ATG3_BECN1 1.63E-03 ATG3_BECN1 1.69E-03 ATG12_ID2 4.08E-05 ATG3_HNGB14.45E-03 TKT_HMGB1 2.65E-03 ATG12_RPS19BP1 4.47E-05 BCL2L1_TKT 5.45E-03BCL2L1_TKT 5.45E-03 ATG12_DIABLO 4.65E-05 CSE1L_DIABLO 5.78E-03ATG3_NAMPT 6.43E-03 ID2_NAMPT 5.93E-05 BCL2_HMGB1 8.00E-03 BCL2_HMGB18.00E-03 DIABLO_STAT3 7.01E-05 ATG12_ATG3 8.21E-03 HMGB1_TWIST1 8.51E-03DIABLO_FAS 7.40E-05 ATG3_NAMPT 8.42E-03 ATG12_ATG3 8.56E-03 ATG12_CSE1L7.98E-05 HMGB1_TWIST1 8.51E-03 CSE1L_DIABLO 9.41`E-03 ATG12_MMP91.04E-04 TKT_HMGB1 9.93E-03 ATG3_TKT 1.01E-02 ATG12_ATG3 1.05E-04LAMP1_HMGB1 1.03E-02 LAMP1_HMGB1 1.03E-02 ATG12_SATB1 1.07E-04 TKT_BECN11.07E-02 TKT_BECN1 1.07E-02 ATG12_SESN2 1.24E-04 HMGB1_TP63 1.13E-02CDH1_HMGB1 1.13E-02 CSE1L_DIABLO 1.26E-04 BCL2_TKT 1.35E-02 HMGB1_TP631.13E-02 ATG12_TCF3 1.35E-04 TKT_CASP3 1.43E-02 TKT_NAMPT 1.29E-02ATG12_FAS 1.36E-04 FASLG_HMGB1 1.43E-02 BCL2_TKT 1.35E-02 ATG12_STAT31.45E-04 TKT_NAMPT 1.49E-02 CSE1L_TKT 1.35E-02 ATG12_NHLHE41 1.60E-04ATG5_HMGB1 1.52E-02 LC3_TKT 1.41E-02 ATG12_NAMPT 1.61E-04 HMGB1_SIRT11.55E-02 TKT_CASP3 1.43E-02 ATG12_ATG7 1.77E-04 ATG12_HMGB1 1.57E-02FASLG_HMGB1 1.43E-02 ID2_BECN1 1.78E-04 HMGB1_RAGE 1.60E-02 CDH2_HMGB11.47E-02 E2F1_FAS 1.81E-04 DIABLO_NAMPT 1.65E-02 ATG5_HMGB1 1.52E-02ATG12_ATG5 1.87E-04 HMGB1_UVRAG 1.66E-02 HMGB1_SIRT1 1.55E-02 ID2_STAT31.91E-04 DIABLO_BECN1 1.67E-02 ATG12_HMGB1 1.57E-02 ATG12_ULK1 2.09E-04BECN1_SATB1 1.70E-02 HMGB1_RAGE 1.60E-02 DIABLO_BECN1 2.39E-04BCL2L1_SIRT1 1.71E-02 HMGB1_UVRAG 1.66E-02 ATG12_LAMP1 2.42E-04BCL2L1_HMGB1 1.73E-02 BCL2L1_SIRT1 1.71E-02 ATG12_LC3 2.50E-04 TKT_SIRT11.73E-02 ATG3_TCF3 1.72E-02 DIABLO_TCF3 2.61E-04 DIABLO_TCF3 1.73E-02BCL2L1_HMGB1 1.73E-02 AKT1_ATG12 2.71E-04 HMGB1_LAMP2 1.75E-02 TKT_SIRT11.73E-02 ATG12_FRAP1 2.72E-04 DIABLO_SATB1 1.80E-02 HMGB1_LAMP2 1.75E-02DIABLO_ID2 2.88E-04 HMGB1_RAPTOR 1.87E-02 TKT_SESN2 1.81E-02 ID2_TCF33.27E-04 E2F1_HMGB1 1.87E-02 HMGB1_MMP2 1.84E-02 DIABLLO_SATB1 3.48E-04ATG5_BECN1 1.95E-02 TKT_AGER 1.86E-02 ATG12_BECN1 3.54E-04 ATG12_SATB11.99E-02 HMGB1_RAPTOR 1.87E-02 ATG12_SITRT1 3.57E-04 BCL2L1_BECN12.00E-02 E2F1_HMGB1 1.87E-02 NAMPT_STAT3 3.61E-04 CASP3_HMGB1 2.03E-02CASP8_HMGB1 1.91E-02 ATG12_BNIP3 3.77E-04 ATG12_CSE1L 2.03E-02 TKT_ID21.92E-02 DIABLO_MMP9 3.89E-04 ATG7_HMGB1 2.05E-02 AKT1_TKT 1.93E-02ATG12_UVRAG 4.34E-04 ATG3_SIRT1 2.05E-02 ATG3_SIRT1 1.96E-02DIABLO_FRAP1 4.45E-04 CASP8_HMGB1 2.17E-02 TKT_RPS19BP1 1.99E-02NAMPT_RPS19BP1 4.56E-04 ATG3_SESN1 2.21E-02 CSE1L_HMGB1 2.00E-02AKT1_NAMPT 4.68E-04 TKT_KIAA1967 2.23E-02 BCL2L1_BECN1 2.00E-02E2F1_UVRAG 5.27E-04 ATG12_BCL2L1 2.23E-02 CASP3_HMGB1 2.03E-02ATG3_DIABLO 5.44E-04 DRAM_HMGB1 2.26E-02 ATG7_HMGB1 2.05E-02 NAMPT_UVRAG5.49E-04 LC3_FASLG 2.26E-02 FRAP1_HMGB1 2.10E-02 BNIP3_DIABLO 5.58E-04HMGB1_KIAA1967 2.27E-02 HMGB1_HMGB2 2.11E-02 DIABLO_LC3 5.81E-04TKT_SESN1 2.28E-02 HMGB1_SATB1 2.19E-02 DIABLO_SIRT1 5.82E-04ATG3_DIABLO 2.33E-02 ATG3_ULK1 2.20E-02 LC3_NAMPT 6.27E-04 DIABLO_SIRT12.35E-02 ATG3_SESN1 2.21E-02 DIABLO_SESN2 6.38E-04 BENC1_HMGB1 2.41E-02CBS_HMGB1 2.22E-02 FAS_STAT3 6.42E-04 AIFM1_HMGB1 2.45E-02 TKT_KIAA19672.23E-02 FAS_NAMPT 7.04E-04 ID2_BECN1 2.49E-02 ATG12_BCL2L1 2.23E-02E2F1_NAMPT 7.36E-04 CSE1L_BECN1 2.52E-02 DRAM_HMGB1 2.26E-02 ATG12_SESN37.46E-04 TKT_ULK1 2.52E-02 LC3_FASLG 2.26E-02 BCL2_TKT 8.14E-04BNIP3_HMGB1 2.52E-02 HMGB1_KIAA1967 2.27E-02 ATG7_NAMPT 8.22E-04TKT_UVRAG 2.54E-02 TKT_SESN1 2.29E-02 ATG7_BECN1 8.79E-04 ATG5_TKT2.54E-02

TABLE 40 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ATG3_BCL2_HMGB1 1.17E-04 DIABLO_ID2_NAMPT8.10E-06 ATG3_BCL2_HMGB1 1.17E-04 ATG3_HMGB1_RAGE 2.50E-04DIABLO_FAS_NAMPT 9.84E-04 ATG3_HMGB1_RAGE 2.50E-04 ATG3_TKT_HMGB12.65E-04 ATG12_ID2_TCF3 1.07E-05 ATG3_HMGB1_UVRAG 3.65E-04ATG3_CDH1_HMGB1 3.47E-04 DIABLO_FAS_STAT3 1.32E-05 ATG3_CASP3_HMGB14.61E-04 ATG3_HMGB1_HMGB2 3.56E-04 ATG12_ID2_MMP9 1.36E-05ATG3_HMGB1_SIRT1 4.72E-04 ATG3_HMGB1_UVRAG 3.65E-04 ATG12_ID2_SATB11.63E-05 ATG3_BECN1_SATB1 4.80E-04 ATG3_CASP3_HMGB1 4.61E-04ATG12_ID2_RPS19BP1 1.70E-05 ATG3_HMGB1_LAMP2 5.94E-04 ATG3_HMGB1_SIRT14.72E-04 ATG12_CSE1L_ID2 1.83E-05 ATG3_HMGB1_RAPTOR 6.47E-04ATG3_BECN1_SATB1 4.93E-04 ATG12_DIABLO_FAS 1.87E-05 ATG3_LC3_BECN16.73E-04 ATG3_HMGB1_SATB1 5.71E-04 ATG12_ID2_SESN2 1.92e-05ATG3_HMGB1_KIAA1967 6.74E-04 ATG3_LC3_BECN1 5.77E-04 ATG12_ID2_NAMPT2.02E-05 BCL2L1_TKT_CASP3 6.77E-04 ATG3_HMGB1_LAMP2 5.94E-04ATG12_CSE1L_DIABLO 2.06E-05 ATG12_ATG3_HMGB1 7.34E-04 ATG3_HMGB1_RAPTOR6.47E-04 ID2_NAMP_STAT3 2.24E-05 BCL2L1_TKT_SIRT1 7.44E-04ATG3_HMGB1_KIAA1967 6.74E-04 ATG12_ID2_BHLHE41 2.27E-05 BCL2L1_TKT_BECN18.13E-04 BCL2L1_TKT_CASP3 6.77E-04 CSE1L_DIABLO_NAMPT 2.34E-05BCL2_TKT_HMGB1 8.79E-04 ATG12_ATG3_HMGB1 7.34E-04 DIABLO_L3_NAMPT2.39E-05 ATG3_BECN1_SESN3 8.82E-04 BCL2L1_TKT_SIRT1 7.44E-04ATG12_FAS_ID2 2.39E-05 ATG3_BNIP3_HMGB1 1.01E-03 ATG3_CIAP2_HMGB17.53E-04 ID2_NAMPT_RPS19BP1 2.39E-05 ATG3_BECN1_HMGB1 1.02E-03BCL2L1_TKT_BECN1 8.13E-04 ID2_MMP9_TCF3 2.43E-05 AIFM1_ATG3_HMGB11.03E-03 BCL2_TKT_HMGB1 8.79E-04 DIABLO_NAMPT_SATB1 2.43E-05ATG3_LAMP1_HMGB1 1.08E-03 ATG3_BECN1_SESN3 8.96E-04 ATG12_CSE1L_MMP92.49E-05 BCL2L1_TKT_FASLG 1.15E-03 ATG3_CASP8_HMGB1 9.58E-04ATG12_MMP9_RPS19BP1 2.49E-05 BCL2_BCL2L1_TKT 1.18E-03 ATG3_CDH2_HMGB19.62E-04 ID2_MMP9_BECN1 2.56E-05 TKT_HMGB1_TWIST1 1.19E-03ATG3_FRAP1_HMGB1 9.83E-04 DIABLO_NAMPT_STAT3 2.60E-05 ATG3_NNMT_HMGB11.23E-03 ATG3_BNIP3_HMGB1 1.01E-03 ATG12_DIABLO_MMP9 2.65E-05BCL2L1_TKT_HMGB1 1.30E-03 ATG3_BECN1_HMGB1 1.02E-03 ATG12_FAS_RPS19BP12.72E-05 ATG3_BCL2L1_BECN1 1.41E-03 ATG3_CBS_HMGB1 1.03E-03DIABLO_FAS_MMP9 2.73E-05 ATG5_TKT_HMGB1 1.44E-03 AIFM1_ATG3_HMGB11.03E-03 IS2_MMP9_NAMPT 2.74E-05 ATG3_FASLG_HMGB1 1.45E-03ATG3_HMGB1_STAT3 1.04E-03 ATG12_ID2_STAT3 2.79E-05 ATG3_MMP9_BECN11.46E-03 ATG3_HMGB1_MMP2 1.06E-03 ATG12_DIABLO_TCF3 2.82E-05ATG3_LAMP1_BECN1 1.51E-03 ATG3_LAMP1_HMGB1 1.08E-03 ATG12_ATG3_ID22.97E-05 ATG3_E2F1_HMGB1 1.56E-03 BCL2L1_TKT_FASLG 1.15E-03ATG12_DIABLO_ID2 2.98E-05 HMGB1_RAPTOR_TWIST1 1.56E-03 ATG3_IABLO_HMGB11.17E-03 CSE1L_DIABLO_STAT3 2.99E-05 AKT1_ATG3_BECN1 1.57E-03BCL2_BCL2L1_TKT 1.18E-03 DIABLO_ID2_STAT3 3.13E-05 ATG3_ULK1_HMGB11.59E-03 TKT_HMGB1_TWIST1 1.19E-03 ATG12_ATG3_RPS19BP1 3.22E-05TKT_HMGB1_SIRT1 1.60E-03 ATG3_NNMT_HMGB1 1.23E-03 ATG12_DIABLO_SATB13.25E-03 ATG3_BAX_HMGB1 1.61E-03 ATG3_MMP9_HMGB1 1.24E-03ATG12_MMP9_TCF3 3.29E-05 ATG3_PTEN_HMGB1 1.65E-03 BCL2L1_TKT_HMGB11.30E-03 ATG3_DIABLO_NAMPT 3.32E-05 ATG3_TKT_HMGB1 1.65E-03ATG3_LAMP1_BECN1 1.39E-03 ATG12_DIABLO_NAMPT 3.37E-05 ATG3_TKT_BECN11.65E-03 ATG3_BCL2L1_BECN1 1.41E-03 ATG12_CSE1L_RPS19BP1 3.38E-05ATG3_HMGB1_TWIST1 1.68E-03 ATG5_TKT_HMGB1 1.44E-03 DIABLO_MMP9_NAMPT3.42E-05 BCL2L1_TKT_UVRAG 1.68E-03 ATG3_FASLG_HMGB1 1.45E-03ATG12_ATG3_DIABLO 3.56E-05 TKT_HMGB1_UVRAG 1.71E-03 ATG3_MMP9_BECN11.48E-03 DIABLO_SATB1_STAT3 3.58E-05 BCL2L1_TKT_CDH2 1.72E-03ATG3_ATG7_BECN1 1.51E-03 ID2_TCF3_STAT3 3.70E-05 BCL2L1_TKT_KIAA19671.72E-05 ATG3_HMGB1_SESN3 1.54E-03 ATG12_RPS19BP1_SATB1 3.72E-05ATG3_BCL2L1_HMGB1 1.79E-03 ATG3_E2F1_HMGB1 1.56E-03 ATG12_DIABLO_STAT33.75E-05 ATG3_ATG5_HMGB1 1.79E-03 HMGB1_RAPTOR_TWIST1 1.56E-03ATG12_TCF3_RPS19BP1 3.85E-05 ATG3_DRAM_HMGB1 1.80E-03 AKT1_ATG3_BECN11.57E-03 IABLO_NAMPT_SESN2 3.87E-05 ATG3_HMGB1_SATB1 1.82E-03ATG3_FAS_HMGB1 1.59E-03 ATG12_DIABLO_SESN2 3.90E-05 ATG3_BCL2L1_TKT1.82E-03 ATG3_ULK1_HMGB1 1.59E-03 ATG12_ULK1_ID2 4.01E-05ATG3_PRKAA1_HMGB1 1.83E-03 TKT_HMGB1_SIRT1 1.60E-03 ATG12_ATG5_ID24.11E-05 TKT_CASP3_HMGB1 1.85E-03 ATG3_BAX_HMGB1 1.61E-03AKT1_DIABLO_NAMPT 4.11E-05 ATG3_XIAP_HMGB1 1.88E-03 TKT_CDH2_HMGB11.64E-03 ATG12_ID2_BECN1 4.13E-05 TKT_HMGB1_KIAA1967 1.89E-03ATG3_PTEN_HMGB1 1.65E-03 ATG12_FAS_MMP9 4.16E-05 TKT_HMGB1_LAMP21.92E-03 ATG3_TKT_BECN1 1.65E-03 AG12_DIABLO_BHLHE41 4.36E-05HMGB1_RAGE_TWIST1 1.92E-03 ATG3_HMGB1_TWIST1 1.68E-03ATG12_RPS19BP1_STAT3 4.39E-05 ATG12_BCL2L1_TKT 1.93E-03 BCL2L1_TKT_UVRAG1.68E-03 DIABLO_NAMPT_RPS19BP1 4.41E-05 ATG3_PTEN_BECN1 1.98E-03

TABLE 41 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ATG3_BCL2_CDH1_HMGB1 9.00E−06 ATG12_ID2_MMP9_TCF32.39E−06 ATG3_BCL2_CDH1_HMGB1 9.00E−06 ATG3_CDH1_HMGB1_UVRAG 3.63E−05DIABLO_FAS_ID2_NAMPT 3.68E−06 ATG3_CDH1_HMGB1_UVRAG 3.63E−05ATG3_BCL2_TKT_HMGB1 3.74E−05 ATG12_CSE1L_ID2_MMP9 4.73E−06ATG3_BCL2_TKT_HMGB1 3.74E−05 ATG3_BCL2_HMGB1_RAGE 3.84E−05DIABLO_ID2_MMP9_NAMPT 5.35E−06 ATG3_BCL2_HMGB1_RAGE 3.84E−05ATG3_BCL2_HMGB1_HMGB2 4.08E−05 DIABLO_FAS_MMP9_NAMPT 5.54E−06ATG3_BCL2_HMGB1_HMGB2 4.08E−05 ATG3_CDH1_HMGB1_SIRT1 4.40E−05DIABLO_ID2_NAMPT_STAT3 5.58E−06 ATG3_CDH1_HMGB1_SIRT1 4.40E−05ATG3_BCL2_HMGB1_MMP2 6.17E−05 ATG12_FAS_ID2_MMP9 5.58E−06ATG3_BCL2_HMGB1_MMP2 6.17E−05 ATG3_HMGB1_HMGB2_RAGE 6.79E−05ATG12_ID2_MMP9_SATB1 6.11E−06 ATG3_HMGB1_HMGB2_RAGE 6.79E−05ATG3_BCL2_BNIP3_HMGB1 7.60E−05 DIABLO_ID2_NAMPT_SATB1 6.14E−06ATG3_BCL2_BNIP3_HMGB1 7.60E−05 ATG3_CDH1_CASP3_HMGB1 7.97E−05ATG12_ID2_MMP9_SESN2 6.36E−06 ATG3_CDH1_CASP3_HMGB1 7.97E−05ATG3_CDH1_HMGB1_KIAA1967 8.12E−05 ATG12_ID2_MMP9_RPS19BP1 6.49E−06ATG3_CDH1_HMGB1_KIAA1967 8.12E−05 ATG3_HMGB1_RAGE_UVRAG 8.15E−05CSE1L_DIABLO_ID2_NAMPT 6.99E−06 ATG3_HMGB1_RAGE_UVRAG 8.15E−05ATG3_HMGB1_RAGE_SIRT1 8.54E−05 DIABLO_ID2_TCF3_NAMPT 7.48E−06ATG3_HMGB1_RAGE_SIRT1 8.54E−05 ATG3_TKT_HMGB1_HMGB2 8.71E−05DIABLO_FAS_NAMPT_SATB1 7.74E−06 ATG3_TKT_HMGB1_UVRAG 8.77E−05ATG3_TKT_HMGB1_UVRAG 8.77E−05 ATG12_DIABLO_FAS_MMP9 7.81E−06ATG3_BCL2_LAMP1_HMGB1 8.79E−05 ATG3_BCL2_LAMP1_HMGB1 8.79E−05DIABLO_FAS_ID2_STAT3 8.24E−06 ATG3_BCL2_HMGB1_RAPTOR 9.44E−05ATG3_BCL2_HMGB1_RAPTOR 9.44E−05 ATG12_ATG3_ID2_TCF3 8.26E−06AIFM1_ATG3_BCL2_HMGB1 1.02E−04 AIFM1_ATG3_BCL2_HMGB1 1.02E−04ATG3_DIABLO_ID2_NAMPT 8.33E−06 ATG3_CASP3_HMGB1_RAGE 1.03E−04ATG3_CASP3_HMGB1_RAGE 1.03E−04 ATG12_ID2_TCF3_STAT3 8.65E−06ATG12_ATG3_HMGB1_RAGE 1.07E−04 ATG12_ATG3_HMGB1_RAGE 1.07E−04DIABLO_FAS_NAMPT_STAT3 8.65E−06 ATG3_TKT_CASP3_HMGB1 1.08E−04ATG3_TKT_CASP3_HMGB1 1.08E−04 ATG12_CSE1L_DIABLO_MMP9 9.06E−06ATG3_TKT_HMGB1_KIAA1967 1.08E−04 ATG3_TKT_HMGB1_KIAA1967 1.08E−04ATG12_ID2_TCF3_SATB1 9.10E−06 ATG3_BCL2L1_TKT_BECN1 1.08E−04ATG3_BCL2L1_TKT_BECN1 1.08E−04 DIABLO_FAS_MMP9_STAT3 9.14E−06ATG12_ATG3_CDH1_HMGB1 1.09E−04 ATG12_ATG3_CDH1_HMGB1 1.09E−04ATG12_ID2_MMP9_BHLHE41 9.26E−06 ATG3_CDH1_HMGB1_RAGE 1.13E−04ATG3_CDH1_HMGB1_RAGE 1.13E−04 ATG12_BNIP3_ID2_MMP9 9.27E−06ATG3_BCL2_FRAP1_HMGB1 1.15E−04 ATG3_BCL2_FRAP1_HMGB1 1.15E−04DIABLO_FAS_SATB1_STAT3 9.29E−06 ATG3_BCL2_HMGB1_LAMP2 1.16E−04ATG3_BCL2_HMGB1_LAMP2 1.16E−04 DIABLO_FAS_NAMPT_RPS19BP1 9.36E−06ATG3_BCL2_DIABLO_HMGB1 1.17E−04 ATG3_BCL2_DIABLO_HMGB1 1.17E−04ATG12_ATG3_ID2_MMP9 9.52E−06 ATG3_TKT_HMGB1_SIRT1 1.17E−04ATG3_TKT_HMGB1_SIRT1 1.17E−04 ATG12_ID2_MMP9_NAMPT 9.68E−06ATG3_BCL2_CBS_HMGB1 1.20E−04 ATG3_BCL2_CBS_HMGB1 1.20E−04DIABLO_FAS_NAMPT_SESN2 9.81E−06 ATG3_BCL2_CASP8_HMGB1 1.24E−04ATG3_BCL2_CASP8_HMGB1 1.24E−04 DIABLO_ID2_NAMPT_SESN2 1.00E−05ATG3_BCL2_PTEN_HMGB1 1.28E−04 ATG3_HMGB1_HMGB2_SATB1 1.27E−04ATG12_ID2_TCF3_RPS19BP1 1.03E−05 ATG3_HMGB1_RAGE_RAPTOR 1.28E−04ATG3_BCL2_PTEN_HMGB1 1.28E−04 ATG12_DIABLO_MMP9_TCF3 1.04E−05ATG3_TKT_HMGB1_RAGE 1.28E−04 ATG3_HMGB1_RAGE_RAPTOR 1.28E−04ATG12_CSE1L_ID2_SATB1 1.05E−05 ATG3_BCL2_CASP3_HMGB1 1.35E−04ATG3_TKT_HMGB1_RAGE 1.28E−04 ATG12_FAS_MMP9_RPS19BP1 1.06E−05ATG3_BCL2_HMGB1_SATB1 1.37E−04 ATG3_BCL2_CASP3_HMGB1 1.35E−04ID2_MMP9_TCF3_STAT3 1.06E−05 ATG3_HMGB1_LAMP2_RAGE 1.39E−04ATG3_BCL2_HMGB1_SATB1 1.37E−04 ATG12_DIABLO_ID2_NAMPT 1.06E−05ATG3_CDH1_HMGB1_LAMP2 1.40E−04 ATG3_HMGB1_LAMP2_RAGE 1.39E−04DIABLO_ID2_TCF3_STAT3 1.07E−05 ATG3_HMGB1_HMGB2_UVRAG 1.41E−04ATG3_CDH1_HMGB1_LAMP2 1.40E−04 ATG12_ULK1_ID2_TCF3 1.08E−05ATG3_BCL2L1_TKT_HMGB1 1.42E−04 ATG3_HMGB1_HMGB2_UVRAG 1.41E−04ATG12_ID2_TCF3_SESN2 1.08E−05 CDH1_HMGB1_TP63_UVRAG 1.42E−04ATG3_BCL2L1_TKT_HMGB1 1.42E−04 BNIP3_CSE1L_DIABLO_MMP9 1.09E−05ATG3_BCL2L1_TKT_CASP3 1.44E−04 CDH1_HMGB1_TP63_UVRAG 1.42E−04ATG12_DIABLO_ID2_TCF3 1.13E−05 ATG3_HMGB1_KIAA1967_RAGE 1.48E−04ATG3_CDH1_HMGB1_HMGB2 1.43E−04 ATG12_ATG5_ID2_MMP9 1.14E−05ATG3_BCL2_DRAM_HMGB1 1.54E−04 ATG3_BCL2L1_TKT_CASP3 1.44E−04ATG12_ID2_SATB1_STAT3 1.14E−05 ATG3_BCL2_HMGB1_UVRAG 1.57E−04ATG3_HMGB1_KIAA1967_RAGE 1.48E−04 ATG12_MMP9_TCF3_RPS19BP1 1.16E−05BCL2_BCL2L1_TKT_CASP3 1.59E−04 ATG3_BCL2_DRAM_HMGB1 1.54E−04ATG12_DIABLO_FAS_ID2 1.17E−05 ATG3_TKT_BECN1_HMGB1 1.59E−04ATG3_LC3_TKT_HMGB1 1.57E−04 ATG12_CSE1L_ID2_SESN2 1.18E−05ATG3_TKT_HMGB1_LAMP2 1.60E−04 ATG3_BCL2_HMGB1_UVRAG 1.57E−04DIABLO_FAS_MMP9_TCF3 1.18E−05 ATG3_BCL2_PRKAA1_HMGB1 1.64E−04ATG3_CDH1_CDH2_HMGB1 1.58E−04 ATG12_ID2_TCF3_BHLHE41 1.19E−05BCL2L1_TKT_CASP3_SIRT1 1.64E−04 BCL2_BCL2L1_TKT_CASP3 1.59E−04ATG12_FAS_ID2_STAT3 1.19E−05 BCL2L1_TKT_CASP3_FASLG 1.64E−04ATG3_TKT_BECN1_HMGB1 1.59E−04 BNIP3_CSE1L_ID2_MMP9 1.20E−05BCL2L1_TKT_CASP3_CDH2 1.68E−04 ATG3_TKT_HMGB1_LAMP2 1.60E−04CSE1L_DIABLO_FAS_NAMPT 1.20E−05 ATG3_BCL2_NNMT_HMGB1 1.68E−04ATG3_BCL2_PRKAA1_HMGB1 1.64E−04 ATG12_CSE1L_ID2_TCF3 1.20E−05ATG3_CDH1_HMGB1_RAPTOR 1.72E−04 BCL2L1_TKT_CASP3_SIRT1 1.64E−04ATG12_ID2_NAMPT_RPS19BP1 1.20E−05 ATG3_BNIP3_HMGB1_RAGE 1.76E−04BCL2L1_TKT_CASP3_FASLG 1.64E−04 ATG12_ID2_MMP9_BECN1 1.22E−05ATG3_BAX_BCL2_HMGB1 1.79E−04 BCL2L1_TKT_CASP3_CDH2 1.68E−04DIABLO_FAS_LC3_NAMPT 1.25E−05 ATG3_BCL2_ID2_HMGB1 1.80E−04ATG3_BCL2_NNMT_HMGB1 1.68E−04 FAS_ID2_NAMPT_RPS19BP1 1.25E−05ATG3_BCL2_HMGB1_STAT3 1.81E−04 CDH1_ID2_MMP9_TCF3 1.45E−03

TABLE 42 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ATG3_BCL2_CDH1_HMGB1_RAGE 3.47E−06DIABLO_FAS_ID2_MMP9_ 1.76E−06 ATG3_BCL2_CDH1_HMGB1_RAGE 3.47E−06 NAMPTATG3_BCL2_CDH1_HMGB1_UVRAG 3.54E−06 ATG12_ATG3_ID2_MMP9_TCF3 1.80E−06ATG3_BCL2_CDH1_HMGB1_ 3.54E−06 UVRAG ATG3_BCL2_CDH1_HMGB1_SIRT1 3.82E−06ATG12_ID2_MMP9_TCF3_SATB1 2.20E−06 ATG3_BCL2_CDH1_HMGB1_SIRT1 3.82E−06ATG3_BCL2_CDH1_HMGB1_ 4.19E−06 ATG12_CSE1L_ID2_MMP9_TCF3 2.30E−06ATG3_BCL2_CDH1_HMGB1_ 4.19E−06 RAPTOR RAPTOR ATG3_BCL2_CDH1_HMGB1_HMGB24.20E−06 ATG12_BNIP3_ID2_MMP9_TCF3 2.40E−06 ATG3_BCL2_CDH1_HMGB1_4.20E−06 HMGB2 ATG3_BCL2_CDH1_HMGB1_ 4.40E−06 ATG12_ID2_MMP9_TCF3_SESN22.40E−06 ATG3_BCL2_CDH1_HMGB1_ 4.40E−06 KIAA1967 KIAA1967ATG3_BCL2_BNIP3_CDH1_HMGB1 5.13E−06 ATG12_ULK1_ID2_MMP9_TCF3 2.40E−06ATG3_BCL2_BNIP3_CDH1_ 5.13E−06 HMGB1 ATG3_BCL2_CDH1_HMGB1_LAMP2 5.17E−06ATG12_ATG5_ID2_MMP9_TCF3 2.80E−06 ATG3_BCL2_CDH1_HMGB1_ 5.17E−06 LAMP2ATG3_BCL2_CDH1_CDH2_HMGB1 5.94E−06 ATG12_FAS_ID2_MMP9_TCF3 2.80E−06ATG3_BCL2_CDH1_CDH2_HMGB1 5.94E−06 ATG3_CDH1_HMGB1_RAGE_SIRT1 6.16E−06DIABLO_FAS_ID2_NAMPT_ 2.85E−06 ATG3_CDH1_HMGB1_RAGE_ 6.16E−06 STAT3SIRT1 ATG3_BCL2_CDH1_CASP3_HMGB1 6.89E−06 ATG12_ID2_MMP9_TCF3_ 3.00E−06ATG3_BCL2_CDH1_CASP3_ 6.89E−06 RPS19BP1 HMGB1 ATG12_ATG3_BCL2_CDH1_HMGB17.15E−06 ATG12_BNIP3_ID2_MMP9_ 3.10E−06 ATG12_ATG3_BCL2_CDH1_ 7.15E−06RPS19BP1 HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1 7.44E−06 ATG12_CSE1L_ID2_MMP9_3.10E−06 AIFM1_ATG3_BCL2_CDH1_ 7.44E−06 SATB1 HMGB1ATG3_BCL2_CASP8_CDH1_HMGB1 8.17E−06 ATG12_CSE1L_ID2_MMP9_ 3.10E−06ATG3_BCL2_CASP8_CDH1_ 8.17E−06 SESN2 HMGB1 ATG3_BCL2_FRAP1_CDH1_HMGB18.58E−06 ATG12_LAMP1_ID2_MMP9_ 3.10E−06 ATG3_BCL2_FRAP1_CDH1_ 8.58E−06TCF3 HMGB1 ATG3_BCL2_CBS_CDH1_HMGB1 8.94E−06 DIABLO_FAS_ID2_NAMPT_3.16E−06 ATG3_BCL2_CBS_CDH1_HMGB1 8.94E−06 SATB1 ATG3_CDH1_HMGB1_RAGE_9.37E−06 ATG12_BNIP3_CSE1L_ID2_ 3.20E−06 ATG3_CDH1_HMGB1_RAGE_ 9.37E−06UVRAG MMP9 UVRAG ATG3_BCL2_TKT_HMGB1_HMGB2 9.94E−06DIABLO_ID2_MMP9_TCF3_ 3.28E−06 ATG3_BCL2_TKT_HMGB1_ 9.94E−06 NAMPT HMGB2ATG3_BCL2_CDH1_HMGB1_MMP2 9.96E−06 ATG12_BNIP3_ID2_MMP9_ 3.30E−06ATG3_BCL2_CDH1_HMGB1_ 9.96E−06 SATB1 MMP2 ATG3_BCL2_NNMT_CDH1_HMGB11.21E−05 ATG12_ID2_MMP9_TCF3_ 3.30E−06 ATG3_BCL2_NNMT_CDH1_ 1.21E−05BHLHE41 HMGB1 ATG3_BCL2_HMGB1_HMGB2_RAGE 1.25E−05ATG12_ID2_MMP9_TCF3_STAT3 3.40E−06 ATG3_BCL2_HMGB1_HMGB2_ 1.25E−05 RAGEATG3_BCL2_CDH1_MMP9_HMGB1 1.30E−05 ATG12_BNIP3_FAS_ID2_MMP9 3.50E−06ATG3_BCL2_CDH1_MMP9_ 1.30E−05 HMGB1 ATG12_ATG3_CDH1_HMGB1_RAGE 1.31E−05ATG12_BNIP3_ID2_MMP9_ 3.70E−06 ATG12_ATG3_CDH1_HMGB1_ 1.31E−05 SESN2RAGE ATG3_CDH1_HMGB1_LAMP2_SIRT1 1.38E−05 ATG12_ATG3_FAS_ID2_MMP93.80E−06 ATG3_CDH1_HMGB1_LAMP2_ 1.38E−05 SIRT1ATG3_BCL2_DIABLO_CDH1_HMGB1 1.42E−05 CSE1L_DIABLO_ID2_MMP9_ 3.80E−06ATG3_BCL2_DIABLO_CDH1_ 1.42E−05 NAMPT HMGB1 ATG3_BCL2L1_TKT_BECN1_CASP31.43E−05 ATG12_DIABLO_ID2_MMP9_ 3.90E−06 ATG3_BCL2L1_TKT_BECN1_ 1.43E−05TCF3 CASP3 ATG3_BCL2_HMGB1_MMP2_RAGE 1.50E−05 DIABLO_ID2_NAMPT_SATB1_3.95E−06 ATG3_BCL2_HMGB1_MMP2_ 1.50E−05 STAT3 RAGEATG3_CDH1_HMGB1_HMGB2_ 1.53E−05 ATG12_ATG3_CSE1L_ID2_ 4.00E−06ATG3_CDH1_HMGB1_HMGB2_ 1.53E−05 UVRAG MMP9 UVRAGATG3_BCL2_DRAM_CDH1_HMGB1 1.56E−05 ATG12_FAS_ID2_MMP9_ 4.00E−06ATG3_BCL2_DRAM_CDH1_ 1.56E−05 RPS19BP1 HMGB1 ATG3_BCL2_TKT_CDH1_HMGB11.60E−05 ATG12_DIABLO_FAS_ID2_ 4.10E−06 ATG3_BCL2_TKT_CDH1_HMGB11.60E−05 MMP9 ATG3_BCL2_TKT_CASP3_HMGB1 1.60E−05 DIABLO_FAS_ID2_MMP9_4.15E−06 ATG3_BCL2_TKT_CASP3_HMGB1 1.60E−05 STAT3ATG3_CDH1_HMGB1_KIAA1967_ 1.70E−05 ATG12_CSE1L_ID2_MMP9_ 4.20E−06ATG3_CDH1_HMGB1_KIAA1967_ 1.70E−05 UVRAG BHLHE41 UVRAGATG3_CDH1_HMGB1_LAMP2_ 1.74E−05 DIABLO_ID2_MMP9_NAMPT_ 4.22E−06ATG3_CDH1_HMGB1_LAMP2_ 1.74E−05 UVRAG STAT3 UVRAGATG3_BCL2_BCL2L1_TKT_HMGB1 1.75E−05 DIABLO_FAS_ID2_NAMPT_ 4.26E−06ATG3_BCL2_BCL2L1_TKT_ 1.75E−05 SESN2 HMGB1 ATG3_BCL2_CDH1_HMGB1_SATB11.75E−05 ATG12_CSE1L_FAS_ID2_MMP9 4.30E−06 ATG3_BCL2_CDH1_HMGB1_1.75E−05 SATB1 ATG3_BCL2L1_TKT_HMGB1_SIRT1 1.77E−05 DIABLO_FAS_ID2_TCF3_4.36E−06 ATG3_BCL2L1_TKT_HMGB1_ 1.77E−05 NAMPT SIRT1ATG3_BCL2_TKT_ID2_HMGB1 1.79E−05 ATG12_ATG3_ID2_MMP9_ 4.50E−06ATG3_BCL2_TKT_ID2_HMGB1 1.79E−05 SATB1 ATG3_CDH1_HMGB1_KIAA1967_1.80E−05 ATG12_BNIP3_ID2_MMP9_ 4.50E−06 ATG3_CDH1_HMGB1_KIAA1967_1.80E−05 RAGE BHLHE41 RAGE ATG3_BCL2_PTEN_CDH1_HMGB1 1.88E−05ATG3_DIABLO_FAS_ID2_ 4.60E−06 ATG3_BCL2_PTEN_CDH1_HMGB1 1.88E−05 NAMPTAIFM1_ATG3_CDH1_HMGB1_SIRT1 1.90E−05 CSE1L_DIABLO_FAS_ID2_ 4.63E−06AIFM1_ATG3_CDH1_HMGB1_ 1.90E−05 NAMPT SIRT1 ATG3_BCL2_CDH1_HMGB1_STAT31.91E−05 ATG12_CSE1L_ID2_MMP9_ 4.70E−06 ATG3_BCL2_CDH1_HMGB1_ 1.91E−05RPS19BP1 STAT3 ATG3_CDH1_CASP3_HMGB1_RAGE 1.93E−05 ATG12_CSE1L_ULK1_ID2_4.70E−06 ATG3_CDH1_CASP3_HMGB1_ 1.93E−05 MMP9 RAGEATG3_BCL2_LC3_TKT_HMGB1 1.94E−05 DIABLO_FAS_ID2_MMP9_TCF3 4.73E−06ATG3_BCL2_LC3_TKT_HMGB1 1.94E−05 ATG3_CDH1_CASP3_HMGB1_ 1.95E−05CSE1L_DIABLO_ID2_NAMPT_ 4.75E−06 ATG3_CDH1_CASP3_HMGB1_ 1.95E−05 UVRAGSTAT3 UVRAG ATG3_BCL2_CDH1_CIAP2_HMGB1 2.00E−05 ATG12_ATG3_ID2_MMP9_4.80E−06 ATG3_BCL2_CDH1_CIAP2_ 2.00E−05 SESN2 HMGB1ATG3_BCL2_BNIP3_HMGB1_RAGE 2.00E−05 DIABLO_ID2_MMP9_TCF3_ 4.81E−06ATG3_BCL2_BNIP3_HMGB1_ 2.00E−05 STAT3 RAGE ATG3_CDH1_HMGB1_RAPTOR_2.00E−05 DIABLO_ID2_TCF3_NAMPT_ 4.84E−06 ATG3_CDH1_HMGB1_RAPTOR_2.00E−05 SIRT1 SATB1 SIRT1 ATG3_CDH1_HMGB1_SIRT1_UVRAG 2.06E−05CSE1L_DIABLO_FAS_MMP9_ 4.94E−06 ATG3_CDH1_HMGB1_SIRT1_ 2.06E−05 NAMPTUVRAG ATG3_CDH1_HMGB1_RAPTOR_ 2.11E−05 DIABLO_FAS_ID2_NAMPT_ 4.95E−06ATG3_CDH1_HMGB1_RAPTOR_ 2.11E−05 UVRAG RPS19BP1 UVRAGATG3_CDH1_HMGB1_KIAA1967_ 2.13E−05 BNIP3_DIABLO_FAS_ID2_ 4.97E−06ATG3_CDH1_HMGB1_KIAA1967_ 2.13E−05 SIRT1 MMP9 SIRT1ATG3_BAX_BCL2_CDH1_HMGB1 2.16E−05 DIABLO_ID2_MMP9_NAMPT_ 4.99E−06ATG3_BAX_BCL2_CDH1_HMGB1 2.16E−05 SATB1 ATG3_BCL2_LAMP1_CDH1_HMGB12.18E−05 ATG12_DIABLO_FAS_MMP9_ 5.00E−06 ATG3_BCL2_LAMP1_CDH1_ 2.18E−05TCF3 HMGB1 ATG3_ATG5_BCL2_CDH1_HMGB1 2.24E−05 ATG12_ATG5_FAS_ID2_MMP95.10E−06 ATG3_ATG5_BCL2_CDH1_HMGB1 2.24E−05 ATG3_BCL2_TKT_HMGB1_RAGE2.24E−05 ATG12_LC3_ID2_MMP9_TCF3 5.10E−06 ATG3_BCL2_TKT_HMGB1_RAGE2.24E−05 ATG3_CDH1_HMGB1_SATB1_ 2.32E−05 ATG12_FAS_ID2_MMP9_STAT35.20E−06 ATG3_CDH1_HMGB1_SATB1_ 2.32E−05 UVRAG UVRAGATG3_BCL2_CDH1_HMGB1_SESN3 2.33E−05 FAS_ID2_MMP9_NAMPT_ 5.21E−06ATG3_BCL2_CDH1_HMGB1_ 2.33E−05 RPS19BP1 ATG3_BCL2_FAS_CDH1_HMGB12.34E−05 ATG12_ID2_MMP9_TCF3_ 5.40E−06 ATG3_BCL2_FAS_CDH1_HMGB1 2.34E−05BECN1 CDH1_ID2_MMP9_TCF3_FASLG 7.12E−03 ATG12_CDH1_ID2_MMP9_TCF32.10E−04 CDH1_ID2_MMP9_TCF3_FASLG 7.12E−03

TABLE 43 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ATG3_BCL2_CDH1_HMGB1_RAGE_ 1.52E−06DIABLO_FAS_ID2_MMP9_ 1.47E−06 ATG3_BCL2_CDH1_HMGB1_ 1.52E−06 RAPTORTCF3_NAMPT RAGE_RAPTOR ATG3_BCL2_BNIP3_CDH1_HMGB1_ 1.55E−06ATG12_ATG3_BNIP3_ID2_ 1.60E−06 ATG3_BCL2_BNIP3_CDH1_ 1.55E−06 RAGEMMP9_TCF3 HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_HMGB2_ 1.57E−06ATG12_BNIP3_CSE1L_ID2_ 1.60E−06 ATG3_BCL2_CDH1_HMGB1_ 1.57E−06 RAGEMMP9_SATB1 HMGB2_RAGE ATG3_BCL2_CDH1_HMGB1_KIAA1967_ 1.61E−06ATG12_ATG3_ID2_MMP9_ 1.70E−06 ATG3_BCL2_CDH1_HMGB1_ 1.61E−06 RAGETCF3_SATB1 KIAA1967_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_ 1.62E−06DIABLO_FAS_ID2_MMP9_ 1.78E−06 ATG3_BCL2_CDH1_HMGB1_ 1.62E−06 SIRT1NAMPT_SATB1 RAGE_SIRT1 ATG3_BCL2_CDH1_HMGB1_HMGB2_ 1.81E−06ATG12_ATG3_ULK1_ID2_ 1.80E−06 ATG3_BCL2_CDH1_HMGB1_ 1.81E−06 RAPTORMMP9_TCF3 HMGB2_RAPTOR ATG3_BCL2_CDH1_CDH2_HMGB1_ 1.82E−06ATG12_BNIP3_CSE1L_ID2_ 1.80E−06 ATG3_BCL2_CDH1_CDH2_ 1.82E−06 RAGEMMP9_SESN2 HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_RAGE_ 2.07E−06DIABLO_FAS_ID2_MMP9_ 1.83E−06 ATG3_BCL2_CDH1_HMGB1_ 2.07E−06 UVRAGNAMPT_STAT3 RAGE_UVRAG ATG3_BCL2_CDH1_CASP3_HMGB1_ 2.08E−06ATG12_ATG3_FAS_ID2_ 1.90E−06 ATG3_BCL2_CDH1_CASP3_ 2.08E−06 RAGEMMP9_TCF3 HMGB1_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_ 2.08E−06ATG12_ATG3_ID2_MMP9_ 1.90E−06 AIFM1_ATG3_BCL2_CDH1_ 2.08E−06 SIRT1TCF3_SESN2 HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_ 2.08E−06ATG12_BNIP3_CSE1L_ID2_ 1.90E−06 ATG3_BCL2_BNIP3_CDH1_ 2.08E−06 UVRAGMMP9_TCF3 HMGB1_UVRAG ATG12_ATG3_BCL2_CDH1_HMGB1_ 2.28E−06CSE1L_DIABLO_FAS_ID2_ 1.94E−06 ATG12_ATG3_BCL2_CDH1_ 2.28E−06 RAGEMMP9_NAMPT HMGB1_RAGE ATG3_BCL2_CDH1_HMGB1_HMGB2_ 2.34E−06ATG12_ATG3_CSE1L_ID2_ 2.00E−06 ATG3_BCL2_CDH1_HMGB1_ 2.34E−06 UVRAGMMP9_TCF3 HMGB2_UVRAG ATG3_BCL2_CDH1_HMGB1_LAMP2_ 2.42E−06ATG12_BNIP3_ID2_MMP9_ 2.00E−06 ATG3_BCL2_CDH1_HMGB1_ 2.42E−06 RAGETCF3_SATB1 LAMP2_RAGE ATG3_BCL2_CDH1_HMGB1_HMGB2_ 2.48E−06DIABLO_FAS_ID2_MMP9_ 2.02E−06 ATG3_BCL2_CDH1_HMGB1_ 2.48E−06 LAMP2NAMPT_SESN2 HMGB2_LAMP2 ATG3_BCL2_CDH1_CDH2_HMGB1_ 2.49E−06ATG12_BNIP3_CSE1L_ID2_ 2.10E−06 ATG3_BCL2_CDH1_CDH2_ 2.49E−06 HMGB2MMP9_BHLHE41 HMGB1_HMGB2 ATG3_BCL2_BCL2L1_TKT_CASP3_ 2.50E−06ATG12_BNIP3_ID2_MMP9_ 2.10E−06 ATG3_BCL2_BCL2L1_TKT_ 2.50E−06 HMGB1TCF3_RPS19BP1 CASP3_HMGB1 AIFM1_ATG3_BCL2_CDH1_HMGB1_ 2.57E−06DIABLO_FAS_ID2_MMP9_ 2.10E−06 AIFM1_ATG3_BCL2_CDH1_ 2.57E−06 UVRAGTCF3_STAT3 HMGB1_UVRAG ATG3_BCL2_CDH1_HMGB1_HMGB2_ 2.59E−06ATG12_ATG3_BNIP3_FAS_ 2.20E−06 ATG3_BCL2_CDH1_HMGB1_ 2.59E−06 KIAA1967ID2_MMP9 HMGB2_KIAA1967 ATG3_BCL2_BNIP3_CDH1_HMGB1_ 2.71E−06ATG12_ATG3_BNIP3_ID2_ 2.20E−06 ATG3_BCL2_BNIP3_CDH1_ 2.71E−06 HMGB2MMP9_SATB1 HMGB1_HMGB2 ATG12_ATG3_CDH1_HMGB1_RAGE_ 2.73E−06ATG12_BNIP3_CSE1L_ID2_ 2.20E−06 ATG12_ATG3_CDH1_HMGB1_ 2.73E−06 SIRT1MMP9_RPS19BP1 RAGE_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_ 2.75E−06ATG12_BNIP3_DIABLO_FAS_ 2.20E−06 ATG3_BCL2_BNIP3_CDH1_ 2.75E−06 RAPTORID2_MMP9 HMGB1_RAPTOR ATG3_BCL2_DRAM_CDH1_HMGB1_ 2.81E−06ATG12_BNIP3_FAS_ID2_ 2.20E−06 ATG3_BCL2_DRAM_CDH1_ 2.81E−06 SIRT1MMP9_RPS19BP1 HMGB1_SIRT1 ATG3_BCL2_BNIP3_CDH1_HMGB1_ 2.86E−06ATG12_CSE1L_ID2_MMP9_ 2.20E−06 ATG3_BCL2_BNIP3_CDH1_ 2.86E−06 LAMP2TCF3_SATB1 HMGB1_LAMP2 AIFM1_ATG3_BCL2_CDH1_HMGB1_ 2.94E−06ATG12_CSE1L_ULK1_ID2_ 2.20E−06 AIFM1_ATG3_BCL2_CDH1_ 2.94E−06 RAGEMMP9_TCF3 HMGB1_RAGE ATG3_BCL2_BNIP3_CDH1_HMGB1_ 2.98E−06ATG12_FAS_ID2_MMP9_ 2.20E−06 ATG3_BCL2_BNIP3_CDH1_ 2.98E−06 KIAA1967TCF3_RPS19BP1 HMGB1_KIAA1967 ATG3_BCL2_CDH1_HMGB1_MMP2_ 3.01E−06DIABLO_FAS_ID2_NAMPT_ 2.27E−06 ATG3_BCL2_CDH1_HMGB1_ 3.01E−06 RAGESATB1_STAT3 MMP2_RAGE AIFM1_ATG3_BCL2_CDH1_HMGB1_ 3.07E−06ATG12_ATG5_BNIP3_ID2_ 2.30E−06 AIFM1_ATG3_BCL2_CDH1_ 3.07E−06 HMGB2MMP9_TCF3 HMGB1_HMGB2 ATG3_BCL2_CDH1_HMGB1_HMGB2_ 3.10E−06ATG12_BNIP3_ID2_MMP9_ 2.30E−06 ATG3_BCL2_CDH1_HMGB1_ 3.10E−06 SIRT1TCF3_SESN2 HMGB2_SIRT1 ATG3_BCL2_CDH1_HMGB1_MMP2_ 3.12E−06ATG12_CSE1L_ID2_MMP9_ 2.30E−06 ATG3_BCL2_CDH1_HMGB1_ 3.12E−06 UVRAGTCF3_SESN2 MMP2_UVRAG ATG3_BCL2_CASP8_CDH1_HMGB1_ 3.14E−06ATG12_ID2_MMP9_TCF3_ 2.30E−06 ATG3_BCL2_CASP8_CDH1_ 3.14E−06 RAGESATB1_SESN2 HMGB1_RAGE ATG3_CDH1_HMGB1_LAMP2_RAGE_ 3.15E−06ATG12_ULK1_ID2_MMP9_ 2.30E−06 ATG3_CDH1_HMGB1_LAMP2_ 3.15E−06 SIRT1TCF3_SATB1 RAGE_SIRT1 ATG3_BCL2_DRAM_CDH1_HMGB1_ 3.17E−06ATG12_ATG3_ATG5_ID2_ 2.40E−06 ATG3_BCL2_DRAM_CDH1_ 3.17E−06 UVRAGMMP9_TCF3 HMGB1_UVRAG ATG3_BCL2_PTEN_CDH1_HMGB1_SIRT1 3.20E−06ATG12_ATG3_BNIP3_CSE1L_ 2.40E−06 ATG3_BCL2_PTEN_CDH1_ 3.20E−06 ID2_MMP9HMGB1_SIRT1 ATG3_BCL2_BCL2L1_TKT_HMGB1_ 3.25E−06 ATG12_ATG3_LAMP1_ID2_2.40E−06 ATG3_BCL2_BCL2L1_TKT_ 3.25E−06 SIRT1 MMP9_TCF3 HMGB1_SIRT1ATG3_BCL2_BNIP3_CDH1_HMGB1_ 3.26E−06 ATG12_BNIP3_DIABLO_ID2_ 2.40E−06ATG3_BCL2_BNIP3_CDH1_ 3.26E−06 SIRT1 MMP9_TCF3 HMGB1_SIRT1ATG3_BCL2_FRAP1_CDH1_HMGB1_ 3.33E−06 ATG12_BNIP3_ULK1_ID2_ 2.40E−06ATG3_BCL2_FRAP1_CDH1_ 3.33E−06 RAGE MMP9_TCF3 HMGB1_RAGEAIFM1_ATG3_BCL2_CDH1_HMGB1_ 3.33E−06 ATG12_DIABLO_FAS_ID2_ 2.40E−06AIFM1_ATG3_BCL2_CDH1_ 3.33E−06 KIAA1967 MMP9_TCF3 HMGB1_KIAA1967ATG3_BCL2_CDH1_HMGB1_LAMP2_ 3.34E−06 ATG12_ULK1_ID2_MMP9_ 2.40E−06ATG3_BCL2_CDH1_HMGB1_ 3.34E−06 RAPTOR TCF3_SESN2 LAMP2_RAPTORATG3_CDH1_HMGB1_RAGE_SIRT1_ 3.37E−06 ATG3_DIABLO_FAS_ID2_ 2.40E−06ATG3_CDH1_HMGB1_RAGE_ 3.37E−06 UVRAG MMP9_NAMPT SIRT1_UVRAGATG3_BCL2_CBS_CDH1_HMGB1_RAGE 3.44E−06 ATG12_ATG3_BNIP3_ID2_ 2.50E−06ATG3_BCL2_CBS_CDH1_ 3.44E−06 MMP9_SESN2 HMGB1_RAGEATG3_BCL2_FRAP1_CDH1_HMGB1_ 3.49E−06 ATG12_ATG3_ID2_MMP9_ 2.50E−06ATG3_BCL2_FRAP1_CDH1_ 3.49E−06 UVRAG TCF3_BHLHE41 HMGB1_UVRAGATG3_BCL2_CBS_CDH1_HMGB1_ 3.51E−06 ATG12_BNIP3_CSE1L_FAS_ 2.50E−06ATG3_BCL2_CBS_CDH1_ 3.51E−06 UVRAG ID2_MMP9 HMGB1_UVRAGATG3_CDH1_HMGB1_HMGB2_RAGE_ 3.61E−06 DIABLO_ID2_MMP9_TCF3_ 2.55E−06ATG3_CDH1_HMGB1_HMGB2_ 3.61E−06 SIRT1 NAMPT_SATB1 RAGE_SIRT1AIFM1_ATG3_BCL2_CDH1_HMGB1_ 3.61E−06 ATG12_ATG3_BNIP3_ID2_ 2.60E−06AIFM1_ATG3_BCL2_CDH1_ 3.61E−06 RAPTOR MMP9_RPS19BP1 HMGB1_RAPTORATG3_BCL2_CDH1_HMGB1_KIAA1967_ 3.63E−06 ATG12_ATG5_ID2_MMP9_ 2.60E−06ATG3_BCL2_CDH1_HMGB1_ 3.63E−06 RAPTOR TCF3_SATB1 KIAA1967_RAPTORATG3_BCL2_BCL2L1_TKT_ID2_CASP3 3.64E−06 ATG12_BNIP3_FAS_ID2_ 2.60E−06ATG3_BCL2_BCL2L1_TKT_ 3.64E−06 MMP9_TCF3 ID2_CASP3ATG3_BCL2_CDH1_HMGB1_RAPTOR_ 3.66E−06 ATG12_ATG3_CSE1L_ID2_ 2.70E−06ATG3_BCL2_CDH1_HMGB1_ 3.66E−06 UVRAG MMP9_SATB1 RAPTOR_UVRAGATG3_BCL2_CASP8_CDH1_HMGB1_ 3.66E−06 ATG12_ATG3_ID2_MMP9_ 2.70E−06ATG3_BCL2_CASP8_CDH1_ 3.66E−06 HMGB2 TCF3_STAT3 HMGB1_HMGB2ATG12_ATG3_BCL2_CDH1_HMGB1_ 3.70E−06 ATG12_ATG5_BNIP3_ID2_ 2.70E−06ATG12_ATG3_BCL2_CDH1_ 3.70E−06 HMGB2 MMP9_SATB1 HMGB1_HMGB2ATG3_BCL2_FRAP1_CDH1_HMGB1_ 3.71E−06 ATG12_BNIP3_ID2_MMP9_ 2.70E−06ATG3_BCL2_FRAP1_CDH1_ 3.71E−06 SIRT1 TCF3_BHLHE41 HMGB1_SIRT1ATG3_BCL2_CDH1_HMGB1_MMP2_ 3.76E−06 ATG12_FAS_ID2_MMP9_ 2.70E−06ATG3_BCL2_CDH1_HMGB1_ 3.76E−06 SIRT1 TCF3_SESN2 MMP2_SIRT1AIFM1_ATG3_CDH1_HMGB1_RAGE_ 3.87E−06 DIABLO_FAS_ID2_MMP9_ 2.73E−06AIFM1_ATG3_CDH1_HMGB1_ 3.87E−06 SIRT1 NAMPT_RPS19BP1 RAGE_SIRT1ATG3_BCL2_FRAP1_CDH1_HMGB1_ 3.94E−06 ATG12_ATG3_CSE1L_ID2_ 2.80E−06ATG3_BCL2_FRAP1_CDH1_ 3.94E−06 HMGB2 MMP9_SESN2 HMGB1_HMGB2ATG3_BCL2_CBS_CDH1_HMGB1_SIRT1 3.98E−06 ATG12_ATG3_ID2_MMP9_ 2.80E−06ATG3_BCL2_CBS_CDH1_ 3.98E−06 TCF3_RPS19BP1 HMGB1_SIRT1ATG3_BCL2_CASP8_CDH1_HMGB1_ 4.00E−06 ATG12_ATG5_BNIP3_FAS_ 2.80E−06ATG3_BCL2_CASP8_CDH1_ 4.00E−06 UVRAG ID2_MMP9 HMGB1_UVRAGATG3_BCL2_PTEN_CDH1_HMGB1_ 4.01E−06 ATG12_ATG5_ULK1_ID2_ 2.80E−06ATG3_BCL2_PTEN_CDH1_ 4.01E−06 UVRAG MMP9_TCF3 HMGB1_UVRAGATG12_ATG3_CDH1_ID2_MMP9_TCF3 7.76E−04 E2F1_FAS_CDH1_ID2_MMP9_ 7.98E−05ATG12_ATG3_CDH1_ID2_ 1.32E−03 TCF3 MMP9_TCF3

TABLE 44 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR 6.40E−07DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1 1.26E−06ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_RAPTOR 6.40E−07ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE 7.49E−07ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1 1.30E−06ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE 7.49E−07ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR 7.69E−07ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SESN2 1.40E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR 7.69E−07ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE 7.99E−07ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1 1.40E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE 7.99E−07ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE 8.59E−07ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3 1.50E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_RAGE 8.59E−07AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 8.85E−07DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2 1.59E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_SIRT1 8.85E−07ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE 9.52E−07ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_BHLHE41 1.60E−06ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_RAGE 9.52E−07ATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 9.81E−07ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SESN2 1.60E−06ATG3_BCL2_DRAM_CDH1_HMGB1_RAGE_SIRT1 9.81E−07ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG 9.88E−07ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3 1.60E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_UVRAG 9.88E−07ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 9.95E−07ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1 1.60E−06ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2 9.95E−07ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 1.01E−06ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1 1.60E−06ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_SIRT1 1.01E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 1.05E−06DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_STAT3 1.62E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_SIRT1 1.05E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE 1.06E−06DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_STAT3 1.65E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_LAMP2_RAGE 1.06E−06ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE 1.08E−06ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3 1.68E−06ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_RAGE 1.08E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 1.13E−06ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1 1.70E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 1.13E−06ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE 1.15E−06ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3 1.70E−06ATG3_BCL2_CDH1_HMGB1_HMGB2_LAMP2_RAGE 1.15E−06ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE 1.15E−06ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_RPS19BP1 1.70E−06ATG12_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE 1.15E−06ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 1.16E−06ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SATB1 1.70E−06ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_KIAA1967 1.16E−06ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 1.17E−06ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1 1.70E−06ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1 1.17E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE 1.18E−06ATG12_BNIP3_CSE1L_ID2_MMP9_SATB1_SESN2 1.70E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE 1.18E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 1.18E−06ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1 1.70E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2 1.18E−06ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE 1.22E−06ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3 1.70E−06ATG12_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE 1.22E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_UVRAG 1.22E−06ATG12_ATG3_ID2_MMP9_TCF3_SATB1_SESN2 1.74E−06ATG3_BCL2_BCL2L1_IKT_CASP3_HMGB1_UVRAG 1.22E−06ATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE 1.23E−06DIABLO_FAS_ID2_MMP9_TCF3_SATB1_STAT3 1.79E−06ATG3_BCL2_CDH1_HMGB1_KIAA1967_MMP2_RAGE 1.23E−06AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE 1.23E−06ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9 1.80E−06AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE 1.23E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 1.24E−06ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9 1.80E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_KIAA1967 1.24E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAPTOR 1.25E−06ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41 1.80E−06ATG3_BCL2_BCL2L1_IKT_CASP3_HMGB1_RAPTOR 1.25E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE 1.25E−06ATG12_BNIP3_CSE1L_DIABLO_FAS_ID2_MMP9 1.80E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE 1.25E−06ATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 1.26E−06ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SESN2 1.80E−06ATG3_BCL2_BCL2L1_TKT_ID2_HMGB2_SIRT1 1.26E−06ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 1.27E−06CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_STAT3 1.81E−06ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 1.27E−06AIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE 1.27E−06ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9 1.89E−06AIFM1_ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE 1.27E−06ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR 1.29E−06ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SATB1 1.90E−06ATG3_BCL2_CDH1_HMGB1_KIAA1967_RAGE_RAPTOR 1.29E−06ATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE 1.29E−06ATG12_ATG3_ULK1_ID2_MMP9_TCF3_SESN2 1.90E−06ATG3_BCL2_DRAM_CDH1_CASP3_HMGB1_RAGE 1.29E−06ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE 1.29E−06ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SESN2 1.90E−06ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_RAGE 1.29E−06ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 1.30E−06ATG12_ATG5_BNIP3_ID2_MMP9_TCF3_SATB1 1.90E−06ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 1.30E−06ATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 1.30E−06ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SESN2 1.90E−06ATG3_TKT_HMGB1_HMGB2_KIAA1967_RAGE_TWIST1 1.30E−06ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 1.32E−06ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3 1.90E−06ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2 1.32E−06ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG 1.33E−06ATG12_BNIP3_ID2_MMP9_TCF3_RPS19BP1_SATB1 1.90E−06ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_UVRAG 1.33E−06AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE 1.34E−06ATG12_ATG3_FAS_ID2_MMP9_TCF3_SATB1 1.91E−06AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_RAGE 1.34E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_LAMP2 1.34E−06ATG12_ATG3_FAS_ID2_MMP9_TCF3_RPS19BP1 1.91E−06ATG3_BCL2_BCL2L1_IKT_CASP3_HMGB1_LAMP2 1.34E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR 1.34E−06ATG12_ATG3_FAS_ID2_MMP9_TCF3_SESN2 1.91E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAPTOR 1.34E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR 1.34E−06ATG12_ATG3_FAS_ULK1_ID2_MMP9_TCF3 1.91E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_RAGE_RAPTOR 1.34E−06ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE 1.35E−06ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_SATB1 1.93E−06ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE 1.35E−06ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG 1.35E−06ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_RPS19BP1 2.00E−06ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_UVRAG 1.35E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR 1.36E−06ATG12_ATG3_CSE1L_ID2_MMP9_TCF3_SESN2 2.00E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAPTOR 1.36E−06ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE 1.38E−06ATG12_ATG3_CSE1L_ULK1_ID2_MMP9_TCF3 2.00E−06ATG3_BCL2_BNIP3_CASP8_CDH1_HMGB1_RAGE 1.38E−06ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG 1.38E−06ATG12_BNIP3_CSE1L_FASJ_D2_MMP9_RPS19BP1 2.00E−06ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_UVRAG 1.38E−06ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 1.39E−06ATG12_BNIP3_CSE1L_ID2_MMP9_BHLHE41_SATB1 2.00E−06ATG3_BCL2_BCL2L1_TKT_HMGB1_HMGB2_SIRT1 1.39E−06ATG3_BCL2_BCL2L1_IKT_CASP3_HMGB1_RAGE 1.40E−06ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_BHLHE41 2.00E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE 1.40E−06AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG 1.42E−06ATG12_BNIP3_ID2_MMP9_TCF3_SATB1_SESN2 2.00E−06AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_UVRAG 1.42E−06ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 1.43E−06ATG12_BNIP3_ULK1_ID2_MMP9_TCF3_SATB1 2.00E−06ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_SIRT1 1.43E−06ATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 1.44E−06DIABLO_FAS_ID2_MMP9_NAMPT_SESN2_STAT3 2.00E−06ATG12_ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1 1.44E−06ATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE 1.45E−06CSE1L_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT 2.04E−06ATG12_ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE 1.45E−06ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 1.46E−06DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2 2.05E−06ATG3_BCL2_PTEN_CDH1_HMGB1_RAGE_SIRT1 1.46E−06ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR 1.46E−06CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1 2.07E−06ATG3_BCL2_CDH1_CASP3_HMGB1_RAGE_RAPTOR 1.46E−06ATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE 1.47E−06ATG12_ATG3_BNIP3_DIABLO_ID2_MMP9_TCF3 2.10E−06ATG3_BCL2_BNIP3_FRAP1_CDH1_HMGB1_RAGE 1.47E−06ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE 1.47E−06ATG12_ATG3_BNIP3_FAS_ID2_MMP9_SATB1 2.10E−06ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE 1.47E−06ATG12_ATG3_CDH1_ID2_MMP9_TCF3_SATB1 1.24E−04ATG3_TKT_CDH1_ID2_MMP9_TCF3_UVRAG 2.52E−05NNMT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG 1.87E−04

TABLE 45 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB23.07E−07 ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_SATB1_ 1.30E−06ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_CDH2_HMGB2 3.07E−07 SESN2ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_ 3.75E−07ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_ 1.30E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE_ 3.75E−07 RAPTOR SATB1 RAPTORATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_ 3.78E−07ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_ 1.30E−06ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_TWIST1_UVRAG 3.78E−07 UVRAG SATB1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_ 3.82E−07ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_ 1.30E−06ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_KIAA1967 3.82E−07 KIAA1967 RPS19BP1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1 3.98E−07DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_ 1.34E−06ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_SIRT1 3.98E−07 STAT3ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1 4.13E−07DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SATB1_ 1.38E−06ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_SIRT1 4.13E−07 SESN2ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_ 4.44E−07ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_ 1.40E−06ATG3_BCL2_BNIP3_CDH1_FASLG_HMGB1_HMGB2_RAGE 4.44E−07 RAGE SATB1ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2 4.57E−07ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_ 1.40E−06ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_HMGB2 4.57E−07 SATB1ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_ 4.63E−07ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_ 1.40E−06ATG3_BCL2_BNIP3_CDH1_CASP3_FASLG_HMGB1_RAGE 4.63E−07 RAGE SESN2ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1 4.63E−07ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_ 1.40E−06ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_SIRT1_TWIST1 4.63E−07 TCF3AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_ 4.72E−07ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_ 1.40E−06AIFM1_ATG3_BCL2_CDH1_CDH2_HMGB1_HMGB2_RAGE 4.72E−07 RAGE TCF3ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_ 4.80E−07ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_SATB1_ 1.40E−06ATG3_BCL2L1_TKT_ID2_CDH2_HMGB2_KIAA1967_ 4.80E−07 TWIST1 SESN2 TWIST1ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_ 4.82E−07ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_ 1.40E−06ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_SIRT1 4.82E−07 SIRT1 SATB1ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_ 4.89E−07ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_ 1.50E−06ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_HMGB2 4.89E−07 HMGB2 BHLHE41_SATB1AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_ 4.90E−07ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_ 1.50E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_ 4.90E−07 RAPTOR SESN2 RAPTORATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_ 4.94E−07ATG3_BCL2_E2F1_LAMP1_TKT_MMP9_CASP3_ 1.55E−06ATG3_BCL2_BNIP3_CDH1_CDH2_HMGB1_HMGB2_RAGE 4.94E−07 RAGE HMGB1ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_UVRAG 5.09E−07ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_ 1.60E−06ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_UVRAG 5.09E−07 SESN2ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_ 5.11E−07ATG12_ATG3_BNIP3_CSE1L_DIABLO_FAS_ID2_ 1.60E−06ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_RAPTOR_ 5.11E−07 TWIST1 MMP9 TWIST1ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1 5.22E−07ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_TCF3_ 1.60E−06ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_HMGB2_SIRT1 5.22E−07 BHLHE41ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_ 5.31E−07ATG12_ATG3_BNIP3_CSE1L_ULK1_ID2_MMP9_ 1.60E−06ATG3_BCL2_DRAM_CDH1_CDH2_HMGB1_HMGB2_RAGE 5.31E−07 RAGE BHLHE41ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1 5.35E−07ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_ 1.60E−06ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_CDH2_HMGB1 5.35E−07 SATB1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_ 5.51E−07ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_ 1.60E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_ 5.51E−07 RAPTOR SATB1 RAPTORAIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_ 5.56E−07ATG12_ATG3_BNIP3_FAS_ID2_MMP9_TCF3_ 1.60E−06AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_RAGE 5.56E−07 RAGE SESN2ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967 5.62E−07ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_BHLHE41_ 1.60E−06ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_KIAA1967 5.62E−07 SATB1ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_ 5.66E−07ATG12_ATG3_BNIP3_ID2_MMP9_TCF3_ 1.60E−06ATG3_BCL2L1_TKT_HMGB1_RAGE_RAPTOR_TWIST1_ 5.66E−07 UVRAG SRPS19BP1_ATB1UVRAG AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 5.66E−07ATG12_ATG3_BNIP3_ULK1_ID2_MMP9_TCF3_ 1.60E−06AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_SIRT1 5.66E−07 SESN2ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_ 5.71E−07ATG12_BNIP3_CSE1L_ID2_MMP9_TCF3_SATB1_ 1.60E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_LAMP2_ 5.71E−07 RAGE SESN2 RAGEATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_ 5.82E−07ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_ 1.60E−06ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_ 5.82E−07 RAPTOR SATB1 RAPTORATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTOR 5.82E−07ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_ 1.60E−06ATG3_BCL2_BCL2L1_TKT_ID2_CASP3_HMGB2_RAPTOR 5.82E−07 SATB1ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGE 5.92E−07ATG12_BNIP3_FAS_ULK1_ID2_MMP9_TCF3_ 1.60E−06ATG3_BCL2_BCL2L1_TKT_CASP3_CDH2_HMGB1_RAGE 5.92E−07 RPS19BP1ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_ 5.93E−07CSE1L_DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_ 1.69E−06ATG3_CDH1_CDH2_HMGB1_HMGB2_KIAA1967_RAGE_ 5.93E−07 TWIST1 STAT3 TWIST1ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_ 5.99E−07ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_ 1.70E−06ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_UVRAG 5.99E−07 UVRAG TCF3ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_ 6.00E−07ATG12_ATG3_ATG5_BNIP3_ID2_MMP9_TCF3_ 1.70E−06ATG3_BCL2_BNIP3_CDH1_HMGB1_HMGB2_KIAA1967_ 6.00E−07 RAGE SESN2 RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_ 6.03E−07ATG12_ATG3_ATG5_BNIP3_ULK1_ID2_MMP9_ 1.70E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_ 6.03E−07 LAMP2 TCF3 LAMP2ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_ 6.05E−07ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_ 1.70E−06ATG3_BCL2L1_TKT_ID2_HMGB2_KIAA1967_TWIST1_ 6.05E−07 UVRAG RPS19BP1 UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1 6.05E−07ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_ 1.70E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_SIRT1 6.05E−07 SATB1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_ 6.09E−07ATG12_ATG3_BNIP3_CSE1L_ID2_MMP9_ 1.70E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_SIRT1 6.09E−07 SIRT1BHLHE41_SESN2 ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_ 6.11E−07ATG12_ATG3_BNIP3_DIABLO_FAS_ID2_MMP9_ 1.70E−06ATG3_BCL2_BCL2L1_TKT_CDH1_CASP3_HMGB1_ 6.11E−07 KIAA1967 SATB1 KIAA1967ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_ 6.14E−07ATG12_ATG3_BNIP3_FAS_ID2_MMP9_RPS19BP1_ 1.70E−06ATG3_BCL2_FRAP1_CDH1_HMGB1_HMGB2_RAGE_ 6.14E−07 RAPTOR SESN2 RAPTORAIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_ 6.23E−07ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_ 1.70E−06AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_KIAA1967_ 6.23E−07 RAGE RPS19BP1 RAGEATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_ 6.25E−07ATG12_ATG3_BNIP3_FAS_ULK1_ID2_MMP9_ 1.70E−06ATG3_LC3_TKT_HMGB1_RAGE_RAPTOR_TWIST1_UVRAG 6.25E−07 UVRAG TCF3ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1 6.26E−07ATG12_ATG5_BNIP3_CSE1L_ID2_MMP9_SATB1_ 1.70E−06ATG3_BCL2_BCL2L1_BNIP3_TKT_ID2_CASP3_SIRT1 6.26E−07 SESN2AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 6.26E−07ATG12_ATG5_BNIP3_CSE1L_ULK1_ID2_MMP9_ 1.70E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_MMP2_RAGE_SIRT1 6.26E−07 SATB1ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_ 6.30E−07ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_SATB1_ 1.70E−06ATG3_BCL2_DRAM_CDH1_HMGB1_HMGB2_RAGE_ 6.30E−07 UVRAG SESN2 UVRAGAIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_ 6.30E−07ATG12_BNIP3_CSE1L_ULK1_ID2_MMP9_TCF3_ 1.70E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_RAGE_SIRT1 6.30E−07 SIRT1 SATB1ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_ 6.33E−07ATG12_BNIP3_DIABLO_FAS_ID2_MMP9_TCF3_ 1.70E−06ATG3_BCL2_CASP8_CDH1_HMGB1_HMGB2_RAGE_ 6.33E−07 RAPTOR SESN2 RAPTORATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1 6.38E−07ATG12_BNIP3_DIABLO_FAS_ULK1_ID2_MMP9_ 1.70E−06ATG3_BCL2_BNIP3_DRAM_CDH1_HMGB1_RAGE_SIRT1 6.38E−07 TCF3ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_ 6.38E−07ATG12_BNIP3_FAS_ID2_MMP9_TCF3_RPS19BP1_ 1.70E−06ATG3_LC3_TKT_HMGB1_KIAA1967_RAGE_TWIST1_ 6.38E−07 UVRAG SESN2 UVRAGATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_ 6.42E−07ATG3_DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_ 1.74E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_ 6.42E−07 KIAA1967 SATB1 KIAA1967AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_ 6.42E−07DIABLO_FAS_ID2_MMP9_TCF3_NAMPT_SESN2_ 1.75E−06AIFM1_ATG3_BCL2_BNIP3_CDH1_HMGB1_RAGE_RAPTOR 6.42E−07 RAPTOR STAT3AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_ 6.43E−07DIABLO_FAS_ID2_MMP9_NAMPT_SATB1_SESN2_ 1.79E−06AIFM1_ATG3_BCL2_CDH1_HMGB1_HMGB2_KIAA1967_ 6.43E−07 RAGE STAT3 RAGEATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_ 6.45E−07ATG12_ATG3_ATG5_BNIP3_CSE1L_FAS_ID2_ 1.80E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_RAGE_RAPTOR 6.45E−07 RAPTOR MMP9ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_ 6.46E−07ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_ 1.80E−06ATG3_CDH1_CDH2_HMGB1_HMGB2_RAGE_TWIST1_ 6.46E−07 UVRAG BHLHE41 UVRAGATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_ 6.46E−07ATG12_ATG3_ATG5_BNIP3_CSE1L_ID2_MMP9_ 1.80E−06ATG3_BCL2_DRAM_CDH1_HMGB1_MMP2_RAGE_SIRT1 6.46E−07 SIRT1 TCF3ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_ 6.46E−07ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_ 1.80E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_ 6.46E−07 UVRAG RPS19BP1 UVRAGATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_ 6.46E−07ATG12_ATG3_ATG5_BNIP3_FAS_ID2_MMP9_ 1.80E−06ATG3_BCL2_CBS_CDH1_HMGB1_HMGB2_RAGE_RAPTOR 6.46E−07 RAPTOR SATB1ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_ 6.56E−07ATG12_ATG3_BNIP3_CSE1L_FAS_ID2_MMP9_ 1.80E−06ATG3_BCL2_BCL2L1_TKT_CASP3_HMGB1_HMGB2_RAGE 6.56E−07 RAGE SESN2ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG 2.26E−05ATG3_TKT_CDH1_ID2_MMP9_TCF3_TP63_UVRAG 1.02E−05ATG3_TKT_CDH1_ID2_MMP9_TCF3_TWIST1_UVRAG 2.26E−05

As can be confirmed from the above tables, each of the markers or theircombination shows p-values low enough to be considered significant interms of all of recurrence, survival, and disease-free survival. Inparticular, in the case of the combination of the two or more markers,all the p-values for recurrence, survival, and disease-free survivalwere low. In particular, it was found that there were cases where thep-value for a single marker was relatively high but the p-valuedecreased when the marker was used in combination with other marker. Asa p-value becomes lower, the statistical significance becomes higher.Thus, the low p-values suggest that the estimation for prognosis ofliver cancer by each of the markers or their combination is highlyaccurate.

This means that the more markers of the present disclosure are combined,the lower p-values, which means higher significance, are shown, whichmeans that the more improved accuracy would be achieved in theestimation for prognosis based on the combinations of the markers.

Thus, it was found that the markers and/or the combinations of markersof Tables 38˜45 are effective in predicting prognosis of liver cancer ofthe B group (recurrence, survival, disease-free survival), and that theprognosis of liver cancer of the B group can be predicted effectively bynucleic acids and antibodies targeted at the markers. Also, it can befound that the prognosis of liver cancer of the B group can be predictedeffectively by the method for predicting prognosis of liver cancer ofthe present disclosure, which is targeted at the markers.

Further, cross-validation was performed for combinations of markerswhich were considered statistically significant. Patients of eachpatient group were randomly divided into two groups (positive group: 39patients; test group: 39 patients). With the reference value which wasconsidered statistically significant in the results of the positivegroup obtained in the same manner as Example 1 fixed, for the testgroup, the accuracy of estimation was calculated to be the level ofp<0.05 or p<0.001 with respect to recurrence, survival and disease-freesurvival.

Among the results of cross-validation of the prediction of the survivalof the B group, a representative example showing the excellent accuracyof prognosis in each aspect is as follows:

Survival: DIABLO_BECN1_SIRT1 (79.7% at the level of p<0.05)

Example 5 Predicting Prognosis of Liver Cancer in the C Group

An experiment was performed in the same manner as in Example 1, exceptfor experimenting on a patient group determined as the C group {a groupof portal vein invasion-positive patients regardless of tumors size andnumber} (69 patients). Kaplan-Meier curves were prepared with respect tothe prediction of recurrence, survival, and disease-free survival andthe results are shown in FIGS. 86˜106. Kaplan-Meier curves forrecurrence are shown in FIGS. 86˜92, Kaplan-Meier curves for survivalare shown in FIGS. 93˜99, and Kaplan-Meier curves for disease-freesurvival are shown in FIGS. 100˜106.

As can be seen from the drawings, in Kaplan-Meier curves completed withrespect to recurrence, survival, and disease-free survival, the abovemarkers form curves where cases of high expression and low expressionare distinctively distinguished from each other. This means that thereare remarkable differences in interval recurrence rate or intervalsurvival rate and cumulative recurrence rate or cumulative survival ratebased thereon between the cases where the marker is in high expressionand low expression, and that consequently, the expression pattern of themarker can be an index showing recurrence possibility or survivalpossibility of patients.

Also, significance tests were performed by log-rank test with respect toeach of the markers and their combination by calculating observationvalues and expected values at every point of recurrence or death toobtain p-values. The results are shown in the following Tables 46˜53.The results of using a marker alone is shown in Table 46, the results ofa combination of two markers are shown in Table 47, the results of acombination of three markers are shown in Table 48, the results of acombination of four markers are shown in Table 49, the results of acombination of five markers are shown in Table 50, the results of acombination of six markers are shown in Table 51, the results of acombination of seven markers are shown in Table 52, and the results of acombination of eight markers are shown in Table 53.

TABLE 46 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value FASLG 3.93E−03 CSE1L 5.07E−03 FASLG 2.36E−03CIAP2 1.27E−02 CIAP2 8.33E−03 CIAP2 1.24E−02 CSE1L 3.17E−02 TCF38.33E−03 FAS 2.44E−02 FAS 3.17E−02 CDH2 9.89E−03 CSE1L 2.62E−02 TCF33.65E−02 FASLG 1.61E−02 TCF3 3.79E−02 ATG3 5.91E−02 BECN1 3.48E−02 LC38.84E−02 ULK1 8.46E−02 CASP3 3.53E−02 CASP3 9.68E−02 LC3 9.21E−02 CDH14.70E−02 ATG3 1.01E−01 BNIP3 9.61E−02 FAS 5.33E−02 ULK1 1.07E−01 E2F11.09E−01 KIAA1967 6.02E−02 RAPTOR 1.24E−01 CASP3 1.16E−01 ULK1 8.01E−02E2F1 1.32E−01 CDH2 1.22E−01 STAT3 8.62E−02 CDH2 1.34E−01 RAPTOR 1.49E−01ATG12 9.77E−02 SATB1 1.57E−01 PTEN 1.50E−01 RAPTOR 1.36E−01 PTEN1.60E−01 TKT 1.89E−01 BCL2 1.48E−01 TKT 1.75E−01 ATG5 1.95E−01 SESN31.75E−01 BNIP3 1.88E−01 SATB1 1.97E−01 UVRAG 2.09E−01 BCL2 1.94E−01 BCL22.03E−01 SESN1 2.11E−01 DIABLO 2.52E−01 XIAP 2.07E−01 XIAP 2.30E−01 XIAP2.54E−01 DIABLO 2.24E−01 SATB1 2.46E−01 ATG5 2.64E−01 RAGE 2.48E−01LAMP2 2.51E−01 LAMP1 2.86E−01 LAMP1 2.82E−01 SESN2 2.82E−01 KIAA19673.05E−01 SESN2 3.03E−01 ATG7 2.84E−01 SESN2 3.46E−01 ATG7 3.03E−01 ID23.01E−01 SESN1 3.65E−01 KIAA1967 3.34E−01 ATG5 3.12E−01 RAGE 3.70E−01NAMPT 3.41E−01 SIRT1 3.73E−01 UVRAG 4.14E−01 SESN1 3.65E−01 NAMPT3.90E−01 FRAP1_ 4.25E−01 FRAP1_ 4.16E−01 AKT1_ 4.04E−01 NAMPT 4.35E−01RPS19BP1 4.18E−01 TKT 4.14E−01 ATG7 4.45E−01 SESN3 4.21E−01 CBS 4.22E−01MMP9 4.75E−01 UVRAG 4.35E−01 NNMT 4.35E−01 RPS19BP1 4.99E−01 DRAM5.20E−01 FRAP1_ 4.69E−01 SESN3 5.13E−01 PRKAA1_ 5.27E−01 BCL2L1 4.71E−01HMGB1 5.82E−01 HMGB1 5.66E−01 RPS19BP1 5.16E−01 PRKAA1_ 6.30E−01 CBS5.92E−01 MMP9 5.16E−01 DRAM 6.45E−01 ATG12 5.93E−01 PRKAA1_ 5.35E−01ATG12 6.46E−01 MMP9 6.08E−01 ATG3 5.63E−01 CBS 7.22E−01 VEGF 6.72E−01CCNG2 5.98E−01 CCNG2 7.23E−01 CASP8 7.09E−01 MMP2 6.51E−01 HMGB27.53E−01 NNMT 7.11E−01 RAGE 6.96E−01 LAMP2 7.58E−01 HMGB2 7.12E−01 LC37.14E−01 BECN1 7.60E−01 CCNG2 7.23E−01 TP63 7.32E−01 CASP8 7.79E−01 BAX7.32E−01 AIFM1 7.42E−01 NNMT 7.92E−01 ID2 7.63E−01 LAMP1 7.43E−01 BCL2L18.02E−01 BCL2L1 7.92E−01 BHLHE41 7.55E−01 ID2 8.19E−01 AGER 7.99E−01CASP8 7.67E−01 AGER 8.21E−01 AIFM1 8.16E−01 TWIST1 7.92E−01 AKT1_8.28E−01 SIRT1 8.25E−01 PTEN 8.51E−01 VEGF 8.48E−01 LAMP2 8.54E−01DIABLO 8.52E−01 MMP2 8.77E−01 AKT1_ 8.61E−01 HMGB1 8.87E−01 AIFM18.88E−01 STAT3 8.91E−01 AGER 9.16E−01 STAT3 9.28E−01 BHLHE41 9.05E−01HMGB2 9.25E−01 TP63 9.37E−01 CDH1 9.08E−01 BNIP3 9.44E−01 CDH1 9.54E−01BECN1 9.29E−01 VEGF 9.48E−01 BAX 9.64E−01 TP63 9.37E−01 BAX 9.68E−01SIRT1 9.77E−01 TWIST1 9.94E−01 E2F1 9.90E−01 BHLHE41 9.80E−01 MMP29.99E−01 DRAM 9.91E−01 TWIST1 9.94E−01

TABLE 47 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value CIAP2_FASLG 1.87E−04 ID2_CIAP2 5.70E−04 FAS_FASLG1.38E−04 E2F1_FASLG 2.16E−04 CASP3_CIAP2 9.60E−04 LC3_FASLG 1.39E−04LC3_FASLG 2.38E−04 ID2_TCF3 1.28E−03 E2F1_FASLG 1.79E−04 DIABLO_FASLG2.65E−04 DIABLO_CDH2 1.58E−03 CIAP2_FASLG 2.48E−04 FAS_FASLG 3.89E−04CSE1L_CDH2 1.67E−03 DIABLO_FASLG 2.51E−04 FASLG_RPS19BP1 4.95E−04CSE1L_TCF3 1.70E−03 FASLG_RPS19BP1 3.71E−04 PTEN_FASLG 7.12E−04CSE1L_CASP3 1.86E−03 FASLG_SESN2 4.41E−04 CASP3_FASLG 7.73E−04CSE1L_RPS19BP1 1.87E−03 CASP3_FASLG 8.51E−04 FASLG_SESN2 7.77E−04CDH2_CIAP2 1.89E−03 FASLG_UVRAG 8.81E−04 FASLG_HMGB1 8.12E−04 ULK1_ID22.44E−03 FRAP1_FASLG 9.82E−04 CDH2_FASLG 9.16E−04 CSE1L_ID2 2.80E−03PTEN_FASLG 1.11E−03 FRAP1_FASLG 9.22E−04 CDH1_CIAP2 3.00E−03 FASLG_HMGB11.13E−03 ATG7_FASLG 1.01E−03 CSE1L_FASLG 3.00E−03 ATG3_FAS 1.13E−03ATG3_FAS 1.15E−03 NNMT_CIAP2 3.02E−03 CASP3_CIAP2 1.17E−03 FASLG_HMGB21.16E−03 CSE1L_MMP9 3.02E−03 TCF3_FASLG 1.24E−03 FASLG_UVRAG 1.20E−03CSE1L_CDH1_ 3.06E−03 ATG7_FASLG 1.25E−03 DIABLO_FAS 1.27E−03CIAP2_RPS19BP1 3.07E−03 PTEN_CIAP2 1.29E−03 FASLG_MMP2 1.35E−03 ID2_CDH23.10E−03 CDH2_FASLG 1.31E−03 TKT_FASLG 1.38E−03 CDH2_RPS19BP1 3.11E−03FASLG_SESN3 1.38E−03 PTEN_CIAP2 1.38E−03 CSE1L_STAT3 3.25E−03 DIABLO_FAS1.41E−03 FAS_LC3 1.44E−03 DIABLO_CASP3 3.29E−03 FAS_LC3 1.44E−03CBS_FASLG 1.50E−03 CDH1_TCF3 3.29E−03 ULK1_FASLG 1.44E−03 AIFM1_FASLG1.51E−03 CSE1L_SIRT1 3.34E−03 CSE1L_FASLG 1.51E−03 CASP3_CIAP2 1.52E−03CIAP2_SESN2 3.36E−03 CBS_FASLG 1.72E−03 FASLG_SESN3 1.65E−03 AIFM1_CIAP23.56E−03 FASLG_HMGB2 1.73E−03 ATG3_FASLG 1.71E−03 DIABLO_KIAA19673.61E−03 FAS_UVRAG 1.76E−03 CASP8_FASLG 1.75E−03 CSE1L_KIAA1967 3.64E−03LAMP1_FASLG 1.83E−03 XIAP_FASLG 1.78E−03 AKT1_CSE1L 3.75E−03 BNIP3_FASLG1.88E−03 AGER_FASLG 1.79E−03 CSE1L_SESN2 3.84E−03 MMP9_FASLG 1.96E−03ATG3_ULK1 1.89E−03 FRAP1_CDH2 3.88E−03 TKT_FASLG 1.98E−03 BNIP3_FASLG1.90E−03 FRAP1_CIAP2 3.97E−03 FASLG_STAT3 2.05E−03 FAS_UVRAG 1.96E−03TCF3_FASLG 4.00E−03 AKT1_FASLG 2.07E−03 CIAP2_RAGE 1.97E−03 FASLG_SESN24.06E−03 FASLG_MMP2 2.08E−03 ATG3_TCF3 2.14E−03 CSE1L_DIABLO 4.12E−03DRAM_FASLG 2.12E−03 FASLG_RAGE 2.25E−03 CSE1L_SATB1 4.13E−03 FASLG_SIRT12.16E−03 E2F1_CIAP2 2.26E−03 MMP9_TCF3 4.22E−03 ATG12_FASLG 2.17E−03FASLG_VEGF 2.38E−03 ATG12_CSE1L 4.34E−03 CIAP2_RAGE 2.19E−03 E2F1_FAS2.40E−03 ATG7_CSE1L 4.35E−03 FAS_LAMP1 2.25E−03 XIAP_CIAP2 2.46E−03CSE1L_BECN1 4.42E−03 ATG5_FASLG 2.25E−03 BCL2L1_FASLG 2.50E−03XIAP_CIAP2 4.44E−03 ATG3_FASLG 2.32E−03 BNIP3_FAS 2.54E−03 CSE1L_FAS4.44E−03 E2F1_FAS 2.32E−03 FASLG_SESN1 2.61E−03 TCF3_RPS19BP1 4.47E−03BECN1_FASLG 2.39E−03 FASLG_KIAA1967 2.66E−03 XIAP_SESN2 4.67E−03E2F1_CIAP2 2.39E−03 AIFM1_CIAP2 2.70E−03 CIAP2_KIAA1967 4.77E−03CASP8_FASLG 2.40E−03 DRAM_FASLG 2.72E−03 TKT_CIAP2 4.80E−03 XIAP_CIAP22.42E−03 ATG3_CIAP2 2.77E−03 PRKAA1_CIAP2 4.81E−03 CDH1_FASLG 2.43E−03CSE1L_FASLG 2.79E−03 CDH2_FASLG 4.84E−03 FASLG_NAMPT 2.44E−03FASLG_RAPTOR 2.83E−03 CSE1L_FRAP1_ 4.87E−03 BNIP3_FAS 2.46E−03TCF3_FASLG 2.84E−03 CSE1L_CIAP2 4.87E−03 FASLG_LAMP2 2.48E−03FASLG_STAT3 2.86E−03 CSE1L_ULK1 4.99E−03 AGER_FASLG 2.50E−03 ULK1_FASLG2.86E−03 PTEN_CIAP2 5.02E−03 ID2_FASLG 2.55E−03 PRKAA1_CIAP2 2.89E−03BCL2L1_CIAP2 5.02E−03 A1FM1_FASLG 2.57E−03 FASLG_SIRT1 2.89E−03CIAP2_VEGF 5.07E−03 FASLG_SESN1 2.61E−03 ATG12_FASLG 2.96E−03 ATG3_TCF35.08E−03 AIFM1_CIAP2 2.64E−03 LAMP1_FASLG 2.98E−03 AKT1_TCF3 5.26E−03PRKAA1_CIAP2 2.77E−03 NNMT_FASLG 3.08E−03 CSE1L_LC3 5.35E−03BCL2L1_CIAP2 2.80E−03 BCL2L1_CIAP2 3.12E−03 TKT_CDH2 5.40E−03 XIAP_FASLG2.82E−03

TABLE 48 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value FAS_LC3_FASLG 1.82E−05 ID2_CIAP2_SESN2 7.24E−05FAS_LC3_FASLG 1.06E−05 DIABLO_FAS_FASLG 3.03E−05 ID2_CASP3_CIAP29.38E−05 DIABLO_FAS_FASLG 1.76E−05 E2F1_LC3_FASLG 3.47E−05 ULK1_ID2_MGB21.10E−04 E2F1_LC3_FASLG 2.26E−05 FAS_FASLG_RPS19BP1 3.73E−05ULK1_ID2_MGB1 1.22E−04 FAS_FASLG_RPS19BP1 2.33E−05 E2F1_FAS_FASLG4.66E−05 DIABLO_ID2_CASP3 1.29E−04 E2F1_FAS_FASLG 2.65E−05FAS_FASLG_UVRAG 5.60E−05 ULK1_ID2_AGER 1.29E−04 FAS_FASLG_UVRAG 3.19E−05DIABLO_LC3_FASLG 6.35E−05 ID2_CIAP2_RPS19BP1 1.40E−04 DIABLO_LC3_FASLG4.70E−05 ATG7_FAS_FASLG 6.73E−05 CASP8_ULK1_ID2 1.64E−04 ATG7_FAS_FASLG4.82E−05 CIAP2_FASLG_SESN3 6.81E−05 ID2_TCF3_CIAP2 1.65E−04FAS_FASLG_SESN2 5.14E−05 CIAP2_FASLG_UVRAG 6.91E−05 FRAP1_ID2_CIAP21.73E−04 LC3_FASLG_SESN2 5.39E−05 BNIP3_LC3_FASLG 7.11E−05AIFM1_CDH1_CIAP2 1.87E−04 FAS_LAMP1_FASLG 5.66E−05 LC3_CIAP2_FASLG8.25E−05 PTEN_CDH1_CIAP2 2.06E−04 ATG3_FAS_FASLG 6.21E−05LC3_FASLG_SESN2 8.48E−05 ULK1_ID2_CIAP2 2.36E−04 CIAP2_FASLG_SESN36.81E−05 FRAP1_LC3_FASLG 8.81E−05 DIABLO_ID2_CDH2 2.42E−04FAS_FRAP1_FASLG 6.84E−05 LC3_FASLG_SESN3 9.71E−05 CDH1_CIAP2_VEGF2.43E−04 FRAP1_LC3_FASLG 7.17E−05 ATG3_FAS_FASLG 1.06E−04CDH1_CCNG2_CIAP2 2.45E−04 BNIP3_LC3_FASLG 7.19E−05 ATG7_LC3_FASLG1.06E−04 BAX_CDH1_CIAP2 2.45E−04 FAS_FASLG_SESN3 7.28E−05FAS_FRAP1_FASLG 1.07E−04 ATG3_ID2_TCF3 2.46E−04 BNIP3_FAS_FASLG 7.32E−05DIABLO_FASLG_SESN2 1.13E−04 ULK1_ID2_MMP2 2.60E−04 DIABLO_FASLG_SESN27.63E−05 DRAM_LC3_FASLG 1.15E−04 CBS_ULK1_ID2 2.65E−04 CIAP2_FASLG_UVRAG7.70E−05 CIAP2_FASLG_HMGB1 1.21E−04 DIABLO_ID2_CIAP2 2.67E−04LC3_FASLG_UVRAG 7.80E−05 FAS_FASLG_SESN3 1.22E−04 LC3_ID2_CIAP2 2.70E−04LC3_CIAP2_FASLG 8.26E−05 LC3_FASLG_UVRAG 1.24E−04 PTEN_ULK1_ID2 2.92E−04DRAM_FAS_FASLG 8.27E−05 CASP3_CIAP2_FASLG 1.26E−04 BAX_ULK1_ID2 3.20E−04LC3_FASLG_SESN3 8.77E−05 FAS_FASLG_SESN2 1.27E−04 DIABLO_PTEN_CDH13.22E−04 FAS_FASLG_STAT3 9.20E−05 PTEN_CIAP2_FASLG 1.30E−04CDH1_CASP3_CIAP2 3.24E−04 ATG7_LC3_FASLG 9.53E−05 DIABLO_FASLG_SESN31.31E−04 ULK1_ID2_CDH2 3.29E−04 ATG5_FAS_FASLG 9.63E−05 ATG7_CIAP2_FASLG1.37E−04 CDH1_CIAP2_RAGE 3.53E−04 E2F1_FASLG_SESN2 9.94E−05LC3_FASLG_SIRT1 1.38E−04 ID2_CDH2_CIAP2 3.55E−04 LC3_ID2_FASLG 1.01E−04LC3_FASLG_RPS19BP1 1.40E−04 NNMT_ID2_CIAP2 3.58E−04 DRAM_LC3_FASLG1.03E−04 FASLG_SESN2_SESN3 1.43E−04 XIAP_CIAP2_SESN2 3.63E−04FAS_TCF3_FASLG 1.04E−04 DRAM_FAS_FASLG 1.46E−04 CSE1L_ID2_CASP3 3.64E−04AKT1_FAS_FASLG 1.05E−04 ID2_CIAP2_FASLG 1.58E−04 CSE1L_FRAP1_CDH23.70E−04 E2F1_ULK1_FASLG 1.05E−04 FAS_FASLG_STAT3 1.58E−04BCL2_ID2_SESN2 3.79E−04 E2F1_TCF3_FASLG 1.06E−04 AKT1_CIAP2_FASLG1.61E−04 AIFM1_ULK1_ID2 3.83E−04 LC3_FASLG_RPS19BP1 1.06E−04DIABLO_FRAP1_FASLG 1.61E−04 ULK1_ID2_RAGE 3.87E−04 LC3_MMP9_FASLG1.09E−04 BNIP3_FAS_FASLG 1.65E−04 DIABLO_CDH1_CCNG2 3.89E−04FAS_FASLG_SIRT1 1.10E−04 FAS_LAMP1_FASLG 1.65E−04 BAX_DIABLO_CDH13.94E−04 FAS_ULK1_FASLG 1.13E−04 TKT_CIAP2_FASLG 1.65E−04 CSE1L_ID2_CDH24.05E−04 FAS_FASLG_NAMPT 1.13E−04 ATG7_DIABLO_FASLG 1.66E−04AIFM1_CIAP2_SESN2 4.17E−04 LC3_FASLG_SIRT1 1.15E−04 FRAP1_FASLG_SESN21.67E−04 NNMT_CDH1_CIAP2 4.20E−04 CASP3_CIAP2_FASLG 1.24E−04E2F1_ULK1_FASLG 1.67E−04 CBS_ID2_CIAP2 4.23E−04 ATG12_FAS_FASLG 1.25E−04DRAM_CIAP2_FASLG 1.69E−04 DIABLO_CDH1_VEGF 4.34E−04 FAS_BECN1_FASLG1.29E−04 PTEN_CASP3_FASLG 1.70E−04 ID2_MMP9_TCF3 4.47E−04 ATG5_LC3_FASLG1.35E−04 LC3_FASLG_NAMPT 1.73E−04 AIFM1_DIABLO_CDH1 4.48E−04LC3_BECN1_FASLG 1.37E−04 PTEN_CDH1_CIAP2 1.73E−04 PRKAA1_CIAP2_SESN24.56E−04 LC3_FASLG_STAT3 1.37E−04 ATG12_CIAP2_FASLG 1.79E−04CDH1_ID2_CIAP2 4.57E−04 E2F1_FASLG_SESN3 1.39E−04 FASLG_RPS19BP1_SESN31.80E−04 CSE1L_CASP3_CIAP2 4.67E−04 AKT1_LC3_FASLG 1.40E−04MMP9_CIAP2_FASLG 1.81E−04 ULK1_ID2_VEGF 4.72E−04 FAS_FASLG_LAMP21.40E−04 LAMP1_CIAP2_FASLG 1.83E−04 ID2_CIAP2_HMGB1 4.73E−04LC3_TCF3_FASLG 1.41E−04 LC3_BECN1_FASLG 1.85E−04 BCL2L1_CDH1_CIAP24.83E−04 LC3_FASLG_NAMPT 1.41E−04 CDH1_CIAP2_FASLG 1.85E−04ID2_CIAP2_MMP2 4.88E−04 LC3_CDH1_FASLG 1.41E−04 BECN1_CIAP2_FASLG1.88E−04 CSE1L_ID2_CIAP2 4.88E−04 ATG12_LC3_FASLG 1.42E−04CIAP2_FASLG_HMGB2 1.90E−04 BCL2L1_CSE1L_CDH1 4.89E−04 PTEN_CDH1_CIAP21.45E−04 E2F1_FASLG_LAMP2 1.93E−04 CSE1L_CDH1_CASP3 4.92E−04LC3_FASLG_LAMP2 1.45E−04 CIAP2_FASLG_SIRT1 1.95E−04 CSE1L_XIAP_SESN24.94E−04 DIABLO_FASLG_SESN3 1.46E−04 PTEN_XIAP_FASLG 1.97E−04PRKAA1_CDH1_CIAP2 4.94E−04 FAS_CDH1_FASLG 1.46E−04

TABLE 49 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value DIABLO_FAS_LC3_FASLG 4.96E−06AIFM1_ID2_CIAP2_SESN2 2.08E−05 DIABLO_FAS_LC3_FASLG 3.51E−06FAS_LC3_FASLG_UVRAG 5.48E−06 PTEN_ID2_CIAP2_SESN2 3.00E−05FAS_LC3_FASLG_UVRAG 3.97E−06 BNIP3_FAS_LC3_FASLG 6.23E−06DIABLO_ID2_CASP3_CIAP2 3.38E−05 E2F1_FAS_LC3_FASLG 4.54E−06DRAM_FAS_LC3_FASLG 6.26E−06 DRAM_FRAP1_CIAP2_TP63 3.54E−05BNIP3_FAS_LC3_FASLG 4.73E−06 E2F1_FAS_LC3_FASLG 6.40E−06BAX_ID2_CIAP2_SESN2 3.66E−05 DRAM_FAS_LC3_FASLG 6.03E−06ATG3_FAS_LC3_FASLG 8.57E−06 ID2_CIAP2_SESN2_VEGF 4.04E−05ATG7_FAS_LC3_FASLG 6.51E−06 ATG7_FAS_LC3_FASLG 9.02E−06DRAM_ID2_CIAP2_SESN2 4.12E−05 FAS_LAMP1_LC3_FASLG 6.58E−06FAS_LC3_FASLG_STAT3 9.45E−06 ID2_CIAP2_RPS19BP1_SESN2 4.18E−05FAS_FRAP1_LC3_FASLG 7.21E−06 FAS_FRAP1_LC3_FASLG 9.88E−06CBS_ID2_CIAP2_SESN2 4.19E−05 ATG3_FAS_LC3_FASLG 7.29E−06FAS_LC3_FASLG_SESN3 1.03E−05 ATG3_ID2_CIAP2_SESN2 4.27E−05FAS_LC3_FASLG_RPS19BP1 7.34E−06 FAS_LC3_FASLG_SIRT1 1.05E−05NNMT_ID2_CIAP2_SESN2 4.31E−05 FAS_LC3_FASLG_SESN3 7.39E−06FAS_LC3_BECN1_FASLG 1.06E−05 DIABLO_ID2_CIAP2_SESN2 4.35E−05FAS_LC3_FASLG_SESN2 7.48E−06 ATG5_FAS_LC3_FASLG 1.10E−05PRKAA1_ID2_CIAP2_SESN2 4.41E−05 ATG5_FAS_LC3_FASLG 7.52E−06FAS_LC3_FASLG_RPS19BP1 1.22E−05 FRAP1_ID2_CIAP2_SESN2 4.44E−05FAS_LC3_FASLG_STAT3 7.79E−06 FAS_LAMP1_LC3_FASLG 1.27E−05DIABLO_DRAM_ID2_CASP3 4.61E−05 FAS_LC3_FASLG_SIRT1 8.50E−06FAS_LC3_FASLG_NAMPT 1.30E−05 XIAP_ID2_CIAP2_SESN2 4.64E−05AKT1_FAS_LC3_FASLG 9.12E−06 AKT1_FAS_LC3_FASLG 1.35E−05ID2_CIAP2_RAGE_SESN2 4.72E−05 FAS_LC3_ID2_FASLG 9.15E−06FAS_LC3_FASLG_SESN2 1.38E−05 DRAM_CIAP2_SESN2_TP63 5.02E−05FAS_LC3_FASLG_NAMPT 9.24E−06 FAS_LC3_MMP9_FASLG 1.49E−05BNIP3_ID2_CIAP2_SESN2 5.18E−05 FAS_LC3_BECN1_FASLG 9.71E−06FAS_FASLG_RPS19BP1_SESN3 1.56E−05 BCL2L1_ID2_CIAP2_SESN2 5.28E−05FAS_LC3_MMP9_FASLG 9.89E−06 FAS_FASLG_RPS19BP1_UVRAG 1.57E−05AIFM1_DIABLO_CDH1_CIAP2 5.36E−05 DIABLO_FAS_FASLG_UVRAG 1.01E−05FAS_LC3_CDH1_FASLG 1.58E−05 ID2_CCNG2_CIAP2_SESN2 5.39E−05ATG12_FAS_LC3_FASLG 1.03E−05 ATG12_FAS_LC3_FASLG 1.60E−05LC3_ID2_CIAP2_SESN2 5.46E−05 FAS_FASLG_RPS19BP1_UVRAG 1.06E−05DIABLO_FAS_FASLG_SESN3 1.66E−05 ID2_CASP3_CIAP2_RPS19BP1 5.80E−05DIABLO_FAS_FASLG_SESN2 1.07E−05 DIABLO_FAS_FASLG_UVRAG 1.69E−05AIFM1_CDH1_CIAP2_SESN2 5.98E−05 FAS_LC3_FASLG_LAMP2 1.07E−05FAS_LC3_FASLG_LAMP2 1.71E−05 ATG3_ID2_TCF3_RPS19BP1 6.06E−05FAS_LC3_CDH1_FASLG 1.09E−05 FAS_LC3_ID2_FASLG 1.72E−05DIABLO_FRAP1_ID2_CDH2 6.20E−05 DIABLO_FAS_FASLG_SESN3 1.22E−05DIABLO_FAS_FASLG_SESN2 1.88E−05 E2F1_ID2_CIAP2_SESN2 6.45E−05FAS_LC3_TCF3_FASLG 1.27E−05 FAS_LC3_BHLHE41_FASLG 1.95E−05ID2_CASP3_CIAP2_SESN2 6.46E−05 E2F1_LC3_ID2_FASLG 1.31E−05DIABLO_DRAM_FAS_FASLG 1.99E−05 DRAM_ID2_CIAP2_RPS19BP1 6.48E−05FAS_LC3_BHLHE41_FASLG 1.31E−05 DIABLO_FAS_FASLG_STAT3 1.99E−05ID2_CIAP2_HMGB1_SESN2 6.56E−05 DIABLO_FAS_LAMP1_FASLG 1.33E−05DRAM_FAS_FASLG_RPS19BP1 2.00E−05 PTEN_ID2_CASP3_CIAP2 6.84E−05DIABLO_DRAM_FAS_FASLG 1.36E−05 DIABLO_FAS_FRAP1_FASLG 2.22E−05ATG3_ID2_MMP9_TCF3 6.87E−05 FAS_FASLG_SESN2_UVRAG 1.39E−05FAS_FASLG_SESN2_UVRAG 2.32E−05 LAMP1_ID2_CIAP2_SESN2 6.91E−05FAS_FASLG_RPS19BP1_SESN3 1.39E−05 ATG3_FAS_FASLG_SESN2 2.35E−05AIFM1_ID2_CASP3_CIAP2 6.91E−05 DIABLO_FAS_FRAP1_FASLG 1.41E−05ATG7_DIABLO_FAS_FASLG 2.37E−05 ATG5_ID2_CIAP2_SESN2 6.93E−05DIABLO_FAS_FASLG_STAT3 1.44E−05 FAS_LC3_TCF3_FASLG 2.38E−05DIABLO_PTEN_CDH1_CIAP2 7.02E−05 ATG7_DIABLO_FAS_FASLG 1.47E−05ATG7_FAS_FASLG_UVRAG 2.49E−05 LAMP1_ID2_CASP3_CIAP2 7.04E−05CSE1L_FAS_LC3_FASLG 1.53E−05 DIABLO_FAS_FASLG_NAMPT 2.61E−05ID2_CIAP2_HMGB2_SESN2 7.11E−05 E2F1_LC3_MMP9_FASLG 1.58E−05DIABLO_FAS_FASLG_SIRT1 2.62E−05 BCL2L1_CSE1L_ID2_SESN2 7.16E−05DRAM_FAS_FASLG_RPS19BP1 1.59E−05 DIABLO_FAS_LAMP1_FASLG 2.62E−05TKT_ID2_CIAP2_SESN2 7.17E−05 DIABLO_FAS_FASLG_RPS19BP1 1.61E−05FAS_FRAP1_FASLG_RPS19BP1 2.62E−05 DIABLO_XIAP_ID2_SESN2 7.18E−05FAS_LC3_ULK1_FASLG 1.62E−05 CSE1L_FAS_LC3_FASLG 2.65E−05FRAP1_LC3_ID2_CIAP2 7.21E−05 DIABLO_FAS_FASLG_SIRT1 1.63E−05DIABLO_FAS_BECN1_FASLG 2.65E−05 ATG7_ID2_CIAP2_SESN2 7.36E−05DIABLO_FAS_ID2_FASLG 1.63E−05 E2F1_LC3_ID2_FASLG 2.74E−05ID2_AGER_CIAP2_SESN2 7.37E−05 AKT1_DIABLO_FAS_FASLG 1.64E−05AKT1_DIABLO_FAS_FASLG 2.74E−05 CSE1L_ID2_CASP3_CIAP2 7.38E−05DIABLO_FAS_FASLG_NAMPT 1.68E−05 ATG3_DIABLO_FAS_FASLG 2.77E−05DRAM_CASP3_CIAP2_TP63 7.39E−05 ATG3_FAS_FASLG_SESN2 1.69E−05E2F1_FAS_FASLG_SESN3 2.77E−05 PTEN_CDH1_ID2_CIAP2 7.41E−05FAS_FASLG_RPS19BP1_SESN2 1.70E−05 ATG7_FAS_FASLG_SESN2 2.79E−05CDH1_ID2_CIAP2_RPS19BP1 7.45E−05 DIABLO_FAS_BECN1_FASLG 1.72E−05DIABLO_FAS_FASLG_RPS19BP1 2.85E−05 ATG3_ULK1_ID2_HMGB1 7.54E−05DIABLO_FAS_CDH1_FASLG 1.76E−05 DRAM_FAS_FASLG_UVRAG 2.86E−05FRAP1_ID2_CIAP2_RPS19BP1 7.63E−05 ATG7_FAS_FASLG_UVRAG 1.77E−05LC3_MMP9_FASLG_SESN2 2.90E−05 DIABLO_PTEN_ID2_CASP3 7.64E−05DIABLO_FAS_FASLG_LAMP2 1.77E−05 FAS_FASLG_SESN3_UVRAG 2.95E−05ID2_CIAP2_SESN2_TP63 7.74E−05 FAS_FRAP1_FASLG_RPS19BP1 1.78E−05DIABLO_FAS_FASLG_LAMP2 2.95E−05 ID2_TCF3_CIAP2_SESN2 7.80E−05FAS_LAMP1_FASLG_UVRAG 1.82E−05 DIABLO_FAS_ID2_FASLG 2.95E−05DIABLO_CDH1_CIAP2_VEGF 7.85E−05 E2F1_FAS_LAMP1_FASLG 1.84E−05E2F1_LC3_FASLG_LAMP2 2.95E−05 ATG3_ULK1_ID2_AGER 7.94E−05ATG7_FAS_FASLG_RPS19BP1 1.89E−05 E2F1_LC3_MMP9_FASLG 2.95E−05ID2_CIAP2_MMP2_SESN2 8.02E−05 E2F1_FAS_FASLG_UVRAG 1.91E−05CDH1_ID2_MMP9_TCF3 3.71E−02 CDH1_ID2_MMP9_TCF3 1.03E−03CDH1_ID2_MMP9_TCF3 3.56E−02

TABLE 50 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value BNIP3_DRAM_FAS_LC3_FASLG 2.75E−06DRAM_ID2_CIAP2_SESN2_TP63 4.30E−06 DIABLO_FAS_LC3_ID2_FASLG 2.53E−06DRAM_FAS_LC3_FASLG_UVRAG 2.77E−06 AIFM1_DRAM_CIAP2_SESN2_ 5.10E−06DRAM_FAS_LC3_FASLG_UVRAG 2.65E−06 TP63 DIABLO_DRAM_FAS_LC3_FASLG3.15E−06 DRAM_FRAP1_CDH1_CIAP2_ 5.59E−06 DIABLO_DRAM_FAS_LC3_FASLG2.69E−06 TP63 ATG3_FAS_LC3_FASLG_SESN3 3.60E−06 ATG12_DRAM_FRAP1_CIAP2_7.10E−06 BNIP3_FAS_LC3_FASLG_UVRAG 2.77E−06 TP63BNIP3_FAS_LC3_FASLG_SESN3 3.69E−06 DRAM_FRAP1_XIAP_CIAP2_ 8.40E−06BNIP3_FAS_LC3_FASLG_SESN2 2.93E−06 TP63 BNIP3_FAS_LC3_FASLG_UVRAG3.69E−06 DRAM_TKT_CIAP2_SESN2_TP63 9.09E−06 BNIP3_DRAM_FAS_LC3_FASLG2.99E−06 ATG3_FAS_LC3_FASLG_SESN2 3.79E−06 AIFM1_CDH1_ID2_CIAP2_1.00E−05 BNIP3_DIABLO_FAS_LC3_FASLG 3.07E−06 SESN2BNIP3_FAS_LC3_FASLG_SESN2 3.94E−06 AIFM1_DRAM_FRAP1_CIAP2_ 1.00E−05FAS_LC3_ID2_FASLG_UVRAG 3.08E−06 TP63 DRAM_FAS_LC3_FASLG_STAT3 3.96E−06DRAM_FRAP1_TKT_CIAP2_ 1.04E−05 DIABLO_FAS_LC3_FASLG_ 3.09E−06 TP63 UVRAGDIABLO_FAS_LC3_BECN1_FASLG 4.05E−06 PTEN_CDH1_ID2_CIAP2_SESN2 1.10E−05DIABLO_FAS_LC3_FASLG_STAT3 3.21E−06 BNIP3_DIABLO_FAS_LC3_FASLG 4.11E−06BAX_CDH1_ID2_CIAP2_SESN2 1.20E−05 DIABLO_FAS_LC3_FASLG_SESN3 3.26E−06ATG7_DRAM_FAS_LC3_FASLG 4.12E−06 DRAM_FRAP1_ID2_CIAP2_TP63 1.37E−05DIABLO_FAS_LC3_FASLG_SIRT1 3.32E−06 DIABLO_FAS_LC3_FASLG_STAT3 4.14E−06DRAM_TKT_CASP3_CIAP2_ 1.39E−05 FAS_LC3_MMP9_FASLG_ 3.33E−06 TP63RPS19BP1 DRAM_FAS_LC3_FASLG_SIRT1 4.15E−06 CDH1_ID2_CCNG2_CIAP2_1.44E−05 ATG5_FAS_LC3_FASLG_UVRAG 3.34E−06 SESN2 DRAM_E2F1_FAS_LC3_FASLG4.20E−06 AIFM1_PTEN_ID2_CIAP2_SESN2 1.50E−05 BNIP3_FAS_LC3_FASLG_SESN33.37E−06 DRAM_FAS_LC3_FASLG_SESN3 4.20E−06 DIABLO_FRAP1_CDH1_ID2_1.54E−05 DIABLO_FAS_LC3_BECN1_FASLG 3.39E−06 CIAP2DRAM_FAS_LC3_BECN1_FASLG 4.22E−06 AIFM1_CBS_ID2_CIAP2_SESN2 1.60E−05DIABLO_FAS_LC3_CDH1_FASLG 3.42E−06 BNIP3_FAS_LC3_FASLG_STAT3 4.35E−06AIFM1_LAMP1_ID2_CIAP2_ 1.60E−05 ATG3_FAS_LC3_FASLG_SESN2 3.46E−06 SESN2BNIP3_FAS_LC3_MMP9_FASLG 4.37E−06 DRAM_ID2_CASP3_CIAP2_TP63 1.60E−05DRAM_E2F1_FAS_LC3_FASLG 3.48E−06 DIABLO_FAS_LC3_ID2_FASLG 4.40E−06DIABLO_PTEN_CDH1_ID2_ 1.63E−05 FAS_LC3_FASLG_SESN2_UVRAG 3.50E−06 CIAP2DIABLO_FAS_LC3_MMP9_FASLG 4.41E−06 CDH1_ID2_CIAP2_SESN2_VEGF 1.67E−05DIABLO_FAS_LC3_FASLG_LAMP2 3.51E−06 ATG5_FAS_LC3_FASLG_UVRAG 4.43E−06DIABLO_CDH1_ID2_CASP3_ 1.70E−05 E2F1_FAS_LC3_ID2_FASLG 3.52E−06 CIAP2ATG5_DRAM_FAS_LC3_FASLG 4.45E−06 AIFM1_ATG3_ID2_CIAP2_SESN2 1.80E−05DIABLO_FAS_LC3_FASLG_ 3.52E−06 NAPMT DIABLO_FAS_LC3_FASLG_SIRT1 4.46E−06AIFM1_BNIP3_ID2_CIAP2_ 1.80E−05 DIABLO_FAS_LC3_MMP9_FASLG 3.54E−06 SESN2FAS_LC3_FASLG_SIRT1_UVRAG 4.47E−06 AIFM1_DIABLO_CDH1_ID2_ 1.80E−05FAS_LC3_FASLG_SIRT1_UVRAG 3.56E−06 CIAP2 DRAM_FAS_FRAP1_LC3_FASLG4.49E−06 ATG3_DRAM_ID2_CIAP2_SESN2 1.80E−05 FAS_LC3_FASLG_SESN3_UVRAG3.64E−06 DIABLO_FAS_LC3_FASLG_SESN3 4.54E−06 AIFM1_BAX_ID2_CIAP2_SESN21.90E−05 FAS_LAMP1_LC3_FASLG_UVRAG 3.65E−06 FAS_LC3_BECN1_FASLG_UVRAG4.55E−06 DRAM_E2F1_CASP3_CIAP2_ 1.92E−05 AKT1_DIABLO_FAS_LC3_FASLG3.70E−06 TP63 ATG3_FAS_LC3_MMP9_FASLG 4.58E−06 AIFM1_ID2_CIAP2_HMGB2_2.00E−05 DIABLO_FAS_FRAP1_LC3_FASLG 3.75E−06 SESN2BNIP3_FAS_LC3_FASLG_SIRT1 4.59E−06 AIFM1_ID2_MMP9_CIAP2_ 2.00E−05DIABLO_FAS_LC3_BHLHE41_ 3.75E−06 SESN2 FASLG BNIP3_FAS_FRAP1_LC3_FASLG4.70E−06 DIABLO_CDH1_ID2_CIAP2_ 2.00E−05 FAS_LC3_FASLG_STAT3_UVRAG3.76E−06 VEGF DIABLO_FAS_LC3_FASLG_UVRAG 4.72E−06 DIABLO_DRAM_XIAP_ID2_2.09E−05 DIABLO_FAS_LC3_FASLG_SESN2 3.76E−06 SESN2DIABLO_FAS_LC3_FASLG_NAMPT 4.72E−06 AIFM1_ATG5_ID2_CIAP2_SESN2 2.10E−05E2F1_FAS_LC3_MMP9_FASLG 3.77E−06 FAS_LC3_MMP9_FASLG_RPS19BP1 4.73E−06AIFM1_ID2_CIAP2_HMGB1_ 2.10E−05 BNIP3_FAS_FRAP1_LC3_FASLG 3.81E−06 SESN2BNIP3_FAS_LC3_BECN1_FASLG 4.74E−06 BAX_DIABLO_CDH1_ID2_CIAP2 2.10E−05DIABLO_FAS_LAMP1_LC3_FASLG 3.81E−06 E2F1_FAS_LC3_MMP9_FASLG 4.74E−06DRAM_FRAP1_NNMT_CIAP2_ 2.14E−05 FAS_LC3_BECN1_FASLG_UVRAG 3.82E−06 TP63FAS_LC3_MMP9_FASLG_UVRAG 4.77E−06 FRAP1_CDH1_ID2_CIAP2_ 2.14E−05AKT1_FAS_LC3_FASLG_UVRAG 3.87E−06 RPS19BP1 ATG3_DIABLO_FAS_LC3_FASLG4.87E−06 DRAM_XIAP_CIAP2_SESN2_ 2.16E−05 BNIP3_FAS_LC3_MMP9_FASLG3.87E−06 TP63 DIABLO_FAS_LC3_BHLHE41_FASLG 4.96E−06AIFM1_DIABLO_ID2_CIAP2_ 2.20E−05 FAS_FRAP1_LC3_FASLG_UVRAG 3.90E−06SESN2 FAS_LC3_ID2_FASLG_UVRAG 4.96E−06 AIFM1_DRAM_ID2_CIAP2_ 2.20E−05BNIP3_FAS_LC3_FASLG_STAT3 3.92E−06 SESN2 DIABLO_FAS_LC3_FASLG_LAMP25.04E−06 AIFM1_ID2_CIAP2_SESN2_ 2.20E−05 FAS_LC3_CDH1_FASLG_UVRAG3.95E−06 DRAM_FAS_LC3_FASLG_SESN2 5.17E−06 AIFM1_TKT_ID2_CIAP2_SESN22.20E−05 FAS_LC3_FASLG_LAMP2_UVRAG 3.97E−06 DRAM_FAS_LAMP1_LC3_FASLG5.29E−06 ATG3_ID2_MMP9_TCF3_ 2.20E−05 FAS_LC3_MMP9_FASLG_UVRAG 3.98E−06RPS19BP1 ATG3_FAS_FRAP1_LC3_FASLG 5.34E−06 ATG5_DRAM_CIAP2_SESN2_2.20E−05 ATG7_FAS_LC3_FASLG_UVRAG 3.99E−06 TP63FAS_LC3_FASLG_STAT3_UVRAG 5.37E−06 CBS_FRAP1_ID2_CIAP2_SESN2 2.27E−05ATG7_DRAM_FAS_LC3_FASLG 4.08E−06 AKT1_BNIP3_FAS_LC3_FASLG 5.37E−06AIFM1_DIABLO_ID2_CASP3_ 2.30E−05 BNIP3_FAS_LC3_FASLG_SIRT1 4.12E−06CIAP2 FAS_LC3_FASLG_SESN3_UVRAG 5.39E−06 AIFM1_NNMT_ID2_CIAP2_ 2.30E−05DRAM_FAS_LAMP1_LC3_FASLG 4.12E−06 SESN2 ATG3_DRAM_FAS_LC3_FASLG 5.40E−06ATG3_DRAM_CIAP2_SESN2_ 2.30E−05 ATG7_BNIP3_FAS_LC3_FASLG 4.12E−06 TP63AKT1_DRAM_FAS_LC3_FASLG 5.42E−06 ATG3_FRAP1_ID2_CIAP2_SESN2 2.30E−05BNIP3_FAS_LAMP1_LC3_FASLG 4.13E−06 FAS_LC3_FASLG_SESN2_UVRAG 5.56E−06BAX_DIABLO_DRAM_ID2_ 2.30E−05 ATG3_FAS_LC3_MMP9_FASLG 4.16E−06 CASP3FAS_LC3_BHLHE41_FASLG_UVRAG 5.58E−06 LAMP1_PTEN_ID2_CIAP2_ 2.31E−05ATG5_DIABLO_FAS_LC3_FASLG 4.20E−06 DRAM_FAS_LC3_FASLG_NAMPT 5.61E−06CDH1_ID2_CIAP2_RAGE_SESN2 2.33E−05 BNIP3_FAS_LC3_ID2_FASLG 4.26E−06FAS_LC3_FASLG_LAMP2_UVRAG 5.67E−06 CBS_DIABLO_ID2_CIAP2_ 2.35E−05ATG12_DIABLO_FAS_LC3_FASLG 4.26E−06 SESN2 ATG7_BNIP3_FAS_LC3_FASLG5.68E−06 DIABLO_CDH1_ID2_CCNG2_ 2.39E−05 E2F1_FAS_LC3_FASLG_SESN34.27E−06 CIAP2 AKT1_FAS_LC3_FASLG_UVRAG 5.78E−06 DIABLO_LAMP1_ID2_CASP3_2.39E−05 AKT1_BNIP3_FAS_LC3_FASLG 4.29E−06 CIAP2 E2F1_FAS_LC3_ID2_FASLG5.85E−06 AIFM1_DRAM_CASP3_CIAP2_ 2.40E−05 FAS_LC3_FASLG_NAMPT_UVRAG4.34E−06 TP63 DRAM_FAS_LC3_CDH1_FASLG 5.86E−06 BCL2L1_DRAM_FRAP1_CIAP2_2.40E−05 ATG12_FAS_LC3_FASLG_UVRAG 4.37E−06 TP63 PTEN_CDH1_ID2_MMP9_TCF38.28E−04 CDH1_ID2_MMP9_TCF3_CIAP2 1.01E−04 PTEN_CDH1_ID2_MMP9_TCF38.28E−04

TABLE 51 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value BNIP3_DRAM_FAS_LC3_FASLG_SESN2 1.87E−06ATG12_DRAM_FRAP1_TKT_ 8.60E−07 BNIP3_DRAM_FAS_LC3_ 1.92E−06 CIAP2_TP63FASLG_SESN2 BNIP3_DRAM_FAS_LC3_FASLG_SESN3 1.96E−06AIFM1_DRAM_TKT_CIAP2_ 1.50E−06 DIABLO_DRAM_FAS_LC3_ 1.94E−06 SESN2_TP63ID2_FASLG ATG3_FAS_LC3_MMP9_FASLG_SESN2 2.02E−06 AIFM1_ATG12_DRAM_FRAP1_1.80E−06 ATG3_FAS_LC3_MMP9_ 1.99E−06 CIAP2_TP63 FASLG_SESN2ATG3_FAS_LC3_MMP9_FASLG_SESN3 2.02E−06 AIFM1_DRAM_ID2_CIAP2_ 1.90E−06DRAM_FAS_LC3_ID2_ 2.04E−06 SESN2_TP63 FASLG_UVRAGATG3_FAS_LC3_FASLG_SESN2_SESN3 2.03E−06 DRAM_TKT_ID2_CIAP2_SESN2_2.37E−06 BNIP3_DRAM_FAS_LC3_ 2.07E−06 TP63 FASLG_UVRAGBNIP3_DRAM_FAS_LC3_MMP9_FASLG 2.06E−06 AIFM1_ATG3_DRAM_CIAP2_ 2.40E−06BNIP3_FAS_LC3_FASLG_ 2.08E−06 SESN2_TP63 SESN2_UVRAGBNIP3_DRAM_FAS_LC3_FASLG_STAT3 2.33E−06 DRAM_FRAP1_TKT_CDH1_ 2.50E−06DIABLO_FAS_LC3_ID2_ 2.12E−06 CIAP2_TP63 FASLG_UVRAGBNIP3_DRAM_FAS_LC3_FASLG_UVRAG 2.35E−06 ATG3_DRAM_ID2_CIAP2_ 2.60E−06DIABLO_FAS_LC3_ID2_ 2.24E−06 SESN2_TP63 FASLG_STAT3BNIP3_DRAM_FAS_LC3_FASLG_SIRT1 2.38E−06 DRAM_PTEN_ID2_CIAP2_ 2.77E−06DIABLO_FAS_LC3_ID2_ 2.25E−06 SESN2_TP63 FASLG_SESN3ATG3_DRAM_FAS_LC3_FASLG_SESN2 2.48E−06 DRAM_FRAP1_TKT_XIAP_ 2.94E−06BNIP3_FAS_LC3_MMP9_ 2.26E−06 CIAP2_TP63 FASLG_UVRAGBNIP3_DRAM_FAS_LC3_BECN1_FASLG 2.48E−06 DRAM_E2F1_FRAP1_CDH1_ 3.19E−06BNIP3_DRAM_FAS_LC3_ 2.27E−06 CIAP2_TP63 FASLG_SESN3DRAM_FAS_LC3_ID2_FASLG_UVRAG 2.50E−06 ATG3_DRAM_FRAP1_CDH1_ 3.30E−06BNIP3_FAS_LC3_ID2_FASLG_ 2.28E−06 CIAP2_TP63 UVRAGBNIP3_FAS_LC3_MMP9_FASLG_UVRAG 2.54E−06 ATG7_DRAM_ID2_CIAP2_ 3.30E−06DRAM_FAS_LC3_MMP9_ 2.34E−06 SESN2_TP63 FASLG_RPS19BP1DRAM_FAS_LC3_MMP9_FASLG_ 2.54E−06 AIFM1_DRAM_FRAP1_CDH1_ 3.40E−06BNIP3_FAS_LC3_MMP9_ 2.34E−06 RPS19BP1 CIAP2_TP63 FASLG_RPS19BP1ATG5_DRAM_FAS_LC3_FASLG_UVRAG 2.58E−06 ATG5_DRAM_ID2_CIAP2_ 3.40E−06BNIP3_FAS_LC3_ID2_FASLG_ 2.37E−06 SESN2_TP63 SESN2DRAM_FAS_LC3_FASLG_SIRT1_UVRAG 2.62E−06 AIFM1_DIABLO_CDH1_ID2_ 3.80E−06BNIP3_DIABLO_FAS_LC3_ 2.37E−06 CIAP2_SESN2 ID2_FASLGDRAM_FAS_LC3_MMP9_FASLG_UVRAG 2.62E−06 AIFM1_BNIP3_DRAM_CIAP2_ 3.90E−06BNIP3_FAS_LC3_MMP9_ 2.37E−06 SESN2_TP63 FASLG_SESN2BNIP3_DRAM_FAS_LC3_ID2_FASLG 2.63E−06 BCL2L1_DRAM_ID2_CIAP2_ 3.98E−06DIABLO_FAS_LC3_ID2_ 2.38E−06 SESN2_TP63 FASLG_SIRT1ATG3_DRAM_FAS_LC3_FASLG_SESN3 2.65E−06 DRAM_NNMT_ID2_CIAP2_ 3.99E−06ATG5_DRAM_FAS_LC3_ 2.39E−06 SESN2_TP63 FASLG_UVRAGBNIP3_FAS_LC3_MMP9_FASLG_SESN3 2.69E−06 CASP8_DRAM_ID2_CIAP2_ 4.01E−06FAS_LC3_MMP9_FASLG_ 2.40E−06 SESN2_TP63 RPS19BP1_UVRAGBNIP3_FAS_LC3_MMP9_FASLG_SESN2 2.71E−06 DRAM_ID2_BHLHE41_CIAP2_ 4.02E−06ATG3_FAS_LC3_FASLG_ 2.41E−06 SESN2_TP63 SESN2_SESN3DRAM_FAS_LC3_BECN1_FASLG_ 2.72E−06 DRAM_FRAP1_CDH1_CIAP2_ 4.07E−06DRAM_FAS_LC3_FASLG_ 2.43E−06 UVRAG RPS19BP1_TP63 SESN2_UVRAGBNIP3_DRAM_FAS_FRAP1_LC3_FASLG 2.72E−06 DRAM_LAMP1_ID2_CIAP2_ 4.11E−06DIABLO_FAS_LC3_ID2_ 2.44E−06 SESN2_TP63 BECN1_FASLGBNIP3_FAS_LC3_FASLG_SESN3_SIRT1 2.75E−06 DRAM_FRAP1_CDH1_ID2_ 4.14E−06DRAM_FAS_LC3_FASLG_ 2.46E−06 CIAP2_TP63 SIRT1_UVRAGDRAM_FAS_LC3_BHLHE41_FASLG_ 2.76E−06 BNIP3_DRAM_ID2_CIAP2_ 4.16E−06FAS_LC3_ID2_FASLG_SESN2_ 2.47E−06 UVRAG SESN2_TP63 UVRAGBNIP3_DRAM_FAS_LC3_FASLG_LAMP2 2.78E−06 DRAM_ID2_MMP9_CIAP2_ 4.20E−06DIABLO_FAS_LC3_CDH1_ 2.48E−06 SESN2_TP63 ID2_FASLGAKT1_BNIP3_DRAM_FAS_LC3_FASLG 2.79E−06 AKT1_DRAM_ID2_CIAP2_ 4.20E−06FAS_LC3_ID2_MMP9_FASLG_ 2.48E−06 SESN2_TP63 RPS19BP1DIABLO_DRAM_FAS_LC3_ID2_FASLG 2.80E−06 DRAM_ID2_CIAP2_RAGE_ 4.20E−06BNIP3_FAS_LC3_FASLG_ 2.51E−06 SESN2_TP63 SESN2_SESN3DRAM_FAS_LC3_FASLG_SESN3_SIRT1 2.82E−06 ATG12_DRAM_FRAP1_XIAP_ 4.30E−06DIABLO_FAS_LC3_ID2_ 2.52E−06 CIAP2_TP63 FASLG_NAMPTATG3_DIABLO_FAS_LC3_MMP9_FASLG 2.84E−06 DRAM_PRKAA1_ID2_CIAP2_ 4.31E−06DIABLO_FAS_LC3_ID2_ 2.53E−06 SESN2_TP63 FASLG_SESN2BNIP3_FAS_LC3_FASLG_SESN3_STAT3 2.87E−06 DRAM_XIAP_ID2_CIAP2_ 4.34E−06DIABLO_FAS_LC3_ID2_ 2.54E−06 SESN2_TP63 FASLG_LAMP2BNIP3_FAS_LC3_BECN1_FASLG_SESN2 2.89E−06 AIFM1_DRAM_PTEN_CIAP2_ 4.40E−06BNIP3_FAS_LC3_FASLG_ 2.56E−06 SESN2_TP63 SESN2_SIRT1BNIP3_FAS_LC3_FASLG_SESN2_SIRT1 2.92E−06 ATG3_DRAM_FRAP1_CASP3_ 4.40E−06BNIP3_FAS_LC3_FASLG_ 2.56E−06 CIAP2_TP63 SESN2_STAT3DIABLO_DRAM_FAS_LC3_MMP9_FASLG 2.92E−06 CASP8_DRAM_FRAP1_CDH1_ 4.47E−06DRAM_FAS_LC3_FASLG_ 2.58E−06 CIAP2_TP63 SESN3_UVRAGBNIP3_FAS_LC3_BECN1_FASLG_SESN3 2.94E−06 AIFM1_ATG5_DRAM_CIAP2_ 4.50E−06DIABLO_DRAM_FAS_LC3_ 2.58E−06 SESN2_TP63 FASLG_STAT3BNIP3_FAS_LC3_FASLG_SESN2_UVRAG 2.94E−06 AIFM1_CASP8_DRAM_CIAP2_4.50E−06 BNIP3_DRAM_FAS_LC3_ 2.59E−06 SESN2_TP63 MMP9_FASLGDRAM_FAS_LC3_FASLG_LAMP2_ 2.95E−06 BCL2L1_DRAM_FRAP1_TKT_ 4.53E−06ATG5_FAS_LC3_ID2_FASLG_ 2.59E−06 UVRAG CIAP2_TP63 UVRAGATG3_FAS_FRAP1_LC3_MMP9_FASLG 2.97E−06 CBS_DRAM_ID2_CIAP2_SESN2_4.58E−06 BNIP3_FAS_LC3_FASLG_ 2.59E−06 TP63 SESN3_UVRAGDRAM_FAS_LC3_BECN1_FASLG_SESN3 2.98E−06 DRAM_FRAP1_NNMT_TKT_ 4.59E−06DRAM_FAS_LC3_BECN1_ 2.59E−06 CIAP2_TP63 FASLG_UVRAGDIABLO_DRAM_FAS_LC3_BECN1_ 2.98E−06 AIFM1_AKT1_DRAM_CIAP2_ 4.60E−06DIABLO_DRAM_FAS_LC3_ 2.60E−06 FASLG SESN2_TP63 CDH1_FASLGATG3_DRAM_FAS_LC3_MMP9_FASLG 2.99E−06 DRAM_FRAP1_PTEN_CDH1_ 4.61E−06AKT1_DIABLO_FAS_LC3_ 2.60E−06 CIAP2_TP63 ID2_FASLGBNIP3_DRAM_FAS_LC3_CDH1_FASLG 3.02E−06 DIABLO_PTEN_CDH1_ID2_ 4.65E−06BNIP3_DIABLO_FAS_LC3_ 2.61E−06 CIAP2_SESN2 MMP9_FASLGDRAM_FAS_LC3_FASLG_SESN2_UVRAG 3.04E−06 DRAM_ID2_CIAP2_SESN2_ 4.67E−06DRAM_FAS_LC3_CDH1_ 2.61E−06 TP63_VEGF FASLG_UVRAGBNIP3_DRAM_FAS_LC3_BHLHE41_ 3.05E−06 AIFM1_DRAM_XIAP_CIAP2_ 4.70E−06DIABLO_FAS_FRAP1_LC3_ 2.62E−06 FASLG SESN2_TP63 ID2_FASLGATG5_DRAM_FAS_LC3_FASLG_SESN3 3.05E−06 BNIP3_DRAM_FRAP1_CDH1_ 4.78E−06BNIP3_DRAM_FAS_LC3_ 2.62E−06 CIAP2_TP63 FASLG_STAT3DRAM_FAS_LC3_FASLG_SESN3_STAT3 3.06E−06 AIFM1_ATG7_DRAM_CIAP2_ 4.80E−06DIABLO_DRAM_FAS_LC3_ 2.62E−06 SESN2_TP63 FASLG_SESN3BNIP3_FAS_LC3_FASLG_SESN2_STAT3 3.06E−06 AIFM1_DRAM_FRAP1_NNMT_ 4.80E−06BNIP3_DIABLO_DRAM_FAS_ 2.63E−06 CIAP2_TP63 LC3_FASLGBNIP3_DIABLO_FAS_LC3_MMP9_FASLG 3.07E−06 AIFM1_DRAM_MMP9_CIAP2_ 4.80E−06DIABLO_DRAM_FAS_LC3_ 2.63E−06 SESN2_TP63 FASLG_SIRT1ATG5_DRAM_FAS_LC3_FASLG_SESN2 3.07E−06 AIFM1_DRAM_PRKAA1_CIAP2_ 4.80E−06BNIP3_DRAM_FAS_FRAP1_ 2.63E−06 SESN2_TP63 LC3_FASLGATG5_FAS_LC3_MMP9_FASLG_UVRAG 3.09E−06 AIFM1_DRAM_CIAP2_RAGE_ 4.90E−06DIABLO_DRAM_FAS_LC3_ 2.63E−06 SESN2_TP63 BECN1_FASLGDIABLO_DRAM_FAS_LC3_BHLHE41_ 3.09E−06 AIFM1_DRAM_FRAP1_XIAP_ 4.90E−06ATG3_FAS_LC3_MMP9_ 2.64E−06 FASLG CIAP2_TP63 FASLG_SESN3DIABLO_DRAM_FAS_LC3_FASLG_ 3.12E−06 AIFM1_DRAM_NNMT_CIAP2_ 4.90E−06DIABLO_FAS_LAMP1_LC3_ 2.64E−06 STAT3 SESN2_TP63 ID2_FASLGATG3_DIABLO_FAS_LC3_FASLG_ 3.13E−06 DRAM_FRAP1_CDH1_CIAP2_ 4.90E−06DRAM_FAS_LC3_FASLG_ 2.64E−06 SESN3 TP63_VEGF LAMP2_UVRAGDRAM_FAS_LC3_TCF3_FASLG_UVRAG 3.13E−06 AIFM1_DRAM_LAMP1_CIAP2_ 5.00E−06ATG5_FAS_LC3_FASLG_ 2.65E−06 SESN2_TP63 SESN2_UVRAGBNIP3_FAS_LC3_MMP9_FASLG_ 3.14E−06 DIABLO_DRAM_FRAP1_XIAP_ 5.01E−06FAS_LC3_MMP9_FASLG_ 2.66E−06 RPS19BP1 CASP3_HMGB2 RPS19BP1_SESN3ATG5_DRAM_FAS_LC3_FASLG_STAT3 3.15E−06 DRAM_TKT_XIAP_CIAP2_ 5.05E−06FAS_LAMP1_LC3_ID2_ 2.66E−06 SESN2_TP63 FASLG_UVRAGATG7_DRAM_FAS_LC3_MMP9_FASLG 3.17E−06 AIFM1_BCL2L1_DRAM_CIAP2_ 5.10E−06BNIP3_DRAM_FAS_LC3_ID2_ 2.67E−06 SESN2_TP63 FASLGLC3_CDH1_ID2_MMP9_TCF3_FASLG 6.15E−05 BAX_CDH1_ID2_MMP9_TCF3_ 2.80E−05LC3_CDH1_ID2_MMP9_TCF3_ 3.51E−05 CIAP2 FASLG

TABLE 52 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 1.14E−06AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 6.50E−07ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 1.44E−06BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 1.35E−06ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 7.10E−07BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 1.54E−06ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 1.37E−06ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 7.20E−07BNIP3_FAS_LC3_ID2_FASLG_SESN2_UVRAG 1.56E−06BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 1.55E−06ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 7.60E−07ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 1.60E−06ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 1.56E−06ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 7.80E−07BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG 1.61E−06ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN3 1.56E−06ATG12_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF 8.10E−07BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 1.62E−06BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 1.62E−06ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63 8.20E−07ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG 1.63E−06BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 1.62E−06ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 8.30E−07BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG 1.65E−06BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG 1.71E−06ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 8.60E−07FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG 1.67E−06BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 1.72E−06ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 8.60E−07BNIP3_DRAM_FAS_LC3_ID2_FASLG_UVRAG 1.70E−06ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3 1.72E−06ATG12_DRAM_FRAP1_TKT_MMP9_CIAP2_TP63 9.30E−07DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG 1.70E−06BNIP3_DRAM_FAS_LC3_FASLG_SESN3_SIRT1 1.72E−06ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 9.40E−07DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 1.72E−06ATG3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG 1.75E−06AIFM1_BCL2L1_DRAM_TKT_CIAP2_SESN2_TP63 9.50E−07ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 1.73E−06BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 1.76E−06AIFM1_ATG12_DRAM_FRAP1_PTEN_CIAP2_TP63 1.00E−06BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SIRT1 1.74E−06BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SIRT1 1.76E−06AIFM1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63 1.00E−06BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 1.74E−06BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG 1.80E−06AIFM1_DRAM_PTEN_ID2_CIAP2_SESN2_TP63 1.00E−06BNIP3_DRAM_FAS_LC3_MMP9_FASLG_UVRAG 1.75E−06BNIP3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 1.83E−06AIFM1_DRAM_TKT_MMP9_CIAP2_SESN2_TP63 1.00E−06BNIP3_DRAM_FAS_LC3_FASLG_SESN2_STAT3 1.77E−06BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 1.83E−06ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 1.00E−06BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG 1.77E−06ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 1.84E−06AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 1.10E−06ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 1.79E−06ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN3 1.85E−06ATG12_DRAM_E2F1_FRAP1_TKT_CIAP2_TP63 1.10E−06DIABLO_DRAM_FAS_LC3_ID2_FASLG_STAT3 1.81E−06ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 1.85E−06ATG12_DRAM_FRAP1_TKT_BHLHE41_CIAP2_TP63 1.10E−06ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2 1.81E−06BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN3 1.87E−06AIFM1_ATG12_DRAM_FRAP1_MMP9_CIAP2_TP63 1.20E−06DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN3 1.82E−06ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 1.88E−06AIFM1_ATG3_DRAM_ID2_CIAP2_SESN2_TP63 1.20E−06BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 1.83E−06BNIP3_DRAM_FAS_LC3_FASLG_SESN3_STAT3 1.88E−06AIFM1_ATG3_DRAM_MMP9_CIAP2_SESN2_TP63 1.20E−06ATG5_DRAM_FAS_LC3_ID2_FASLG_UVRAG 1.84E−06ATG3_FAS_LC3_ID2_FASLG_SESN2_SESN3 1.90E−06ATG12_DRAM_FRAP1_TKT_CIAP2_HMGB1_TP63 1.20E−06BNIP3_DRAM_FAS_LC3_BECN1_FASLG_SESN2 1.84E−06ATG3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 1.90E−06AIFM1_ATG12_DRAM_TKT_CIAP2_SESN2_TP63 1.30E−06BNIP3_DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1 1.84E−06ATG5_DRAM_FAS_LC3_MMP9_FASLG_UVRAG 1.91E−06AIFM1_BNIP3_DRAM_TKT_CIAP2_SESN2_TP63 1.30E−06ATG5_FAS_LC3_ID2_FASLG_SESN2_UVRAG 1.86E−06ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2 1.92E−06AIFM1_DRAM_ID2_MMP9_CIAP2_SESN2_TP63 1.30E−06ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2 1.87E−06ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN3 1.92E−06AIFM1_DRAM_LAMP1_TKT_CIAP2_SESN2_TP63 1.30E−06DIABLO_DRAM_FAS_LC3_ID2_FASLG_UVRAG 1.87E−06BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2 1.93E−06DRAM_FRAP1_TKT_CASP3_CIAP2_HMGB2_TP63 1.32E−06DIABLO_DRAM_FAS_LC3_CDH1_ID2_FASLG 1.88E−06ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2 1.93E−06AIFM1_AKT1_ATG12_DRAM_FRAP1_CIAP2_TP63 1.40E−06DRAM_FAS_LC3_ID2_FASLG_SIRT1_UVRAG 1.88E−06ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN3 1.93E−06AIFM1_DRAM_PRKAA1_TKT_CIAP2_SESN2_TP63 1.40E−06DIABLO_DRAM_FAS_LC3_ID2_FASLG_SIRT1 1.89E−06ATG3_FAS_LC3_FASLG_SESN2_SESN3_SIRT1 1.94E−06AIFM1_DRAM_TKT_CIAP2_RAGE_SESN2_TP63 1.40E−06BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 1.89E−06BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG 1.94E−06AIFM1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 1.40E−06FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 1.89E−06ATG3_FAS_LC3_BHLHE41_FASLG_SESN2_SESN3 1.94E−06ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63 1.40E−06BNIP3_FAS_LC3_ID2_MMP9_FASLG_UVRAG 1.89E−06BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 1.95E−06AIFM1_AKT1_DRAM_TKT_CIAP2_SESN2_TP63 1.50E−06DIABLO_DRAM_FAS_LC3_ID2_BECN1_FASLG 1.90E−06ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 1.95E−06AIFM1_ATG12_DRAM_FRAP1_CIAP2_TP63_VEGF 1.50E−06DRAM_FAS_LC3_ID2_FASLG_SESN3_UVRAG 1.90E−06BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG 1.97E−06AIFM1_ATG3_DRAM_NNMT_CIAP2_SESN2_TP63 1.50E−06ATG3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 1.90E−06BNIP3_FAS_LC3_MMP9_FASLG_SESN2_UVRAG 1.98E−06AIFM1_BAX_DRAM_ID2_CIAP2_SESN2_TP63 1.50E−06BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN2 1.91E−06BNIP3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN3 1.99E−06AIFM1_DRAM_NNMT_ID2_CIAP2_SESN2_TP63 1.50E−06BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN3 1.92E−06ATG3_FAS_LC3_BECN1_FASLG_SESN2_SESN3 2.00E−06DRAM_FRAP1_NNMT_TKT_XIAP_CIAP2_TP63 1.56E−06BNIP3_FAS_LC3_ID2_FASLG_SESN2_SESN3 1.93E−06BNIP3_DRAM_FAS_LC3_FASLG_SESN2_UVRAG 2.00E−06BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 1.60E−06DIABLO_DRAM_FAS_LC3_ID2_FASLG_LAMP2 1.93E−06ATG7_BNIP3_DRAM_FAS_LC3_MMP9_FASLG 2.00E−06AIFM1_ATG12_ATG3_DRAM_FRAP1_CIAP2_TP63 1.60E−06BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2 1.94E−06BNIP3_DRAM_FAS_LC3_MMP9_FASLG_STAT3 2.01E−06AIFM1_ATG7_DRAM_ID2_CIAP2_SESN2_TP63 1.60E−06ATG5_DRAM_FAS_LC3_FASLG_SESN2_UVRAG 1.95E−06BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 2.01E−06AIFM1_DRAM_TKT_CIAP2_SESN2_TP63_VEGF 1.60E−06DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_UVRAG 1.95E−06ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 2.03E−06ATG12_ATG3_DRAM_FRAP1_TKT_CIAP2_TP63 1.60E−06DRAM_FAS_LAMP1_LC3_ID2_FASLG_UVRAG 1.97E−06BNIP3_FAS_LC3_MMP9_FASLG_SESN3_SIRT1 2.04E−06AIFM1_AKT1_DRAM_ID2_CIAP2_SESN2_TP63 1.70E−06DIABLO_DRAM_FAS_LC3_ID2_FASLG_SESN2 1.97E−06ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN3 2.05E−06AIFM1_ATG12_ATG7_DRAM_FRAP1_CIAP2_TP63 1.70E−06ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2 1.97E−06BNIP3_DRAM_FAS_LC3_FASLG_LAMP2_SESN3 2.07E−06AIFM1_ATG3_BCL2L1_DRAM_CIAP2_SESN2_TP63 1.70E−06AKT1_BNIP3_DRAM_FAS_LC3_FASLG_SESN2 1.97E−06ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2 2.07E−06AIFM1_ATG7_DRAM_TKT_CIAP2_SESN2_TP63 1.70E−06DRAM_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 1.97E−06BNIP3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG 2.07E−06AIFM1_BCL2L1_DRAM_ID2_CIAP2_SESN2_TP63 1.70E−06ATG3_DRAM_FAS_LC3_FASLG_SESN2_SESN3 1.98E−06ATG3_FAS_LC3_FASLG_LAMP2_SESN2_SESN3 2.08E−06AIFM1_CBS_DRAM_TKT_CIAP2_SESN2_TP63 1.70E−06ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 1.99E−06BNIP3_FAS_LC3_MMP9_TCF3_FASLG_UVRAG 2.10E−06AIFM1_DRAM_PTEN_TKT_CIAP2_SESN2_TP63 1.70E−06BNIP3_FAS_LC3_MMP9_FASLG_RPS19BP1_SESN3 1.99E−06BNIP3_FAS_LC3_MMP9_BECN1_FASLG_SESN2 2.10E−06AIFM1_DRAM_TKT_BHLHE41_CIAP2_SESN2_TP63 1.70E−06DRAM_FAS_LC3_ID2_FASLG_STAT3_UVRAG 1.99E−06ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN3 2.12E−06ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_TP63 1.70E−06BNIP3_DRAM_FAS_LC3_CDH1_FASLG_UVRAG 1.99E−06BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2 2.12E−06BCL2L1_DRAM_TKT_ID2_CIAP2_SESN2_TP63 1.72E−06ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2 1.99E−06BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2 2.14E−06BAX_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 1.74E−06DRAM_FAS_LC3_ID2_BECN1_FASLG_UVRAG 1.99E−06FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG 1.22E−05CBS_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3 1.03E−05E2F1_LC3_CDH1_ID2_MMP9_TCF3_FASLG 4.14E−06

TABLE 53 Recurrence Survival Disease-free survival Marker p-value Markerp-value Marker p-value ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_ 9.17E−07AIFM1_ATG12_DRAM_FRAP1_IKT_MMP9_CIAP2_TP63 3.20E−07ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3 1.21E−06 SESN3ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_SESN3 1.07E−06AIFM1_ATG12_DRAM_FRAP1_NNMT_TKT_CIAP2_TP63 4.70E−07BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG 1.21E−06ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_ 1.07E−06AIFM1_ATG12_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 5.00E−07ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 1.22E−06 SIRT1ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3 1.14E−06AIFM1_ATG12_DRAM_FRAP1_IKT_CIAP2_TP63_VEGF 5.00E−07BNIP3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG 1.27E−06ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_ 1.16E−06ATG12_DRAM_FRAP1_PTEN_TKT_XIAP_CIAP2_TP63 5.20E−07BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG 1.31E−06 SESN3ATG3_FAS_LC3_MMP9_BHLHE41_FASLG_SESN2_ 1.16E−06AIFM1_ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 5.40E−07ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_SESN3 1.32E−06 SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_ 1.16E−06AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_SATB1_TP63 5.70E−07BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 1.32E−06 SIRT1ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_ 1.18E−06AIFM1_AKT1_ATG12_DRAM_FRAP1_TKT_CIAP2_TP63 5.80E−07BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_UVRAG 1.33E−06 SESN3BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_ 1.22E−06AIFM1_ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 5.80E−07BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3 1.34E−06 SESN2ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2 1.24E−06ATG12_BCL2L1_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 5.80E−07ATG3_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG 1.35E−06BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 1.25E−06AIFM1_ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 6.00E−07DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_UVRAG 1.36E−06ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_ 1.26E−06AIFM1_ATG12_DRAM_FRAP1_PTEN_MMP9_CIAP2_TP63 6.10E−07ATG5_DRAM_FAS_LC3_ID2_FASLG_SESN2_UVRAG 1.37E−06 SESN3ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_ 1.26E−06ATG12_DRAM_E2F1_FRAP1_TKT_MMP9_CIAP2_TP63 6.10E−07BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3 1.37E−06 SESN3ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_ 1.29E−06ATG12_BCL2L1_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 6.20E−07ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 1.38E−06 SESN3ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN2 1.31E−06ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF 6.20E−07BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1 1.38E−06ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_ 1.31E−06ATG12_DIABLO_DRAM_FRAP1_TKT_CDH1_CIAP2_TP63 6.20E−07ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG 1.38E−06 SESN3BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_ 1.32E−06AIFM1_ATG3_DRAM_ID2_MMP9_CIAP2_SESN2_TP63 6.30E−07ATG3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SESN2 1.39E−06 UVRAGBNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_ 1.33E−06ATG12_CBS_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 6.30E−07ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_SIRT1 1.39E−06 SESN3BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN3_ 1.37E−06ATG12_DRAM_FRAP1_LAMP1_TKT_XIAP_CIAP2_TP63 6.30E−07BNIP3_FAS_LC3_ID2_MMP9_TCF3_FASLG_UVRAG 1.39E−06 SIRT1ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_ 1.39E−06ATG12_BCL2L1_DRAM_FRAP1_LAMP1_TKT_CIAP2_ 6.40E−07DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 1.40E−06 SESN2 TP63ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_ 1.39E−06ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_HMGB1_TP63 6.40E−07ATG3_FAS_LC3_CDH1_MMP9_FASLG_SESN2_SESN3 1.42E−06 SIRT1BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_ 1.40E−06AIFM1_ATG12_DRAM_FRAP1_PRKAA1_TKT_CIAP2_ 6.50E−07BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1 1.43E−06 UVRAG TP63ATG3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_ 1.41E−06AIFM1_DRAM_PTEN_ID2_MMP9_CIAP2_SESN2_TP63 6.50E−07ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_UVRAG 1.43E−06 SESN2BNIP3_DRAM_FAS_LC3_MMP9_FASLG_LAMP2_ 1.44E−06ATG12_ATG7_BCL2L1_DRAM_FRAP1_TKT_CIAP2_TP63 6.50E−07ATG3_FAS_LC3_MMP9_FASLG_LAMP2_SESN2_SESN3 1.44E−06 SESN2BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_ 1.45E−06ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63_VEGF 6.50E−07ATG3_FAS_LC3_MMP9_BECN1_FASLG_SESN2_SESN3 1.45E−06 STAT3BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_ 1.45E−06AIFM1_ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63 6.60E−07ATG3_DIABLO_FAS_LC3_ID2_MMP9_FASLG_SESN2 1.45E−06 SESN3ATG3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_ 1.45E−06AIFM1_ATG12_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 6.60E−07BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAG 1.47E−06 SESN2ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_ 1.45E−06ATG12_ATG7_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 6.70E−07ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG 1.47E−06 SESN3BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_ 1.45E−06ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63_VEGF 6.70E−07BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2 1.47E−06 SESN3ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_ 1.45E−06ATG12_DRAM_FRAP1_LAMP1_PTEN_TKT_CIAP2_TP63 6.90E−07BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 1.47E−06 UVRAGATG3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SESN3 1.46E−06ATG12_BCL2L1_DRAM_FRAP1_TKT_CIAP2_RAGE_TP63 7.00E−07BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SESN3 1.48E−06ATG3_DRAM_FAS_LC3_BHLHE41_FASLG_SESN2_ 1.46E−06AIFM1_ATG12_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 7.10E−07ATG3_FAS_LC3_ID2_MMP9_TCF3_FASLG_SESN2 1.48E−06 SESN3AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_ 1.46E−06AIFM1_ATG12_DIABLO_DRAM_FRAP1_CDH1_CIAP2_ 7.10E−07BNIP3_FAS_LC3_ID2_MMP9_FASLG_RPS19BP1_SESN3 1.49E−06 SESN3 TP63BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_ 1.46E−06ATG12_BCL2L1_DRAM_FRAP1_PRKAA1_TKT_CIAP2_ 7.10E−07ATG3_BNIP3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 1.50E−06 SESN2 TP63BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_SIRT1 1.49E−06ATG12_CBS_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 7.10E−07BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN2_UVRAG 1.51E−06BNIP3_DRAM_FAS_LC3_ID2_BECN1_FASLG_SESN2 1.49E−06ATG12_DRAM_FRAP1_LAMP1_PRKAA1_TKT_CIAP2_ 7.20E−07ATG5_FAS_LC3_ID2_MMP9_FASLG_SESN2_UVRAG 1.51E−06 TP63ATG3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_ 1.49E−06ATG12_DRAM_FRAP1_LAMP1_TKT_CIAP2_RAGE_TP63 7.20E−07BNIP3_FAS_LC3_CDH1_ID2_FASLG_SESN2_UVRAG 1.51E−06 SESN2ATG3_DRAM_FAS_LC3_ID2_MMP9_FASLG_SESN3 1.50E−06ATG12_ATG7_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 7.30E−07ATG5_BNIP3_DRAM_FAS_LC3_MMP9_FASLG_SESN2 1.52E−06BNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_SIRT1 1.50E−06ATG12_BCL2L1_BNIP3_DRAM_FRAP1_TKT_CIAP2_TP63 7.30E−07BNIP3_FAS_LC3_ID2_FASLG_SESN2_SIRT1_UVRAG 1.52E−06ATG3_DIABLO_FAS_LC3_MMP9_FASLG_SESN2_ 1.51E−06ATG12_CBS_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF 7.30E−07ATG3_FAS_FRAP1_LC3_MMP9_FASLG_SESN2_SESN3 1.52E−06 SESN3ATG3_DRAM_FAS_FRAP1_LC3_MMP9_FASLG_ 1.51E−06AIFM1_ATG3_DRAM_NNMT_ID2_CIAP2_SESN2_TP63 7.40E−07BNIP3_DRAM_FAS_LC3_CDH1_ID2_FASLG_SESN2 1.52E−06 SESN2BNIP3_DRAM_FAS_LC3_MMP9_BHLHE41_FASLG_ 1.52E−06AIFM1_DRAM_NNMT_PTEN_ID2_CIAP2_SESN2_TP63 7.40E−07BNIP3_CSE1L_FAS_LC3_MMP9_FASLG_SESN3_UVRAG 1.53E−06 SESN2ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3_ 1.53E−06ATG12_CBS_DRAM_FRAP1_PTEN_TKT_CIAP2_TP63 7.40E−07AKT1_BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2 1.53E−06 STAT3ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_ 1.54E−06ATG12_DRAM_FRAP1_PTEN_TKT_MMP9_CIAP2_TP63 7.40E−07BNIP3_DRAM_FAS_LC3_ID2_FASLG_LAMP2_SESN2 1.54E−06 UVRAGBNIP3_DRAM_FAS_LC3_MMP9_TCF3_FASLG_ 1.55E−06AIFM1_ATG12_ATG3_DRAM_FRAP1_MMP9_CIAP2_TP63 7.50E−07ATG3_ATG5_FAS_LC3_MMP9_FASLG_SESN2_SESN3 1.54E−06 STAT3BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_ 1.55E−06AIFM1_ATG12_CASP8_DRAM_TKT_CIAP2_SESN2_TP63 7.50E−07BNIP3_DRAM_FAS_LC3_CDH1_FASLG_SESN2_UVRAG 1.54E−06 SESN3BNIP3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_ 1.55E−06ATG12_ATG7_CBS_DRAM_FRAP1_TKT_CIAP2_TP63 7.50E−07BNIP3_FAS_LC3_ID2_FASLG_LAMP2_SESN2_UVRAG 1.55E−06 SESN2ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_ 1.56E−06ATG12_BCL2L1_DRAM_FRAP1_TKT_XIAP_CIAP2_TP63 7.50E−07BNIP3_FAS_LC3_ID2_BECN1_FASLG_SESN2_UVRAG 1.55E−06 UVRAGATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_ 1.56E−06AIFM1_ATG12_DRAM_PTEN_TKT_CIAP2_SESN2_TP63 7.60E−07BNIP3_FAS_LC3_MMP9_TCF3_FASLG_SESN2_UVRAG 1.55E−06 SESN2BNIP3_DRAM_FAS_LC3_MMP9_TCF3_BECN1_ 1.57E−06AIFM1_BCL2L1_DRAM_NNMT_TKT_CIAP2_SESN2_TP63 7.60E−07BNIP3_DRAM_FAS_LC3_ID2_TCF3_FASLG_UVRAG 1.56E−06 FASLGBNIP3_CSE1L_DRAM_FAS_LC3_MMP9_FASLG_ 1.57E−06ATG12_DRAM_E2F1_FRAP1_NNMT_TKT_CIAP2_TP63 7.60E−07AKT1_ATG3_FAS_LC3_MMP9_FASLG_SESN2_SESN3 1.56E−06 SESN3ATG3_DRAM_FAS_LC3_ULK1_MMP9_FASLG_ 1.59E−06ATG12_ATG7_DRAM_FRAP1_TKT_CIAP2_TP63_VEGF 7.70E−07ATG3_DRAM_FAS_LC3_MMP9_FASLG_SESN2_SIRT1 1.56E−06 SESN3BNIP3_DRAM_FAS_LC3_ID2_FASLG_SESN2_STAT3 1.59E−06ATG12_BNIP3_DRAM_FRAP1_LAMP1_TKT_CIAP2_TP63 7.70E−07ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_UVRAG 1.57E−06ATG5_DRAM_FAS_LC3_MMP9_FASLG_SESN2_ 1.59E−06ATG12_CBS_DRAM_FRAP1_PRKAA1_TKT_CIAP2_TP63 7.70E−07ATG3_DRAM_FAS_LC3_CDH1_MMP9_FASLG_SESN2 1.57E−06 SIRT1ATG3_FAS_LC3_ULK1_MMP9_FASLG_SESN2_ 1.60E−06ATG12_DIABLO_DRAM_FRAP1_CDH1_ID2_CIAP2_TP63 7.70E−07BNIP3_DRAM_FAS_LAMP1_LC3_ID2_FASLG_SESN2 1.57E−06 SESN3BNIP3_DRAM_FAS_LC3_ID2_MMP9_FASLG_UVRAG 1.60E−06ATG12_DRAM_FRAP1_PRKAA1_TKT_XIAP_CIAP2_TP63 7.70E−07ATG3_FAS_FRAP1_LC3_ID2_MMP9_FASLG_SESN2 1.57E−06ATG3_FAS_LC3_MMP9_TCF3_FASLG_SESN3_SIRT1 1.60E−06ATG12_DRAM_FRAP1_TKT_XIAP_CIAP2_RAGE_TP63 7.70E−07BNIP3_DRAM_FAS_LC3_MMP9_BECN1_FASLG_SESN2 1.58E−06ATG3_FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG 3.78E−06ATG3_DIABLO_FRAP1_CDH1_ID2_MMP9_TCF3_AGER 3.50E−06FAS_LC3_CDH1_ID2_MMP9_TCF3_FASLG_UVRAG 2.48E−06

The above tables present the p-value for each of the genes and theircombinations.

As can be confirmed from the above tables, each of the markers or theircombination shows p-values low enough to be considered significant interms of all of recurrence, survival, and disease-free survival. Inparticular, in the case of the combination of the two or more markers,all the p-values for recurrence, survival, and disease-free survivalwere low. In particular, it was found that there were cases where thep-value for a single marker was relatively high but the p-valuedecreased when the marker was used in combination with other marker. Asa p-value becomes lower, the statistical significance becomes higher.Thus, the low p-values suggest that the estimation for prognosis ofliver cancer by each of the markers or their combination is highlyaccurate.

This means that the more markers of the present disclosure are combined,the lower p-values, which means higher significance, are shown, whichmeans that the more improved accuracy would be achieved in theestimation for prognosis based on the combinations of the markers.

Thus, it was found that the markers and/or the combinations of markersof Tables 41˜48 are effective in predicting prognosis of liver cancer ofthe C group (recurrence, survival, disease-free survival), and that theprognosis of liver cancer of the C group can be predicted effectively bynucleic acids and antibodies targeted at the markers. Also, it can befound that the prognosis of liver cancer of the C group can be predictedeffectively by the method for predicting prognosis of liver cancer ofthe present disclosure, which is targeted at the markers.

Further, cross-validation was performed for combinations of markerswhich were considered statistically significant. Patients of eachpatient group were randomly divided into two groups (positive group: 35patients; test group: 34 patients). With the reference value which wasconsidered statistically significant in the results of the positivegroup obtained in the same manner as Example 1 fixed, for the testgroup, the accuracy of estimation was calculated to be the level ofp<0.05 or p<0.001 with respect to recurrence, survival and disease-freesurvival.

Among the results of cross-validation of the prediction of therecurrence, survival and disease-free survival of the C group,representative examples showing the excellent accuracy of prognosis ineach aspect are as follows:

Recurrence: FAS_TCF3_FASLG_RPS19BP1 (69.0% at the level of p<0.05)

Survival: CASP3_CDH2_CIAP2 (77.0% at the level of p<0.05)

Disease-free survival: FAS_TCF3_FASLG (75.0% at the level of p<0.05)

INDUSTRIAL APPLICABILITY

The present disclosure provides a marker for predicting prognosis ofliver cancer, a composition or kit for predicting prognosis of livercancer, preferably a composition or kit for predicting prognosis ofliver cancer for predicting liver cancer according to stage, and amethod for predicting prognosis of liver cancer. The marker, compositionor kit, and method of the present disclosure make it possible toeffectively predict prognosis of liver cancer, preferably, prognosis ofliver cancer according to stage.

1. A composition or kit for predicting prognosis of liver cancercomprising nucleic acids which are specific to each of one or at leasttwo genes selected from the group described in Table 1, or antibodieswhich are specific to proteins encoded by said genes; and for predictingprognosis of liver cancer according to stage in one or more groupsselected from A1 group {a group of portal vein invasion-negativepatients in stage 0 or A of BCLC (Barcelona-Clinic Liver Cancer) stagingsystem, having one tumor which is 5 cm or less in size, or 3 or lesstumors which are 3 cm or less in size}, A2 group {a group of portal veininvasion-negative patients, having a tumor which is more than 5 cm insize}, B group {a group of portal vein invasion-negative patients inintermediate stage of BCLC staging system, having plural tumors whichare more than 3 cm in size or plural tumors which are more than 3 innumber}, or C group {a group of portal vein invasion-positive patientsregardless of tumors size and number}.
 2. The composition or kit ofclaim 1, wherein the group consisting of genes is a group consisting ofthe genes described in Table
 2. 3. The composition or kit of claim 2,wherein the group consisting of genes further comprises the genesdescribed in Table
 3. 4. The composition or kit of claim 1, wherein theprognosis is prediction of recurrence, survival, or disease-freesurvival.
 5. The composition or kit of claim 1 for predicting theprognosis of recurrence of the A1 group, wherein the genes are one ormore selected from the genes or groups of genes described in Table
 4. 6.The composition or kit of claim 1 for predicting the prognosis ofsurvival of the A1 group, wherein the genes are one or more selectedfrom the genes or groups of genes described in Table
 5. 7. Thecomposition or kit of claim 1 for predicting the prognosis ofdisease-free survival of the A1 group, wherein the genes are one or moreselected from the genes or groups of genes described in Table
 6. 8. Thecomposition or kit of claim 1 for predicting the prognosis of recurrenceof the A2 group, wherein the genes are one or more selected from thegenes or groups of genes described in Table
 7. 9. The composition or kitof claim 1 for predicting the prognosis of survival of the A2 group,wherein the genes are one or more selected from the genes or groups ofgenes described in Table
 8. 10. The composition or kit of claim 1 forpredicting the prognosis of disease-free survival of the A2 group,wherein the genes are one or more selected from the genes or groups ofgenes described in Table
 9. 11. The composition or kit of claim 1 forpredicting the prognosis of recurrence of the B group, wherein the genesare one or more selected from the genes or groups of genes described inthe following Table: Table
 10. 12. The composition or kit of claim 1 forpredicting the prognosis of survival of the B group, wherein the genesare one or more selected from the genes or groups of genes described inTable
 11. 13. The composition or kit of claim 1 for predicting theprognosis of disease-free survival of the B group, wherein the genes areone or more selected from the genes or groups of genes described inTable
 12. 14. The composition or kit of claim 1 for predicting theprognosis of recurrence of the C group, wherein the genes are one ormore selected from the genes or groups of genes described in Table 13.15. The composition or kit of claim 1 for predicting the prognosis ofsurvival of the C group, wherein the genes are one or more selected fromthe genes or groups of genes described in Table
 14. 16. The compositionor kit of claim 1 for predicting the prognosis of disease-free survivalof the C group, wherein the genes are one or more selected from thegenes or groups of genes described in Table
 15. 17. The composition orkit of claim 1, wherein the nucleic acids are primers or probes.
 18. Thecomposition or kit of claim 1, wherein the prognosis of liver cancer isprediction of prognosis after liver resection for cancer.
 19. Thecomposition or kit for predicting prognosis of liver cancer comprisingnucleic acids which are specific to each of one or at least two genesselected from the group described in Table 2, or antibodies which arespecific to proteins encoded by said genes.
 20. The composition or kitof claim 19, wherein the group of genes further comprises the genesdescribed in Table
 3. 21. The composition or kit of claim 19, whereinthe nucleic acids are primers or probes.
 22. The composition or kit ofclaim 19, wherein the predicting prognosis of liver cancer is predictingprognosis after liver resection for cancer.
 23. A method of forpredicting prognosis of liver cancer according to stage comprising (A)detecting one or more selected from the expression level or expressionpattern of one or at least two genes selected from the group consistingof the genes described in Table 1 in samples obtained from patients ofliver cancer; and (B) comparing the results of the (A) step with themeasurement results of the control groups to predict prognosis of livercancer, wherein the patients of liver cancer are in one or more groupsselected from A1 group {a group of portal vein invasion-negativepatients in stage 0 or A of BCLC (Barcelona-Clinic Liver Cancer) stagingsystem, having a tumor which is 5 cm or less in size, or 3 or lesstumors which are 3 cm or less in size}, A2 group {a group of portal veininvasion-negative patients, having a tumor which is more than 5 cm insize}, B group {a group of portal vein invasion-negative patients inintermediate stage of BCLC staging system, having plural tumors whichare more than 3 cm in size or plural tumors which are more than 3 innumber}, or C group {a group of portal vein invasion-positive patientsregardless of tumors size and number}.
 24. The method of claim 23,wherein the group consisting of genes is a group consisting of the genesdescribed in Table
 2. 25. The method of claim 23, wherein the groupconsisting of genes further comprises the genes described in Table 3.26. The method of claim 23 for predicting the prognosis of recurrence ofthe A1 group, wherein the genes are one or more selected from the genesor groups of genes described in Table
 4. 27. The method of claim 23 forpredicting the prognosis of survival of the A1 group, wherein the genesare one or more selected from the genes or groups of genes described inTable
 5. 28. The method of claim 23 for predicting the prognosis ofdisease-free survival of the A1 group, wherein the genes are one or moreselected from the genes or groups of genes described in Table
 6. 29. Themethod of claim 23 for predicting the prognosis of recurrence of the A2group, wherein the genes are one or more selected from the genes orgroups of genes described in Table
 7. 30. The method of claim 23 forpredicting the prognosis of survival of the A2 group, wherein the genesare one or more selected from the genes or groups of genes described inTable
 8. 31. The method of claim 23 for predicting the prognosis ofdisease-free survival of the A2 group, wherein the genes are one or moreselected from genes or groups of genes described in Table
 9. 32. Themethod of claim 23 for predicting the prognosis of recurrence of the Bgroup, wherein the genes are one or more selected from the genes orgroups of genes described in Table
 10. 33. The method of claim 23 forpredicting the prognosis of survival of the B group, wherein the genesare one or more selected from the genes or groups of genes described inTable
 11. 34. The method of claim 23 for predicting the prognosis ofdisease-free survival of the B group, wherein the genes are one or moreselected from the genes or groups of genes described in Table
 12. 35.The method of claim 23 for predicting the prognosis of recurrence of theC group, wherein the genes are one or more selected from the genes orgroups of genes described in Table
 13. 36. The method of claim 23 forpredicting the prognosis of survival of the C group, wherein the genesare one or more selected from the genes or groups of genes described inTable
 14. 37. The method of claim 23 for predicting the prognosis ofdisease-free survival of the C group, wherein the genes are one or moreselected from the genes or groups of genes described in Table
 15. 38.The method of 23, wherein the expression level or expression pattern ofa protein is detected by one or more selected from RT-PCR, competitiveRT-PCR, real-time RT-PCT, RNase protection assay, Northern blot, DNAmicroarray, western bolt, ELISA (enzyme linked immunosorbent assay),radioimmunoassay, radioimmunodiffusion, Ouchterlony immunodiffusion,rocket immunoelectrophoresis, tissue immunity staining,immunoprecipitation assay, complement fixation assay, FACS or proteinchip.
 39. A method for predicting prognosis of liver cancer comprising(A) detecting in one or more selected from the expression level orexpression pattern of one or at least two gene selected from the groupconsisting of the genes described in Table 2 in samples obtained frompatients of liver cancer; and (B) comparing the results of the (A) stepwith the measurement results of the control groups to predict theprognosis of liver cancer.
 40. The method of claim 39, wherein the groupconsisting of genes further comprises the genes described in Table 3.41. The method of claim 39, wherein the expression level or expressionpattern of a protein is detected by one or more selected from RT-PCR,competitive RT-PCR, real-time RT-PCT, RNase protection assay, Northernblot, DNA microarray, western bolt, ELISA (enzyme linked immunosorbentassay), radioimmunoassay, radioimmunodiffusion, Ouchterlonyimmunodiffusion, rocket immunoelectrophoresis, tissue immunity staining,immunoprecipitation assay, complement fixation assay, FACS or proteinchip.